Could This Be the ‘Holy Grail for Cell Therapy’?

Notch Therapeutics is a Canadian company with a potential breakthrough in the form of a cost-effective and reliable manufacturing platform called Engineered Thymic Niche. The technology can create universally compatible T-cells from donor stem cells on an industrial scale, offering an efficient way to mass manufacture T-cell therapies that are of consistent quality.
[Notch Therapeutics]
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IN8bio Completes Treatment of First Cohort in Phase I Clinical Trial with Gamma Delta T-Cell Therapy in Patients with Newly Diagnosed Glioblastoma Multiforme

IN8bio, Inc. announced an update from the ongoing Phase I clinical trial of INB-200, its DeltEx drug resistant immunotherapy , MGMT-gene modified gamma delta T-cells in patients with newly diagnosed GBM.
[IN8bio, Inc.]
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Emerging Understanding of Apoptosis in Mediating Mesenchymal Stem Cell Therapy

Investigators summarize the emerging understanding of apoptosis in mediating mesenchymal stem cell transplant, highlighting the potential of apoptotic extracellular vesicles as cell-free therapeutics.
[Cell Death & Disease]
Fu, Y., Sui, B., Xiang, L., Yan, X., Wu, D., Shi, S., & Hu, X. (2021). Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy. Cell Death & Disease, 12(6), 1–12. https://doi.org/10.1038/s41419-021-03883-6 Cite
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Human Umbilical Cord Mesenchymal Stem Cell Transfusion in Immune Non-Responders with AIDS: A Multicenter Randomized Controlled Trial

The authors examined the safety and efficacy of human umbilical cord mesenchymal stem cell infusion for immune non-responder patients with chronic HIV-1 infection, who represented an unmet medical need even in the era of efficient antiretroviral therapy.
[Signal Transduction and Targeted Therapy]
Wang, L., Zhang, Z., Xu, R., Wang, X., Shu, Z., Chen, X., Wang, S., Liu, J., Li, Y., Wang, L., Zhang, M., Yang, W., Wang, Y., Huang, H., Tu, B., Liang, Z., Li, L., Li, J., Hou, Y., … Wang, F.-S. (2021). Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS: a multicenter randomized controlled trial. Signal Transduction and Targeted Therapy, 6(1), 1–8. https://doi.org/10.1038/s41392-021-00607-2 Cite
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Systemic Transplantation of Adult Multipotent Stem Cells Functionally Rejuvenates Aged Articular Cartilage

Researchers demonstrated that systemic transplantation of adult multipotent muscle-derived stem/progenitor cells- isolated from young mice-rejuvenates the knee articular cartilage of naturally aged mice.
[Aging and Disease]
Seth D. Thompson, R. P., & Seth D. Thompson, R. P. (2021). Systemic Transplantation of Adult Multipotent Stem Cells Functionally Rejuvenates Aged Articular Cartilage. Aging and Disease, 12(3), 726–731. https://doi.org/10.14336/AD.2020.1118 Cite
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Type 2 Diabetes Mellitus Duration and Obesity Alter the Efficacy of Autologously Transplanted Bone Marrow-Derived Mesenchymal Stem/Stromal Cells

Investigators tested the hypothesis that autologous bone-marrow mesenchymal stem cell (BM-MSC) administration in type 2 diabetes patient was safe and that the efficacy of the treatment was dependant on the quality of the autologous BM-MSC population and administration routes.
[Stem Cells Translational Medicine]
Nguyen, L. T., Hoang, D. M., Nguyen, K. T., Bui, D. M., Nguyen, H. T., Le, H. T. A., Hoang, V. T., Bui, H. T. H., Dam, P. T. M., Hoang, X. T. A., Ngo, A. T. L., Le, H. M., Phung, N. Y., Vu, D. M., Duong, T. T., Nguyen, T. D., Ha, L. T., Bui, H. T. P., Nguyen, H. K., … Bui, A. V. (n.d.). Type 2 diabetes mellitus duration and obesity alter the efficacy of autologously transplanted bone marrow-derived mesenchymal stem/stromal cells. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/sctm.20-0506 Cite
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Sorrento and Researchers at Karolinska Institutet Have Signed a Research Collaboration Agreement on iPSC-Derived Dimeric Antigen Receptor-Modified Natural Killer (DAR-NK) Cells With The Vision to Bring “Off-The-Shelf” NK Cell-Based Cancer Treatments Rapidly to Patients

Sorrento Therapeutics, Inc. announced that the Company has entered into an additional collaborative agreement with NextGenNK Competence Center-associated research groups at the Department of Medicine, Huddinge, Karolinska Institutet  in Stockholm, Sweden, aimed at producing novel cell-based therapeutics using natural killer cells derived from induced pluripotent stem cells.
[Sorrento Therapeutics, Inc.]
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Mesenchymal Stem Cells Loaded with Oncolytic Reovirus Enhances Antitumor Activity in Mice Models of Colorectal Cancer

Investigators evaluated the in vitro and in vivo antitumor capability of adipose-derived mesenchymal stem cells as a new vehicle for Dearing strain of reovirus loading.
[Biochemical Pharmacology]
Babaei, A., Soleimanjahi, H., Soleimani, M., & Arefian, E. (2021). Mesenchymal stem cells loaded with oncolytic reovirus enhances antitumor activity in mice models of colorectal cancer. Biochemical Pharmacology, 114644. https://doi.org/10.1016/j.bcp.2021.114644 Cite
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T Cells Armed with C-X-C Chemokine Receptor Type 6 Enhance Adoptive Cell Therapy for Pancreatic Tumors

Scientists showed that forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.
[Nature Biomedical Engineering]
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Sciatic Nerve Regeneration After Traumatic Injury Using Magnetic Targeted Adipose-derived Mesenchymal Stem Cells

Adipose-derived mesenchymal stem cells were loaded with citric acid coated superparamagnetic iron oxide nanoparticles, systemically transplanted and magnetically recruited to the injured sciatic nerve.
[Acta Biomaterialia]
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Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury Treatment

Researchers report on the development of an enhanced synergistic combination therapy comprising polyacetal–curcumin nanoconjugate and neural stem cells derived from induced pluripotent stem cells + mesenchymal stem cells treatment as a treatment option for severe sub-acute traumatic spinal cord injury.
[International Journal of Molecular Sciences]
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