Category Archives: Cord Blood

Cord Blood News is an online publication and email newsletter dedicated to sharing the newest publications, reviews, and news updates in the field of cord blood stem cell research.
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Summarizing the latest research and reviews since 2009, Cord Blood News keeps members of the scientific and medical community up-to-date on the latest discoveries and research publications related to cord blood stem cell research. Specific topics include the characterization, expansion, culture, and therapeutic uses of cord blood, Wharton’s jelly, and amniotic fluid-derived stem cells. The publication serves as a valuable resource to keep scientists current with the latest clinical trials, policy updates, event postings, and career opportunities.

A Novel Therapeutic Approach for Inflammatory Bowel Disease by Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells to Repair Intestinal Barrier via TSG-6

Two separate dextran sulfate sodium and 2,4,6-trinitrobenzenesulfonic acid induced inflammatory bowel disease mouse models were intraperitoneally administered MSCs-Exo extracted from human umbilical cord MSC culture supernatant.
[Stem Cell Research & Therapy]
Yang, S., Liang, X., Song, J., Li, C., Liu, A., Luo, Y., Ma, H., Tan, Y., & Zhang, X. (2021). A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6. Stem Cell Research & Therapy, 12(1), 315. https://doi.org/10.1186/s13287-021-02404-8 Cite
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PRL-1 Overexpressed Placenta-Derived Mesenchymal Stem Cells Suppress Adipogenesis in Graves’ Ophthalmopathy through SREBP2/HMGCR Pathway

Investigators constructed PRL-1 overexpressed human placental mesenchymal stem cells in an attempt to enhance the suppressive function of adipogenesis in Graves’ ophthalmopathy animal models.
[Stem Cell Research & Therapy]
Park, M., Kim, J. Y., Kang, J. M., Lee, H. J., Banga, J. P., Kim, G. J., & Lew, H. (2021). PRL-1 overexpressed placenta-derived mesenchymal stem cells suppress adipogenesis in Graves’ ophthalmopathy through SREBP2/HMGCR pathway. Stem Cell Research & Therapy, 12(1), 304. https://doi.org/10.1186/s13287-021-02337-2 Cite
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Human Umbilical Cord Mesenchymal Stromal Cell Treatment of Severe COVID-19 Patients: A Three-Month Follow-Up Study Following Hospital Discharge

In this three-month follow-up study, researchers examined discharged patients who had received human umbilical cord-MSC therapy to assess the safety of this therapy and the health-related quality of life of these patients.
[Stem Cells and Development]
Feng, G., Shi, L., Huang, T., Ji, N., Zheng, Y., Lin, H., Niu, C., Wang, Y., Li, R., Huang, M., Chen, X., Shu, L., Wu, M., Deng, K., Wei, J., Wang, X., Cao, Y., & Yan, J. (2021). Human umbilical cord mesenchymal stromal cell treatment of severe COVID-19 patients: a three-month follow-up study following hospital discharge. Stem Cells and Development. https://doi.org/10.1089/scd.2021.0015 Cite
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Human Umbilical Cord Mesenchymal Stem Cells in Type 2 Diabetes Mellitus: The Emerging Therapeutic Approach

The authors focus on the latest research and applications of human-derived umbilical cord MSC in the treatment and management of T2DM, exploring and systematizing the key effects of both umbilical cord MSC and its factor-rich secretome accordingly with the major complications associated to T2DM.
[Cell and Tissue Research]
Gomes, A., Coelho, P., Soares, R., & Costa, R. (2021). Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic approach. Cell and Tissue Research. https://doi.org/10.1007/s00441-021-03461-4 Cite
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3D Bioprinting of Polythiophene Materials for Promoting Stem Cell Proliferation in a Nutritionally Deficient Environment

PMNT was confirmed to promote human umbilical cord-derived MSC proliferation in a serum-free medium by driving cell cycles and up-regulating gene expression in the pathways of biosynthesis and the metabolism.
[ACS Applied Materials & Interfaces]
Zhao, H., Xu, J., Zhang, E., Qi, R., Huang, Y., Lv, F., Liu, L., Gu, Q., & Wang, S. (2021). 3D Bioprinting of Polythiophene Materials for Promoting Stem Cell Proliferation in a Nutritionally Deficient Environment. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.1c04967 Cite
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Non-Transplantable Cord Blood Units as a Source for Adoptive Immunotherapy of Leukemia and a Paradigm of Circular Economy in Medicine

Scientists explored the feasibility of generating bivalent-Leuk-STs directed against Wilms tumor 1 and preferentially expressed antigen in melanoma from umbilical cord blood units disqualified for allogeneic hematopoietic stem cell transplantation.
[British Journal of Haematology]
Koukoulias, K., Papadopoulou, A., Kouimtzidis, A., Papayanni, P.-G., Papaloizou, A., Sotiropoulos, D., Yiangou, M., Costeas, P., Anagnostopoulos, A., Yannaki, E., & Kaloyannidis, P. (n.d.). Non-transplantable cord blood units as a source for adoptive immunotherapy of leukaemia and a paradigm of circular economy in medicine. British Journal of Haematology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjh.17464 Cite
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Melatonin Augments the Neuroprotective Effects of Hypothermia in Lambs following Perinatal Asphyxia

Scientists induced asphyxia in fetal sheep via umbilical cord occlusion until mean arterial blood pressure fell from 55 ± 3 mmHg in sham controls to 18-20 mmHg.
[Journal of Pineal Research]
Aridas, J. D., Yawno, T., Sutherland, A. E., Nitsos, I., Wong, F. Y., Hunt, R. W., Ditchfield, M., Fahey, M. C., Malhotra, A., Wallace, E. M., Gunn, A. J., Jenkin, G., & Miller, S. L. (n.d.). Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia. Journal of Pineal Research, n/a(n/a), e12744. https://doi.org/https://doi.org/10.1111/jpi.12744 Cite
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hAECs and Their Exosomes Improve Cardiac Function after Acute Myocardial Infarction in Rats

Researchers cultured human amniotic epithelial cells (hAECs) and extracted exosomes from culture supernatants. They established a stable acute myocardial infarction model in rats and treated them with hAECs, exosomes, or PBS.
[Aging]
Aging | hAECs and their exosomes improve cardiac function after acute myocardial infarction in rats - Full Text. (n.d.). Retrieved June 2, 2021, from https://www.aging-us.com/article/203066/text Cite
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Matrigel/Umbilical Cord-Derived Mesenchymal Stem Cells Promote Granulosa Cell Proliferation and Ovarian Vascularization in a Mouse Model of Premature Ovarian Failure

Investigators aimed to fabricate a Matrigel scaffold loaded with human umbilical cord-derived MSCs and explore its potential to restore ovarian function and repair ovarian structures in vitro and in vivo.
[Stem Cells and Development]
Zhou, yao, Zhou, J., Xu, X., Du, F., Nie, M., Hu, L., Ma, Y., Liu, M., Yu, S., Zhang, J., & Chen, Y. (2021). Matrigel/umbilical cord-derived mesenchymal stem cells promote granulosa cell proliferation and ovarian vascularization in a mouse model of premature ovarian failure. Stem Cells and Development. https://doi.org/10.1089/scd.2021.0005 Cite
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Interleukin-1β-Induced Matrix Metalloproteinase-3 via ERK1/2 Pathway to Promote Mesenchymal Stem Cell Migration

Scientists proposed that IL-1β influences human umbilical cord Wharton’s jelly derived mesenchymal stem cells migration involving matrix metalloproteinase-3.
[PLOS ONE]
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Analysis of Outcomes of Single-Unit Cord Blood Transplantation with Umbilical Cord Blood Units Processed with Two Different Red Blood Cell Sedimentation Reagents

Retrospective data analysis compared laboratory and clinical outcomes following single-unit umbilical cord blood transplantation performed between 1999 and 2015.
[Transfusion]
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