Efficacy of Topical and Systemic Transplantation of Mesenchymal Stem Cells in a Rat Model of Diabetic Ischemic Wounds

Scientists compared the effects of topical and systemic transplantation mesenchymal stem cells on diabetic ischemic wound healing and explored the underlying mechanisms.
[Stem Cell Research & Therapy]
Yan, J., Liang, J., Cao, Y., El Akkawi, M. M., Liao, X., Chen, X., Li, C., Li, K., Xie, G., & Liu, H. (2021). Efficacy of topical and systemic transplantation of mesenchymal stem cells in a rat model of diabetic ischemic wounds. Stem Cell Research & Therapy, 12(1), 220. https://doi.org/10.1186/s13287-021-02288-8 Cite
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Transient Rest Restores Functionality in Exhausted CAR-T Cells through Epigenetic Remodeling

Using murine xenograft models and an in vitro model wherein tonic CAR signaling induces hallmark features of exhaustion, researchers tested the effect of transient cessation of receptor signaling, or rest, on the development and maintenance of exhaustion.
[Science]
Weber, E. W., Parker, K. R., Sotillo, E., Lynn, R. C., Anbunathan, H., Lattin, J., Good, Z., Belk, J. A., Daniel, B., Klysz, D., Malipatlolla, M., Xu, P., Bashti, M., Heitzeneder, S., Labanieh, L., Vandris, P., Majzner, R. G., Qi, Y., Sandor, K., … Mackall, C. L. (2021). Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling. Science, 372(6537). https://doi.org/10.1126/science.aba1786 Cite
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Synapsin-Caveolin-1 Gene Therapy Preserves Neuronal and Synaptic Morphology and Prevents Neurodegeneration in a Mouse Model of Alzheimer’s Disease

Scientists indicated that SynCav1 gene therapy may be an option for Alzheimer’s disease and potentially in other forms of neurodegeneration caused by unknown etiology.
[Molecular Therapy-Methods & Clinical Development]
Wang, S., Leem, J. S., Podvin, S., Hook, V., Kleschevnikov, N., Savchenko, P., Dhanani, M., Zhou, K., Kelly, I. C., Zhang, T., Miyanohara, A., Nguyen, P., Kleschevnikov, A., Wagner, S. L., Trojanowski, J. Q., Roth, D. M., Patel, H. H., Patel, P. M., & Head, B. P. (2021). Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of Alzheimer’s disease. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2021.03.021 Cite
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Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy

Researchers identified two markers for myogenic cell purification: CDH13, which purified most of the myogenic cells, and FGFR4, which purified a subset of muscle progenitor cells.
[Stem Cell Reports]
Nalbandian, M., Zhao, M., Sasaki-Honda, M., Jonouchi, T., Lucena-Cacace, A., Mizusawa, T., Yasuda, M., Yoshida, Y., Hotta, A., & Sakurai, H. (2021). Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.03.004 Cite
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Lotus-Root-Shaped Cell-Encapsulated Construct as a Retrieval Graft for Long-Term Transplantation of Human iPSC-Derived β-Cells

Researchers developed a lotus-root-shaped cell-encapsulated construct as a graft that can be retrieved after long-term human-stem-cell-derived pancreatic beta cell transplantation.
[iScience]
Ozawa, F., Nagata, S., Oda, H., Yabe, S. G., Okochi, H., & Takeuchi, S. (2021). Lotus-root-shaped cell-encapsulated construct as a retrieval graft for long-term transplantation of human iPSC-derived β-cells. IScience, 0(0). https://doi.org/10.1016/j.isci.2021.102309 Cite
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Stem Cell-Based Approaches in Cardiac Tissue Engineering: Controlling the Microenvironment for Autologous Cells

The authors provide a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue.
[Biomedicine & Pharmacotherapy]
Augustine, R., Dan, P., Hasan, A., Khalaf, I. M., Prasad, P., Ghosal, K., Gentile, C., McClements, L., & Maureira, P. (2021). Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells. Biomedicine & Pharmacotherapy, 138, 111425. https://doi.org/10.1016/j.biopha.2021.111425 Cite
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A Cross-Talk between CAR T Cell Subsets and the Tumor Microenvironment Is Essential for Sustained Cytotoxic Activity

Researchers report an essential cross-talk between CAR T cell subsets and the TME for tumor control in an immunocompetent mouse B cell lymphoma model of anti-CD19 CAR T cell therapy.
[Science Immunology]
Boulch, M., Cazaux, M., Loe-Mie, Y., Thibaut, R., Corre, B., Lemaître, F., Grandjean, C. L., Garcia, Z., & Bousso, P. (2021). A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity. Science Immunology, 6(57). https://doi.org/10.1126/sciimmunol.abd4344 Cite
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Enhancing CAR-T Cell Efficacy in Solid Tumors by Targeting the Tumor Microenvironment

The authors summarize the inhibitory factors that affect the function of CAR-T cells in tumor microenvironment and discuss approaches to improve CAR-T cell efficacy for solid tumor treatment by targeting those barriers.
[Cellular & Molecular Immunology]
Liu, G., Rui, W., Zhao, X., & Lin, X. (2021). Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment. Cellular & Molecular Immunology, 1–11. https://doi.org/10.1038/s41423-021-00655-2 Cite
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Lyophilized Powder of Mesenchymal Stem Cell Supernatant Attenuates Acute Lung Injury through the IL-6–P-STAT3–p63–JAG2 Pathway

Intratracheal bleomycin was used to induce acute lung injury in mice, and intratracheal MSCs in a supernatant lyophilized powder was administered as a treatment.
[Stem Cell Research & Therapy]
Peng, W., Chang, M., Wu, Y., Zhu, W., Tong, L., Zhang, G., Wang, Q., Liu, J., Zhu, X., Cheng, T., Li, Y., Chen, X., Weng, D., Liu, S., Zhang, H., Su, Y., Zhou, J., Li, H., & Song, Y. (2021). Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6–p-STAT3–p63–JAG2 pathway. Stem Cell Research & Therapy, 12(1), 216. https://doi.org/10.1186/s13287-021-02276-y Cite
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Realizing Innate Potential: CAR-NK Cell Therapies for Acute Myeloid Leukemia

While acute myeloid leukemia represents an intuitive disease in which to investigate chimeric antigen receptor (CAR) based immunotherapies, key biological differences to B-cell malignancies have complicated progress to date.
[Cancers]
Gurney, M., & O’Dwyer, M. (2021). Realizing Innate Potential: CAR-NK Cell Therapies for Acute Myeloid Leukemia. Cancers, 13(7), 1568. https://doi.org/10.3390/cancers13071568 Cite
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The Effect of Bone Marrow-Derived Mesenchymal Stem Cell Co-Transplantation with Hematopoietic Stem Cells on Liver Fibrosis Alleviation and Survival in Patients with Class III β-Thalassemia Major

The authors evaluated the effect of co-transplantation of bone marrow-derived MSC with HSCs on the liver fibrosis alleviation and transplant outcomes in class III beta-thalassemia major.
[Stem Cell Research & Therapy]
Rostami, T., Kasaeian, A., Maleki, N., Nikbakht, M., Kiumarsi, A., Tavangar, S. M., Taheri, A. P. H., Mousavi, S. A., & Ghavamzadeh, A. (2021). The effect of bone marrow-derived mesenchymal stem cell co-transplantation with hematopoietic stem cells on liver fibrosis alleviation and survival in patients with class III β-thalassemia major. Stem Cell Research & Therapy, 12(1), 213. https://doi.org/10.1186/s13287-021-02242-8 Cite
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