Impact of Donor Source on Allogeneic Hematopoietic Stem Cell Transplantation for Mature T- and NK-Cell Neoplasms in the Kyoto Stem Cell Transplantation Group

39 patients received bone marrow or peripheral blood stem cell transplantation from related donors, 37 received BMT/PBSCT from unrelated donors, and 35 received cord blood transplantation
[Biology of Blood and Marrow Transplantation]
Watanabe, M., Kanda, J., Arai, Y., Hishizawa, M., Nishikori, M., Ishikawa, T., Imada, K., Ueda, Y., Akasaka, T., Yonezawa, A., Nohgawa, M., Kitano, T., Itoh, M., Takeoka, T., Moriguchi, T., Yago, K., Arima, N., Anzai, N., Watanabe, M., … Takaori-Kondo, A. (2020). Impact of donor source on allogeneic hematopoietic stem cell transplantation for mature T- and NK-cell neoplasms in the Kyoto Stem Cell Transplantation Group. Biology of Blood and Marrow Transplantation, 0(0). https://doi.org/10.1016/j.bbmt.2020.07.032 Cite
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Human Stem Cell Based Tissue Engineering for In Vivo Cartilage Repair: A Systematic Review

The authors systematically review literature pertaining to hematopoietic stem cell (HSC) based tissue engineering strategies in animal models of chondral repair such that trends may be identified and the utility of HSCs in chondral repair can be elucidated
[Tissue Engineering]
Kabir, W., Di Bella, C., Gould, D., Jo, I., & Choong, P. (2020). Human Stem Cell Based Tissue Engineering for In Vivo Cartilage Repair: A Systematic Review. Tissue Engineering Part B: Reviews. https://doi.org/10.1089/ten.TEB.2020.0155 Cite
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Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study

67 patients were treated with Wharton’s jelly mesenchymal stem cells. The treated patients were paired with 67 reference patients from the PRO-ACT database which contains patient records from 23 amyotrophic lateral sclerosis clinical studies
[Stem Cell Reviews and Reports]
Barczewska, M., Maksymowicz, S., Zdolińska-Malinowska, I., Siwek, T., & Grudniak, M. (2020). Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10016-7 Cite
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IMAC Holdings Receives FDA Authorization to Initiate Clinical Study of Its Umbilical Cord-Derived Allogenic Mesenchymal Stem Cells for the Treatment of Bradykinesia Due to Parkinson’s Disease

IMAC Holdings, Inc. announced the United States Food and Drug Administration approved its investigational new drug application, which IMAC submitted in May 2020, for the use of umbilical cord-derived allogenic mesenchymal stem cells for the treatment of bradykinesia, or the gradual loss and slowing down of spontaneous body movement, due to Parkinson’s disease.
[IMAC Holdings, Inc. (GlobeNewswire, Inc.) ]
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Anti-Abortion Ethicists and Scientists Dominate Trump’s Fetal Tissue Review Board

Research advocates were eager to learn who Health and Human Services Secretary Alex Azar would appoint to the board and to see its ideological makeup. On July 31st they got their first look as it gathered online for a one-time meeting run by the National Institutes of Health.
[ScienceInsider]
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Twitter Account of Embattled #MeTooSTEM Founder Suspended

Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
[ScienceInsider]
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Donor Stem Cell-Derived Paroxysmal Nocturnal Hemoglobinuria after Umbilical Cord Blood Transplantation

The authors report here a patient with adult T‐cell leukemia/lymphoma, who developed paroxysmal nocturnal hemoglobinuria seven years after umbilical cord blood transplantation.
[European Journal of Haematology]
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Temporally Altered miRNA Expression in a Piglet Model of Hypoxic Ischemic Brain Injury

Researchers report serial changes in six circulating, cross-species/bridging biomarkers in a clinically relevant porcine model of neonatal hypoxic ischemic encephalopathy with functional analysis.
[Molecular Neurobiology]
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MSCs-Released TGFβ1 Generate CD4+CD25+Foxp3+ in T-Reg Cells of Human SLE PBMC

The authors used a post-test control group design. MSCs were obtained from human umbilical cord blood and characterized according to their surface antigen expression and multilineage differentiation capacities.
[Journal of the Formosan Medical Association]
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Comparison of Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Isolated from Cryopreserved Material and Extracted by Explantation and Digestion Methods Utilizing a Split Manufacturing Model

Umbilical cord (UC)-derived MSCs were isolated from 10 UC tissue samples by both explantation and enzymatic digestion methods to allow for comparison of cells from the same donor.
[Cytotherapy]
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Effects of Conditioned Medium from Bone Marrow Cells on Human Umbilical Cord Perivascular Cells

Investigators evaluated the effects of human bone marrow (hBM)-conditioned medium derived from different stages of hBM MSC culture on the osteogenic capacity of perivascular tissue of the human umbilical cord.
[Tissue Engineering]
Kajiyama, S., Nagashima, Y., Funatsu, T., Suzuki, T., Fukaya, M., Matsushima, Y., Nagano, T., Davies, J. E., & Gomi, K. (2020). Effects of conditioned medium from bone marrow cells on human umbilical cord perivascular cells. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2020.0025 Cite
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Intrathecal Administration of the Extracellular Vesicles Derived from Human Wharton’s Jelly Stem Cells Inhibit Inflammation and Attenuate the Activity of Inflammasome Complexes after Spinal Cord Injury in Rats

Scientists investigated immunomodulatory potential of human Wharton’s jelly mesenchymal stem cells derived extracellular vesicles on inflammasome activity one week after spinal cord injury in rats.
[Neuroscience Research]
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