Chronic Expression of p16INK4a in the Epidermis Induces Wnt-Mediated Hyperplasia and Promotes Tumor Initiation

Scientists found that prolonged expression of transgenic p16INK4a in the mouse epidermis induced hyperplasia and dysplasia, involving high proliferation rates of keratinocytes not expressing the transgene.
[Nature Communications]
Azazmeh, N., Assouline, B., Winter, E., Ruppo, S., Nevo, Y., Maly, A., Meir, K., Witkiewicz, A. K., Cohen, J., Rizou, S. V., Pikarsky, E., Luxenburg, C., Gorgoulis, V. G., & Ben-Porath, I. (2020). Chronic expression of p16 INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation. Nature Communications, 11(1), 2711. https://doi.org/10.1038/s41467-020-16475-3 Cite
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Massively Parallel Reporter Assays of Melanoma Risk Variants Identify MX2 as a Gene Promoting Melanoma

Researchers showed that melanocyte-specific expression of human MX2 in a zebrafish model demonstrated accelerated melanoma formation in a BRAFV600E background.
[Nature Communications]
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Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness

Using a cancer cell model to trigger non-lethal caspase activation, the authors found that melanoma cancer cells undergoing failed apoptosis have a particular transcriptomic signature associated with focal adhesions, transendothelial migration, and modifications of the actin cytoskeleton.
[Cell Reports]
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Intracellular Virus Sensor MDA5 Exacerbates Vitiligo by Inducing the Secretion of Chemokines in Keratinocytes under Virus Invasion

Researchers clarified that virus invasion significantly activated MDA5 and further potentiated the keratinocyte-derived CXCL10 and CXCL16 which are the two vital chemokines for the cutaneous infiltration of CD8+ T cells in vitiligo.
[Cell Death & Disease]
Zhuang, T., Yi, X., Chen, J., Kang, P., Chen, X., Chen, J., Cui, T., Chang, Y., Ye, Z., Ni, Q., Wang, Y., Du, P., Li, B., Liu, L., Jian, Z., Li, K., Gao, T., Li, S., & Li, C. (2020). Intracellular virus sensor MDA5 exacerbates vitiligo by inducing the secretion of chemokines in keratinocytes under virus invasion. Cell Death & Disease, 11(6), 1–14. https://doi.org/10.1038/s41419-020-2665-z Cite
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POU4F1 Promotes the Resistance of Melanoma to BRAF Inhibitors through MEK/ERK Pathway Activation and MITF Up-Regulation

The authors report that over-expressed POU4F1 contributed to the acquired resistance of melanoma cells to Vemurafenib. POU4F1 also promoted the activation of ERK signaling pathway via transcriptional regulation on MEK expression.
[Cell Death & Disease]
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Topical Application of Endothelin Receptor A Antagonist Attenuates Imiquimod-Induced Psoriasiform Skin Inflammation

Researchers investigated the effects of endothelin-1 (ET-1) receptor antagonist on imiquimod-induced psoriasiform dermatitis in a mouse model and found that ET-1 and endothelin A receptor axis played an important role in the pathogenesis of psoriasis.
[Scientific Reports]
Topical application of endothelin receptor a antagonist attenuates imiquimod-induced psoriasiform skin inflammation | Scientific Reports. (n.d.). Retrieved June 15, 2020, from https://www.nature.com/articles/s41598-020-66490-z Cite
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Percutaneous Absorption of Resveratrol and Its Oligomers to Relieve Psoriasiform Lesions: In Silico, In Vitro and In Vivo Evaluations

Scientists investigated the antipsoriatic activity of topical administration of resveratrol oligomers and explored the effect of the number of resveratrol subunits on skin absorption to establish the structure-permeation relationship.
[International Journal of Pharmaceutics]
Cheng, C.-Y., Lin, Y.-K., Yang, S.-C., Alalaiwe, A., Lin, C.-J., Fang, J.-Y., & Lin, C.-F. (2020). Percutaneous absorption of resveratrol and its oligomers to relieve psoriasiform lesions: In silico, in vitro and in vivo evaluations. International Journal of Pharmaceutics, 585, 119507. https://doi.org/10.1016/j.ijpharm.2020.119507 Cite
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GDNF Promotes Hair Formation and Cutaneous Wound Healing by Targeting Bulge Stem Cells

Using a Gfra1 (glial-cell-derived neurotrophic factor (GDNF) family receptor alpha 1) knock-in reporter mouse line, GDNF signaling was found to occur within hair bulge stem cells during the initiation of the hair cycle and early stages of hair formation after depilation.
[NPJ Regenerative Medicine]
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Induction of IRAK-M in Melanoma Induces Caspase-3 Dependent Apoptosis by Reducing TRAF6 and Calpastatin Levels

Scientists showed that IRAK-M, a negative regulator of MyD88 signaling, was deficient or low in melanoma and expression levels correlated with patient survival. Inducing IRAK-M expression using genetic approaches or epigenetic modifiers initiated apoptosis by prompting its interaction with TRAF6.
[Communications Biology]
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Pre-Clinical Modeling of Cutaneous Melanoma

The authors discuss the current available repertoire of melanoma models including two- and three-dimensional tissue cultures, organoids, genetically engineered mice and patient-derived xenograft.
[Nature Communications]
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Mitochondria in Skin Health, Aging, and Disease

Scientists discuss the essential role of mitochondria in regulating normal and abnormal skin physiology and the possibility of targeting this organelle in various skin disorders.
[Cell Death & Disease]
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