The authors explore the ways in which systemic cues and circulating factors affect the initiation of regeneration, the regenerative process, and its outcome.
[NPJ Regenerative Medicine]
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The authors demonstrated that FOSL1 served as the dominate AP1 family member and was significantly upregulated in head and neck squamous cell carcinoma (HNSCC) tumor tissues and correlated with metastasis of HNSCC.
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Zhang, M., Hoyle, R. G., Ma, Z., Sun, B., Cai, W., Cai, H., Xie, N., Zhang, Y., Hou, J., Liu, X., Chen, D., Kellogg, G. E., Harada, H., Sun, Y., Wang, C., & Li, J. (2021). FOSL1 Promotes Metastasis of Head and Neck Squamous Cell Carcinoma Through Super-Enhancer-Driven Transcription Program. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.03.024 Cite
Investigators established and characterized fibroblast cell cultures from the skin sample of a newborn common hippopotamus in this study.
[Cell Biology International]
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Wang, T., Li, Z., Wei, J., Zheng, D., Wang, C., Xu, C., Chen, W., & Wang, B. (n.d.). Establishment and characterization of fibroblast cultures derived from a female common hippopotamus (Hippopotamus amphibius) skin biopsy. Cell Biology International, n/a(n/a). https://doi.org/https://doi.org/10.1002/cbin.11596 Cite
Scientists showed that skin maturation was affected by culture in macrophage medium, while macrophages showed reduced viability, altered cell morphology and decreased response to pro- and anti-inflammatory stimuli in skin differentiation media, both in 2D and 3D.
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Devonian Health Group, Inc. provided further details on previously announced results of Thykamine™ Phase II clinical trial for the treatment of mild-to-moderate atopic dermatitis.
[Devonian Health Group, Inc.]
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The authors discovered an unexpected interaction between the cytoprotective transcription factor NRF2 and p63- a key player in epithelial morphogenesis.
[Nucleic Acids Research]
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Researchers investigated the correlation of miR-125a with disease severity and inflammation in psoriasis patients, and the effect of miR-125a on proliferation, apoptosis as well as its target signaling pathway in keratinocytes.
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The authors investigated the role of non-coding RNA-activated by DNA damage (NORAD) in the development of psoriasis.
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Investigators discussed the wound-healing process, present methods used for stem cells administration, methods of enhancing stem cells potency and human studies.
Researchers provide the first evidence that autophagy occured in melanocytes and fibroblasts from non-lesional skin of vitiligo patients, as a result of metabolic surveillance response.
[Cell Death & Disease]
By identifying NADPH oxidase 4 (Nox4) as a protective source of reactive oxygen species (ROS) in cancerogen-induced cancer, researchers provided a piece of knowledge for understanding the role of moderate production of ROS in preventing the initiation of malignancies.
[Proceedings of the National Academy of Sciences of the United States of America]
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Helfinger, V., Gall, F. F. von, Henke, N., Kunze, M. M., Schmid, T., Rezende, F., Heidler, J., Wittig, I., Radeke, H. H., Marschall, V., Anderson, K., Shah, A. M., Fulda, S., Brüne, B., Brandes, R. P., & Schröder, K. (2021). Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors. Proceedings of the National Academy of Sciences, 118(11). https://doi.org/10.1073/pnas.2020152118 Cite