Investigators tested whether the inflammatory nature of oncolytic viruses and their ability to remodel the tumor microenvironment may help to recruit and potentiate the functionality of CAR T cells.
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Evgin, L., Huff, A. L., Wongthida, P., Thompson, J., Kottke, T., Tonne, J., Schuelke, M., Ayasoufi, K., Driscoll, C. B., Shim, K. G., Reynolds, P., Monie, D. D., Johnson, A. J., Coffey, M., Young, S. L., Archer, G., Sampson, J., Pulido, J., Perez, L. S., & Vile, R. (2020). Oncolytic virus-derived type I interferon restricts CAR T cell therapy. Nature Communications, 11(1), 3187. https://doi.org/10.1038/s41467-020-17011-z Cite
Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
Marker Therapeutics, Inc. announced that the United States Adopted Names Council has approved “zelenoleucel” as the nonproprietary name for MT-401, a multi-tumor-associated antigen-specific T cell product candidate for the treatment of patients with acute myeloid leukemia following allogeneic stem cell transplant in both adjuvant and active disease settings.
[Marker Therapeutics, Inc.]
Platelet recovery following autologous stem cell transplantation (ASCT) was affected by insufficient hematopoietic recovery at stem cell harvest, a need for repeated apheresis, and high fever early after ASCT, particularly when the amount of infused stem cells was insufficient.
[Annals of Hematology]
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Nagayama, T., Ashizawa, M., Ikeda, T., Kawaguchi, S., Toda, Y., Ito, S., Ochi, S., Mashima, K., Umino, K., Minakata, D., Nakano, H., Yamasaki, R., Morita, K., Kawasaki, Y., Yamamoto, C., Fujiwara, S., Hatano, K., Sato, K., Oh, I., … Kanda, Y. (2020). Factors that predict delayed platelet recovery after autologous stem cell transplantation for lymphoma or myeloma. Annals of Hematology. https://doi.org/10.1007/s00277-020-04112-4 Cite
The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of Wharton’s jelly‐derived mesenchymal stem cells in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]
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Abbaszadeh, H., Ghorbani, F., Derakhshani, M., Movassaghpour, A. A., Yousefi, M., Talebi, M., & Shamsasenjan, K. (n.d.). Regenerative potential of Wharton’s jelly-derived mesenchymal stem cells: A new horizon of stem cell therapy. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.29810 Cite
Scientists compared the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone and iliac bone in vitro and in vivo.
[Journal of Tissue Engineering]
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Investigators demonstrated that the adoptive transfer of gingiva derived mesenchymal stem cells homes to and maintains in the kidney and had a robust therapeutic effect in a spontaneous lupus nephritis model.
[Journal of Autoimmunity]
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Dang, J., Xu, Z., Xu, A., Liu, Y., Fu, Q., Wang, J., Huang, F., Zheng, Y., Qi, G., Sun, B., Bellanti, J. A., Kandalam, U., Emam, H. A., Jarjour, W., & Zheng, S. G. (2020). Human gingiva-derived mesenchymal stem cells are therapeutic in lupus nephritis through targeting of CD39−CD73 signaling pathway. Journal of Autoimmunity, 102491. https://doi.org/10.1016/j.jaut.2020.102491 Cite
The authors investigated whether donor natural killer cells and interleukin-2 gene modification exerted anti-relapse effects on allogeneic hematopoietic stem-cell transplantation after establishing a mouse model of acute leukemia.
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Scientists investigated adding haplo-identical CD34+ cells to double unit cord blood (CB) grafts to facilitate early haplo-identical donor-derived neutrophil recovery prior to CB engraftment.
A bipartisan group of US senators proposed sweeping—and controversial—changes in how the federal government manages academic research in the face of threats from other countries.