Electrical Stimulation to Human Dermal Papilla Cells for Hair Regenerative Medicine

The authors demonstrated that electrical stimulation (ES) with a polypyrrole-modified electrode upregulated trichogenic gene expression in human dermal papilla cells in vitro, and the activated cells when transplanted into mice generated double the number of hairs compared to that without the ES.
[Journal of Bioscience and Bioengineering]
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Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

Scientists showed that androgen receptor-mediated paracrine signaling, mainly TGF-β signaling, from dermal papilla (DP) cells induced apoptosis of microvascular endothelial cells in the DP of balding scalp of androgenetic alopecia.
[Journal of Investigative Dermatology]
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Expression Pattern and Immunoregulatory Roles of Galectin-1 and Galectin-3 in Atopic Dermatitis and Psoriasis

Researchers evaluated galectin (Gal)-1 and Gal-3 levels, which are beta-galactoside-binding proteins with immunomodulatory functions and examined their effects on human keratinocytes stimulated with either interleukin (IL)-4 or IL-17A.
[Inflammation]
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Skin Deep: The Role of the Microbiota in Cutaneous Autoimmunity

Besides direct inflammatory effects at the skin barrier, microbiota may contribute to the pathogenesis of skin autoimmune diseases by metabolites, recall immune cell responses, and permeation of antigens to the subepidermal space.
[Journal of Investigative Dermatology]
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Identifying Candidates for Immunotherapy with Cemiplimab to Treat Advanced Cutaneous Squamous Cell Carcinoma: An Expert Opinion

A multi-disciplinary advisory group of Italian cutaneous squamous cell carcinoma (CSCC) experts was convened to develop criteria to assist in identifying appropriate candidates for cemiplimab therapy in advanced CSCC, based on the literature and clinical experience.
[Therapeutic Advances in Medical Oncology]
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A Systematic Review: Metabolomics-Based Identification of Altered Metabolites and Pathways in the Skin Caused by Internal and External Factors

A cross-study comparison of the extracted studies from different databases identified 364 metabolites, whose concentrations were considerably altered by the following factor groups: irradiation, xenobiotics, aging, and skin diseases, mainly psoriasis.
[Experimental Dermatology]
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AVITA Medical Establishes Proof of Concept for Novel Treatments Using Genetically-Modified Skin Cells

AVITA Medical, Inc. announced that preclinical data successfully established proof of concept in two key areas of cell-based gene therapy – skin rejuvenation and epidermolysis bullosa.
[AVITA Medical, Inc.]
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Caffeine Improves the Cytotoxic Effect of Dacarbazine on B16F10 Murine Melanoma Cells

Caffeine has been studied as a potentiating agent in chemotherapy against some types of cancer, but there are few reports on its effects on melanoma. Scientists investigated caffeine’s ability to enhance the effects of dacarbazine in vitro.
[Bioorganic Chemistry]
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Deficiency of Vitamin D Receptor in Keratinocytes Augments Dermal Fibrosis and Inflammation in a Mouse Model of HOCl-Induced Scleroderma

The authors demonstrated that the ablation of vitamin D receptor in keratinocytes greatly exacerbated dermal fibrosis in HOCl-induced scleroderma in mice.
[Biochemical and Biophysical Research Communications]
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ROS-Mediated Anti-angiogenic Activity of Cerium Oxide Nanoparticles in Melanoma Cells

Investigators established a robust synthesis method for faceted nanoceria with primary particle diameters of 5–6 nm. The nanoceria were not cytotoxic to a human melanoma cell line at doses up to 400 μg/mL and were dose-dependently internalized by the cells.
[Journal of the American Chemical Society]
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PlncRNA-1 Stimulates Hair Follicle Stem Cell Differentiation in Wound Healing via the EZH2/ZEB1/MAPK1 Axis

PlncRNA-1 inhibits ZEB1 and activated MAPK1 signaling through upregulating EZH2, thereby enhancing the proliferation and differentiation of hair follicle stem cells and wound healing.
[Journal of Gene Medicine]
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