A Novel Therapeutic Approach for Inflammatory Bowel Disease by Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells to Repair Intestinal Barrier via TSG-6

Two separate dextran sulfate sodium and 2,4,6-trinitrobenzenesulfonic acid induced inflammatory bowel disease mouse models were intraperitoneally administered MSCs-Exo extracted from human umbilical cord MSC culture supernatant.
[Stem Cell Research & Therapy]
Yang, S., Liang, X., Song, J., Li, C., Liu, A., Luo, Y., Ma, H., Tan, Y., & Zhang, X. (2021). A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6. Stem Cell Research & Therapy, 12(1), 315. https://doi.org/10.1186/s13287-021-02404-8 Cite
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PRL-1 Overexpressed Placenta-Derived Mesenchymal Stem Cells Suppress Adipogenesis in Graves’ Ophthalmopathy through SREBP2/HMGCR Pathway

Investigators constructed PRL-1 overexpressed human placental mesenchymal stem cells in an attempt to enhance the suppressive function of adipogenesis in Graves’ ophthalmopathy animal models.
[Stem Cell Research & Therapy]
Park, M., Kim, J. Y., Kang, J. M., Lee, H. J., Banga, J. P., Kim, G. J., & Lew, H. (2021). PRL-1 overexpressed placenta-derived mesenchymal stem cells suppress adipogenesis in Graves’ ophthalmopathy through SREBP2/HMGCR pathway. Stem Cell Research & Therapy, 12(1), 304. https://doi.org/10.1186/s13287-021-02337-2 Cite
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Human Umbilical Cord Mesenchymal Stromal Cell Treatment of Severe COVID-19 Patients: A Three-Month Follow-Up Study Following Hospital Discharge

In this three-month follow-up study, researchers examined discharged patients who had received human umbilical cord-MSC therapy to assess the safety of this therapy and the health-related quality of life of these patients.
[Stem Cells and Development]
Feng, G., Shi, L., Huang, T., Ji, N., Zheng, Y., Lin, H., Niu, C., Wang, Y., Li, R., Huang, M., Chen, X., Shu, L., Wu, M., Deng, K., Wei, J., Wang, X., Cao, Y., & Yan, J. (2021). Human umbilical cord mesenchymal stromal cell treatment of severe COVID-19 patients: a three-month follow-up study following hospital discharge. Stem Cells and Development. https://doi.org/10.1089/scd.2021.0015 Cite
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Human Umbilical Cord Mesenchymal Stem Cells in Type 2 Diabetes Mellitus: The Emerging Therapeutic Approach

The authors focus on the latest research and applications of human-derived umbilical cord MSC in the treatment and management of T2DM, exploring and systematizing the key effects of both umbilical cord MSC and its factor-rich secretome accordingly with the major complications associated to T2DM.
[Cell and Tissue Research]
Gomes, A., Coelho, P., Soares, R., & Costa, R. (2021). Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic approach. Cell and Tissue Research. https://doi.org/10.1007/s00441-021-03461-4 Cite
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3D Bioprinting of Polythiophene Materials for Promoting Stem Cell Proliferation in a Nutritionally Deficient Environment

PMNT was confirmed to promote human umbilical cord-derived MSC proliferation in a serum-free medium by driving cell cycles and up-regulating gene expression in the pathways of biosynthesis and the metabolism.
[ACS Applied Materials & Interfaces]
Zhao, H., Xu, J., Zhang, E., Qi, R., Huang, Y., Lv, F., Liu, L., Gu, Q., & Wang, S. (2021). 3D Bioprinting of Polythiophene Materials for Promoting Stem Cell Proliferation in a Nutritionally Deficient Environment. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.1c04967 Cite
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Non-Transplantable Cord Blood Units as a Source for Adoptive Immunotherapy of Leukemia and a Paradigm of Circular Economy in Medicine

Scientists explored the feasibility of generating bivalent-Leuk-STs directed against Wilms tumor 1 and preferentially expressed antigen in melanoma from umbilical cord blood units disqualified for allogeneic hematopoietic stem cell transplantation.
[British Journal of Haematology]
Koukoulias, K., Papadopoulou, A., Kouimtzidis, A., Papayanni, P.-G., Papaloizou, A., Sotiropoulos, D., Yiangou, M., Costeas, P., Anagnostopoulos, A., Yannaki, E., & Kaloyannidis, P. (n.d.). Non-transplantable cord blood units as a source for adoptive immunotherapy of leukaemia and a paradigm of circular economy in medicine. British Journal of Haematology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjh.17464 Cite
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Melatonin Augments the Neuroprotective Effects of Hypothermia in Lambs following Perinatal Asphyxia

Scientists induced asphyxia in fetal sheep via umbilical cord occlusion until mean arterial blood pressure fell from 55 ± 3 mmHg in sham controls to 18-20 mmHg.
[Journal of Pineal Research]
Aridas, J. D., Yawno, T., Sutherland, A. E., Nitsos, I., Wong, F. Y., Hunt, R. W., Ditchfield, M., Fahey, M. C., Malhotra, A., Wallace, E. M., Gunn, A. J., Jenkin, G., & Miller, S. L. (n.d.). Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia. Journal of Pineal Research, n/a(n/a), e12744. https://doi.org/https://doi.org/10.1111/jpi.12744 Cite
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hAECs and Their Exosomes Improve Cardiac Function after Acute Myocardial Infarction in Rats

Researchers cultured human amniotic epithelial cells (hAECs) and extracted exosomes from culture supernatants. They established a stable acute myocardial infarction model in rats and treated them with hAECs, exosomes, or PBS.
[Aging]
Aging | hAECs and their exosomes improve cardiac function after acute myocardial infarction in rats - Full Text. (n.d.). Retrieved June 2, 2021, from https://www.aging-us.com/article/203066/text Cite
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Matrigel/Umbilical Cord-Derived Mesenchymal Stem Cells Promote Granulosa Cell Proliferation and Ovarian Vascularization in a Mouse Model of Premature Ovarian Failure

Investigators aimed to fabricate a Matrigel scaffold loaded with human umbilical cord-derived MSCs and explore its potential to restore ovarian function and repair ovarian structures in vitro and in vivo.
[Stem Cells and Development]
Zhou, yao, Zhou, J., Xu, X., Du, F., Nie, M., Hu, L., Ma, Y., Liu, M., Yu, S., Zhang, J., & Chen, Y. (2021). Matrigel/umbilical cord-derived mesenchymal stem cells promote granulosa cell proliferation and ovarian vascularization in a mouse model of premature ovarian failure. Stem Cells and Development. https://doi.org/10.1089/scd.2021.0005 Cite
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Interleukin-1β-Induced Matrix Metalloproteinase-3 via ERK1/2 Pathway to Promote Mesenchymal Stem Cell Migration

Scientists proposed that IL-1β influences human umbilical cord Wharton’s jelly derived mesenchymal stem cells migration involving matrix metalloproteinase-3.
[PLOS ONE]
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Analysis of Outcomes of Single-Unit Cord Blood Transplantation with Umbilical Cord Blood Units Processed with Two Different Red Blood Cell Sedimentation Reagents

Retrospective data analysis compared laboratory and clinical outcomes following single-unit umbilical cord blood transplantation performed between 1999 and 2015.
[Transfusion]
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