Investigators aimed to fabricate a Matrigel scaffold loaded with human umbilical cord-derived MSCs and explore its potential to restore ovarian function and repair ovarian structures in vitro and in vivo.
[Stem Cells and Development]
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Zhou, yao, Zhou, J., Xu, X., Du, F., Nie, M., Hu, L., Ma, Y., Liu, M., Yu, S., Zhang, J., & Chen, Y. (2021). Matrigel/umbilical cord-derived mesenchymal stem cells promote granulosa cell proliferation and ovarian vascularization in a mouse model of premature ovarian failure. Stem Cells and Development. https://doi.org/10.1089/scd.2021.0005 Cite
Scientists proposed that IL-1β influences human umbilical cord Wharton’s jelly derived mesenchymal stem cells migration involving matrix metalloproteinase-3.
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Retrospective data analysis compared laboratory and clinical outcomes following single-unit umbilical cord blood transplantation performed between 1999 and 2015.
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Investigators conducted a multicenter phase 2a study to explore whether eltrombopag, a thrombopoietin-receptor agonist, would enhance platelet recovery after umbilical cord blood transplantation.
[Leukemia & Lymphoma]
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The authors review the biological mechanisms of endometrial regeneration, and research progress and challenges for adult stem cell therapy for damaged endometrium.
[Molecular Reproduction & Development]
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Logistic and negative binomial regression were used to assess the impact of maternal peripheral parasitemia, symptomatic malaria, and placental malaria on cord blood maternal microchimerism.
[The Journal of Infectious Diseases]
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A first genetic hit led to the expansion of pre-leukemic B-cell clones, which were detectable in healthy newborn cord blood. These pre-leukemic clones gave rise to clinically overt leukemia in only about 0.2% of carriers.
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A systematic approach to molecular monitoring, histopathological assessment and chimerism testing is proposed. These proposed recommendations aim to increase the accuracy and uniformity of reporting and to thereby facilitate the development of more consistent approaches.
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cGMP valproic acid-mediated expansion was initiated with CD34+ cells isolated from cryopreserved primary umbilical cord blood collections, and the functionality after a second cryopreservation step of the expanded product evaluted in vitro and in mouse xenografts.
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After transfer of human cord blood-derived hematopoietic stem and progenitor cells, transgenic mice on the NSGW41 background, termed NSGW41hIL7, showed elevated and prolonged human cellularity in the thymus.
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The combination of AFM13 and IL-12/15/18 pre-activation of blood and cord-blood-derived NK cells was investigated in vitro and in vivo.
[Clinical Cancer Research]
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