Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy

The authors focus on the physiological barriers of cationic liposomes (CLs) against cancer gene therapy and the effects of lipid compositions on governing transfection efficiency, and briefly discuss the impacts of particle size, membrane charge density and surface modification on the fate of CLs in vivo, which may provide guidance for their preclinical studies.
[Molecular Therapy-Methods & Clinical Development]
Liu, C., Zhang, L., Zhu, W., Guo, R., Sun, H., Chen, X., & Deng, N. (2020). Barriers and strategies of cationic liposomes for cancer gene therapy. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2020.07.015 Cite
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Human Ex Vivo Spinal Cord Slice Culture as a Useful Model of Neural Development, Lesion, and Allogeneic Neural Cell Therapy

Scientists applied experimental allogeneic human neural cell therapy after injury in ex vivo spinal cord slices.
[Stem Cell Research & Therapy]
Lin, C., Calzarossa, C., Fernandez-Zafra, T., Liu, J., Li, X., Ekblad-Nordberg, Å., Vazquez-Juarez, E., Codeluppi, S., Holmberg, L., Lindskog, M., Uhlén, P., & Åkesson, E. (2020). Human ex vivo spinal cord slice culture as a useful model of neural development, lesion, and allogeneic neural cell therapy. Stem Cell Research & Therapy, 11(1), 320. https://doi.org/10.1186/s13287-020-01771-y Cite
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Efficacy of Stem Cell Therapy for Burn Wounds: A Systematic Review and Meta-Analysis of Preclinical Studies

Meta-analysis showed that stem cell therapy exerts a healing function for burn wounds, mainly through angiogenesis and anti-inflammatory actions.
[Stem Cell Research & Therapy]
Li, Y., Xia, W., Van der Merwe, L., Dai, W., & Lin, C. (2020). Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies. Stem Cell Research & Therapy, 11(1), 322. https://doi.org/10.1186/s13287-020-01839-9 Cite
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Lentiviral Gene Therapy Vectors Encoding VIP Suppressed Diabetes-Related Inflammation and Augmented Pancreatic Beta-Cell Proliferation

The therapeutic efficacy of LentiVIP was tested in a multiple low-dose STZ-induced animal model of type 1 diabetes. LentiVIP delivery into diabetic animals reduced hyperglycemia, improved glucose tolerance, and prevented weight loss.
[Gene Therapy]
Erendor, F., Sahin, E. O., Sanlioglu, A. D., Balci, M. K., Griffith, T. S., & Sanlioglu, S. (2020). Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation. Gene Therapy, 1–12. https://doi.org/10.1038/s41434-020-0183-3 Cite
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The Conditioned Medium of Human Embryonic Stem Cell‐Derived Mesenchymal Stem Cells Alleviates Neurological Deficits and Improves Synaptic Recovery in Experimental Stroke

Researchers investigated the effect of CM derived from human embryonic MSCs on experimental ischemic stroke.
[Journal of Cellular Physiology]
Taei, A. A., Dargahi, L., Nasoohi, S., Hassanzadeh, G., Kadivar, M., & Farahmandfar, M. (n.d.). The conditioned medium of human embryonic stem cell-derived mesenchymal stem cells alleviates neurological deficits and improves synaptic recovery in experimental stroke. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.29981 Cite
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Engineering CAR-T Cells for Next-Generation Cancer Therapy

Investigators highlight recent strategies to improve chimeric antigen therapy (CAR)-T cell therapy by engineering the CAR protein, T cells, and the interaction between T cells and other components in the tumor microenvironment.
[Cancer Cell]
Hong, M., Clubb, J. D., & Chen, Y. Y. (2020). Engineering CAR-T Cells for Next-Generation Cancer Therapy. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.07.005 Cite
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Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy

Scientists found that incorporation of the CD3ε cytoplasmic domain into a second-generation chimeric antigen receptor (CAR) improved antitumor activity of CAR-T cells.
[Cell]
Wu, W., Zhou, Q., Masubuchi, T., Shi, X., Li, H., Xu, X., Huang, M., Meng, L., He, X., Zhu, H., Gao, S., Zhang, N., Jing, R., Sun, J., Wang, H., Hui, E., Wong, C. C., & Xu, C. (2020). Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.07.018 Cite
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Strategic Alliance a Shot in the Arm for Stem Cell Commercialization Efforts

Several Canadian-made cell therapies will take a major step closer to the clinic thanks to a new collaboration between the Ontario Institute for Regenerative Medicine and the Centre for Commercialization of Cancer Immunotherapy and Regenerative Medicine.
[Ontario Institute for Regenerative Medicine]
Press Release

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Probucol Enhances the Therapeutic Efficiency of Mesenchymal Stem Cells in the Treatment of Erectile Dysfunction in Diabetic Rats by Prolonging their Survival Time via Nrf2 Pathway

The authors investigated therapeutic efficiency and potential mechanism of probucol combined with mesenchymal stem cells.
[Stem Cell Research & Therapy]
Wang, H., Zhang, K., Ruan, Z., Sun, D., Zhang, H., Lin, G., Hu, L., Zhao, S., & Fu, Q. (2020). Probucol enhances the therapeutic efficiency of mesenchymal stem cells in the treatment of erectile dysfunction in diabetic rats by prolonging their survival time via Nrf2 pathway. Stem Cell Research & Therapy, 11(1), 302. https://doi.org/10.1186/s13287-020-01788-3 Cite
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Humanized Mice Are Precious Tools for Preclinical Evaluation of CAR T and CAR NK Cell Therapies

Researchers discuss innovative developments in the CAR T-cell therapy field that benefited from evaluation in humanized mice, illustrated by multiple examples.
[Cancers]
Mhaidly, R., & Verhoeyen, E. (2020). Humanized Mice Are Precious Tools for Preclinical Evaluation of CAR T and CAR NK Cell Therapies. Cancers, 12(7), 1915. https://doi.org/10.3390/cancers12071915 Cite
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Intracerebral Transplantation of HLA‐Homozygous Human iPSC‐Derived Neural Precursors Ameliorates the Behavioral and Pathological Deficits in a Rodent Model of Ischemic Stroke

The authors investigated the therapeutic potential of neural precursor cells derived from human HLA‐homozygous induced pluripotent stem cells following intracerebral transplantation into a rodent model of middle cerebral artery occlusion.
[Cell Proliferation]
Noh, J.-E., Oh, S.-H., Lee, S., Lee, S., Kim, Y. H., Park, H. J., Ju, J. H., Kim, H. S., Huh, J. Y., & Song, J. (n.d.). Intracerebral transplantation of HLA-homozygous human iPSC-derived neural precursors ameliorates the behavioural and pathological deficits in a rodent model of ischaemic stroke. Cell Proliferation, n/a(n/a), e12884. https://doi.org/10.1111/cpr.12884 Cite
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An Effective Vaginal Gel to Deliver CRISPR/Cas9 System Encapsulated in Poly (β-Amino Ester) Nanoparticles for Vaginal Gene Therapy

By conducting flow cytometry of the cervical cells, scientists found that poly PBAE-GFP-NPs-mMMT gel was more efficient than PBAE-GFP-NPs-HTT gel in delivering exogenous DNA intravaginally.
[Ebiomedicine]
Niu, G., Jin, Z., Zhang, C., He, D., Gao, X., Zou, C., Zhang, W., Ding, J., Das, B. C., Severinov, K., Hitzeroth, I. I., Debata, P. R., Ma, X., Tian, X., Gao, Q., Wu, J., You, Z., Tian, R., Cui, Z., … Hu, Z. (2020). An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy. EBioMedicine, 58. https://doi.org/10.1016/j.ebiom.2020.102897 Cite
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