Comparison Study of Stem Cell-Derived Extracellular Vesicles for Enhanced Osteogenic Differentiation

Investigators evaluated the osteogenic capability of placental stem cell-derived extracellular vesicles (EVs) and compared them to the well-characterized bone marrow MSC-derived EVs. EVs were extracted from three designated time points after osteogenic differentiation.
[Tissue Engineering]
Pishavar, E., Copus, J., Atala, A., & Lee, S. J. (2020). Comparison Study of Stem Cell-Derived Extracellular Vesicles for Enhanced Osteogenic Differentiation. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2020.0194 Cite
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Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis

Researchers found that human umbilical cord MSCs-derived small extracellular vesicles were successfully absorbed by lung tissue after intratracheal administration, and remained in the lungs for at least 72 hours.
[Stem Cells and Development]
You, J., Zhou, O., Liu, J., Zou, W., Zhang, L., Tian, D., Dai, J., Luo, Z., Liu, E., Fu, Z., & Zou, L. (2020). Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0156 Cite
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Umbilical Cord: An Allogenic Tissue for Potential Treatment of COVID-19

Scientists review the current evidences and explore the potential therapeutic use of allogenic umbilical cord (UC) and/or Wharton’s jelly (WJ)-derived MSCs for the treatment of COVID-19. Although preliminary preclinical and clinical studies indicate that their use is safe and potentially effective, more multi-center, randomized, controlled trials are needed to adequately assess the safety and efficacy of UC and/or WJ-derived MSCs for the treatment of COVID-19.
[Human Cell]
Rodriguez, H. C., Gupta, M., Cavazos-Escobar, E., El-Amin, S. F., & Gupta, A. (2020). Umbilical cord: an allogenic tissue for potential treatment of COVID-19. Human Cell. https://doi.org/10.1007/s13577-020-00444-5 Cite
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Maternal HIV Status Skews Transcriptomic Response in Infant Cord Blood Monocytes Exposed to BCG

HIV-unexposed (HU) and HIV-exposed uninfected (HEU) infant cord blood monocytes were treated with Bacillus Calmette-Guerín (BCG) and transcriptionally profiled with the Nanostring nCounter platform. Differential expression and pathway enrichment analyses were performed, and transcripts were identified with enhanced or dampened BCG responses.
[AIDS]
Jones, C. I., Rose, S. L., Shutt, A., Cairo, C., Bourgeois, N. M., Charurat, M., Sodora, D. L., & Wood, M. P. (2020). Maternal HIV status skews transcriptomic response in infant cord blood monocytes exposed to BCG. AIDS, Publish Ahead of Print. https://doi.org/10.1097/QAD.0000000000002706 Cite
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Therapeutic Advancement in Neuronal Transdifferentiation of Mesenchymal Stromal Cells for Neurological Disorders

The authors give a brief description of MSCs, their sources and markers, and the different attempts that have been made towards achieving the goal of differentiating MSCs into neurons.
[Journal of Molecular Neuroscience]
Choudhary, P., Gupta, A., & Singh, S. (2020). Therapeutic Advancement in Neuronal Transdifferentiation of Mesenchymal Stromal Cells for Neurological Disorders. Journal of Molecular Neuroscience. https://doi.org/10.1007/s12031-020-01714-5 Cite
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Allogeneic Hematopoietic Stem Cell Transplantation in Cutaneous T-Cell Lymphomas

The authors describe the role of allogeneic hematopoietic stem cell transplantation in cutaneous T-cell lymphomas, and summarize the published data and future perspectives in this area.
[Cancers]
Dumont, M., Peffault de Latour, R., Ram-Wolff, C., Bagot, M., & de Masson, A. (2020). Allogeneic Hematopoietic Stem Cell Transplantation in Cutaneous T-Cell Lymphomas. Cancers, 12(10), 2856. https://doi.org/10.3390/cancers12102856 Cite
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UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections

Scientists assessed T cell reconstitution in patients transplanted with UM171-expanded cord blood (CB) grafts and retrospectively compared it to that of patients receiving unmanipulated CB transplants.
[Biology of Blood and Marrow Transplantation]
Dumont-Lagacé, M., Li, Q., Tanguay, M., Chagraoui, J., Kientega, T., Cardin, G. B., Brasey, A., Trofimov, A., Carli, C., Ahmad, I., Bambace, N. M., Bernard, L., Kiss, T. L., Roy, J., Roy, D.-C., Lemieux, S., Perreault, C., Rodier, F., Dufresne, S. F., … Delisle, J.-S. (2020). UM171-expanded cord blood transplants support robust T cell reconstitution with low rates of severe infections. Biology of Blood and Marrow Transplantation, 0(0). https://doi.org/10.1016/j.bbmt.2020.09.031 Cite
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Derivation of Three Human Induced Pluripotent Stem Cell Lines (JUCTCi014-A, JUCTCi015-A, JUCTCi016-a) from Mesenchymal Stem Cells (MSCs) Derived from Bone Marrow, Adipose Tissue and Wharton’s Jelly Samples

Researchers created human induced pluripotent stem cells (hiPSCs) from different MSC sources to evaluate the capacity of MSC-derived iPSCs to differentiate into any cell type of the human body and to serve as an alternative source for iPSC generation.
[Journal of Materials Chemistry B]
Ababneh, N. A., Al-Kurdi, B., Barham, R., Ali, D., Sharar, N., Abuarqoub, D., Jafar, H., Salah, B., & Awidi, A. (2020). Derivation of three human induced pluripotent stem cell lines (JUCTCi014-A, JUCTCi015-A, JUCTCi016-A) from mesenchymal stem cells (MSCs) derived from bone marrow, adipose tissue and Wharton’s jelly samples. Stem Cell Research, 49, 102000. https://doi.org/10.1016/j.scr.2020.102000 Cite
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Mesenchymal Stem Cells-Derived Mitochondria Transplantation Mitigates I/R-Induced Injury, Abolishes I/R-Induced Apoptosis, and Restores Motor Function in Acute Ischemia Stroke Rat Model

Investigators report that the mitochondrial transplantation ameliorated the reperfusion/ischemia-induced damages as reflected by declined blood creatine phosphokinase level, abolished apoptosis, decreased astroglyosis and microglia activation, reduced infarct size, and improved motor function.
[Brain Research Bulletin]
Pourmohammadi-Bejarpasi, Z., Roushandeh, A. M., Saberi, A., Rostami, M. K., Toosi, S. M. R., Jahanian-Najafabadi, A., Tomita, K., Kuwahara, Y., Sato, T., & Roudkenar, M. H. (2020). Mesenchymal stem cells-derived mitochondria transplantation mitigates I/R-induced injury, abolishes I/R-induced apoptosis, and restores motor function in acute ischemia stroke rat model. Brain Research Bulletin, 165, 70–80. https://doi.org/10.1016/j.brainresbull.2020.09.018 Cite
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Efficacy of Allogeneic Cord Blood Platelet Gel on Wounds of Dystrophic Epidermolysis Bullosa Patients after Pseudosyndactyly Surgery

The authors investigated the therapeutic effects of allogeneic platelet gel prepared from umbilical cord blood in a group of children diagnosed with dystrophic epidermolysis bullosa eligible for surgical correction of pseudosyndactyly in the hand.
[Wound Repair and Regeneration]
Torkamaniha, E., Amirkhani, M. A., Dahmardehei, M., Rebulla, P., Piccin, A., Hortamani, S., Heidari‐Kharaji, M., Mansouri, P., Hamidieh, A. A., & Nilforoushzadeh, M. A. (n.d.). Efficacy of Allogeneic Cord Blood Platelet Gel on Wounds of Dystrophic Epidermolysis Bullosa Patients after Pseudosyndactyly Surgery. Wound Repair and Regeneration, n/a(n/a). https://doi.org/10.1111/wrr.12865 Cite
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Cellular Immunotherapies in Pre-Clinical Large Animal Models of Transplantation

Investigators highlight the contributions of large animal models to the development and fine-tuning of hematopoietic cell transplant and additional cellular therapies to improve organ transplantation outcomes.
[Biology of Blood and Marrow Transplantation]
Matar, A. J., Crepeau, R. L., & Duran-Struuck, R. (2020). Cellular Immunotherapies in Pre-Clinical Large Animal Models of Transplantation. Biology of Blood and Marrow Transplantation, 0(0). https://doi.org/10.1016/j.bbmt.2020.09.032 Cite
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