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Cell Therapy News
Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.
Cytomegalovirus Reactivation in Patients with Large B-Cell Lymphoma Treated with Chimeric Antigen Receptor T-Cell Therapy
[International Journal of Hematology] Using the pp65 antigenemia assay, scientists showed a similar incidence of cytomegalovirus reactivation, onset, and risk factors to those in the previous reports using PCR.
Unlocking the Potential: Advancements and Applications of Gene Therapy in Severe Disorders
[Annals of Medicine] The authors summarize recent advances in gene therapy, its background, molecular basis, gene-editing techniques, and its foremost applications in severe disorders, such as cancer, monogenic disorders, etc.
CSF1R+ Myeloid-Monocytic Cells Drive CAR-T Cell Resistance in Aggressive B Cell Lymphoma
[Cancer Cell] To elucidate factors associated with CAR-T therapy resistance, investigators conducted high-dimensional analyses of pre- and post-CAR-T cell specimens.
Design and Evaluation of Biodegradable Self-Immolative Lipids for RNA Delivery
[Advanced Healthcare Materials] A new family of ionizable cationic lipids called “Self-Immolative Lipids” is reported. This innovative lipid architecture was designed to overcome a critical challenge in non-viral gene therapy: the need for a delivery vector that is both efficacious and stable during biodistribution while remaining biodegradable upon reaching the target cell.
Somatic Gene Delivery Faithfully Recapitulates a Molecular Spectrum of High-Risk Sarcomas
[Nature Communications] Scientists described the development of a genetically-controlled, yet versatile mouse modeling platform allowing delivery of different genetic lesions by muscle electroporation in wildtype mice.
Neonatal Systemic Gene Therapy Restores Cardiorespiratory Function in a Rat Model of Pompe Disease
[Molecular Therapy] A novel Pompe rat model was used to test the hypothesis that neonatal gene therapy with adeno-associated virus serotype 9 restores cardiorespiratory neuromuscular function across the lifespan.
Gene Therapy with Covalently-Closed-End AAV Vector for Spinal Muscular Atrophy
[Molecular Therapy] Investigators reported first-in-human experience with a covalently closed-end adeno-associated virus vector. High quality clinical grade cceAAV vector based on AAV9 produced in 200 liters of suspension 293 cells with a total yield of 4.3 × 1016 vector genomes.
Enhancing Anti-Tumor Immunity of Natural Killer Cells through Targeting IL-15R Signaling
[Cancer Cell] Researchers performed genome-wide CRISPR screens to reveal the complete IL-15R signaling mechanism in natural killer cells and discovered that ubiquitin-dependent IL-15R degradation is the dominant mechanism restraining IL-15R signaling.
Enhancement of CRISPR-Cas12a System through Universal Circular RNA Design
[Cell Reports Methods] Scientists developed a light-triggerable circular RNA system for dynamic LbCas12a regulation. By employing circular CRISPR guide RNA (crRNA) or a split circular universal direct repeat region with a replaceable spacer, they resolved the incompatibility between isothermal amplification and CRISPR detection.
Emerging Strategies of Cell and Gene Therapy Targeting Tumor Immune Microenvironment
[Clinical Cancer Research] The authors write a foundational overview of the classification of cell and gene therapy in treating solid tumors and explore how it targets the cross-talk between cancer cells and the tumor immune microenvironment from cellular and molecular perspectives.
Mesoblast Maintains Momentum with FDA on Accelerated Approval Pathway for Revascor® in Ischemic Heart Failure and Label Extension for Ryoncil® in Adults with GvHD
[Mesoblast (GlobeNewswire)] Mesoblast provided an update on continued momentum with US FDA regarding both accelerated approval pathway for Revascor® in the treatment of patients with ischemic chronic heart failure with reduced ejection fraction and inflammation, and label extension for Ryoncil® in adults with steroid refractory acute graft versus host disease (SR-aGvHD).
Engineering CRISPR System-Based Bacterial Outer Membrane Vesicle Potentiates T Cell Immunity for Enhanced Cancer Immunotherapy
[Advanced Materials] The engineered E. coli BL21-derived outer membrane vesicles enable the packaging of multiple genes, resulting in a 7-fold increase in DNA enrichment efficiency and gene silencing in vitro.
Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.
