Investigators performed a controlled, non-randomized, Phase I clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.
[Signal Transduction and Targeted Therapy]
6445212 IPLEFHR3 items 1 apa default asc 1
Meng, F., Xu, R., Wang, S., Xu, Z., Zhang, C., Li, Y., Yang, T., Shi, L., Fu, J., Jiang, T., Huang, L., Zhao, P., Yuan, X., Fan, X., Zhang, J.-Y., Song, J., Zhang, D., Jiao, Y., Liu, L., … Wang, F.-S. (2020). Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial. Signal Transduction and Targeted Therapy, 5(1), 1–7. https://doi.org/10.1038/s41392-020-00286-5 Cite
Scientists directly compared the efficacy of the transplantation of dental pulp stem cells (DPSCs) and the administration of the secreted factors from DPSCs on diabetic polyneuropathy.
[International Journal of Molecular Sciences]
1254621 HHTVUSQB items 1 apa default asc 1
The authors highlight the multifaceted behavior of proline, glutamic acid, serine, and threonine nuclear proteins (PEST-NPs) in cancer biology. They summarize a number of studies to address the influence of structure and PEST‐mediated posttranslational modifications on activation, localization, stability, and protein–protein interactions of PEST‐NPs.
[Journal of Cellular Physiology]
1254621 YFUAQLLA items 1 apa default asc 1
The authors provide a comprehensive resource for understanding human islet cell maturation and provides important insights into maturation of human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) and other SC-islet cell types to enable future differentiation strategy improvements.
6630899 AKDVHNN8 items 1 apa default asc 1
Indee Labs is a biotechnology company developing the µVS Delivery SystemTM for non-viral intracellular or gene delivery. The team at Indee Labs was awarded a grant from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, to develop the µVS Delivery SystemTM for modified regulatory T cells.
[Indee Labs (BusinessWire, Inc.)]
A recent study reported on the use of chimeric antigen receptor (CAR) T cell therapy as a novel senolytic approach and demonstrated improved cancer outcome and reversal of senescence-associated pathologies in animal models. Scientists aim to discuss the opportunities and limitations of translating such a therapeutic strategy into the clinic.
1254621 JHABAPUI items 1 apa default asc 1
In an MLL-AF9 AML mouse model, genetic deletion of β-catenin, or even all four Tcf/Lef family transcription factors that interact with β-catenin, did not affect AML onset in primary recipients, or the ability of leukemic stem cells in propagating AML in secondary recipients.
1254621 HXHN5GQ5 items 1 apa default asc 1
Scientists demonstrated therapeutic potential of CAR T cells targeting ICAM-1 in preclinical models of systemic and intraperitoneal metastases of gastric cancer.
1254621 NTN9HSJA items 1 apa default asc 1
Researchers retrospectively analyzed the outcomes of 214 severe aplastic anemia patients who underwent allogeneic hematopoietic stem cell transplantation with r-ATG or ATG-Fresenius.
[Biology of Blood and Marrow Transplantation]
1254621 X9K9E27J items 1 apa default asc 1
Investigators performed islet transplantation in diabetic mice by combining three components—microencapsulated islets, mesenchymal stem cell-CellSaic, and a mesh bag that encapsulates them and enables their removal.
1254621 2LKIZZJW items 1 apa default asc 1
Primary HLH is a family of devastating primary immune deficiencies with limited treatment options and no gene therapies under clinical testing. Expression Therapeutics has developed a promising and potentially curative gene therapy candidate for familial HLH type 3.
[Expression Therapeutics (PR Newswire Association LLC.)]