Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

Single-Cell Analysis of Anti-BCMA CAR T Cell Therapy in Patients with Central Nervous System Autoimmunity

[Science Immunology] Investigators performed single-cell multi-omics sequencing of paired cerebrospinal fluid and blood samples from patients with neuromyelitis optica spectrum disorder treated with anti–B cell maturation antigen (BCMA) CAR T cells.

Unveiling the Proteome-Wide Autoreactome Enables Enhanced Evaluation of Emerging CAR-T Therapies in Autoimmunity

[European Journal Of Clinical Investigation] Researchers leveraged advances in programmable-phage immunoprecipitation methodology to explore the modulation, or lack thereof, of autoantibody profiles, proteome-wide, in both health and disease.

Arming Vδ2 T Cells With Chimeric Antigen Receptors to Combat Cancer

[Clinical Cancer Research] Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, investigators discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.

Engineered CRISPR-Cas12a for Higher-Order Combinatorial Chromatin Perturbations

[Nature Biotechnology] Investigators engineered an Acidaminococcus Cas12a (AsCas12a) variant, multiplexed transcriptional interference AsCas12a, that incorporated R1226A, a mutation that stabilized the ribonucleoprotein–DNA complex via DNA nicking.

Global Effort Aims to Protect Health and Safety of Human ‘Guinea Pigs’ in Drug Trials

[Science Insider] Over the past two years, an international group of ethicists, scientists, regulators, and other stakeholders has sought ways to better protect people who join trials as paid, healthy volunteers rather than as patients hoping for an effective treatment.

Atrial Arrhythmias Following CAR-Chimeric Antigen Receptor T Cell Therapy: Incidence, Risk Factors and Biomarker Profile

[British Journal Of Haematology] The authors conducted a pharmacovigilance study to assess the reporting of atrial arrhythmias following CD19-directed CAR-T.

Engineered CD47 Protects T Cells for Enhanced Antitumour Immunity

[Nature] Researchers administered anti-CD47 antibodies in combination with adoptively transferred T cells with the goal of enhancing antitumour efficacy but observed abrogated therapeutic benefit due to rapid macrophage-mediated clearance of T cells expressing CARs or engineered T cell receptors.

CAR T Cell Membrane Camouflaged Nanocatalyst Augments CAR T Cell Therapy Efficacy against Solid Tumor

[Small] A CAR T cell membrane-camouflaged nanocatalyst (ACSP@TCM) was prepared to augment CAR T cell therapy efficacy against solid tumors. ACSP@TCM was prepared by encapsulating core/shell Au/Cu2-xSe and 3-bromopyruvate with a CAR T cell membrane.

Generation of Allogeneic CAR-NKT Cells from Hematopoietic Stem and Progenitor Cells Using a Clinically Guided Culture Method

[Nature Biotechnology] The authors described a clinically guided method to differentiate and expand IL-15-enhanced allogeneic CAR-NKT cells with high yield and purity.

Efficacy and Safety of Novel Multifunctional M10 CAR-T Cells in HIV-1-Infected Patients: A Phase I, Multicenter, Single-Arm, Open-Label Study

[Cell Discovery] Investigators reported newly developed anti-HIV-1 CAR-T cells armed with endogenic broadly neutralizing antibodies (bNAbs) and the follicle-homing receptor CXCR5, termed M10 cells.

Valrubicin-Loaded Immunoliposomes for Specific Vesicle-Mediated Cell Death in the Treatment of Hematological Cancers

[Cell Death & Disease] Following the transplantation of human pediatric B-cell acute lymphoblastic leukemia, T-cell acute lymphoblastic leukemia, or acute myeloid leukemia in immunodeficient NSG mice, investigators generated patient-derived xenograft models, which were treated with valrubicin-loaded immunoliposomes loaded with antibodies to target CD19, CD7 or CD33.

GLUT1 Overexpression Enhances CAR T Cell Metabolic Fitness and Anti-Tumor Efficacy

[Molecular Therapy] Using mouse models of acute lymphoblastic leukemia (ALL), renal cell carcinoma (RCC), and glioblastoma (GBM), we show that enforced expression of the glucose transporter GLUT1 enhances anti-tumor efficacy and promotes favorable CAR T cell phenotypes for two clinically relevant CAR designs, 19-28z and IL13Rα2-BBz.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.