The authors describe several recent advances in the field of anti-B-cell maturation antigen CAR T-cell therapy and multiple myeloma.
6445212 NA6ILQYJ items 1 apa default asc 1
Using RNA sequencing (RNA-seq) analysis, researchers showed that exon 3 and exons 7–10 of GPC2 were expressed in cancer but was minimally expressed in normal tissues.
[Cell Reports Medicine]
6445218 3TWPC4VM items 1 apa default asc 1
Li, N., Torres, M. B., Spetz, M. R., Wang, R., Peng, L., Tian, M., Dower, C. M., Nguyen, R., Sun, M., Tai, C.-H., Val, N. de, Cachau, R., Wu, X., Hewitt, S. M., Kaplan, R. N., Khan, J., Croix, B. S., Thiele, C. J., & Ho, M. (2021). CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. Cell Reports Medicine, 0(0). https://doi.org/10.1016/j.xcrm.2021.100297 Cite
Scientists generated a herpes simplex 1-based oncolytic viruses expressing human IL-15/IL-15Rα sushi domain fusion protein, as well as off-the-shelf EGFR-CAR NK cells, and studied their monotherapy and combination efficacy in vitro and in multiple glioblastoma mouse models.
6445212 XGCNLGJ6 items 1 apa default asc 1
The authors investigated the immunosuppressive and immunomodulation abilities of Withaferin A and its effect on long-term islet allograft survival.
6445212 MJQ3BP9M items 1 apa default asc 1
Researchers analyzed the oxidative damage in models of liver injury characterized by biliary epithelial cells/hepatic progenitor cells (HPCs) activation and defined the impact of redox balance perturbation on HPC fate. They then identified Nuclear factor (erythroid-derived 2)-like 2 as the main transcription factor involved in the activation of HPCs.
[NPJ Regenerative Medicine]
6445212 N8L54BFI items 1 apa default asc 1
Scientists present the history of CAR-T cell therapy, and then expand on various developments in the CAR ectodomain. They discuss different formats, each with their own advantages and disadvantages, as well as the developments in affinity tuning, avidity effects, epitope location, and influence of the extracellular spacer.
[Medicinal Research Reviews]
6445212 JM3FHJHU items 1 apa default asc 1
GlycoMimetics, Inc. announced that clinicians at Washington University School of Medicine in St. Louis have dosed the first patient in an investigator-sponsored trial evaluating uproleselan as a prophylactic agent to reduce gastrointestinal toxicities associated with high-dose melphalan in autologous hematopoietic cell transplantation for multiple myeloma.
6445212 nan items 1 apa default asc 1
Investigators described five Wolman disease patients diagnosed in infancy that were treated at Royal Manchester Children’s Hospital receiving enzyme replacement therapy with dietary substrate reduction then hematopoietic stem cell transplant — multimodal therapy.
[Orphanet Journal of Rare Diseases]
6445212 MR8G5LH7 items 1 apa default asc 1
Epothilone D could promote the neuronal differentiation of neural stem cells by upregulating Apol8, which might provide a promising therapeutic target for spinal cord injury repair.
[Stem Cell Research & Therapy]
6445212 4IGUGRN7 items 1 apa default asc 1
The authors investigated whether functional reinnervation of denervated muscle could be achieved by early or delayed transplantation after denervation.
[Journal of Tissue Engineering and Regenerative Medicine]
6445212 RDWN9DBX items 1 apa default asc 1
Scientists examined the abundance and butyrogenic capacity of butyrate producing bacteria in 28 healthy donors and 201 patients after allogeneic stem cell transplantation.
[Clinical infectious Diseases]
6445212 IIALJNXG items 1 apa default asc 1