Intrathecal Administration of the Extracellular Vesicles Derived from Human Wharton’s Jelly Stem Cells Inhibit Inflammation and Attenuate the Activity of Inflammasome Complexes after Spinal Cord Injury in Rats

Scientists investigated immunomodulatory potential of human Wharton’s jelly mesenchymal stem cells derived extracellular vesicles on inflammasome activity one week after spinal cord injury in rats.
[Neuroscience Research]
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Strategic Alliance a Shot in the Arm for Stem Cell Commercialization Efforts

Several Canadian-made cell therapies will take a major step closer to the clinic thanks to a new collaboration between the Ontario Institute for Regenerative Medicine and the Centre for Commercialization of Cancer Immunotherapy and Regenerative Medicine.
[Ontario Institute for Regenerative Medicine]
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Neonatal Genetics of Gene Expression Reveal Potential Origins of Autoimmune and Allergic Disease Risk

Investigators mapped expression quantitative trait loci in resting myeloid cells and CD4+ T cells from cord blood samples, as well as in response to lipopolysaccharide or phytohemagglutinin stimulation, respectively.
[Nature Communications]
Huang, Q. Q., Tang, H. H. F., Teo, S. M., Mok, D., Ritchie, S. C., Nath, A. P., Brozynska, M., Salim, A., Bakshi, A., Holt, B. J., Khor, C. C., Sly, P. D., Holt, P. G., Holt, K. E., & Inouye, M. (2020). Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk. Nature Communications, 11(1), 3761. https://doi.org/10.1038/s41467-020-17477-x Cite
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Subarachnoid Transplantation of Human Umbilical Cord Mesenchymal Stem Cell in Rodent Model with Subacute Incomplete Spinal Cord Injury: Preclinical Safety and Efficacy Study

The authors performed cellular, kinematic, physiological, and anatomical analyses, either in vitro or in vivo, to comprehensively evaluate the safety and efficacy associated with subarachnoid transplantation of human umbilical cord mesenchymal stem cells in rats with subacute incomplete spinal cord injury.
[Experimental Cell Research]
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French Science Bill Promises Boost to Public R&D

The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider]
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Foreign Researchers Accused of Hiding Links to Chinese Military

Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
[The Scientist]
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Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells Maintains and Partially Improves Visual Function in Patients with Advanced Retinitis Pigmentosa

Investigators conducted a Phase I/II clinical trial aiming to evaluate the safety and efficacy of intravenous administration of umbilical cord MSCs in advanced retinitis pigmentosa patients.
[Stem Cells and Development]
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SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45 Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome

Investigators demonstrated for the first time that ACE2 and the entry-facilitating transmembrane protease TMPRSS2 were expressed on very small CD133+CD34+LinCD45 cells in human umbilical cord blood, which could be specified into functional hematopoietic stem cells and endothelial progenitor cells.
[Stem Cell Reviews and Reports]
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Prophylactic Therapy with Human Amniotic Fluid Stem Cells Improved Survival in a Rat Model of Lipopolysaccharide-Induced Neonatal Sepsis through Immunomodulation via Aggregates with Peritoneal Macrophages

Amniotic fluid stem cells were isolated as CD117-positive cells from human amniotic fluid. Three-day-old rat pups were intraperitoneally treated with lipopolysaccharide to mimic neonatal sepsis.
[Stem Cell Research & Therapy]
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GMP-Grade CD34+ Selection from HLA-Homozygous Licensed Cord Blood Units and Short-Term Expansion under European ATMP Regulations

Among 20 639 licensed Düsseldorf cord blood units, 139 potential HLA‐h donors were identified with the most frequent 10 German haplotypes.
[Vox Sanguinis]
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Regeneration of the Rotator Cuff Tendon-to-Bone Interface Using Umbilical Cord-Derived Mesenchymal Stem Cells and Gradient Extracellular Matrix Scaffolds from Adipose Tissue in a Rat Model

Researchers investigated the efficacy of a biomimetic hydroxyapatite-gradient scaffold isolated from adipose tissue with umbilical cord derived MSCs on the regeneration of the structure of the tendone-to-bone interface by analyzing the histological and biomechanical changes in a rat repair model.
[Acta Biomaterialia]
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hUC-MSCs Ameliorated CUMS-Induced Depression by Modulating Complement C3 Signaling-Mediated Microglial Polarization during Astrocyte-Microglia Crosstalk

Human umbilical cord (hUC)-MSCs were administered into chronic unpredictable mild stress model mice through the tail vein once a week for four weeks. After the administration of hUC-MSCs, the depression-like and anxiety-like phenotypes, neuronal histopathology, synaptic-related protein expression and inflammatory index of the mice were assessed.
[Brain Research Bulletin]
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