Mesenchymal Stromal Cells: Putative Microenvironmental Modulators Become Cell Therapy

Scientists discuss potential mechanisms of action for the therapeutic effects of MSC transplantation, experimental models that dissect tissue modulating function of MSCs, and approaches for identifying MSC effects in vivo by integrating biomarkers of disease and MSC activity.
[Cell Stem Cell]
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CAR-T Cell Therapy in T Cell Malignancies: Is Success a Low-Hanging Fruit?

Investigators highlight the preclinical and clinical efforts made for addressing these drawbacks and also review additional potent stratagems that could improve CAR-T therapy in T cell malignancies.
[Stem Cell Research & Therapy]
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Emerging Approaches to Improve Allogeneic Hematopoietic Cell Transplantation Outcomes for Non-malignant Diseases

Scientists discuss the current approach to each of these clinical issues and how emerging novel therapeutics hold promise to advance transplant care for patients with non-malignant diseases.
[Blood]
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Additional Benefit of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cell Therapy on Sepsis Syndrome-Associated Acute Kidney Injury in Rat Treated with Antibiotic

Investigators tested whether human induced-pluripotent stem-cell-derived mesenchymal-stem-cells would offer an additional benefit to the rodent with acute kidney injury associated sepsis syndrome undergoing ciprofloxacin therapy.
[Stem Cell Research & Therapy]
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ZBP1-MLKL Necroptotic Signaling Potentiates Radiation-Induced Antitumor Immunity via Intratumoral STING Pathway Activation

Researchers developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release.
[Science Advances]
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Century Therapeutics and Outpace Bio Enter Research Collaboration in CAR Engineering

Century Therapeutics and Outpace Bio announced a research collaboration in CAR engineering. The collaboration will bring together Century’s CAR and protein engineering expertise with Outpace’s protein design and synthetic biology capabilities to enhance CAR functionality by combining Outpace’s optimized CAR spacer technology with Century’s VHH domain binders.
[Century Therapeutics (GlobeNewswire, Inc.)]
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Systematic Review and Meta-Analysis Determining the Benefits of In Vivo Genetic Therapy in Spinal Muscular Atrophy Rodent Models

The authors performed a systematic review of relevant publications and extracted median survival and details of experimental design. A random effects meta-analysis was used to estimate and compare efficacy.
[Gene Therapy]
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ATG and Post-Transplant Cyclophosphamide Predisposes to Inferior Outcome When Using Cryopreserved Stem Cell Grafts

Scientists analyzed the outcomes of 483 patients who received HSCT between August 2017 and August 2020 in aretrospective study, comparing the outcomes between those who received cryopreserved or fresh peripheral blood stem cell grafts.
[European Journal of Haematology]
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Enhancing Adoptive CD8 T Cell Therapy by Systemic Delivery of Tumor Associated Antigens

Scientists showed that systemic delivery of tumor-associated antigens facilitated in vivo priming and expansion of previously non-activated T cells and enhanced the cytotoxicity of activated T cells.
[Scientific Reports]
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Comparing the Renoprotective Effects of BM-MSCs versus BM-MSC-Exosomes, When Combined with an Anti-Fibrotic Drug, in Hypertensive Mice

Scientists determined whether serelaxin (RLX) could enhance the therapeutic efficacy of bone-marrow-derived- mesecnymal stem cell-exosomes (BM-MSC-EXO), and compared the renoprotective effects of RLX and BM-MSC-EXO versus RLX and BM-MSCs in mice with hypertensive CKD.
[Biomedicine & Pharmacotherapy]
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UC Riverside Receives $5M CIRM Grant to Train Scientists in Stem Cell Research

The University of California, Riverside, has received a grant of $5 million from the California Institute for Regenerative Medicine, the state’s stem cell agency, to train young scientists and physicians in stem cell research.
[University of California, Riverside]
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