Amniotic Fluid Stem Cell Administration Can Prevent Epithelial Injury from Necrotizing Enterocolitis

The authors examined the effects of amniotic fluid and mesenchymal stem cells on the prevention of intestinal injury during experimental necrotizing enterocolitis.
[Pediatric Research]
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Human Umbilical Cord-Blood-Derived Mesenchymal Stem Cell Can Improve the Clinical Outcome and Joint Space Width after High Tibial Osteotomy

Scientists compared the clinical and radiological results of human umbilical cord-blood derived MSC cartilage regeneration procedures combined with high tibial osteotomy (HTO) to those of microfracture with HTO.
[Knee]
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Mesenchymal Stem Cell-Derived Exosome-Containing Linc00632 Regulates GATA Binding Protein-3 Expression in Allergic Rhinitis by Interacting with Enhancer of Zeste Homolog 2 to Inhibit T Helper Cell 2 Differentiation

Human umbilical cord MSC-derived exosome dramatically inhibited Th2 differentiation, decreased GATA binding protein-3 protein expressions and IL-4 levels by about two times in CD4+ T cells.
[International Archives of Allergy and Immunology]
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Human Placental Mesenchymal Stem/Stromal Cells (pMSCs) Inhibit Agonist-Induced Platelet Functions Reducing Atherosclerosis and Thrombosis Phenotypes

The authors investigated the consequences of interaction between placenta MSCs and platelets, and its impact on platelet-mediated atherosclerosis in vitro.
[Journal of Cellular and Molecular Medicine]
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Assessment of HLA-B Genetic Variation with an HLA-B Leader Tool and Implications in Clinical Transplantation

To optimize the selection of stem cell transplant sources based on the HLA-B leader, an HLA-B Leader Assessment Tool was developed to automate the assignment of leader genotypes, define HLA-B leader match statuses, and rank order candidate stem cell sources according to clinical risk.
[Blood Advances]
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Celularity and Oncternal Therapeutics Enter into Research Collaboration to Evaluate Targeted Placental-Derived Cellular Therapies

Celularity Inc. and Oncternal Therapeutics, Inc. announced they have entered into a research collaboration to evaluate placental derived-cellular therapies targeting receptor-tyrosine kinase-like Orphan Receptor 1.
[Celularity, Inc.]
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Mesenchymal Stem Cells Act as Stimulators of Neurogenesis and Synaptic Function in a Rat Model of Alzheimer’s Disease

The possible roles of human umbilical mesenchymal stromal cord and adipose mesenchymal stem cells in neurogenesis and synaptic function were investigated using a β-amyloid 1-42-induced Alzheimer’s disease rat model.
[Heliyon]
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Effects of Single and Multiple Transplantations of Human Umbilical Cord Mesenchymal Stem Cells on the Recovery of Ovarian Function in the Treatment of Premature Ovarian Failure in Mice

Scientists compared the effect of single and multiple injections of human umbilical cord blood-MSCs on ovarian function repair in chemotherapy-induced premature ovarian failure.
[Journal of Ovarian Research]
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Intracerebroventricular Injection of Human Umbilical Cord Blood Mesenchymal Stem Cells in Patients with Alzheimer’s Disease Dementia: A Phase I Clinical Trial

Researchers conducted a Phase I clinical trial in nine patients with mild-to-moderate Alzheimer’s disease dementia to evaluate the safety and dose-limiting toxicity of three repeated intracerebroventricular injections of human umbilical cord blood–derived MSCs.
[Alzheimer’s Research & Therapy]
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Assessment of Long-Term In Vitro Multiplied Human Wharton’s Jelly-Derived Mesenchymal Stem Cells prior to Their Use in Clinical Administration

The authors analyzed cellular, molecular, and chromosomal alterations in Wharton’s jelly-derived MSCs during their in vitrosequential passages.
[Cells Tissues Organs]
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Effect of HGF-Transfected Human Umbilical Cord Mesenchymal Stem Cells on Hepatic Stellate Cells by Regulating TGF-β1/Smads Signaling Pathway

Investigators explored the possible mechanism of HGF-transfected human umbilical cord MSCs in inhibiting the proliferation and activation of hepatic stellate cells-T6.
[Stem Cells and Development]
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