Scientists determined the safety and explored efficacy of umbilical cord mesenchymal stem cell infusions in subjects with COVID‐19 scute respiratory distress syndrome. A double‐blind, Phase I/IIa, randomized, controlled trial was performed.
[Stem Cells Translational Medicine]
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Lanzoni, G., Linetsky, E., Correa, D., Cayetano, S. M., Alvarez, R. A., Kouroupis, D., Gil, A. A., Poggioli, R., Ruiz, P., Marttos, A. C., Hirani, K., Bell, C. A., Kusack, H., Rafkin, L., Baidal, D., Pastewski, A., Gawri, K., Leñero, C., Mantero, A. M. A., … Ricordi, C. (n.d.). Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/sctm.20-0472 Cite
Intravascular cell labeling, cell transplantation, and fate-mapping studies established that classical CD14+ blood monocytes derived from ematopoietic stem and progenitor cells migrated into lung tissue and gave rise to human interstitial and alveolar macrophages.
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Evren, E., Ringqvist, E., Tripathi, K. P., Sleiers, N., Rives, I. C., Alisjahbana, A., Gao, Y., Sarhan, D., Halle, T., Sorini, C., Lepzien, R., Marquardt, N., Michaëlsson, J., Smed-Sörensen, A., Botling, J., Karlsson, M. C. I., Villablanca, E. J., & Willinger, T. (2020). Distinct developmental pathways from blood monocytes generate human lung macrophage diversity. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.12.003 Cite
Scientists combined bulk and single-cell transcriptional profiling of lymphoid cells, myeloid cells, and hematopoietic stem-progenitor cells from fetal, perinatal, and adult developmental stages to demonstrate that the fetal-to-adult transition occurred progressively along a continuum of maturity.
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Bunis, D. G., Bronevetsky, Y., Krow-Lucal, E., Bhakta, N. R., Kim, C. C., Nerella, S., Jones, N., Mendoza, V. F., Bryson, Y. J., Gern, J. E., Rutishauser, R. L., Ye, C. J., Sirota, M., McCune, J. M., & Burt, T. D. (2021). Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells. Cell Reports, 34(1). https://doi.org/10.1016/j.celrep.2020.108573 Cite
Monash University congratulates the School of Clinical Sciences student Amber Wang – the highest achieving student in the 2020 BMedSc(Hons) cohort. Wang’s research title was “Effect of Umbilical Cord Blood Cell Therapy on Grey Matter Vascular Injury in the Growth-Restricted Fetal Brain”.
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Overall HLA class I mismatch was also a significant risk factor and the predictor of post-cord blood transplantation viral infection, probably due to the insufficient cytotoxic T cell recognition and dendritic cell priming.
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Iemura, T., Arai, Y., Kanda, J., Kitawaki, T., Hishizawa, M., Kondo, T., Yamashita, K., & Takaori-Kondo, A. (2020). Impact of HLA class I allele-level mismatch on viral infection within 100 days after cord blood transplantation. Scientific Reports, 10(1), 21150. https://doi.org/10.1038/s41598-020-78259-5 Cite
Human umbilical cord-MSCs were cultured on polyacrylamide hydrogels with stiffnesses corresponding to Young’s modulus of 13-16kPa and 62-68kPa which mimic the stiffnesses of healthy heart tissue and fibrotic myocardium.
Scientists performed an in-depth evaluation of the primitiveness, migration, adhesion, maturation, mitochondrial behavior, and pathway mechanisms of this platform using conventional assays followed by the evaluation of engraftment potential of the expanded CD34+ cells in an in vivo murine model.
[Stem Cell Research & Therapy]
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Allogeneic human umbilical cord Wharton’s jelly stem cells increase several-fold the expansion of human cord blood CD34+ cells both in vitro and in vivo | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved December 16, 2020, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-02048-0 Cite
Wharton’s jelly-derived mesenchymal stem cells were seeded on a polyurethane scaffold combined with a hydrogel based on bovine serum albumin .
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Lutzweiler, G., Barthes, J., Charles, A. L., Ball, V., Louis, B., Geny, B., & Vrana, N. E. (2020). Improving the colonization and functions of Wharton’s Jelly-derived mesenchymal stem cells by a synergetic combination of porous polyurethane scaffold with an albumin-derived hydrogel. Biomedical Materials, 16(1), 015005. https://doi.org/10.1088/1748-605x/abaf05 Cite
Investigators discuss and evaluate research surrounding these key assumptions and the clinical success of in utero stem cell transplantationin the treatment of thalassemia.
[Stem Cells and Development]
Researchers developed an alginate scaffold with human umbilical cord mesenchymal stem cell exosomes to treat nerve injury-induced pain. In vitro studies of PC12 and HEK293 cells were used to evaluate the neuroprotective and neurotrophic effects of exosomes.
[Journal of Pain Research]
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Hsu, J.-M., Shiue, S.-J., Yang, K. D., Shiue, H.-S., Hung, Y.-W., Pannuru, P., Poongodi, R., Lin, H.-Y., & Cheng, J.-K. (2020, December 4). <p>Locally Applied Stem Cell Exosome-Scaffold Attenuates Nerve Injury-Induced Pain in Rats</p>. Journal of Pain Research. https://doi.org/10.2147/JPR.S286771 Cite
A dual-enzymatically cross-linked gelatin hydrogel with hydrogen horseradish peroxidase and galactose oxidase was proposed to combine human umbilical cord mesenchymal stem cells for facilitating nerve regeneration post-spinal cord injury.
[Journal of Materials Chemistry B]
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Yao, M., Li, J., Zhang, J., Ma, S., Wang, L., Gao, F., & Guan, F. (2020). Dual-enzymatically cross-linked gelatin hydrogel enhances neural differentiation of human umbilical cord mesenchymal stem cells and functional recovery in experimental murine spinal cord injury. Journal of Materials Chemistry B. https://doi.org/10.1039/D0TB02033H Cite