Comparative Analysis of the Therapeutic Effects of Amniotic Membrane and Umbilical Cord Derived Mesenchymal Stem Cells for the Treatment of Type 2 Diabetes

Researchers compared the therapeutic efficacy of mesenchymal stem cells derived from amniotic membrane and umbilical cord of the same donor in the alleviation of type 2 diabetes mellitus symptoms and explored the underlying mechanisms.
[Stem Cell Reviews and Reports]
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Comparison of Single and Repeated Dosing of Anti-inflammatory Human Umbilical Cord Mesenchymal Stromal Cells in a Mouse Model of Polymicrobial Sepsis

Scientists investigated immunomodulatory effects of a novel mesenchymal stem cell product in mouse endotoxemia and polymicrobial sepsis models.
[Stem Cell Reviews and Reports]
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Amniotic Fluid-Derived Stem Cell Potential for Therapeutic and Surgical Use: A Review of the Literature

Scientists investigate the current literature surrounding amniotic fluid-derived stem cell culture and use, with an emphasis on the benefits for spina bifida treatment.
[Prenatal Diagnosis]
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Placental Mammals Acquired Functional Sequences in NRK for Regulating the CK2-PTEN-AKT Pathway and Placental Cell Proliferation

Scientists showed the molecular evolution of NCK-interacting kinase-related kinase, which confered its function for inhibiting placental cell proliferation.
[Molecular Biology and Evolution]
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Transplantation of Umbilical Cord-Derived Mesenchymal Stem Cells Promotes the Recovery of Thin Endometrium in Rats

The authors investigated the repair of thin endometrium in rats using the umbilical cord mesenchymal stem cells and the mechanisms involved.
[Scientific Reports]
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Human Umbilical Cord Blood Mesenchymal Stem Cells-Derived Exosomal microRNA-503-3p Inhibits Progression of Human Endometrial Cancer Cells through Downregulating MEST

Researchers investigated the influence of human umbilical cord blood mesenchymal stem cells-derived exosomal microRNA-503-3p on human endometrial cancer cells by mediating mesoderm-specific transcript (MEST).
[Cancer Gene Therapy]
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Human Umbilical Cord Mesenchymal Stem Cells Improve the Necrosis and Osteocyte Apoptosis in Glucocorticoid-Induced Osteonecrosis of the Femoral Head Model through Reducing the Macrophage Polarization

The protein expression of AKT, mTOR, p-AKT and p-mTOR was detected using western blot assay. The results showed that human umbilical cord mesenchymal stem cells treatment prominently promoted the glucocorticoid-induced the decrease of the collagen level and the increase of TRAP positive cells.
[International Journal of Stem Cells]
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Evaluation of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells Conditioning Medium (hWJ-MSCs-CM) or Scorpion Venom Breast Cancer Cell Line In Vitro

Researchers evaluated the anticancer potential of Egyptian scorpion Leiurus quinquestriatus venom or human Wharton’s jelly-derived mesenchymal stem cells conditioning medium/conditioning medium against breast cancer cell line as an alternative effective cancer biotherapy.
[Theranostics]
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Maternal Mid-Gestational and Child Cord Blood Immune Signatures Are Strongly Associated with Offspring Risk of ASD

Investigators measured levels of 60 cytokines and growth factors in 869 maternal mid-gestational and 807 child cord blood plasma samples from 457 autism spectrum disorders and 497 control children from the Norwegian Autism Birth Cohort.
[Molecular Psychiatry]
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Intramuscular and Intratendinous Placenta-Derived Mesenchymal Stromal-Like Cell Treatment of a Chronic Quadriceps Tendon Rupture

The quadriceps tendon was reconstructed applying a conventional suture anchor repair procedure combined with a synthetic mesh augmentation and additional intramuscular and intratendineous placenta-derived adherent mesenchymal stromal-like cell injections as an individualized treatment approach.
[Journal of Cachexia Sarcopenia and Muscle]
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Expression Profiling of lncRNAs and mRNAs in Placental Site Trophoblastic Tumor (PSTT) by Microarray

The expression levels of long noncoding RNAs and mRNAs in four human placental site trophoblastic tumor tissues and four normal placental villi were investigated.
[International Journal of Medical Sciences]
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