Chondrogenic and BMP-4 Primings Confer Osteogenesis Potential to Human Cord Blood Mesenchymal Stromal Cells Delivered with Biphasic Calcium Phosphate Ceramics

The authors evaluated the in vitro osteogenic potential of unprimed, osteogenically primed, or chondrogenically primed cord blood MSCs and bone marrow MSCs and their in vivo bone forming capacity following ectopic implantation on biphasic calcium phosphate ceramics in nude mice.
[Scientific Reports]
Brennan, M. Á., Barilani, M., Rusconi, F., de Lima, J., Vidal, L., Lavazza, C., Lazzari, L., Giordano, R., & Layrolle, P. (2021). Chondrogenic and BMP-4 primings confer osteogenesis potential to human cord blood mesenchymal stromal cells delivered with biphasic calcium phosphate ceramics. Scientific Reports, 11(1), 6751. https://doi.org/10.1038/s41598-021-86147-9 Cite
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Efficient Lentiviral Transduction Method to Gene Modify Cord Blood CD8+ T Cells for Cancer Therapy Applications

Researchers optimized a protocol for expansion and lentiviral vector transduction of CB CD8+ T cells, achieving a transduction efficiency up to 83%.
[Molecular Therapy-Methods & Clinical Development]
Presti, V. L., Cornel, A. M., Plantinga, M., Dünnebach, E., Kuball, J., Boelens, J. J., Nierkens, S., & Til, N. P. van. (2021). Efficient lentiviral transduction method to gene modify cord blood CD8+ T cells for cancer therapy applications. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2021.03.015 Cite
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Umbilical Cord Blood-Derived Microglia-Like Cells to Model COVID-19 Exposure

Scientists generated patient-derived microglial-like cell models unique to each neonate from reprogrammed umbilical cord blood mononuclear cells, adapting and extending a novel methodology previously validated for adult peripheral blood mononuclear cells.
[Translational Psychiatry]
Sheridan, S. D., Thanos, J. M., De Guzman, R. M., McCrea, L. T., Horng, J. E., Fu, T., Sellgren, C. M., Perlis, R. H., & Edlow, A. G. (2021). Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure. Translational Psychiatry, 11(1), 1–9. https://doi.org/10.1038/s41398-021-01287-w Cite
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Reversion of Early- and Late-Stage β-Cell Dedifferentiation by Human Umbilical Cord-Derived Mesenchymal Stem Cells in Type 2 Diabetic Mice

Investigators observed β-cell dedifferentiation in type 2 diabetes mellitus and investigated the reversal effect of umbilical cord-derived MSCs on early- and late-stage β-cell dedifferentiation.
[Cytotherapy]
Li, B., Cheng, Y., Yin, Y., Xue, J., Yu, S., Gao, J., Liu, J., Zang, L., & Mu, Y. (2021). Reversion of early- and late-stage β-cell dedifferentiation by human umbilical cord-derived mesenchymal stem cells in type 2 diabetic mice. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2021.01.005 Cite
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Stem Cell Treatment Improves Post Stroke Neurological Outcomes: A Comparative Study in Male and Female Rats

Researchers hypothesised that MSC treatment would effectively promote the recovery of sensory and motor function in both males and females, despite any apparent sex differences in post-stroke brain injury.
[Stroke and Vascular Neurology]
Nalamolu, K. R., Chelluboina, B., Fornal, C. A., Challa, S. R., Pinson, D. M., Wang, D. Z., Klopfenstein, J. D., & Veeravalli, K. K. (2021). Stem cell treatment improves post stroke neurological outcomes: a comparative study in male and female rats. Stroke and Vascular Neurology, svn. https://doi.org/10.1136/svn-2020-000834 Cite
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Biomimetic Cell-Adhesive Ligand-Functionalized Peptide Composite Hydrogels Maintain Stemness of Human Amniotic Mesenchymal Stem Cells

Scientists investigated the effects of the incorporation of cell-adhesive ligands in 3D self-assembling peptide hydrogels to modulate stem cell survival, proliferation, maintenance of stemness, and osteogenic differentiation.
[Regenerative Biomaterials]
Zhang, L., Xiong, N., Liu, Y., & Gan, L. (2021). Biomimetic cell-adhesive ligand-functionalized peptide composite hydrogels maintain stemness of human amniotic mesenchymal stem cells. Regenerative Biomaterials, 8(rbaa057). https://doi.org/10.1093/rb/rbaa057 Cite
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New ASH Research Restart Award to Help Ensure Research Continuity and Workforce Stability during Pandemic

The American Society of Hematology announced the names of 19 talented early-career investigators who will receive critical funding to support their resumption of research that was paused amid pandemic-related shutdowns and uncertainty.
[Amercian Society of Hematology]
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Predictive Analytics and Cord Blood Banking: Toward Utilization-Based Unit Selection

The authors present a multi-parameter linear regression model capable of identifying cord blood units that would process poorly, despite meeting established pre-process total nucleated cell and CD34+ quality thresholds.
[Cytotherapy]
Wynn, L. A., & Madrigal, A. (2021). Predictive analytics and cord blood banking: toward utilization-based unit selection. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2021.01.002 Cite
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Celularity Announces Fast Track Designation by the FDA for its Natural Killer Cell Therapy CYNK-001 in the Treatment of Recurrent Glioblastoma Multiforme

Celularity Inc. announced that the company has received Fast Track Designation from the FDA for its non-genetically modified cryopreserved human placental hematopoietic stem cell-derived natural killer cell therapy, CYNK-001, for the treatment of adults with recurrent glioblastoma multiforme.
[Celularity, Inc.]
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Umbilical Cord-Derived Mesenchymal Stromal Cells Immunomodulate and Restore Actin Dynamics and Phagocytosis of LPS-Activated Microglia via PI3K/Akt/Rho GTPase Pathway

Researchers elucidated whether human umbilical cord-derived MSCs can exert immunomodulatory effect and change the phenotype of activated microglia.
[Cell Death Discovery]
Mukai, T., Di Martino, E., Tsuji, S., Blomgren, K., Nagamura-Inoue, T., & Ådén, U. (2021). Umbilical cord-derived mesenchymal stromal cells immunomodulate and restore actin dynamics and phagocytosis of LPS-activated microglia via PI3K/Akt/Rho GTPase pathway. Cell Death Discovery, 7(1), 1–13. https://doi.org/10.1038/s41420-021-00436-w Cite
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Amniotic Membrane-Mesenchymal Stromal Cells Secreted Factors and Extracellular Vesicle-miRNAs: Anti-Inflammatory and Regenerative Features for Musculoskeletal Tissues

37 cytokines/chemokines were identified at varying abundance, some of which involved in both chemotaxis and homeostasis of inflammatory cells and in positive remodeling of extracellular matrix, often damaged in tendinopathy and osteoarthritis.
[Stem Cells Translational Medicine]
Ragni, E., Papait, A., Orfei, C. P., Silini, A. R., Colombini, A., Viganò, M., Libonati, F., Parolini, O., & Girolamo, L. de. (n.d.). Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal tissues. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/sctm.20-0390 Cite
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