Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomal miR-27b Attenuates Subretinal Fibrosis via Suppressing Epithelial–Mesenchymal Transition by Targeting HOXC6

Human umbilical cord-derived mesenchymal stem cells were successfully cultured and identified, and exosomes were isolated from the supernatant by ultracentrifugation.
[Stem Cell Research & Therapy]
Li, D., Zhang, J., Liu, Z., Gong, Y., & Zheng, Z. (2021). Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial–mesenchymal transition by targeting HOXC6. Stem Cell Research & Therapy, 12(1), 24. https://doi.org/10.1186/s13287-020-02064-0 Cite
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Perinatal Gram-Positive Bacteria Exposure Elicits Distinct Cytokine Responses In Vitro

The authors stimulated freshly isolated umbilical blood mononuclear cells with lysates of E. faecalis, S. agalacticae, and S. aureus collected from pregnant women in preterm labor.
[International Journal of Molecular Sciences]
Reuschel, E., Toelge, M., Haeusler, S., Deml, L., Seelbach-Goebel, B., & Solano, M. E. (2021). Perinatal Gram-Positive Bacteria Exposure Elicits Distinct Cytokine Responses In Vitro. International Journal of Molecular Sciences, 22(1), 332. https://doi.org/10.3390/ijms22010332 Cite
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Single-Cell Transcriptome Analysis of Uncultured Human Umbilical Cord Mesenchymal Stem Cells

Scientists investigated freshly isolated, uncultured umbilical cord (UC)-MSCs by single-cell RNA sequencing and found two populations of UC-MSCs.
[Stem Cell Research & Therapy]
Zhang, S., Wang, J. Y., Li, B., Yin, F., & Liu, H. (2021). Single-cell transcriptome analysis of uncultured human umbilical cord mesenchymal stem cells. Stem Cell Research & Therapy, 12(1), 25. https://doi.org/10.1186/s13287-020-02055-1 Cite
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Feasibility of Reduced-Dose Posttransplant Cyclophosphamide and Cotransplantation of Peripheral Blood Stem Cells and Umbilical Cord-Derived Mesenchymal Stem Cells for SAA

Scientists evaluated the effectiveness and safety of reduced-dose cyclophosphamide, 20 mg/kg for 13 patients in matched sibling donor hematopoietic stem cell transplantation (HSCT) cohort and 25 mg/kg for 22 patients in haplo-HSCT cohort, on days +3, +4 combined with cotransplantation of peripheral blood stem cells and human umbilical cord-derived MSCs for severe aplastic anemia (SAA).
[Scientific Reports]
Zu, Y., Zhou, J., Fu, Y., Fang, B., Liu, X., Zhang, Y., Yu, F., Zuo, W., Zhou, H., Gui, R., Li, Z., Liu, Y., Zhao, H., Zhang, C., & Song, Y. (2021). Feasibility of reduced-dose posttransplant cyclophosphamide and cotransplantation of peripheral blood stem cells and umbilical cord-derived mesenchymal stem cells for SAA. Scientific Reports, 11(1), 253. https://doi.org/10.1038/s41598-020-80531-7 Cite
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Hypoxia-Induced Amniotic Fluid Stem Cell Secretome Augments Cardiomyocyte Proliferation and Enhances Cardioprotective Effects under Hypoxic-Ischemic Conditions

Researchers hypothesized that modulation of oxygen conditions during uman amniotic fluid stem cell generation enriches soluble bioactive factors and confers enhanced regenerative and cardioprotective effects on cardiovascular cells.
[Scientific Reports]
Kukumberg, M., Phermthai, T., Wichitwiengrat, S., Wang, X., Arjunan, S., Chong, S. Y., Fong, C.-Y., Wang, J.-W., Rufaihah, A. J., & Mattar, C. N. Z. (2021). Hypoxia-induced amniotic fluid stem cell secretome augments cardiomyocyte proliferation and enhances cardioprotective effects under hypoxic-ischemic conditions. Scientific Reports, 11(1), 163. https://doi.org/10.1038/s41598-020-80326-w Cite
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Human Umbilical Cord Perivascular Cells Maintain Regenerative Traits Following Exposure to Cyclophosphamide

Investigators evaluated two properties of a novel source of MSCs- first trimester human umbilical cord perivascular cells- that may render them a promising candidate for chemotherapeutic gonadal injury prevention.
[Cancer Letters]
Zohni, K., Lopez, L., Mander, P., Szaraz, P., Filice, M., Wyse, B. A., Garcia, M., Gat, I., Glass, K., Gauthier-Fisher, A., & Librach, C. L. (2020). Human umbilical cord perivascular cells maintain regenerative traits following exposure to cyclophosphamide. Cancer Letters. https://doi.org/10.1016/j.canlet.2020.12.035 Cite
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Сord Blood Hematopoietic Stem Cells Ex Vivo Enhance the Bipotential Commitment of Adipose Mesenchymal Stromal Progenitors

Hematopoietic stem progenitor cells from cord blood were cocultured with growth-arrested adipose mesenchymal stromal cells. Commitment-related transcriptional and secretory profiles as well as hematopoiesis-supportive activity of intact and osteo-induced MSCs were examined.
[Life Sciences]
Buravkova, L. B., Ezdakova, M. I., Andrianova, I. V., Gornostaeva, A. N., Bobyleva, P. I., & Andreeva, E. R. (2020). Сord blood hematopoietic stem cells ex vivo enhance the bipotential commitment of adipose mesenchymal stromal progenitors. Life Sciences, 118970. https://doi.org/10.1016/j.lfs.2020.118970 Cite
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Progress and Challenges of Amniotic Fluid Derived Stem Cells in Therapy of Ischemic Heart Disease

Amniotic fluid stem cells (AFSCs), a relatively novel source of stem cells, have been exploited for their ability of pluripotent differentiation. In addition, since AFSCs are weakly positive for the major histocompatibility class II molecules, they may have high immune tolerance.
[International Journal of Molecular Sciences]
Fang, Y.-H., Wang, S. P. H., Chang, H.-Y., Yang, P.-J., Liu, P.-Y., & Liu, Y.-W. (2021). Progress and Challenges of Amniotic Fluid Derived Stem Cells in Therapy of Ischemic Heart Disease. International Journal of Molecular Sciences, 22(1), 102. https://doi.org/10.3390/ijms22010102 Cite
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Proteomic Analysis and Cell Viability of Nine Amnion, Chorion, Umbilical Cord, and Amniotic Fluid–Derived Products

Investigators determined the full proteome and examine cell viability in nine commercial amnion products using an unbiased bottom-up shotgun proteomics approach and confocal microscopy.
[Cartilage]
Becktell, L., Matuska, A. M., Hon, S., Delco, M. L., Cole, B. J., Begum, L., Zhang, S., & Fortier, L. A. (2020). Proteomic Analysis and Cell Viability of Nine Amnion, Chorion, Umbilical Cord, and Amniotic Fluid–Derived Products. CARTILAGE, 1947603520976767. https://doi.org/10.1177/1947603520976767 Cite
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Umbilical Cord Tissue as a Source of Young Cells for the Derivation of Induced Pluripotent Stem Cells Using Non-Integrating Episomal Vectors and Feeder-Free Conditions

The authors demonstrated that umbilical cord tissue-MSCs could be easily isolated without expensive enzymatic treatment or columns and reprogramed well using episomal vectors, which could allow for the removal of the reprogramming factors after a few passages.
[Cells]
Mohamed, A., Chow, T., Whiteley, J., Fantin, A., Sorra, K., Hicks, R., & Rogers, I. M. (2021). Umbilical Cord Tissue as a Source of Young Cells for the Derivation of Induced Pluripotent Stem Cells Using Non-Integrating Episomal Vectors and Feeder-Free Conditions. Cells, 10(1), 49. https://doi.org/10.3390/cells10010049 Cite
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HUCMSCs Transplantation Combined with Ultrashort Wave Therapy Attenuates Neuroinflammation in Spinal Cord Injury through NUR77/ NF-κB Pathway

Low-dose Ultrashort Wave was treated one day after spinal cord injury (SCI) and human umbilical cord mesenchymal stem cell suspension was transferred to the lesion using a micro-syringe seven days after SCI.
[Life Sciences]
Wang, S., Jia, Y., Cao, X., Feng, S., Na, L., Dong, H., Gao, J., & Zhang, L. (2020). HUCMSCs transplantation combined with ultrashort wave therapy attenuates neuroinflammation in spinal cord injury through NUR77/ NF-κB pathway. Life Sciences, 118958. https://doi.org/10.1016/j.lfs.2020.118958 Cite
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