Matrigel/Umbilical Cord-Derived Mesenchymal Stem Cells Promote Granulosa Cell Proliferation and Ovarian Vascularization in a Mouse Model of Premature Ovarian Failure

Investigators aimed to fabricate a Matrigel scaffold loaded with human umbilical cord-derived MSCs and explore its potential to restore ovarian function and repair ovarian structures in vitro and in vivo.
[Stem Cells and Development]
Zhou, yao, Zhou, J., Xu, X., Du, F., Nie, M., Hu, L., Ma, Y., Liu, M., Yu, S., Zhang, J., & Chen, Y. (2021). Matrigel/umbilical cord-derived mesenchymal stem cells promote granulosa cell proliferation and ovarian vascularization in a mouse model of premature ovarian failure. Stem Cells and Development. https://doi.org/10.1089/scd.2021.0005 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Interleukin-1β-Induced Matrix Metalloproteinase-3 via ERK1/2 Pathway to Promote Mesenchymal Stem Cell Migration

Scientists proposed that IL-1β influences human umbilical cord Wharton’s jelly derived mesenchymal stem cells migration involving matrix metalloproteinase-3.
[PLOS ONE]
Full Article
Bookmark

No account yet? Register

0
Share

Analysis of Outcomes of Single-Unit Cord Blood Transplantation with Umbilical Cord Blood Units Processed with Two Different Red Blood Cell Sedimentation Reagents

Retrospective data analysis compared laboratory and clinical outcomes following single-unit umbilical cord blood transplantation performed between 1999 and 2015.
[Transfusion]
Abstract
Bookmark

No account yet? Register

0
Share

Eltrombopag for Enhancement of Platelet Engraftment in Patients Undergoing Allogeneic Cord Blood Transplantation

Investigators conducted a multicenter phase 2a study to explore whether eltrombopag, a thrombopoietin-receptor agonist, would enhance platelet recovery after umbilical cord blood transplantation.
[Leukemia & Lymphoma]
Abstract
Bookmark

No account yet? Register

0
Share

Adult Stem Cells in Endometrial Regeneration: Molecular Insights and Clinical Applications

The authors review the biological mechanisms of endometrial regeneration, and research progress and challenges for adult stem cell therapy for damaged endometrium.
[Molecular Reproduction & Development]
Full Article
Bookmark

No account yet? Register

0
Share

Peripheral Plasmodium falciparum Infection in Early Pregnancy Is Associated with Increased Maternal Microchimerism in the Offspring

Logistic and negative binomial regression were used to assess the impact of maternal peripheral parasitemia, symptomatic malaria, and placental malaria on cord blood maternal microchimerism.
[The Journal of Infectious Diseases]
Abstract
Bookmark

No account yet? Register

0
Share

Towards Prevention of Childhood ALL by Early-Life Immune Training

A first genetic hit led to the expansion of pre-leukemic B-cell clones, which were detectable in healthy newborn cord blood. These pre-leukemic clones gave rise to clinically overt leukemia in only about 0.2% of carriers.
[Blood]
Abstract
Bookmark

No account yet? Register

0
Share

Allogeneic Hematopoietic Cell Transplantation for Myelofibrosis: Proposed Definitions and Management Strategies for Graft Failure, Poor Graft Function and Relapse: Best Practice Recommendations of the EBMT Chronic Malignancies Working Party

A systematic approach to molecular monitoring, histopathological assessment and chimerism testing is proposed. These proposed recommendations aim to increase the accuracy and uniformity of reporting and to thereby facilitate the development of more consistent approaches.
[Leukemia]
Abstract
Bookmark

No account yet? Register

0
Share

Evaluation of a Clinical-Grade, Cryopreserved, Ex Vivo-Expanded Stem Cell Product from Cryopreserved Primary Umbilical Cord Blood Demonstrates Multilineage Hematopoietic Engraftment in Mouse Xenografts

cGMP valproic acid-mediated expansion was initiated with CD34+ cells isolated from cryopreserved primary umbilical cord blood collections, and the functionality after a second cryopreservation step of the expanded product evaluted in vitro and in mouse xenografts.
[Cytotherapy]
Full Article
Bookmark

No account yet? Register

0
Share

Enhanced Differentiation of Functional Human T Cells in NSGW41 Mice with Tissue-Specific Expression of Human Interleukin-7

After transfer of human cord blood-derived hematopoietic stem and progenitor cells, transgenic mice on the NSGW41 background, termed NSGW41hIL7, showed elevated and prolonged human cellularity in the thymus.
[Leukemia]
Full Article
Bookmark

No account yet? Register

0
Share

Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Cord Blood-Derived NK Cells Facilitates CAR-Like Responses against CD30+ Malignancies

The combination of AFM13 and IL-12/15/18 pre-activation of blood and cord-blood-derived NK cells was investigated in vitro and in vivo.
[Clinical Cancer Research]
Abstract
Bookmark

No account yet? Register

0
Share
Share