Caudatin Isolated from Cynanchum auriculatum Inhibits Breast Cancer Stem Cell Formation via a GR/YAP Signaling

Caudatin inhibited breast cancer cell proliferation, mammosphere formation and tumor growth. Caudatin decreased the CD44+/CD24 and aldehyde dehydrogenase positive cell proportions and the levels of c-Myc, Oct4, Sox2, and CD44.
[Biomolecules]
Zhen, X., Choi, H. S., Kim, J.-H., Kim, S.-L., Liu, R., Ko, Y.-C., Yun, B.-S., & Lee, D.-S. (2020). Caudatin Isolated from Cynanchum auriculatum Inhibits Breast Cancer Stem Cell Formation via a GR/YAP Signaling. Biomolecules, 10(6), 925. https://doi.org/10.3390/biom10060925 Cite
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Prognostic Value of Circulating Tumor Cells Detected with the CellSearch System in Esophageal Cancer Patients: A Systematic Review and Meta-Analysis

The authors demonstrated that circulating tumor cells positivity determined by the CellSearch system were correlated with the prognosis of esophageal carcinoma (EC) patients and might indicate a poor therapeutic response to chemotherapy in EC patients.
[BMC Cancer]
Li, Y., Wu, G., Yang, W., Wang, X., Duan, L., Niu, L., Zhang, Y., Liu, J., Hong, L., & Fan, D. (2020). Prognostic value of circulating tumor cells detected with the CellSearch system in esophageal cancer patients: a systematic review and meta-analysis. BMC Cancer, 20(1), 581. https://doi.org/10.1186/s12885-020-07059-x Cite
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Marker Therapeutics Receives USAN Approval for “Zelenoleucel” as Nonproprietary Name for MT-401, Multi-Tumor-Associated Antigen Targeted T Cell Product for Acute Myeloid Leukemia

Marker Therapeutics, Inc. announced that the United States Adopted Names Council has approved “zelenoleucel” as the nonproprietary name for MT-401, a multi-tumor-associated antigen-specific T cell product candidate for the treatment of patients with acute myeloid leukemia following allogeneic stem cell transplant in both adjuvant and active disease settings.
[Marker Therapeutics, Inc.]
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Molecular Characterization of Circulating Tumor Cells Identifies Predictive Markers for Outcome in Primary, Triple‐Negative Breast Cancer Patients

mRNA profiles of circulating tumor cells were analysed in patients with triple‐negative breast cancer before and after therapy to identify additional treatment options.
[Journal of Cellular and Molecular Medicine]
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Cytochrome P450 1B1 Polymorphism Drives Cancer Cell Stemness and Patient Outcome in Head-and-Neck Carcinoma

From head-and-neck squamous cell carcinoma cell lines not expressing CYP1B1, investigators generated isogenic derivatives expressing the two forms. Proliferation, invasiveness, stem cell characteristics, sensitivity to anticancer agents and transcriptome were analyzed.
[British Journal of Cancer]
Morvan, V. L., Richard, É., Cadars, M., Fessart, D., Broca-Brisson, L., Auzanneau, C., Pasquies, A., Modesto, A., Lusque, A., Mathoulin-Pélissier, S., Lansiaux, A., & Robert, J. (2020). Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma. British Journal of Cancer, 1–13. https://doi.org/10.1038/s41416-020-0932-5 Cite
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Quantitative Proteomics Reveals Specific Metabolic Features of Acute Myeloid Leukemia Stem Cells

By comparing leukemic stem cells (LSCs) to leukemic blasts and healthy hematopoietic stem and progenitor cells (HSPCs), researchers validated candidate LSC markers and highlight novel and potentially targetable proteins that are absent or only lowly expressed in HSPCs.
[Blood]
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Signaling Inhibitors Accelerate the Conversion of Mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment

Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
[Scientific Reports]

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Isoprenylcysteine Carboxylmethyltransferase Is Required for the Impact of Mutant KRAS on TAZ Protein Level and Cancer Cell Self-Renewal

The authors found that suppression of isoprenylcysteine carboxylmethyltransferase resulted in reduced self-renewal/stemness in KRAS-driven pancreatic and breast cancer cells.
[Oncogene]
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Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia

Scientists report that a positive modulator of canonical WNT signaling pathway, RSPO-LGR4, upregulates key self-renewal genes and is essential for leukemia stem cell self-renewal in a subset of acute myeloid leukemia.
[Cell Stem Cell]
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p53 Destabilizing Protein Skews Asymmetric Division and Enhances NOTCH Activation to Direct Self-Renewal of TICs

Researchers identified TBC1D15-mediated oncogenic mechanisms and tested the tumorigenic roles of TBC1D15 in vivo.
[Nature Communications]
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Tocilizumab Potentiates Cisplatin Cytotoxicity and Targets Cancer Stem Cells in Triple‐Negative Breast Cancer

Tocilizumab suppressed the stemness‐related characteristics of triple‐negative breast cancer cells, through the inhibition of the Wnt/β‐catenin breast cancer stem cell‐related pathway.
[Molecular Carcinogenesis]
Alraouji, N. N., Al‐Mohanna, F. H., Ghebeh, H., Arafah, M., Almeer, R., Al‐Tweigeri, T., & Aboussekhra, A. (n.d.). Tocilizumab potentiates cisplatin cytotoxicity and targets cancer stem cells in triple-negative breast cancer. Molecular Carcinogenesis, n/a(n/a). https://doi.org/10.1002/mc.23234 Cite
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