Umbilical Cord Mesenchymal Stem Cells for COVID-19 Acute Respiratory Distress Syndrome: A Double-Blind, Phase I/IIa, Randomized Controlled Trial

Scientists determined the safety and explored efficacy of umbilical cord mesenchymal stem cell infusions in subjects with COVID‐19 scute respiratory distress syndrome. A double‐blind, Phase I/IIa, randomized, controlled trial was performed.
[Stem Cells Translational Medicine]
Lanzoni, G., Linetsky, E., Correa, D., Cayetano, S. M., Alvarez, R. A., Kouroupis, D., Gil, A. A., Poggioli, R., Ruiz, P., Marttos, A. C., Hirani, K., Bell, C. A., Kusack, H., Rafkin, L., Baidal, D., Pastewski, A., Gawri, K., Leñero, C., Mantero, A. M. A., … Ricordi, C. (n.d.). Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/sctm.20-0472 Cite
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Distinct Developmental Pathways from Blood Monocytes Generate Human Lung Macrophage Diversity

Intravascular cell labeling, cell transplantation, and fate-mapping studies established that classical CD14+ blood monocytes derived from ematopoietic stem and progenitor cells migrated into lung tissue and gave rise to human interstitial and alveolar macrophages.
[Immunity]
Evren, E., Ringqvist, E., Tripathi, K. P., Sleiers, N., Rives, I. C., Alisjahbana, A., Gao, Y., Sarhan, D., Halle, T., Sorini, C., Lepzien, R., Marquardt, N., Michaëlsson, J., Smed-Sörensen, A., Botling, J., Karlsson, M. C. I., Villablanca, E. J., & Willinger, T. (2020). Distinct developmental pathways from blood monocytes generate human lung macrophage diversity. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.12.003 Cite
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Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells

Scientists combined bulk and single-cell transcriptional profiling of lymphoid cells, myeloid cells, and hematopoietic stem-progenitor cells from fetal, perinatal, and adult developmental stages to demonstrate that the fetal-to-adult transition occurred progressively along a continuum of maturity.
[Cell Reports]
Bunis, D. G., Bronevetsky, Y., Krow-Lucal, E., Bhakta, N. R., Kim, C. C., Nerella, S., Jones, N., Mendoza, V. F., Bryson, Y. J., Gern, J. E., Rutishauser, R. L., Ye, C. J., Sirota, M., McCune, J. M., & Burt, T. D. (2021). Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells. Cell Reports, 34(1). https://doi.org/10.1016/j.celrep.2020.108573 Cite
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School of Clinical Sciences at Monash Health student Amber Wang tops the 2020 BMedSc(Hons) Cohort

Monash University congratulates the School of Clinical Sciences student Amber Wang – the highest achieving student in the 2020 BMedSc(Hons) cohort. Wang’s research title was “Effect of Umbilical Cord Blood Cell Therapy on Grey Matter Vascular Injury in the Growth-Restricted Fetal Brain”.
[Monash University]
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Impact of HLA Class I Allele-Level Mismatch on Viral Infection within 100 Days after Cord Blood Transplantation

Overall HLA class I mismatch was also a significant risk factor and the predictor of post-cord blood transplantation viral infection, probably due to the insufficient cytotoxic T cell recognition and dendritic cell priming.
[Scientific Reports]
Iemura, T., Arai, Y., Kanda, J., Kitawaki, T., Hishizawa, M., Kondo, T., Yamashita, K., & Takaori-Kondo, A. (2020). Impact of HLA class I allele-level mismatch on viral infection within 100 days after cord blood transplantation. Scientific Reports, 10(1), 21150. https://doi.org/10.1038/s41598-020-78259-5 Cite
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Matrix Stiffness Regulates Myocardial Differentiation of Human Umbilical Cord Mesenchymal Stem Cells

Human umbilical cord-MSCs were cultured on polyacrylamide hydrogels with stiffnesses corresponding to Young’s modulus of 13-16kPa and 62-68kPa which mimic the stiffnesses of healthy heart tissue and fibrotic myocardium.
[Aging]
Aging | Matrix stiffness regulates myocardial differentiation of human umbilical cord mesenchymal stem cells - Full Text. (n.d.). Retrieved December 16, 2020, from https://www.aging-us.com/article/202244/text Cite
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Allogeneic Human Umbilical Cord Wharton’s Jelly Stem Cells Increase Several-Fold the Expansion of Human Cord Blood CD34+ Cells Both In Vitro and In Vivo

Scientists performed an in-depth evaluation of the primitiveness, migration, adhesion, maturation, mitochondrial behavior, and pathway mechanisms of this platform using conventional assays followed by the evaluation of engraftment potential of the expanded CD34+ cells in an in vivo murine model.
[Stem Cell Research & Therapy]
Allogeneic human umbilical cord Wharton’s jelly stem cells increase several-fold the expansion of human cord blood CD34+ cells both in vitro and in vivo | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved December 16, 2020, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-02048-0 Cite
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Improving the Colonization and Functions of Wharton’s Jelly-Derived Mesenchymal Stem Cells by a Synergetic Combination of Porous Polyurethane Scaffold with an Albumin-Derived Hydrogel

Wharton’s jelly-derived mesenchymal stem cells were seeded on a polyurethane scaffold combined with a hydrogel based on bovine serum albumin .
[Biomedical Materials]
Lutzweiler, G., Barthes, J., Charles, A. L., Ball, V., Louis, B., Geny, B., & Vrana, N. E. (2020). Improving the colonization and functions of Wharton’s Jelly-derived mesenchymal stem cells by a synergetic combination of porous polyurethane scaffold with an albumin-derived hydrogel. Biomedical Materials, 16(1), 015005. https://doi.org/10.1088/1748-605x/abaf05 Cite
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The Theoretical Basis of In Utero Hematopoietic Stem Cell Transplantation and Its Use in the Treatment of Blood Disorders

Investigators discuss and evaluate research surrounding these key assumptions and the clinical success of in utero stem cell transplantationin the treatment of thalassemia.
[Stem Cells and Development]
Tai-macarthur, S., Lombardi, G., & Shangaris, P. (2020). The Theoretical Basis of In Utero Hematopoietic Stem Cell Transplantation and its use in the treatment of Blood disorders. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0181 Cite
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Locally Applied Stem Cell Exosome-Scaffold Attenuates Nerve Injury-Induced Pain in Rats

Researchers developed an alginate scaffold with human umbilical cord mesenchymal stem cell exosomes to treat nerve injury-induced pain. In vitro studies of PC12 and HEK293 cells were used to evaluate the neuroprotective and neurotrophic effects of exosomes.
[Journal of Pain Research]
Hsu, J.-M., Shiue, S.-J., Yang, K. D., Shiue, H.-S., Hung, Y.-W., Pannuru, P., Poongodi, R., Lin, H.-Y., & Cheng, J.-K. (2020, December 4). <p>Locally Applied Stem Cell Exosome-Scaffold Attenuates Nerve Injury-Induced Pain in Rats</p>. Journal of Pain Research. https://doi.org/10.2147/JPR.S286771 Cite
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Dual-Enzymatically Cross-Linked Gelatin Hydrogel Enhances Neural Differentiation of Human Umbilical Cord Mesenchymal Stem Cells and Functional Recovery in Experimental Murine Spinal Cord Injury

A dual-enzymatically cross-linked gelatin hydrogel with hydrogen horseradish peroxidase and galactose oxidase was proposed to combine human umbilical cord mesenchymal stem cells for facilitating nerve regeneration post-spinal cord injury.
[Journal of Materials Chemistry B]
Yao, M., Li, J., Zhang, J., Ma, S., Wang, L., Gao, F., & Guan, F. (2020). Dual-enzymatically cross-linked gelatin hydrogel enhances neural differentiation of human umbilical cord mesenchymal stem cells and functional recovery in experimental murine spinal cord injury. Journal of Materials Chemistry B. https://doi.org/10.1039/D0TB02033H Cite
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