Applications of the Amniotic Membrane in Tissue Engineering and Regeneration: The Hundred-Year Challenge

This review highlights the development of the Amnio-M over the years and the implication of new and emerging nanotechnology to support expanding its use for tissue engineering and clinical applications.
[Stem Cell Research & Therapy]
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Silencing of Nrf Genes in the Human Placenta as Measured by SDS-PAGE and Western Blotting Techniques

Researchers reported the presence of nuclear factor erythroid 2-related factor (Nrf)1, Nrf2 and Nrf3 proteins in both human primary trophoblast and human trophoblast choriocarcinoma cell line (BeWo).
[Placenta]
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Expression of Tissue Factor and TF-Mediated Integrin Regulation in HTR-8/SVneo Trophoblast Cells

Scientists ascertained the expression of tissue factor in HTR-8/SVneo trophoblast cell line and its role in signal transduction of integrin regulation concerning the invasion of trophoblasts.
[Journal of Reproductive Immunology]
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Relationship between Donor-Specific HPA-15 Antibodies and Poor Graft Function in HPA-15 Mismatched Cord Blood Transplantation

Investigators encountered a case of human platelet antigen 15 (HPA-15) mismatched cord blood transplantation with a high HPA-15b antibody titer. Prolonged poor graft function and megakaryocyte aplasia with sustained high-titer HPA-15b antibodies were attenuated by rituximab therapy, and rapid recovery of hematopoiesis was achieved.
[International Journal of Hematology]
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The Placenta as a Target of Opioid Drugs

The authors discuss the current human and rodent studies that have examined the effects of opioids on the placenta.
[Biology of Reproduction]
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Mapping the Cord Blood Transcriptome of Pregnancies Affected by Early Maternal Anemia to Identify Signatures of Fetal Programming

Researchers leveraged global transcriptome- and accompanying epigenome-wide changes in 48 umbilical cord blood (UCB) from newborns of early pregnancy (EP)-anemic Tanzanian mothers and 50 controls to identify differentially expressed genes in UCB exposed to maternal EP-anemia.
[Journal of Clinical Endocrinology & Metabolism]
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Asymmetric Expression of Proteins in the Granules of the Placentomal Binucleate Cells in Giraffa camelopardalis

Gold labelled lectin histochemistry and protein immunocytochemistry were used on deplasticised 1 μm sections of a wide variety of ruminant placentomes with a wide range of antibodies and lectins.
[Biology of Reproduction]
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The Effect of Progesterone Administration on the Expression of Metastasis Tumor Antigens (MTA1 and MTA3) in Placentas of Normal and Dexamethasone-Treated Rats

A group of genes called MTAs play a role in proliferation and apoptosis. MTA1 upregulates trophoblasts proliferation and differentiation, while MTA3 downregulates proliferation and induces apoptosis. Researchers hypothesized that during IUGR, placental MTA1 decreased and MTA3 increased and this was reversed by P4 treatment.
[Molecular Biology Reports]
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Introduction of an Efficient Method for Placenta Decellularization with High Potential to Preserve Ultrastructure and Support Cell Attachment

Human placenta was decellularized by four protocols and decellularization efficacy was compared by hematoxylin and eosin, 4′,6-diamidino-2-phenylindole staining, and DNA measurement.
[Artificial Organs]
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Environmental Constraints and Pathologies That Modulate Equine Placental Genes and Development

Placental development is dependent on the maternal environment that can be affected by several factors that may affect foetal development as well as long-term offspring health.
[Reproduction]
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Affimed Announces Completion of Enrollment in REDIRECT, the Registration-Directed Study of AFM13 in PTCL, and Provides Business Update

Affimed N.V., announced that it has completed enrollment in the REDIRECT study and provided a business update.
[Affimed N.V. Inc.]
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