Melanoma Stem Cell Maintenance and Chemo-Resistance Are Mediated by CD133 Signal to PI3K-Dependent Pathways

The functional analysis of CD133+ and CD133 cells in vitro and in vivo revealed that melanoma progression and treatment resistance are the consequences of CD133 signal to PI3K pathway.
[Oncogene]
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CDK5RAP3 as Tumor Suppressor Negatively Regulates Self-Renewal and Invasion and Is Regulated by ERK1/2 Signaling in Human Gastric Cancer

Researchers showed that CDK5 regulatory subunit-associated protein 3 was weakly expressed in gastric cancer stem-like cells (CSCs) and was negatively correlated with the gastric CSC marker CD44.
[British Journal of Cancer]
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TGF-β Induced EMT and Stemness Characteristics are Associated with Epigenetic Regulation in Lung Cancer

Scientists determined whether EMT and stemness characteristics induced by TGF-β might be associated with epigenetic regulation in lung cancer.
[Scientific Reports]
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JAM-A Functions as a Female Microglial Tumor Suppressor in Glioblastoma

Investigators studied the role of microenvironmental junctional adhesion molecule-A (JAM-A) in mediating glioblastoma growth.
[Neuro-Oncology]
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Targeting CD70 with Cusatuzumab Eliminates Acute Myeloid Leukemia Stem Cells in Patients Treated with Hypomethylating Agents

Scientists demonstrated that leukemia stem cells upregulated the tumor necrosis factor family ligand CD70 in response to hypomethylating agent treatment resulting in increased CD70/CD27 signaling.
[Nature Medicine]
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Protein Sumoylation with SUMO1 Promoted by Pin1 in Glioma Stem Cells Augments Glioblastoma Malignancy

Researchers investigated the protein sumoylation status, the major sumoylated substrate and the key regulatory enzyme in glioma stem cells to explore the therapeutic potential of disrupting protein sumoylation for glioblastoma treatment.
[Neuro-Oncology]
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NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]
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Gender Gap in Research Output Widens during Pandemic

A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist]
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Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying [the online testing] criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]
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COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]
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Radiotherapy Targeting Cancer Stem Cells “Awakens” Them to Induce Tumor Relapse and Metastasis in Oral Cancer

Researchers summarzse methods for the identification of oral CSCs and then focus on the characteristics of a CSC subpopulation induced by radiation, hereafter referred to as “awakened” CSCs, to highlight their response to radiotherapy and potential role in tumor recurrence and metastasis post-radiotherapy as well as potential therapeutics targeting CSCs.
[International Journal of Oral Science]
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