Sorrento Announces Updated Positive Results of Phase Ib Study of COVI-MSC™ for Treatment of ICU COVID-19 Patients

Sorrento Therapeutics, Inc. announced updated positive results from its Phase Ib study of human allogeneic adipose-derived MSCs for patients suffering from COVID-19-induced acute respiratory distress (ARD) or acute respiratory distress syndrome (ARDS).
[Sorrento Therapeutics, Inc. ]
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Cynata Expands MEND Clinical Trial in COVID-19 and Respiratory Failure

Cynata Therapeutics Limited announced that it has received ethics committee approval to expand recruitment criteria in its active MEseNchymal coviD-19 (MEND) clinical trial.
[Cynata Therapeutics Limited (GlobeNewswire)]
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Scaffold-Free Cell-Based Tissue Engineering Therapies: Advances, Shortfalls and Forecast

The authors critically discuss advancements and shortfalls of scaffold-free cell-based tissue engineering strategies, along with pioneering concepts that have the potential to transform regenerative and reparative medicine.
[NPJ Regenerative Medicine]
De Pieri, A., Rochev, Y., & Zeugolis, D. I. (2021). Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast. Npj Regenerative Medicine, 6(1), 1–15. https://doi.org/10.1038/s41536-021-00133-3 Cite
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Promises and Challenges of Adoptive T-cell Therapies for Solid Tumors

Advances are being made in cell-manufacturing approaches that have the potential to establish cell-therapies as credible therapeutic options. T-cell therapies face many challenges but hold great promise for improving clinical outcomes for patients with solid tumours.
[British Journal of Cancer]
Morotti, M., Albukhari, A., Alsaadi, A., Artibani, M., Brenton, J. D., Curbishley, S. M., Dong, T., Dustin, M. L., Hu, Z., McGranahan, N., Miller, M. L., Santana-Gonzalez, L., Seymour, L. W., Shi, T., Van Loo, P., Yau, C., White, H., Wietek, N., Church, D. N., … Ahmed, A. A. (2021). Promises and challenges of adoptive T-cell therapies for solid tumours. British Journal of Cancer, 1–18. https://doi.org/10.1038/s41416-021-01353-6 Cite
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Photoreceptor Precursor Cell Integration into Rodent Retina after Treatment with Novel Glycopeptide PKX-001

Scientist found that only when human photoreceptor precursor cells were pre‐incubated with PKX‐001 prior to transplantation, did the cells integrate and mature into cone photoreceptors expressing S‐opsin or L/M opsin.
[Journal of Tissue Engineering and Regenerative Medicine]
Viringipurampeer, I. A., Yanai, A., Nizamudheen, V. S., Gregory‐Evans, C. Y., & Gregory‐Evans, K. (n.d.). Photoreceptor precursor cell integration into rodent retina after treatment with novel glycopeptide PKX-001. Journal of Tissue Engineering and Regenerative Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/term.3193 Cite
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Transplantation of Apoptosis‐Resistant Endothelial Progenitor Cells Improves Renal Function in Diabetic Kidney Disease

Reduction of protein/creatinin was observed in p53sh‐endothelial progenitor cell (EPC)‐transplanted mice more than null‐EPC or null‐mouse mesenchymal stromal cell transplanted mice.
[Journal of the American Heart Association]
Kundu Nabanita, Nandula Seshagiri R., Asico Laureano D., Fakhri Mona, Banerjee Jaideep, Jose Pedro A., & Sen Sabyasachi. (n.d.). Transplantation of Apoptosis‐Resistant Endothelial Progenitor Cells Improves Renal Function in Diabetic Kidney Disease. Journal of the American Heart Association, 0(0), e019365. https://doi.org/10.1161/JAHA.120.019365 Cite
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Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?

A number of immune regulatory cellular therapies, including regulatory T cells and mesenchymal stromal cells, have emerged as novel alternative therapies for the control of transplant alloresponses. Clinical studies have demonstrated their feasibility and safety, however developing our understanding of the impact of cellular therapeutics in vivo requires advanced immune monitoring strategies.
[Frontiers in Immunology]
Stark, H. L., Wang, H. C., Kuburic, J., Alzhrani, A., Hester, J., & Issa, F. (2021). Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When? Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.664244 Cite
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Bone Marrow‐Derived Mesenchymal Stem Cells Improve Rat Islet Graft Revascularization by Upregulating ISL1

Researchers identified the insulin gene enhancer binding protein‐1 (ISL-1) protein as a potential modulator in bone marrow‐derived mesenchymal stem cell (BMSC)‐mediated revascularization of islet grafts. They demonstrated that the survival rate and insulin secretion of islets were increased in the presence of BMSCs, indicating that BMSCs promoted islet revascularization in a coculture system and rat diabetes model.
[Stem Cells]
Wang, Y., Wang, J.-W., Li, Y., Tian, X.-H., Feng, X.-S., Zhang, S.-C., Liu, P.-J., Xue, W.-J., Zheng, J., & Ding, X.-M. (n.d.). Bone marrow-derived mesenchymal stem cells improve rat islet graft revascularization by upregulating ISL1. STEM CELLS, n/a(n/a). https://doi.org/https://doi.org/10.1002/stem.3378 Cite
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Prevention of Acquired Sensorineural Hearing Loss in Mice by In Vivo Htra2 Gene Editing

Scientists developed CRISPR/Cas9 strategies to prevent aminoglycoside-induced deafness, a common type of acquired non-inherited sensorineural hearing loss, via disrupting the Htra2 gene in the inner ear which is involved in apoptosis but has not been investigated in cochlear hair cell protection.
[Genome Biology]
Gu, X., Wang, D., Xu, Z., Wang, J., Guo, L., Chai, R., Li, G., Shu, Y., & Li, H. (2021). Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing. Genome Biology, 22(1), 86. https://doi.org/10.1186/s13059-021-02311-4 Cite
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Human Periodontal Ligament Stem Cells Transplanted with Nanohydroxyapatite/Chitosan/Gelatin 3D Porous Scaffolds Promote Jaw Bone Regeneration in Swine

Investigators evaluated the bone regeneration potential of nanohydroxyapatite/chitosan/gelatin three-dimensional porous scaffold with human periodontal ligament stem cells in critical-sized jaw bone defects in minipigs.
[Stem Cells and Development]
Zhao, Q., Li, G., Wang, T., Jin, Y., Lu, W., & Ji, J. (2021). Human Periodontal Ligament Stem Cells Transplanted with Nanohydroxyapatite/chitosan/gelatin 3D Porous Scaffolds Promote Jaw Bone Regeneration in Swine. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0204 Cite
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Current Status and Perspective of CAR-T and CAR-NK Cell Therapy Trials in Germany

The authors take a closer look at the commercial CAR-T cell therapies, as well as on CAR-T and CAR-NK cell products, which are currently under evaluation in clinical trials, that are being conducted in Germany.
[Gene Therapy]
Albinger, N., Hartmann, J., & Ullrich, E. (2021). Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany. Gene Therapy, 1–15. https://doi.org/10.1038/s41434-021-00246-w Cite
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