Effect of Conditioned Medium from Human Umbilical Cord-Derived Mesenchymal Stromal Cells on Rejuvenation of Nucleus Pulposus Derived Stem/Progenitor Cells from Degenerated Intervertebral Disc

Scientists analyzed the expression of mesenchymal stem cell (MSC) and nucleus pulposus cell specific surface markers, pluripotency related genes, multilineage potential and cell proliferative capacity of nucleus pulposus- derived stem/progenitor cells from degenerated disc upon incubation with the conditioned medium which was collected from the umbilical cord derived MSCs.
[International Journal of Stem Cells]
Zeng, X., Lin, J., Wu, H., Yu, J., Tu, M., Cheang, L. H., & Zhang, J. (n.d.). Effect of Conditioned Medium from Human Umbilical Cord-Derived Mesenchymal Stromal Cells on Rejuvenation of Nucleus Pulposus Derived Stem/Progenitor Cells from Degenerated Intervertebral Disc. International Journal of Stem Cells. https://doi.org/10.15283/ijsc20027 Cite
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Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells in Treatment of Cesarean Section Skin Scars: A Randomized Clinical Trial

Ninety primiparous singleton pregnant women undergoing elective cesarean section were randomly allocated to receive placebo, low-dose, or high-dose transdermal hydrogel umbilical cord-MSCs on the surface of the skin incision.
[Stem Cell Research & Therapy]
Fan, D., Zeng, M., Xia, Q., Wu, S., Ye, S., Rao, J., … Liu, Z. (2020). Efficacy and safety of umbilical cord mesenchymal stem cells in treatment of cesarean section skin scars: a randomized clinical trial. Stem Cell Research & Therapy, 11(1), 244. https://doi.org/10.1186/s13287-020-01695-7 Cite
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Comparison of Efficacy and Health-Related Quality of Life of First-Line Haploidentical Hematopoietic Stem Cell Transplantation with Unrelated Cord Blood Infusion and First-Line Immunosuppressive Therapy for Acquired Severe Aplastic Anemia

Scientists retrospectively compared the efficacy and health-related quality of life of first-line haploidentical hematopoietic stem cell transplantation combined with unrelated cord blood infusion and first-line immunosuppressive therapy in acquired severe aplastic anemia patients.
[Leukemia]
Abstract

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NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]
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Gender Gap in Research Output Widens during Pandemic

A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist]
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Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying [the online testing] criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]
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A Circular RNA Map for Human Induced Pluripotent Stem Cells of Fetal Origin

Reprogramming was achieved by a footprint-free strategy. Self-renewal and pluripotency of cord blood MSC-human induced pluripoent stem cells (hiPSC) were investigated in vitro and in vivo, compared to parental MSC, to embryonic stem cells and to F-hiPSC.
[Ebiomedicine]
Barilani, M., Cherubini, A., Peli, V., Polveraccio, F., Bollati, V., Guffanti, F., … Lazzari, L. (2020). A circular RNA map for human induced pluripotent stem cells of foetal origin. EBioMedicine, 57. https://doi.org/10.1016/j.ebiom.2020.102848 Cite
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A Scaffold Laden with Mesenchymal Stem Cell-Derived Exosomes for Promoting Endometrium Regeneration and Fertility Restoration through Macrophage Immunomodulation

A novel and viable cell-free therapeutic strategy by umbilical cord-MSC-derived exosomes was proposed.
[Acta Biomaterialia]
Xin, L., Lin, X., Zhou, F., Li, C., Wang, X., Yu, H., … Zhang, S. (2020). A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2020.06.029 Cite
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Ursodeoxycholic Acid Improves Feto-Placental and Offspring Metabolic Outcomes in Hypercholanemic Pregnancy

Researchers analyzed the lipid profile of fetal serum from untreated intrahepatic cholestasis of pregnancy (ICP), ursodeoxycholic acid (UDCA)-treated ICP and uncomplicated pregnancies and found that UDCA ameliorated ICP-associated fetal dyslipidemia.
[Scientific Reports]
Borges Manna, L., Papacleovoulou, G., Flaviani, F., Pataia, V., Qadri, A., Abu-Hayyeh, S., … Williamson, C. (2020). Ursodeoxycholic acid improves feto-placental and offspring metabolic outcomes in hypercholanemic pregnancy. Scientific Reports, 10(1), 10361. https://doi.org/10.1038/s41598-020-67301-1 Cite
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COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]
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Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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