Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy in Patients with COVID-19: A Phase I Clinical Trial

Investigators performed a controlled, non-randomized, Phase I clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.
[Signal Transduction and Targeted Therapy]
Meng, F., Xu, R., Wang, S., Xu, Z., Zhang, C., Li, Y., Yang, T., Shi, L., Fu, J., Jiang, T., Huang, L., Zhao, P., Yuan, X., Fan, X., Zhang, J.-Y., Song, J., Zhang, D., Jiao, Y., Liu, L., … Wang, F.-S. (2020). Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial. Signal Transduction and Targeted Therapy, 5(1), 1–7. https://doi.org/10.1038/s41392-020-00286-5 Cite
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Direct Comparison of Therapeutic Effects on Diabetic Polyneuropathy between Transplantation of Dental Pulp Stem Cells and Administration of Dental Pulp Stem Cell-Secreted Factors

Scientists directly compared the efficacy of the transplantation of dental pulp stem cells (DPSCs) and the administration of the secreted factors from DPSCs on diabetic polyneuropathy.
[International Journal of Molecular Sciences]
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Multifaceted Behavior of PEST Sequence Enriched Nuclear Proteins in Cancer Biology and Role in Gene Therapy

The authors highlight the multifaceted behavior of proline, glutamic acid, serine, and threonine nuclear proteins (PEST-NPs) in cancer biology. They summarize a number of studies to address the influence of structure and PEST‐mediated posttranslational modifications on activation, localization, stability, and protein–protein interactions of PEST‐NPs.
[Journal of Cellular Physiology]
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Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation

The authors provide a comprehensive resource for understanding human islet cell maturation and provides important insights into maturation of human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) and other SC-islet cell types to enable future differentiation strategy improvements.
[Cell Reports]
Augsornworawat, P., Maxwell, K. G., Velazco-Cruz, L., & Millman, J. R. (2020). Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation. Cell Reports, 32(8). https://doi.org/10.1016/j.celrep.2020.108067 Cite
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Indee Labs Awarded Grant from the National Institute of Allergy and Infectious Diseases

Indee Labs is a biotechnology company developing the µVS Delivery SystemTM for non-viral intracellular or gene delivery. The team at Indee Labs was awarded a grant from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, to develop the µVS Delivery SystemTM for modified regulatory T cells.
[Indee Labs (BusinessWire, Inc.)]
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Senolytic CAR T Cells in Solid Tumors and Age-Related Pathologies

A recent study reported on the use of chimeric antigen receptor (CAR) T cell therapy as a novel senolytic approach and demonstrated improved cancer outcome and reversal of senescence-associated pathologies in animal models. Scientists aim to discuss the opportunities and limitations of translating such a therapeutic strategy into the clinic.
[Molecular Therapy]
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β-Catenin and γ-Catenin Are Dispensable for T Lymphocytes and AML Leukemic Stem Cells

In an MLL-AF9 AML mouse model, genetic deletion of β-catenin, or even all four Tcf/Lef family transcription factors that interact with β-catenin, did not affect AML onset in primary recipients, or the ability of leukemic stem cells in propagating AML in secondary recipients.
[eLife]
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Chimeric Antigen Receptor T Cell Therapy Targeting ICAM-1 in Gastric Cancer

Scientists demonstrated therapeutic potential of CAR T cells targeting ICAM-1 in preclinical models of systemic and intraperitoneal metastases of gastric cancer.
[Molecular Therapy-Oncolytics]
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Comparison of Two Different Rabbit Antithymocyte Globulin (r-ATG) Preparations:Thymocyte r-ATG versus T Lymphoblast Cell Line r-ATG in Allogeneic Hematopoietic Stem Cell Transplantation for Acquired Severe Aplastic Anemia: Propensity Score-Matched Analysis

Researchers retrospectively analyzed the outcomes of 214 severe aplastic anemia patients who underwent allogeneic hematopoietic stem cell transplantation with r-ATG or ATG-Fresenius.
[Biology of Blood and Marrow Transplantation]
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A New Islet Transplantation Method Combining Mesenchymal Stem Cells with Recombinant Peptide Pieces, Microencapsulated Islets, and Mesh Bags

Investigators performed islet transplantation in diabetic mice by combining three components—microencapsulated islets, mesenchymal stem cell-CellSaic, and a mesh bag that encapsulates them and enables their removal.
[Biomedicines]
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Expression Therapeutics Announces Success in Developing a Stem Cell Lentiviral Gene Therapy for Hemophagocytic Lymphohistiocytosis (HLH)

Primary HLH is a family of devastating primary immune deficiencies with limited treatment options and no gene therapies under clinical testing. Expression Therapeutics has developed a promising and potentially curative gene therapy candidate for familial HLH type 3.
[Expression Therapeutics (PR Newswire Association LLC.)]
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