Abrogation of HLA Surface Expression Using CRISPR/Cas9 Genome Editing: A Step Toward Universal T Cell Therapy

Host rejection driven by HLA disparity in adoptively transferred allogeneic T cells remains a key obstacle to the universal donor T cell therapy. To evade donor HLA-mediated immune rejection, scientists attempted to eliminate T cell’s HLA through the CRISPR/Cas9 gene editing system.
[Scientific Reports]
Lee, J., Sheen, J. H., Lim, O., Lee, Y., Ryu, J., Shin, D., Kim, Y. Y., & Kim, M. (2020). Abrogation of HLA surface expression using CRISPR/Cas9 genome editing: a step toward universal T cell therapy. Scientific Reports, 10(1), 17753. https://doi.org/10.1038/s41598-020-74772-9 Cite
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XenoTherapeutics Granted US Patent Covering Method of Producing Clinically Acceptable Porcine Cells, Tissues, and Organs for Human Xenotransplantation

XenoTherapeutics announced that the US Patent and Trademark Office has granted US Patent No. 10,799,614 to XenoTherapeutics, the patent covering methods for producing live-cell biological products from source animal donors for human xenotransplantation.
[XenoTherapeutics (GlobeNewswire, Inc.)]
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Allogene Therapeutics and MD Anderson Announce Strategic Collaboration to Accelerate Advancement of Allogeneic CAR T Therapy (AlloCAR T™)

Allogene Therapeutics, Inc. and The University of Texas MD Anderson Cancer Center announced a strategic five-year collaboration agreement for the preclinical and clinical investigation of AlloCAR T candidates across Allogene’s broad portfolio of hematologic and solid tumors.
[Allogene Therapeutics, Inc.]
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Precision BioSciences Announces US Patent Trial and Appeal Board Upholds Allogeneic CAR T Patents

Precision BioSciences, Inc. announced that the US Patent and Trademark Office’s Patent Trial and Appeal Board has ruled in favor of Precision BioSciences in two patent interference proceedings that challenged nine US patents owned by Precision.
[Precision BioSciences, Inc.]
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Multiscale Fluorescent Tracking of Immune Cells in the Liver with a Highly Biocompatible Far-Red Emitting Polymer Probe

A newly-designed water-soluble far-red emitting polymer probe, 19K-6H, with a large Stokes shift, was thus evaluated for the tracking of primary immune CD8 T cells. 19K-6H-labelled primary CD8 T cells were injected to mice in a classical model of immune mediated hepatitis.
[Scientific Reports]
Multiscale fluorescent tracking of immune cells in the liver with a highly biocompatible far-red emitting polymer probe | Scientific Reports. (n.d.). Retrieved October 16, 2020, from https://www.nature.com/articles/s41598-020-74621-9 Cite
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Hepatic Stem Cell Numb Gene Is a Potential Target of Huang Qi Decoction Against Cholestatic Liver Fibrosis

Cholestatic liver fibrosis rats transplanted into rat bone marrow-derived mesenchymal stem cells with knocked down Numb gene were treated with Huang Qi Decoction.
[Scientific Reports]
Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis | Scientific Reports. (n.d.). Retrieved October 19, 2020, from https://www.nature.com/articles/s41598-020-74324-1 Cite
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Donor-Derived CD19 CAR-T Cell Therapy of Relapse of CD19-Positive B-ALL Post Allotransplant

Forty-three subjects with B-cell acute lymphoblastic leukemia relapsing post allotransplant received CAR-T cells were analyzed.
[Leukemia]
Zhang, C., Wang, X.-Q., Zhang, R.-L., Liu, F., Wang, Y., Yan, Z.-L., Song, Y.-P., Yang, T., Li, P., Wang, Z., Ma, Y.-Y., Gao, L., Liu, Y., Gao, L., Kong, P.-Y., Liu, J., Tan, X., Zhong, J. F., Chen, Y.-Q., … Zhang, X. (2020). Donor-derived CD19 CAR-T cell therapy of relapse of CD19-positive B-ALL post allotransplant. Leukemia, 1–8. https://doi.org/10.1038/s41375-020-01056-6 Cite
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CASZ1b Is a Novel Transcriptional Corepressor of Mineralocorticoid Receptor

Knockdown of CASZ1b via RNA interference increased the expression levels of the aldosterone-induced MR target genes epithelial Na+ channel-α and serum/glucocorticoid regulated kinase 1 by approximately twofold and 2.3-fold.
[Hypertension Research]
Yokota, K., Shibata, H., Kurihara, I., Kobayashi, S., Murai-Takeda, A., & Itoh, H. (2020). CASZ1b is a novel transcriptional corepressor of mineralocorticoid receptor. Hypertension Research, 1–10. https://doi.org/10.1038/s41440-020-00562-5 Cite
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Pluristem Announces Clearance to Move Forward with Enrollment for Cohort II in an Investigator-Led Phase I/II Chronic Graft vs Host Disease Study

Pluristem Therapeutics Inc. announced that it has received clearance from the safety committee of an investigator initiated Phase I/II study to move forward with patient enrollment for cohort II. The study will evaluate PLX-PAD cells in the treatment of steroid-refractory chronic graft vs. host disease and is led by Principal Investigator Prof. Ron Ram, Director of the Hematology Blood and Marrow Stem Cell Transplantation Unit at Tel Aviv Sourasky Medical Center, Ichilov Hospital, Israel.
[Pluristem Therapeutics Inc.]
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SUSA2 Is an F-Box Protein Required for Autoimmunity Mediated by Paired NLRs SOC3-CHS1 and SOC3-TN2

Scientists report the identification of suppressor of Senescence-Associated E3 Ubiquitin Ligase 1 (SAUL1) 2 (susa2) and susa3 from the saul1-1 suppressor screen.
[Nature Communications]
Liang, W., Tong, M., & Li, X. (2020). SUSA2 is an F-box protein required for autoimmunity mediated by paired NLRs SOC3-CHS1 and SOC3-TN2. Nature Communications, 11(1), 5190. https://doi.org/10.1038/s41467-020-19033-z Cite
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Assessment of Long Non-Coding RNA Expression Reveals Novel Mediators of the Lung Tumor Immune Response

Scientists identified the landscape of tumor-infiltrating immune cells in the context of long non-coding RNA, known regulators of gene expression. They examined the lncRNA profiles of lung adenocarcinoma tumors by interrogating RNA sequencing data from microdissected and non-microdissected samples.
[Scientific Reports]
Assessment of long non-coding RNA expression reveals novel mediators of the lung tumour immune response | Scientific Reports. (n.d.). Retrieved October 16, 2020, from https://www.nature.com/articles/s41598-020-73787-6 Cite
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