Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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A Self-Sustaining Endocytic-Based Loop Promotes Breast Cancer Plasticity Leading to Aggressiveness and Pro-Metastatic Behavior

Investigators report that Epsin 3 is an oncogene with prognostic and therapeutic relevance in breast cancer.
[Nature Communications]
Schiano Lomoriello, I., Giangreco, G., Iavarone, C., Tordonato, C., Caldieri, G., Serio, G., Confalonieri, S., Freddi, S., Bianchi, F., Pirroni, S., Bertalot, G., Viale, G., Disalvatore, D., Tosoni, D., Malabarba, M. G., Disanza, A., Scita, G., Pece, S., Pilcher, B. K., … Di Fiore, P. P. (2020). A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior. Nature Communications, 11(1), 3020. https://doi.org/10.1038/s41467-020-16836-y Cite
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Dual Role of WISP1 in Maintaining Glioma Stem Cells and Tumor-Supportive Macrophages in Glioblastoma

Researchers showed that glioma stem cells (GSCs) secreted the Wnt‐induced signaling protein 1 (WISP1) to facilitate a pro-tumor microenvironment by promoting the survival of both GSCs and tumor-associated macrophages.
[Nature Communications]
Tao, W., Chu, C., Zhou, W., Huang, Z., Zhai, K., Fang, X., Huang, Q., Zhang, A., Wang, X., Yu, X., Huang, H., Wu, Q., Sloan, A. E., Yu, J. S., Li, X., Stark, G. R., Rich, J. N., & Bao, S. (2020). Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma. Nature Communications, 11(1), 3015. https://doi.org/10.1038/s41467-020-16827-z Cite
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MicroRNA-128-3p Enhances the Chemosensitivity of Temozolomide in Glioblastoma by Targeting c-Met and EMT

The effects of miR-128-3p and temozolomide (TMZ) on the proliferation of glioblastoma cells were investigated by cell counting kit-8. Transwell and intracerebral invasion assays were applied to determine the effects of the combination of miR-128-3p and TMZ on the invasion and migration of glioblastoma in vitro and in vivo.
[Scientific Reports]
Zhao, C., Guo, R., Guan, F., Ma, S., Li, M., Wu, J., Liu, X., Li, H., & Yang, B. (2020). MicroRNA-128-3p Enhances the Chemosensitivity of Temozolomide in Glioblastoma by Targeting c-Met and EMT. Scientific Reports, 10(1), 9471. https://doi.org/10.1038/s41598-020-65331-3 Cite
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Caveolin-1 Inhibits Breast Cancer Stem Cells via c-Myc-Mediated Metabolic Reprogramming

Scientists demonstrated that the downregulation of caveolin-1 usually occurred in breast cancer stem cells and was associated with a metabolic switch from mitochondrial respiration to aerobic glycolysis.
[Cell Death & Disease]
Wang, S., Wang, N., Zheng, Y., Yang, B., Liu, P., Zhang, F., Li, M., Song, J., Chang, X., & Wang, Z. (2020). Caveolin-1 inhibits breast cancer stem cells via c-Myc-mediated metabolic reprogramming. Cell Death & Disease, 11(6), 1–16. https://doi.org/10.1038/s41419-020-2667-x Cite
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A Positive Feedback Loop between c-Myc Up-Regulation, Glycolytic Shift and Histone Acetylation Enhances Cancer Stem Cell-Like Property and Tumorigenicity of Cr(VI)-Transformed Cells

Researchers investigated the potential role and mechanism of metabolism dysregulation in chronic hexavalent chromium [Cr(VI)] carcinogenesis. It was found that Cr(VI)-transformed cells displayed glycolytic shift, which depends on the up-regulation of c-Myc.
[Toxicological Sciences]
Clementino, M., Xie, J., Yang, P., Li, Y., Lin, H.-P., Fenske, W. K., Tao, H., Kondo, K., Yang, C., & Wang, Z. (n.d.). A positive feedback loop between c-Myc up-regulation, glycolytic shift and histone acetylation enhances cancer stem cell-like property and tumorigenicity of Cr(VI)-transformed cells. Toxicological Sciences. https://doi.org/10.1093/toxsci/kfaa086 Cite
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Ibuprofen Mediates Histone Modification to Diminish Cancer Cell Stemness Properties via a COX2-Dependent Manner

The authors report that ibuprofen diminished cancer cell stemness properties that include reducing the ALDH+ subpopulation, side population and sphere formation in three cancer types.
[British Journal of Cancer]
Shen, W., Zhang, X., Du, R., Gao, W., Wang, J., Bao, Y., Yang, W., Luo, N., & Li, J. (2020). Ibuprofen mediates histone modification to diminish cancer cell stemness properties via a COX2-dependent manner. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-0906-7 Cite
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ARS2/MAGL Signaling in Glioblastoma Stem Cells Promotes Self-Renewal and M2-Like Polarization of Tumor-Associated Macrophages

Investigators demonstrated that arsenite-resistance protein 2 (ARS2), a zinc finger protein that is essential for early mammalian development, played critical roles in glioblastoma stem cell maintenance and M2-like tumor-associated macrophage polarization.
[Nature Communications]
Yin, J., Kim, S. S., Choi, E., Oh, Y. T., Lin, W., Kim, T.-H., Sa, J. K., Hong, J. H., Park, S. H., Kwon, H. J., Jin, X., You, Y., Kim, J. H., Kim, H., Son, J., Lee, J., Nam, D.-H., Choi, K. S., Shi, B., … Park, J. B. (2020). ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages. Nature Communications, 11(1), 2978. https://doi.org/10.1038/s41467-020-16789-2 Cite
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Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells

Scientists identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, suppressed SCLC expansion in culture and in vivo.
[Cancer Cell]
Coles, G. L., Cristea, S., Webber, J. T., Levin, R. S., Moss, S. M., He, A., Sangodkar, J., Hwang, Y. C., Arand, J., Drainas, A. P., Mooney, N. A., Demeter, J., Spradlin, J. N., Mauch, B., Le, V., Shue, Y. T., Ko, J. H., Lee, M. C., Kong, C., … Sage, J. (2020). Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.05.003 Cite
AbstractGraphical Abstract
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Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Researchers showed that genetic depletion and pharmacological inhibition of fat mass and obesity-associated protein dramatically attenuated leukemia stem/initiating cell self-renewal and reprogrammed immune response by suppressing expression of immune checkpoint genes, especially LILRB4.
[Cancer Cell]
Su, R., Dong, L., Li, Y., Gao, M., Han, L., Wunderlich, M., Deng, X., Li, H., Huang, Y., Gao, L., Li, C., Zhao, Z., Robinson, S., Tan, B., Qing, Y., Qin, X., Prince, E., Xie, J., Qin, H., … Chen, J. (2020). Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.04.017 Cite
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CSL Behring and Seattle Children’s Research Institute to Advance Gene Therapy Treatments for Primary Immunodeficiency Diseases

Seattle Children’s Research Institute and CSL Behring announced a strategic alliance to develop stem cell gene therapies for primary immunodeficiency diseases.
[Seattle Children’s Research Institute]
Press Release
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