UK Sickle Cell Gene Therapy Research Awarded $3.1M Grant

Researchers at the University of York in the UK have been awarded a $3.1 million grant to accelerate research supporting stem cell gene therapy to treat sickle cell disease.
[Sickle Cell Disease News]
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Sana Biotechnology Obtains Exclusive License from National Institutes of Health for CD22 CAR Construct

Sana Biotechnology, Inc. announced that the company entered into an agreement with the National Cancer Institution, an institute of the National Institutes of Health, for worldwide exclusive commercial rights to the NIH’s CD22 CAR with a fully-human binder for use in certain in vivo gene therapy and ex vivo allogeneic CAR T applications for B cell malignancies.
[Sana Biotechnology, Inc.]
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Clonal Evolution in Patients Developing Therapy-Related Myeloid Neoplasms Following Autologous Stem Cell Transplantation

Clonal hematopoiesis was associated with increasing age and with a factor 6 increase in the risk of developing therapy-related myeloid neoplasms following autologous stem cell transplantation.
[Bone Marrow Transplantation]
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Century Therapeutics and Bristol Myers Squibb Enter into a Strategic Collaboration to Develop iPSC-Derived Allogeneic Cell Therapies

Century Therapeutics and Bristol Myers Squibb announced a research collaboration and license agreement to develop and commercialize up to four iPSC derived, engineered natural killer cell and / or T cell programs for hematologic malignancies and solid tumors.
[Century Therapeutics]
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B Cells Imprint Adoptively Transferred CD8+ T Cells with Enhanced Tumor Immunity

Researchers investigated how tumor-specific murine CD8+ T cells and human tumor infiltrating lymphocytes were impacted when expanded ex vivo with the TLR9 agonist CpG.
[Journal For Immunotherapy of Cancer]
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Tissue Engineered Vascular Grafts Transform into Autologous Neovessels Capable of Native Function and Growth

Scientists used an integrative computational-experimental approach to elucidate the natural history of neovessel formation in a large animal preclinical model.
[Communications Medicine]
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A BAFF Ligand-Based CAR-T Cell Targeting Three Receptors and Multiple B Cell Cancers

Investigators developed a B cell-activating factor (BAFF) ligand-based CAR and generated BAFF CAR-T cells using a non-viral gene delivery method.
[Nature Communications]
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Comparable Anti-CMV Responses of Transplant Donor and Third-Party CMV-Specific T Cells for Treatment of CMV Infection after Allogeneic Stem Cell Transplantation

The in vivo recovery of cytomegalovirus (CMV)-specific immunity after CMV-cytotoxic T lymphocytes (CTL) infusion was comparable in two groups. A detailed analysis of the source of recovered CMV-CTLs showed the proliferation and expansion of graft-derived endogenous CMV-CTLs in both groups.
[Cellular & Molecular Immunology]
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Engineered Clustered Myoblast Cell Injection Augments Angiogenesis and Muscle Regeneration in Peripheral Artery Disease

Clustered cells from myoblast cell sheets obtained from C57/BL6 mice were administered into ischemic mouse muscles seven days after induction of ischemia.
[Molecular Therapy]
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D2HGDH-Mediated D2HG Catabolism Enhances the Anti-Tumor Activities of CAR-T Cells in an Immunosuppressive Microenvironment

In vivo xenograft experiments confirmed D2HGDH-OE CAR-T cell decreased serum D-2-hydroxyglutarate (D2HG) and improved the overall survival of mice bearing NALM6 cancer cells with mutation IDH1.
[Molecular Therapy]
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Possibility of Adiponectin Use to Improve Islet Transplantation Outcomes

In in vitro assessment, released insulin at high glucose stimulation, insulin content, and expressions of vascular endothelial growth factor and integrin β1 were improved in adiponectin-treated islets.
[Scientific Reports]
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