Dual Role of WISP1 in Maintaining Glioma Stem Cells and Tumor-Supportive Macrophages in Glioblastoma

Researchers showed that glioma stem cells (GSCs) secreted the Wnt‐induced signaling protein 1 (WISP1) to facilitate a pro-tumor microenvironment by promoting the survival of both GSCs and tumor-associated macrophages.
[Nature Communications]
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MicroRNA-128-3p Enhances the Chemosensitivity of Temozolomide in Glioblastoma by Targeting c-Met and EMT

The effects of miR-128-3p and temozolomide (TMZ) on the proliferation of glioblastoma cells were investigated by cell counting kit-8. Transwell and intracerebral invasion assays were applied to determine the effects of the combination of miR-128-3p and TMZ on the invasion and migration of glioblastoma in vitro and in vivo.
[Scientific Reports]
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Caveolin-1 Inhibits Breast Cancer Stem Cells via c-Myc-Mediated Metabolic Reprogramming

Scientists demonstrated that the downregulation of caveolin-1 usually occurred in breast cancer stem cells and was associated with a metabolic switch from mitochondrial respiration to aerobic glycolysis.
[Cell Death & Disease]
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A Positive Feedback Loop between c-Myc Up-Regulation, Glycolytic Shift and Histone Acetylation Enhances Cancer Stem Cell-Like Property and Tumorigenicity of Cr(VI)-Transformed Cells

Researchers investigated the potential role and mechanism of metabolism dysregulation in chronic hexavalent chromium [Cr(VI)] carcinogenesis. It was found that Cr(VI)-transformed cells displayed glycolytic shift, which depends on the up-regulation of c-Myc.
[Toxicological Sciences]
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Ibuprofen Mediates Histone Modification to Diminish Cancer Cell Stemness Properties via a COX2-Dependent Manner

The authors report that ibuprofen diminished cancer cell stemness properties that include reducing the ALDH+ subpopulation, side population and sphere formation in three cancer types.
[British Journal of Cancer]
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ARS2/MAGL Signaling in Glioblastoma Stem Cells Promotes Self-Renewal and M2-Like Polarization of Tumor-Associated Macrophages

Investigators demonstrated that arsenite-resistance protein 2 (ARS2), a zinc finger protein that is essential for early mammalian development, played critical roles in glioblastoma stem cell maintenance and M2-like tumor-associated macrophage polarization.
[Nature Communications]
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Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells

Scientists identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, suppressed SCLC expansion in culture and in vivo.
[Cancer Cell]
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Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Researchers showed that genetic depletion and pharmacological inhibition of fat mass and obesity-associated protein dramatically attenuated leukemia stem/initiating cell self-renewal and reprogrammed immune response by suppressing expression of immune checkpoint genes, especially LILRB4.
[Cancer Cell]
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CSL Behring and Seattle Children’s Research Institute to Advance Gene Therapy Treatments for Primary Immunodeficiency Diseases

Seattle Children’s Research Institute and CSL Behring announced a strategic alliance to develop stem cell gene therapies for primary immunodeficiency diseases.
[Seattle Children’s Research Institute]
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SH3RF3 Promotes Breast Cancer Stem-Like Properties via JNK Activation and PTX3 Upregulation

Scientists identified a scaffold protein SH3RF3 that was upregulated in CSCs of breast cancer clinical tumors and cancer cell lines, and enhanced the CSC properties of breast cancer cells.
[Nature Communications]
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Critical Role of SOX2–IGF2 Signaling in Aggressiveness of Bladder Cancer

Researchers found SOX2 expression signifies poor recurrence-free survival and correlates with advanced pathological grade in bladder cancer. SOX2 silencing attenuated bladder cancer cell growth, while its expression promoted cancer cell survival and proliferation.
[Scientific Reports]
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