G-CSF Secreted by Mutant IDH1 Glioma Stem Cells Abolishes Myeloid Cell Immunosuppression and Enhances the Efficacy of Immunotherapy

The authors showed that the efficacy of immune-stimulatory gene therapy was enhanced in isocitrate-dehydrogenase 1 (mIDH1) gliomas, due to the reprogramming of the myeloid cells’ compartment infiltrating the tumor microenvironment.
[Science Advances]
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Stereospecific Inhibition of AMPK by (R)-Crizotinib Induced Changes to the Morphology and Properties of Cancer and Cancer Stem Cell-Like Cells

While (R)-crizotinib induced changes in morphologies or sizes of cells, (S)-crizotinib did not. Pretreatment with (R)-crizotinib suppressed the proliferation of cancer or CSC-like cells in vitro and tumor growth in vivo.
[European Journal of Pharmacology]
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ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression

Mechanistically, ALDH1A1 decreased the intracellular pH in breast cancer cells to promote phosphorylation of TAK1, activated NFκB signaling, and increased the secretion of granulocyte macrophage colony-stimulating factor, which led to myeloid-derived suppressor cell expansion and immunosuppression.
[Cancer Research]
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SIRPα-αCD123 Fusion Antibodies Targeting CD123 in Conjunction with CD47 Blockade Enhance the Clearance of AML-Initiating Cells

SIRPα-αCD123 antibodies were generated by fusing the extracellular domain of SIRPα to an αCD123 antibody. The binding properties of the antibodies were analyzed by flow cytometry and surface plasmon resonance.
[Journal of Hematology & Oncology]
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Self-Functional Gold Nanoprobes for Intra-Nuclear Epigenomic Monitoring of Cancer Stem-Like Cells

Investigators developed unique sub-10 nm Self-functional Gold Nanoprobes as a CSC epigenomic monitoring platform that could easily maneuver into the nucleus while not producing any conformal changes to the genomic DNA.
[Biosensors & Bioelectronics]
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An Enhancer-Driven Stem Cell-Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer

Intestinal tissue from transgenic mice and patients were analyzed by histopathology and immunostaining. Human CRC cells and neoplastic murine organoids were genetically manipulated for functional studies.
[Gastroenterology]
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Inhibition of Autophagy Mitigates Cell Migration and Invasion in Thyroid Cancer

Validated papillary, follicular, and anaplastic human thyroid cancer cell lines in culture were first assessed for autophagic capacity after bafilomycin clamping.
[Surgery]
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Tinzaparin Inhibits VL30 Retrotransposition Induced by Oxidative Stress and/or VEGF in HC11 Mouse Progenitor Mammary Cells: Association between Inhibition of Cancer Stem Cell Proliferation and Mammosphere Disaggregation

The authors investigated the effect of tinzaparin on VL30 retrotransposition‑positive mouse HC11 mammary stem‑like epithelial cells, previously reported to be associated with induced mammosphere/cancer stem cell (CSC) generation and tumorigenesis.
[Oncology Reports]
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Adaptive Mechanoproperties Mediated by the Formin FMN1 Characterize Glioblastoma Fitness for Invasion

Scientists identified clones of patient-derived glioma propagating cells that were either highly proliferative or highly invasive and compared their cellular architecture, migratory, and biophysical properties.
[Developmental Cell]
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Macrophages and Cancer Stem Cells: A Malevolent Alliance

In view of the recent success in oncology obtained by stimulating the immune system, scientists discuss some macrophage-targeted therapeutic strategies that may also affect the CSCs and interrupt their malevolent alliance.
[Molecular Medicine]
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Lung Cancer Stem Cells and Their Clinical Implications

Mouse models of lung cancer have shown that lung CSCs reside in niches that are essential for the maintenance of stemness, plasticity, enable antitumor immune evasion, and provide metastatic potential.
[Cold Spring Harbor Perspectives in Medicine]
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