Investigators assessed whether multilineage MSCs, best known for immunomodulation toward T cells, could be therapeutic for highly virulent bacterial infections via modulation of polymorphonuclear neutrophils.
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Wang, L.-T., Wang, H.-H., Chiang, H.-C., Huang, L.-Y., Chiu, S.-K., Siu, L. K., Liu, K.-J., Yen, M.-L., & Yen, B. L. (2020). Human Placental MSC-Secreted IL-1β Enhances Neutrophil Bactericidal Functions during Hypervirulent Klebsiella Infection. Cell Reports, 32(13). https://doi.org/10.1016/j.celrep.2020.108188 Cite
The authors examine the various factors to be considered when developing a hMSC manufacturing process using microcarriers and bioreactors and their potential impact on the final product.
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Silva Couto, P., Rotondi, M. C., Bersenev, A., Hewitt, C. J., Nienow, A. W., Verter, F., & Rafiq, Q. A. (2020). Expansion of human mesenchymal stem/stromal cells (hMSCs) in bioreactors using microcarriers: lessons learnt and what the future holds. Biotechnology Advances, 107636. https://doi.org/10.1016/j.biotechadv.2020.107636 Cite
The human placenta-derived (hP) MSCs-derived exosomes were extracted using a sequential centrifugation approach. Then, the effects of hPMSCs-Exos on angiogenesis were analysis both in vitro and in vivo. In addition, the sensory and locomotor functions of mice after spinal cord injury were also analyzed.
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Preconditioning with ethionamide promoted the proliferation of Wharton’s jelly-derived MSCs by activating phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated protein kinase kinase (MEK)/extracellular signal-regulated kinase 1/2 signaling.
[International Journal of Molecular Sciences]
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Lee, N.-H., Myeong, S. H., Son, H. J., Hwang, J. W., Lee, N. K., Chang, J. W., & Na, D. L. (2020). Ethionamide Preconditioning Enhances the Proliferation and Migration of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells. International Journal of Molecular Sciences, 21(19), 7013. https://doi.org/10.3390/ijms21197013 Cite
Different scaffold configurations were characterized in terms of morphology and a mechanical response, and their interactions with two types of stem cells and bone marrow MSCs were assessed.
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Liu, X., Baldit, A., de Brosses, E., Velard, F., Cauchois, G., Chen, Y., Wang, X., de Isla, N., & Laurent, C. (2020). Characterization of Bone Marrow and Wharton’s Jelly Mesenchymal Stromal Cells Response on Multilayer Braided Silk and Silk/PLCL Scaffolds for Ligament Tissue Engineering. Polymers, 12(9), 2163. https://doi.org/10.3390/polym12092163 Cite
Scientists summarize the results of preclinical and clinical studies dealing with the introduction of epithelial and mesenchymal stem cells of the afterbirth origin to the liver failure therapy.
[Stem Cell Reviews and Reports]
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Patients were randomly assigned to receive a single dose of intrathecal ex vivo-expanded Wharton’s jelly-MSCs from human umbilical cord or placebo and were then switched to the other arm at six months.
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Albu, S., Kumru, H., Coll, R., Vives, J., Vallés, M., Benito-Penalva, J., Rodríguez, L., Codinach, M., Hernández, J., Navarro, X., & Vidal, J. (2020). Clinical effects of intrathecal administration of expanded Wharton jelly mesenchymal stromal cells in patients with chronic complete spinal cord injury: a randomized controlled study. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2020.08.008 Cite
Investigators used tandem mass tag labeling technology followed by tandem mass spectrometry to compare the peptidomic profile of preterm and term umbilical cord MSC conditioned medium.
[Stem Cell Research & Therapy]
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Wang, Y., Zhang, L., Wu, Y., Zhu, R., Wang, Y., Cao, Y., Long, W., Ji, C., Wang, H., & You, L. (2020). Peptidome analysis of umbilical cord mesenchymal stem cell (hUC-MSC) conditioned medium from preterm and term infants. Stem Cell Research & Therapy, 11(1), 414. https://doi.org/10.1186/s13287-020-01931-0 Cite
Scientists provide a comprehensive overview on the progression of clinical trials for retinal degeneration treatment using four types of stem/progenitor cell-based transplantation to replace degenerative retinal cells and/or to supplement trophic factors from the aspects of safety, effectiveness and their respective advantages and disadvantages.
[Cell Death & Disease]
Investigators showed that a phosphorylation of threonine-107 in the Glyoxalase 1 protein, mediated by Ca2+/calmodulin-dependent kinase II delta, is associated with elevated catalytic efficiency of Glo1.
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Morgenstern, J., Katz, S., Krebs-Haupenthal, J., Chen, J., Saadatmand, A., Cortizo, F. G., Moraru, A., Zemva, J., Campos, M. C., Teleman, A., Backs, J., Nawroth, P., & Fleming, T. (2020). Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1. Cell Reports, 32(12). https://doi.org/10.1016/j.celrep.2020.108160 Cite
Adenoviral vectors carrying genes encoding vascular endothelial growth factor, glial cell-derived neurotrophic factor and neural cell adhesion molecule or gene engineered umbilical cord blood mononuclear cells overexpressing recombinant vascular endothelial growth factor, glial cell-derived neurotrophic factor, and neural cell adhesion molecule were intrathecally injected before distal occlusion of the middle cerebral artery in rats.
[International Journal of Molecular Sciences]
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Markosyan, V., Safiullov, Z., Izmailov, A., Fadeev, F., Sokolov, M., Kuznetsov, M., Trofimov, D., Kim, E., Kundakchyan, G., Gibadullin, A., Salafutdinov, I., Nurullin, L., Bashirov, F., & Islamov, R. (2020). Preventive Triple Gene Therapy Reduces the Negative Consequences of Ischemia-Induced Brain Injury after Modelling Stroke in a Rat. International Journal of Molecular Sciences, 21(18), 6858. https://doi.org/10.3390/ijms21186858 Cite