Summarizing the latest research and reviews since 2009, Cord Blood News keeps members of the scientific and medical community up-to-date on the latest discoveries and research publications related to cord blood stem cell research. Specific topics include the characterization, expansion, culture, and therapeutic uses of cord blood, Wharton’s jelly, and amniotic fluid-derived stem cells. The publication serves as a valuable resource to keep scientists current with the latest clinical trials, policy updates, event postings, and career opportunities.
Scientists analyzed the expression of mesenchymal stem cell (MSC) and nucleus pulposus cell specific surface markers, pluripotency related genes, multilineage potential and cell proliferative capacity of nucleus pulposus- derived stem/progenitor cells from degenerated disc upon incubation with the conditioned medium which was collected from the umbilical cord derived MSCs.
Zeng, X., Lin, J., Wu, H., Yu, J., Tu, M., Cheang, L. H., & Zhang, J. (n.d.). Effect of Conditioned Medium from Human Umbilical Cord-Derived Mesenchymal Stromal Cells on Rejuvenation of Nucleus Pulposus Derived Stem/Progenitor Cells from Degenerated Intervertebral Disc. International Journal of Stem Cells. https://doi.org/10.15283/ijsc20027Cite
Ninety primiparous singleton pregnant women undergoing elective cesarean section were randomly allocated to receive placebo, low-dose, or high-dose transdermal hydrogel umbilical cord-MSCs on the surface of the skin incision.
Fan, D., Zeng, M., Xia, Q., Wu, S., Ye, S., Rao, J., … Liu, Z. (2020). Efficacy and safety of umbilical cord mesenchymal stem cells in treatment of cesarean section skin scars: a randomized clinical trial. Stem Cell Research & Therapy, 11(1), 244. https://doi.org/10.1186/s13287-020-01695-7Cite
Scientists retrospectively compared the efficacy and health-related quality of life of first-line haploidentical hematopoietic stem cell transplantation combined with unrelated cord blood infusion and first-line immunosuppressive therapy in acquired severe aplastic anemia patients.
On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying [the online testing] criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
Reprogramming was achieved by a footprint-free strategy. Self-renewal and pluripotency of cord blood MSC-human induced pluripoent stem cells (hiPSC) were investigated in vitro and in vivo, compared to parental MSC, to embryonic stem cells and to F-hiPSC.
Barilani, M., Cherubini, A., Peli, V., Polveraccio, F., Bollati, V., Guffanti, F., … Lazzari, L. (2020). A circular RNA map for human induced pluripotent stem cells of foetal origin. EBioMedicine, 57. https://doi.org/10.1016/j.ebiom.2020.102848Cite
Researchers analyzed the lipid profile of fetal serum from untreated intrahepatic cholestasis of pregnancy (ICP), ursodeoxycholic acid (UDCA)-treated ICP and uncomplicated pregnancies and found that UDCA ameliorated ICP-associated fetal dyslipidemia.
Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.