Pioneering Duplication Detector Trawls Thousands of Coronavirus Preprints

Amid concerns that the torrent of research papers on COVID-19 could be leading to an excess of sloppy work, a computer scientist who develops automated programs to spot duplicate images in research papers is running his software across the world’s coronavirus preprints. So far, his efforts have yielded mixed success and some controversy.
[Nature News]
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Inactivating p53 Is Essential for Nerve Growth Factor Receptor to Promote Melanoma-Initiating Cell-Stemmed Tumorigenesis

Researchers report that a feedback inhibition of p53 by nerve growth factor receptor played an essential role in maintaining the sphere formation and proliferation of melanoma-initiating cells (MICs), and in promoting MIC-derived melanoma growth in vivo.
[Cell Death & Disease]
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Fucoidan Refined by Sargassum confusum Indicate Protective Effects Suppressing Photo-Oxidative Stress and Skin Barrier Perturbation in UVB-Induced Human Keratinocytes

Algae was extracted using Celluclast, and fucoidan fractions were recovered by step gradient ethanol precipitation. Refined fucoidan fractions were treated to human HaCaT keratinocytes and exposed to ultraviolet B.
[International Journal of Biological Macromolecules]
Fernando, I. P. S., Dias, M. K. H. M., Madusanka, D. M. D., Han, E. J., Kim, M. J., Jeon, Y.-J., & Ahn, G. (2020). Fucoidan refined by Sargassum confusum indicate protective effects suppressing photo-oxidative stress and skin barrier perturbation in UVB-induced human keratinocytes. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.07.136 Cite
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Oral Exposure to BDE-209 Modulates Metastatic Spread of Melanoma in C57BL/6 Mice Inoculated with B16-F10 Cells

In vitro studies showed that decabromodiphenyl ether interfered with murine melanoma cells, modulating cell death rates, proliferation and migration, important events for cancer progression.
[Chemosphere]
Brito, P. M., Biscaia, S. M. P., de Souza, T. L., Ramos, A. B., Leão-Buchir, J., de Almeida Roque, A., de Lima Bellan, D., da Silva Trindade, E., Filipak Neto, F., & de Oliveira Ribeiro, C. A. (2020). Oral exposure to BDE-209 modulates metastatic spread of melanoma in C57BL/6 mice inoculated with B16–F10 cells. Chemosphere, 260, 127556. https://doi.org/10.1016/j.chemosphere.2020.127556 Cite
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Dialog between Skin and Its Microbiota: Emergence of “Cutaneous Bacterial Endocrinology”

The authors demonstrate that there is a cutaneous microbial endocrinology and this emerging concept will certainly have important consequences in dermatology.
[Experimental Dermatology]
Racine, P.-J., Janvier, X., Clabaut, M., Catovic, C., Souak, D., Boukerb, A. M., Groboillot, A., Konto‐Ghiorghi, Y., Duclairoir‐Poc, C., Lesouhaitier, O., Orange, N., Chevalier, S., & Feuilloley, M. G. J. (n.d.). Dialog between skin and its microbiota: Emergence of “Cutaneous Bacterial Endocrinology.” Experimental Dermatology, n/a(n/a). https://doi.org/10.1111/exd.14158 Cite
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Mesenchymal Stromal Cell‐Derived Factors Promote the Colonization of Collagen 3D Scaffolds with Human Skin Cells

Scientists investigated whether the therapeutic potential of an acellular porous scaffold made of type I collagen could be improved by the addition of a powerful trophic agent in the form of mesenchymal stromal cells conditioned medium in order to be used as an acellular scaffold for skin wound healing treatment.
[Journal of Cellular and Molecular Medicine]
Tutuianu, R., Rosca, A.-M., Kaya, M. G. A., Pruna, V., Neagu, T. P., Lascar, I., Simionescu, M., & Titorencu, I. (n.d.). Mesenchymal stromal cell-derived factors promote the colonization of collagen 3D scaffolds with human skin cells. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15507 Cite
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Extracellular Vesicle‐Enclosed MiR‐486‐5p Mediates Wound Healing with Adipose‐Derived Stem Cells by Promoting Angiogenesis

Researchers investigated the role of adipose‐derived stem cells‐extracellular vesicles in the cutaneous wound healing accompanied with the study on the specific cargo‐medicated effects on wound healing.
[Journal of Cellular and Molecular Medicine]
Lu, Y., Wen, H., Huang, J., Liao, P., Liao, H., Tu, J., & Zeng, Y. (n.d.). Extracellular vesicle-enclosed miR-486-5p mediates wound healing with adipose-derived stem cells by promoting angiogenesis. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15387 Cite
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Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells

Investigators showed that arrector pili muscles and sympathetic nerves form a dual-component niche to modulate hair follicle stem cell activity.
[Cell]
Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells: Cell. (n.d.). Retrieved July 20, 2020, from https://www.cell.com/cell/fulltext/S0092-8674(20)30808-4?rss=yes Cite
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Direct Identification of Bacterial and Human Proteins from Infected Wounds in Living 3D Skin Models

Scientists demonstrated a novel and highly accurate approach for the rapid identification of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) directly from infected wounds in 3D in vitro skin models.
[Scientific Reports]
Havlikova, J., May, R. C., Styles, I. B., & Cooper, H. J. (2020). Direct identification of bacterial and human proteins from infected wounds in living 3D skin models. Scientific Reports, 10(1), 11900. https://doi.org/10.1038/s41598-020-68233-6 Cite
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IDEAYA Announces IDE196 Program Update and Clinical Protocol Criteria Met for Cohort Expansion in Skin Melanoma for Phase 2 GNAQ/11 Basket Trial

IDEAYA Biosciences, Inc. announced that it has met the clinical protocol criteria for cohort expansion in the cutaneous melanoma cohort of its Phase II basket arm evaluating IDE196 monotherapy in solid tumors harboring GNAQ or GNA11 hotspot mutations (GNAQ/11).
[IDEAYA]
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Adipose Stem Cells from Type 2 Diabetic Mice Exhibit Therapeutic Potential in Wound Healing

This study compared the phenotypes of adipose tissue-derived mesenchymal stem cells harvested from high-fat diet, streptozotocin-induced type 2 diabetes (T2D) and healthy Chow diet-fed C57BL/6 mice in vitro and their therapeutic effects for the treatment of wound healing in a mouse model of T2D.
[Stem Cell Research & Therapy]
Adipose stem cells from type 2 diabetic mice exhibit therapeutic potential in wound healing | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved July 20, 2020, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01817-1 Cite
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MC2 Therapeutics Announces Submission of Marketing Authorization Application in EU for Wynzora® Cream (50 µg/g calcipotriol and 0.5 mg/g Betamethasone (as Dipropionate))

MC2 Therapeutics announced the submission of its Marketing Authorization Application in EU for Wynzora® Cream for the treatment of plaque psoriasis.
[MC2 Therapeutics]
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