Athersys Reports That Healios Has Completed Enrollment in the ONE-BRIDGE Study of MultiStem® for Acute Respiratory Distress Syndrome in Japan

Athersys, Inc. announced that its partner HEALIOS K.K. has completed enrollment in the ONE-BRIDGE study in Japan evaluating MultiStem® in patients with acute respiratory distress syndrome (ARDS) caused by pneumonia.
[Athersys, Inc]
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Post-Transplant Food Anaphylaxis in an Adult Cord Blood Transplant Recipient (Ms. No. IJHM-D-20-01037R1)

Scientists describe a case of new-onset food anaphylaxis after cord blood transplantation (CBT) in an adult patient that demonstrated that post-CBT allergen-challenge was not a risk for long-term allergic sensitization, even in adult recipients.
[International Journal of Hematology]
Kawahara, A., Nakanishi, T., Goto, M., Akao, K., Katsuragi, T., & Tsukada, J. (2021). Post-transplant food anaphylaxis in an adult cord blood transplant recipient (Ms. No. IJHM-D-20-01037R1). International Journal of Hematology. https://doi.org/10.1007/s12185-021-03140-8 Cite
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A Composite Scaffold of Wharton’s Jelly and Chondroitin Sulphate Loaded with Human Umbilical Cord Mesenchymal Stem Cells Repairs Articular Cartilage Defects in Rat Knee

In vitro experiments involved identification of the human umbilical cord MSCs, construction of the biomimetic composite scaffolds by the physical and chemical crosslinking of Wharton’s jelly (WJ) and chondroitin sulfate, and testing of the biomechanical properties of both the composite scaffold and the WJ scaffold.
[Journal of Materials Science-Materials in Medicine]
Li, Z., Bi, Y., Wu, Q., Chen, C., Zhou, L., Qi, J., Xie, D., Song, H., Han, Y., Qu, P., Zhang, K., Wu, Y., & Yin, Q. (2021). A composite scaffold of Wharton’s jelly and chondroitin sulphate loaded with human umbilical cord mesenchymal stem cells repairs articular cartilage defects in rat knee. Journal of Materials Science: Materials in Medicine, 32(4), 36. https://doi.org/10.1007/s10856-021-06506-w Cite
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Beneficial Effects of Human Umbilical Cord Blood Mononuclear Cells on Persistent Erectile Dysfunction After Treatment of 5-Alpha Reductase Inhibitor in Rats

In vivo erectile function, in vitro relaxant and contractile responses of CC, protein expression and localization of PDE5, eNOS, nNOS, HIF-1α, and smooth muscle content in penile tissue.
[Journal of Sexual Medicine]
Oztekin, C. V., Yilmaz-Oral, D., Kaya-Sezginer, E., Kirlangic, O. F., Ozen, F. Z., Ozdal, B., Topcu, H. O., & Gur, S. (2021). Beneficial Effects of Human Umbilical Cord Blood Mononuclear Cells on Persistent Erectile Dysfunction After Treatment of 5-Alpha Reductase Inhibitor in Rats. The Journal of Sexual Medicine, 0(0). https://doi.org/10.1016/j.jsxm.2021.02.005 Cite
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Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Attenuate the Inflammation of Severe Steroid-Resistant Asthma by Reshaping Macrophage Polarization

Investigators evaluated the effects of MSC-exosomes on airway hyper responsiveness, inflammation, histopathology, and macrophage polarization in severe, steroid-resistant asthma in mice.
[Stem Cell Research & Therapy]
Dong, B., Wang, C., Zhang, J., Zhang, J., Gu, Y., Guo, X., Zuo, X., Pan, H., Hsu, A. C.-Y., Wang, G., & Wang, F. (2021). Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization. Stem Cell Research & Therapy, 12(1), 204. https://doi.org/10.1186/s13287-021-02244-6 Cite
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Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis

Human umbilical cord (HUC)-MSCs were separated from the umbilical cord using the adherence method. Surface markers of HUC-MSCs were detected by flow cytometry for MSC identification.
[Cancer Biotherapy and Radiopharmaceuticals]
Ye, H., Pan, J., Gong, E., Cai, X., Xu, C., Li, Y., Zheng, H., & Cao, Z. (2021). Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis. Cancer Biotherapy and Radiopharmaceuticals. https://doi.org/10.1089/cbr.2020.3855 Cite
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Single-Cell Transcriptome Profiling Reveals Molecular Heterogeneity in Human Umbilical Cord Tissue and Culture-Expanded Mesenchymal Stem Cells

The heterogeneity and the characteristics of cultured umbilical cord MSCs and the cognate human umbilical cord tissue at single‐cell resolution remains poorly defined.
[FEBS Journal]
Wang, Q., Li, J., Wang, S., Deng, Q., Wang, K., Dai, X., An, Y., Dong, G., Ke, W., Chen, F., Liu, L., Yang, H., Du, Y., Zhao, W., & Shang, Z. (n.d.). Single-cell transcriptome profiling reveals molecular heterogeneity in human umbilical cord tissue and culture-expanded mesenchymal stem cells. The FEBS Journal, n/a(n/a). https://doi.org/https://doi.org/10.1111/febs.15834 Cite
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Stem Cell-Based Approaches in Cardiac Tissue Engineering: Controlling the Microenvironment for Autologous Cells

The authors provide a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue.
[Biomedicine & Pharmacotherapy]
Augustine, R., Dan, P., Hasan, A., Khalaf, I. M., Prasad, P., Ghosal, K., Gentile, C., McClements, L., & Maureira, P. (2021). Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells. Biomedicine & Pharmacotherapy, 138, 111425. https://doi.org/10.1016/j.biopha.2021.111425 Cite
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Sorrento Announces Updated Positive Results of Phase Ib Study of COVI-MSC™ for Treatment of ICU COVID-19 Patients

Sorrento Therapeutics, Inc. announced updated positive results from its Phase Ib study of human allogeneic adipose-derived MSCs for patients suffering from COVID-19-induced acute respiratory distress (ARD) or acute respiratory distress syndrome (ARDS).
[Sorrento Therapeutics, Inc. ]
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Cynata Expands MEND Clinical Trial in COVID-19 and Respiratory Failure

Cynata Therapeutics Limited announced that it has received ethics committee approval to expand recruitment criteria in its active MEseNchymal coviD-19 (MEND) clinical trial.
[Cynata Therapeutics Limited (GlobeNewswire)]
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NGF Nanoparticles Enhance the Potency of Transplanted Human Umbilical Cord Mesenchymal Stem Cells for Myocardial Repair

In vitro, nerve growth factor significantly improved the proliferation of human umbilical cord MSCs and mitigated cytotoxicity and apoptosis under hypoxic injury.
[American Journal of Physiology-Heart and Circulatory Physiology]
Luo, W., Gong, Y., Qiu, F., Yuan, Y., Jia, W., Liu, Z., & Gao, L. (2021). NGF Nanoparticles Enhance the Potency of Transplanted Human Umbilical Cord Mesenchymal Stem Cells for Myocardial Repair. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.00855.2020 Cite
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