B Cell Depletion Abrogates Immune Mediated Cytopenia and Rejection of Cord Blood Transplantation in Hurler Syndrome

Researchers studied 57 patients in two centers who received myeloablative conditioning for cord blood transplant in Hurler syndrome, and reported a significant improvement in event-free survival with reduced incidence of graft failure and without any evidence of immune-mediated cytopenia in those patients that had received rituximab.
[Bone Marrow Transplantation]
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Small Intestinal Submucosa Membrane Modified by Fusion Peptide-Mediated Extracellular Vesicles to Promote Tissue Regeneration

Extracellular vesicles (EVs) derived from umbilical cord MSCs can achieve rapid cell proliferation and migration with little immune response by creating a satisfactory microenvironment. Fusion peptide-mediated EVs were able to modify the surface of the small intestinal submucosa membrane via specific combination.
[Advanced Healthcare Materials]
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Blood and Immune Development in Human Fetal Bone Marrow and Down Syndrome

Hematopoietic progenitors from fetal liver, fetal bone marrow and cord blood exhibited transcriptional and functional differences that contributed to tissue-specific identity and cellular diversification.
[Nature]
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Involvement of Various Chemokine/Chemokine Receptor Axes in Trafficking and Oriented Locomotion of Mesenchymal Stem Cells in Multiple Sclerosis Patients

Researchers hypothesized that the chemokine/chemokine receptor axes network have crucial and efficacious impacts on behavior of the MSCs.
[Cytokine]
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Management of Toxic Optic Neuropathy via a Combination of Wharton’s Jelly-Derived Mesenchymal Stem Cells with Electromagnetic Stimulation

Researchers investigated the effect of the combination of Wharton’s jelly derived MSCs and high frequency repetitive electromagnetic stimulation in the therapy of toxic optic neuropathies with severe symptoms after the available current therapy modalities which were unsucessful.
[Stem Cell Research & Therapy]
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Metformin Enhances the Osteogenesis and Angiogenesis of Human Umbilical Cord Mesenchymal Stem Cells for Tissue Regeneration Engineering

Researchers explored the effects of metformin on the osteogenesis, adipogenesis and angiogenesis of human umbilical cord-MSCs, and attempted to explain the molecular fluctuations of metformin through the mapping of protein profiles.
[International Journal of Biochemistry & Cell Biology]
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Haploidentical vs. Sibling, Unrelated, or Cord Blood Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia

Scientists compared overall survival between haploidentical hematopoietic cell transplantation (HCT) using post-transplant cyclophosphamid and HLA-matched sibling donor, 8/8 HLA-matched unrelated donor, 7/8 HLA-matched UD, or umbilical cord blood HCT.
[Blood Advances]
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Total Body Irradiation-Containing Conditioning Regimens without Antithymocyte Globulin in Adults with Aplastic Anemia Undergoing Umbilical Cord Blood Transplantation

The authors compared transplantation outcomes between a fludarabine (Flu)- and melphalan-based regimen and a Flu- and cyclophosphamide-based regimen
[Annals of Hematology]
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Titers of SARS CoV-2 Antibodies in Cord Blood of Neonates Whose Mothers Contracted SARS CoV-2 (COVID-19) during Pregnancy and in Those Whose Mothers Were Vaccinated with mRNA to SARS CoV-2 during Pregnancy

Scientists compared neonatal immunity after vaccination against SARS-CoV-2 during pregnancy to that achieved after maternal infection.
[Journal of Perinatology]
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Amniotic Fluid Stem Cell Administration Can Prevent Epithelial Injury from Necrotizing Enterocolitis

Investigators examined the effects of stem cells derived from amniotic fluid and MSCs on the prevention of intestinal injury during experimental necrotizing enterocolitis.
[Pediatric Research]
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Altered Effect of Killer Immunoglobulin-Like Receptor–Ligand Mismatch by Graft versus Host Disease Prophylaxis in Cord Blood Transplantation

The difference in the effect of killer immunoglobulin-like receptor–ligand mismatch was retrospectively assessed between patients who received cord blood transplantation for acute leukemia, myelodysplastic syndrome, or chronic myeloid leukemia, as well as GVHD prophylaxis comprising tacrolimus plus methotrexate or mycophenolate mofetil.
[Bone Marrow Transplantation]
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