CART-Cell Therapy: Recent Advances and New Evidence in Multiple Myeloma

The authors describe several recent advances in the field of anti-B-cell maturation antigen CAR T-cell therapy and multiple myeloma.
[Cancers]
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CAR T Cells Targeting Tumor-Associated Exons of Glypican 2 Regress Neuroblastoma in Mice

Using RNA sequencing (RNA-seq) analysis, researchers showed that exon 3 and exons 7–10 of GPC2 were expressed in cancer but was minimally expressed in normal tissues.
[Cell Reports Medicine]
Li, N., Torres, M. B., Spetz, M. R., Wang, R., Peng, L., Tian, M., Dower, C. M., Nguyen, R., Sun, M., Tai, C.-H., Val, N. de, Cachau, R., Wu, X., Hewitt, S. M., Kaplan, R. N., Khan, J., Croix, B. S., Thiele, C. J., & Ho, M. (2021). CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. Cell Reports Medicine, 0(0). https://doi.org/10.1016/j.xcrm.2021.100297 Cite
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An Oncolytic Virus Expressing IL-15/IL-15Rα Combined with off-the-Shelf EGFR-CAR NK Cells Targets Glioblastoma

Scientists generated a herpes simplex 1-based oncolytic viruses expressing human IL-15/IL-15Rα sushi domain fusion protein, as well as off-the-shelf EGFR-CAR NK cells, and studied their monotherapy and combination efficacy in vitro and in multiple glioblastoma mouse models.
[Cancer Research]
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Withaferin A Inhibits Lymphocyte Proliferation, Dendritic Cell Maturation In Vitro and Prolongs Islet Allograft Survival

The authors investigated the immunosuppressive and immunomodulation abilities of Withaferin A and its effect on long-term islet allograft survival.
[Scientific Reports]
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Inhibition of Nuclear Factor (Erythroid-Derived 2)-like 2 Promotes Hepatic Progenitor Cell Activation and Differentiation

Researchers analyzed the oxidative damage in models of liver injury characterized by biliary epithelial cells/hepatic progenitor cells (HPCs) activation and defined the impact of redox balance perturbation on HPC fate. They then identified Nuclear factor (erythroid-derived 2)-like 2 as the main transcription factor involved in the activation of HPCs.
[NPJ Regenerative Medicine]
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The Antigen-Binding Moiety in the Driver’s Seat of CARs

Scientists present the history of CAR-T cell therapy, and then expand on various developments in the CAR ectodomain. They discuss different formats, each with their own advantages and disadvantages, as well as the developments in affinity tuning, avidity effects, epitope location, and influence of the extracellular spacer.
[Medicinal Research Reviews]
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GlycoMimetics Announces Investigator-Sponsored Phase II Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation

GlycoMimetics, Inc. announced that clinicians at Washington University School of Medicine in St. Louis have dosed the first patient in an investigator-sponsored trial evaluating uproleselan as a prophylactic agent to reduce gastrointestinal toxicities associated with high-dose melphalan in autologous hematopoietic cell transplantation for multiple myeloma.
[GlycoMimetics, Inc.]
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Enzyme Replacement Therapy and Hematopoietic Stem Cell Transplant: A New Paradigm of Treatment in Wolman Disease

Investigators described five Wolman disease patients diagnosed in infancy that were treated at Royal Manchester Children’s Hospital receiving enzyme replacement therapy with dietary substrate reduction then hematopoietic stem cell transplant — multimodal therapy.
[Orphanet Journal of Rare Diseases]
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Upregulation of Apol8 by Epothilone D Facilitates the Neuronal Relay of Transplanted NSCs in Spinal Cord Injury

Epothilone D could promote the neuronal differentiation of neural stem cells by upregulating Apol8, which might provide a promising therapeutic target for spinal cord injury repair.
[Stem Cell Research & Therapy]
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Optimal Conditions for Graft Survival and Reinnervation of Denervated Muscles after Embryonic Motoneuron Transplantation into Peripheral Nerves Undergoing Wallerian Degeneration

The authors investigated whether functional reinnervation of denervated muscle could be achieved by early or delayed transplantation after denervation.
[Journal of Tissue Engineering and Regenerative Medicine]
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Prolonged Suppression of Butyrate Producing Bacteria Is Associated with Acute Gastrointestinal Graft-versus-Host Disease and Transplant Related Mortality after Allogeneic Stem Cell Transplantation

Scientists examined the abundance and butyrogenic capacity of butyrate producing bacteria in 28 healthy donors and 201 patients after allogeneic stem cell transplantation.
[Clinical infectious Diseases]
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