Gender Gap in Research Output Widens during Pandemic

A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist]
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Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying [the online testing] criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]
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A Circular RNA Map for Human Induced Pluripotent Stem Cells of Fetal Origin

Reprogramming was achieved by a footprint-free strategy. Self-renewal and pluripotency of cord blood MSC-human induced pluripoent stem cells (hiPSC) were investigated in vitro and in vivo, compared to parental MSC, to embryonic stem cells and to F-hiPSC.
[Ebiomedicine]
Barilani, M., Cherubini, A., Peli, V., Polveraccio, F., Bollati, V., Guffanti, F., … Lazzari, L. (2020). A circular RNA map for human induced pluripotent stem cells of foetal origin. EBioMedicine, 57. https://doi.org/10.1016/j.ebiom.2020.102848 Cite
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A Scaffold Laden with Mesenchymal Stem Cell-Derived Exosomes for Promoting Endometrium Regeneration and Fertility Restoration through Macrophage Immunomodulation

A novel and viable cell-free therapeutic strategy by umbilical cord-MSC-derived exosomes was proposed.
[Acta Biomaterialia]
Xin, L., Lin, X., Zhou, F., Li, C., Wang, X., Yu, H., … Zhang, S. (2020). A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2020.06.029 Cite
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Ursodeoxycholic Acid Improves Feto-Placental and Offspring Metabolic Outcomes in Hypercholanemic Pregnancy

Researchers analyzed the lipid profile of fetal serum from untreated intrahepatic cholestasis of pregnancy (ICP), ursodeoxycholic acid (UDCA)-treated ICP and uncomplicated pregnancies and found that UDCA ameliorated ICP-associated fetal dyslipidemia.
[Scientific Reports]
Borges Manna, L., Papacleovoulou, G., Flaviani, F., Pataia, V., Qadri, A., Abu-Hayyeh, S., … Williamson, C. (2020). Ursodeoxycholic acid improves feto-placental and offspring metabolic outcomes in hypercholanemic pregnancy. Scientific Reports, 10(1), 10361. https://doi.org/10.1038/s41598-020-67301-1 Cite
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COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]
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Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
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Chi-Med Announces Fruquintinib Granted US FDA Fast Track Designation for Metastatic Colorectal Cancer

Hutchison China MediTech Limited announced that the FDA has granted Fast Track Designation for the development of fruquintinib, for the treatment of patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and, if RAS wild-type, an anti-epidermal growth factor receptor therapy.
[Hutchison China MediTech Limited ]
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NMPA Accepts Bio-Thera Solutions’ Biologics License Application (BLA) for BAT1706, A Proposed Biosimilar to Avastin®

Bio-Thera Solutions announced that the China National Medical Products Administration (NMPA) has accepted the Biologics License Application for BAT1706, a proposed biosimilar to Avastin®.
[Bio-Thera Solutions (Business Wire, Inc.)]
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Regenerative Potential of Wharton’s Jelly‐Derived Mesenchymal Stem Cells: A New Horizon of Stem Cell Therapy

The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of Wharton’s jelly‐derived mesenchymal stem cells in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]
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