Sanofi: FDA Approves Dupixent® (Dupilumab) as First Biologic Medicine for Children Aged 6 to 11 Years with Moderate-to-Severe Atopic Dermatitis

The US FDA have approved Dupixent® for children aged 6 to 11 years with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.
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Achilles Therapeutics Doses First Patient in Phase I/II Study in Recurrent or Metastatic Malignant Melanoma

Achilles Therapeutics have announced that it has dosed the first patient in a Phase I/II study of a clonal neoantigen T cell therapy in patients with recurrent or metastatic malignant melanoma.
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Common Germline Variants of the Human Apoe Gene Modulate Melanoma Progression and Survival

Scientists reported that, in a reversal of their effect on Alzheimer’s disease, the APOE4 and APOE2 variants conferred favorable and poor outcomes in melanoma, respectively.
[Nature Medicine]

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Overcoming Genetically-Based Resistance Mechanisms to PD-1 Blockade

Human melanoma cell lines with JAK1/2 knockout became insensitive to interferon-induced antitumor effects, while B2M knockout were no longer recognized by antigen-specific T cells and hence, resistant to cytotoxicity.
[Cancer Discovery]
Torrejon, D. Y., Abril-Rodriguez, G., Champhekar, A. S., Tsoi, J., Campbell, K. M., Kalbasi, A., Parisi, G., Zaretsky, J. M., Garcia-Diaz, A., Puig-Saus, C., Cheung-Lau, G., Wohlwender, T., Krystofinski, P., Vega-Crespo, A., Lee, C. M., Mascaro, P., Grasso, C. S., Berent-Maoz, B., Comin-Anduix, B., … Ribas, A. (2020). Overcoming genetically-based resistance mechanisms to PD-1 blockade. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-19-1409 Cite
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Extracellular Serine Controls Epidermal Stem Cell Fate and Tumor Initiation

Researchers revealed extracellular serine as a critical determinant of epidermal stem cell fate and provided insight into how nutrient availability was integrated with stem cell fate decisions during tumor initiation.
[Nature Cell Biology]
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The Msi1-mTOR Pathway Drives the Pathogenesis of Mammary and Extramammary Paget’s Disease

Investigators identified MSI1 ectopic overexpression in basal epithelial cells of human Paget’s disease (PD) skin, and showed that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological, single-cell and molecular levels.
[Cell Research]
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Activin-Mediated Alterations of the Fibroblast Transcriptome and Matrisome Control the Biomechanical Properties of Skin Wounds

The authors provided mechanistic insight into the roles of activin in wound repair and fibrosis and identified the functional consequences of alterations in the wound matrisome at the biomechanical level.
[Nature Communications]

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Trace Amines Produced by Skin Bacteria Accelerate Wound Healing in Mice

Scientists showed that trace amines (TA)-producing Staphylococcus epidermidis strains expressing SadA were predominant on human skin and that TA accelerated wound healing.
[Communications Biology]

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Loss of Spry1 Reduces Growth of BRAFV600-Mutant Cutaneous Melanoma and Improves Response to Targeted Therapy

Spry1 knockdown in three BRAFV600-mutant cutaneous melanoma cell lines markedly induced cell cycle arrest and apoptosis, repressed cell proliferation in vitro, and impaired tumor growth in vivo.
[Cell Death & Disease]

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Genetic Target Modulation Employing CRISPR/Cas9 Identifies Glyoxalase 1 as a Novel Molecular Determinant of Invasion and Metastasis in A375 Human Malignant Melanoma Cells In Vitro and In Vivo

Using A375 human malignant melanoma cells with glyoxalase 1 (GLO1) deletion, engineered using CRISPR/Cas9, the authors reported the identification of GLO1 as a novel molecular determinant of invasion and metastasis in malignant melanoma.
[Cancers]

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Pre-mRNA Processing Factor 3 Enhances the Progression of Keratinocyte-Derived Cutaneous Squamous Cell Carcinoma by Regulating the JAK2/STAT3 Pathway

Researchers indicated that pre-mRNA processing factor 3 served as a tumor active factor in cutaneous squamous cell carcinomas by targeting the JAK2/STAT3 pathway.
[Scientific Reports]

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Pivotal Role of CD103 in the Development of Psoriasiform Dermatitis

Investigators reported that CD103 regulated the development of psoriasiform dermatitis through the control of the function of dermal conventional dendritic cells. Deficiency in CD103 exacerbated psoriasiform dermatitis, accompanied by excessive epidermal hyperplasia and infiltration of inflammatory leukocytes.
[Scientific Reports]

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