CSL Behring and Seattle Children’s Research Institute to Advance Gene Therapy Treatments for Primary Immunodeficiency Diseases

Seattle Children’s Research Institute and CSL Behring announced a strategic alliance to develop stem cell gene therapies for primary immunodeficiency diseases.
[Seattle Children’s Research Institute]
Press Release
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SH3RF3 Promotes Breast Cancer Stem-Like Properties via JNK Activation and PTX3 Upregulation

Scientists identified a scaffold protein SH3RF3 that was upregulated in CSCs of breast cancer clinical tumors and cancer cell lines, and enhanced the CSC properties of breast cancer cells.
[Nature Communications]
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Critical Role of SOX2–IGF2 Signaling in Aggressiveness of Bladder Cancer

Researchers found SOX2 expression signifies poor recurrence-free survival and correlates with advanced pathological grade in bladder cancer. SOX2 silencing attenuated bladder cancer cell growth, while its expression promoted cancer cell survival and proliferation.
[Scientific Reports]
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Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal

The authors found increased mRNA expression of mitochondrial intermembrane assembly pathway substrates in acute myeloid leukemia stem cells.
[Cell Stem Cell]
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Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors

Researchers showed integrin-linked kinase, a key constituent of focal adhesions, is highly expressed in TKI-nonresponsive patient cells and their LSCs.
[Cell Stem Cell]
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NCCN Foundation Awards Leading Young Investigators Advancing Cancer Research for Adults and Children

The National Comprehensive Cancer Network® and the NCCN Foundation® announced five new recipients for the 10th annual NCCN Foundation Young Investigator Awards Program.
[National Comprehensive Cancer Network]
Editorial
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