SUPT4H1-Edited Stem Cell Therapy Rescues Neuronal Dysfunction in a Mouse Model for Huntington’s Disease

Transplanting SUPT4H1-edited Huntington’s disease (HD)-induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) into the YAC128 HD transgenic mouse model improved motor function compared to unedited HD iPSC-NPCs.
[NPJ Regenerative Medicine]
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Neurofilament Light Chain Serum Levels Correlate with the Severity of Neurotoxicity after CAR T Cell Treatment

Researchers examined whether serum levels of neurofilament light chain, a marker of neuroaxonal injury, correlated with the severity of immune effector cell-associated neurotoxicity syndrome.
[Blood Advances]
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CD19/BAFF-R Dual-Targeted CAR T Cells for the Treatment of Mixed Antigen-Negative Variants of Acute Lymphoblastic Leukemia

To mitigate antigen escape and potentially improve the durability of remission, scientists developed a dual-targeting approach using an optimized, bispecific CAR construct that targets both CD19 and BAFF-R.
[Leukemia]
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Japan University Uses iPS Cells to Treat Spinal Cord Injury for First Time

Keio University in Tokyo said it has started the world’s first clinical test using induced pluripotent stem cells, or iPS cells, to treat patients with spinal cord injuries.
[Kyodo News]
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Tubastatin a Maintains Adult Skeletal Muscle Stem Cells in a Quiescent State Ex Vivo and Improves Their Engraftment Ability In Vivo

Investigators showed that Tubastatin A, an Hdac6 inhibitor, prevented primary cilium resorption, maintained quiescence, and enhanced skeletal muscle stem cells survival ex vivo.
[Stem Cell Reports]
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Inducing Human Retinal Pigment Epithelium-Like Cells from Somatic Tissue

The authors stably induced retinal pigment epithelium-like cells from human fibroblasts by conditional overexpression of both broad plasticity and lineage-specific transcription factors.
[Stem Cell Reports]
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IL-13Rα2 Humanized scFv-Based CAR T Cells Exhibit Therapeutic Activity against Glioblastoma with Increased Expansion and Reduced Cytokine Production

Investigators constructed a CAR targeting interleukin-13 receptor α2 according to a murine antibody, and then humanized the single-chain variable fragment sequence to generate another CAR.
[Molecular Therapy-Oncolytics]
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A Randomized Controlled Trial of Stem Cell Injection for Tendon Tear

Scientists performed a randomized, controlled study to investigate the effects of mesenchymal stem cell injection for treating partial tears in the supraspinatus tendon.
[Scientific Reports]
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Neural Stem Cells Therapy for Ischemic Stroke: Progress and Challenges

The authors provide a futher understanding of the therapeutic role of neural stem cells for ischemic stroke, and evaluate their prospects for future application in clinical patients of ischemic stroke.
[Translational Stroke Research]
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Physical Exercise Promotes Integration of Grafted Cells and Functional Recovery in an Acute Stroke Rat Model

Neural progenitor cell (NPC) transplantation, combined with physical exercise, showed significant improvement in both structural and behavioral outcomes in stroke-damaged rats.
[Stem Cell Reports]
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Subcutaneous Nanotherapy Repurposes the Immunosuppressive Mechanism of Rapamycin to Enhance Allogeneic Islet Graft Viability

Researchers demonstrated that subcutaneous delivery via poly(ethylene glycol)-b-poly(propylene sulfide) polymersome nanocarriers significantly altered rapamycin’s cellular biodistribution to repurpose its mechanism of action for tolerance, instead of immunosuppression, and minimize side effects.
[Nature Nanotechnology]
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