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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Bortezomib Suppresses Acute Myelogenous Leukemia Stem-Like KG-1a Cells via NF-κB Inhibition and the Induction of Oxidative Stress
[Journal Of Cellular And Molecular Medicine] Scientists investigated the anti-acute myelogenous leukemia (AML) activity of bortezomib, emphasizing its anti-leukemic stem cells potential, using KG-1a cells, an AML cell line with stem-like properties.
Integrated Drug Profiling and CRISPR Screening Identify BCR::ABL1-Independent Vulnerabilities in Chronic Myeloid Leukemia
[Cell Reports Medicine] The authors performed ex vivo drug screening of CML CD34+ leukemic stem/progenitor cells using 100 single drugs and tyrosine kinase inhibitor-drug combinations and identify sensitivities to Wee1, MDM2, and BCL2 inhibitors.
Dutch Cancer Society Grant to Study How Fatty Liver Disease Can Contribute to Liver Cancer
[Hubrecht Institute] Delilah Hendriks, researcher from the Organoid group, Oncode researcher, and affiliated group leader at the Princess Máxima Center has received a Young Investigator Grant from the Dutch Cancer Society.
Oncolytic Herpes Simplex Virus Expressing IL-2 Controls Glioblastoma Growth and Improves Survival
[Journal For Immunotherapy Of Cancer] The authors developed G47Δ-mIL2 using the flip-flop herpes simplex virus BAC system to deliver IL-2 locally within the tumor microenvironment (TME). They then tested its efficacy in orthotopic mouse GBM models and evaluated immune profiles in the treated tumors and spleens by flow cytometry and immunohistochemistry.
Cancer Stem Cell-Immune Cell Crosstalk in the Tumor Microenvironment for Liver Cancer Progression
[Frontiers Of Medicine] Scientists shed light on the bidirectional crosstalk between liver CSCs and immune cells for liver cancer progression, as well as the underlying molecular mechanisms after presenting an overview of liver CSCs characteristic and their microenvironment.
TAK1 Inhibition Leads to RIPK1-Dependent Apoptosis in Immune-Activated Cancers
[Cell Death & Disease] To identify novel therapeutic approaches, researchers performed CRISPR/Cas9 knockout screens and discovered TGFβ activated kinase (TAK1) as a selective survival factor in a significant fraction of glioma stem cells.
MSLN Induced EMT, Cancer Stem Cell Traits and Chemotherapy Resistance of Pancreatic Cancer Cells
[Heliyon] The authors investigated the potential roles of mesothelin (MSLN) in chemoresistance and its relationship with proliferation, epithelial-mesenchymal transition, and cancer stemness of pancreatic cancer cells. Human pancreatic cancer cell lines ASPC-1 and Mia PaCa-2 with high and low expression of MSLN, respectively, were selected.
Tumor Endothelial Cell-Derived Sfrp1 Supports the Maintenance of Cancer Stem Cells via Wnt Signaling
[In Vitro Cellular & Developmental Biology - Animal] Investigators elucidated angiocrine factors related to CSC maintenance, focusing on Secreted frizzled-related protein 1 (Sfrp1). Although Sfrp1 is a Wnt pathway-related factor, its impact on tumor tissues remains unknown.
DNMT1/miR-152-3p/SOS1 Signaling Axis Promotes Self-Renewal and Tumor Growth of Cancer Stem-Like Cells Derived from Non-small Cell Lung Cancer
[Clinical Epigenetics] Researchers elucidated the underlying mechanism involving the DNMT1/miR-152-3p/SOS1 axis in regulating the self-renewal and tumor growth of lung cancer stem-like cells.
A Multistep In Silico Approach Identifies Potential Glioblastoma Drug Candidates via Inclusive Molecular Targeting of Glioblastoma Stem Cells
[Molecular Neurobiology] Researchers used a multistep in silico screening strategy to identify repurposed candidate drugs against selected therapeutic molecular targets in glioblastoma with potential to concomitantly target glioblastoma stem cells.
Evaxion Announces Phase II Clinical Trial Update: First Patient Completed Dosing with Personalized Cancer Vaccine EVX-01
[Evaxion Biotech A/S] Evaxion Biotech A/S announced that the first patient in its EVX-01 Phase II trial in metastatic melanoma received the last vaccine dose in combination with KEYTRUDA®. The company initiated its Phase II clinical study to assess the efficacy, safety, and ability to induce a tumor-specific immune response of the EVX-01 cancer vaccine in metastatic melanoma patients.
Dynamic Molecular Network Analysis of iPSC-Purkinje Cells Differentiation Delineates Roles of ISG15 in SCA1 at the Earliest Stage
[Communications Biology] The authors investigated the earliest molecular pathology of spinocerebellar ataxia type 1 (SCA1), a rare familial neurodegenerative disease that primarily induces death and dysfunction of cerebellum Purkinje cells.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
