A Cross-Species Analysis of Systemic Mediators of Repair and Complex Tissue Regeneration

The authors explore the ways in which systemic cues and circulating factors affect the initiation of regeneration, the regenerative process, and its outcome.
[NPJ Regenerative Medicine]
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FOSL1 Promotes Metastasis of Head and Neck Squamous Cell Carcinoma through Super-Enhancer-Driven Transcription Program

The authors demonstrated that FOSL1 served as the dominate AP1 family member and was significantly upregulated in head and neck squamous cell carcinoma (HNSCC) tumor tissues and correlated with metastasis of HNSCC.
[Molecular Therapy]
Zhang, M., Hoyle, R. G., Ma, Z., Sun, B., Cai, W., Cai, H., Xie, N., Zhang, Y., Hou, J., Liu, X., Chen, D., Kellogg, G. E., Harada, H., Sun, Y., Wang, C., & Li, J. (2021). FOSL1 Promotes Metastasis of Head and Neck Squamous Cell Carcinoma Through Super-Enhancer-Driven Transcription Program. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.03.024 Cite
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Establishment and Characterization of Fibroblast Cultures Derived from a Female Common Hippopotamus (Hippopotamus amphibius) Skin Biopsy

Investigators established and characterized fibroblast cell cultures from the skin sample of a newborn common hippopotamus in this study.
[Cell Biology International]
Wang, T., Li, Z., Wei, J., Zheng, D., Wang, C., Xu, C., Chen, W., & Wang, B. (n.d.). Establishment and characterization of fibroblast cultures derived from a female common hippopotamus (Hippopotamus amphibius) skin biopsy. Cell Biology International, n/a(n/a). https://doi.org/https://doi.org/10.1002/cbin.11596 Cite
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In Vitro Skin Culture Media Influence the Viability and Inflammatory Response of Primary Macrophages

Scientists showed that skin maturation was affected by culture in macrophage medium, while macrophages showed reduced viability, altered cell morphology and decreased response to pro- and anti-inflammatory stimuli in skin differentiation media, both in 2D and 3D.
[Scientific Reports]
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Devonian Health Group Provides More Details on Previously Announced Positive Topline Results from Phase II Clinical Trial of Thykamine™ in Adult Population with Mild-to-Moderate Atopic Dermatitis and the Grant of Stock Options.

Devonian Health Group, Inc. provided further details on previously announced results of Thykamine™ Phase II clinical trial for the treatment of mild-to-moderate atopic dermatitis.
[Devonian Health Group, Inc.]
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Interaction of the NRF2 and p63 Transcription Factors Promotes Keratinocyte Proliferation in the Epidermis

The authors discovered an unexpected interaction between the cytoprotective transcription factor NRF2 and p63- a key player in epithelial morphogenesis.
[Nucleic Acids Research]
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MicroRNA-125a Correlates with Decreased Psoriasis Severity and Inflammation and Represses Keratinocyte Proliferation

Researchers investigated the correlation of miR-125a with disease severity and inflammation in psoriasis patients, and the effect of miR-125a on proliferation, apoptosis as well as its target signaling pathway in keratinocytes.
[Dermatology]
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LncRNA NORAD Engages in Psoriasis by Binding to miR-26a to Regulate Keratinocyte Proliferation

The authors investigated the role of non-coding RNA-activated by DNA damage (NORAD) in the development of psoriasis.
[Autoimmunity]
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An Update on Stem Cells Applications in Burn Wound Healing

Investigators discussed the wound-healing process, present methods used for stem cells administration, methods of enhancing stem cells potency and human studies.
[Experimental Dermatology]
Ullah, S., Mansoor, S., Ayub, A., Ejaz, M., Zafar, H., Feroz, F., Khan, A., & Ali, M. (2021). An update on stem cells applications in burn wound healing. Tissue and Cell, 72, 101527. https://doi.org/10.1016/j.tice.2021.101527 Cite
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A Protective Role for Autophagy in Vitiligo

Researchers provide the first evidence that autophagy occured in melanocytes and fibroblasts from non-lesional skin of vitiligo patients, as a result of metabolic surveillance response.
[Cell Death & Disease]
Bastonini, E., Kovacs, D., Raffa, S., delle Macchie, M., Pacifico, A., Iacovelli, P., Torrisi, M. R., & Picardo, M. (2021). A protective role for autophagy in vitiligo. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03592-0 Cite
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Genetic Deletion of Nox4 Enhances Cancerogen-Induced Formation of Solid Tumors

By identifying NADPH oxidase 4 (Nox4) as a protective source of reactive oxygen species (ROS) in cancerogen-induced cancer, researchers provided a piece of knowledge for understanding the role of moderate production of ROS in preventing the initiation of malignancies.
[Proceedings of the National Academy of Sciences of the United States of America]
Helfinger, V., Gall, F. F. von, Henke, N., Kunze, M. M., Schmid, T., Rezende, F., Heidler, J., Wittig, I., Radeke, H. H., Marschall, V., Anderson, K., Shah, A. M., Fulda, S., Brüne, B., Brandes, R. P., & Schröder, K. (2021). Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors. Proceedings of the National Academy of Sciences, 118(11). https://doi.org/10.1073/pnas.2020152118 Cite
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