Propionic Acid Produced by Cutibacterium acnes Fermentation Ameliorates Ultraviolet B-Induced Melanin Synthesis

The authors identified a natural acidic formulation to reduce skin pigmentation. The metabolite propionic acid was the most abundant fatty acid in the filtrate from Pluronic F68 fermentation of Cutibacterium acnes and reduced the DOPA-positive melanocytes by significantly inhibiting cellular tyrosinase activity via binding to the free fatty acid receptor 2.
[Scientific Reports]
Kao, H.-J., Wang, Y.-H., Keshari, S., Yang, J. J., Simbolon, S., Chen, C.-C., & Huang, C.-M. (2021). Propionic acid produced by Cutibacterium acnes fermentation ameliorates ultraviolet B-induced melanin synthesis. Scientific Reports, 11(1), 11980. https://doi.org/10.1038/s41598-021-91386-x Cite
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PARP Inhibitors Talazoparib and Niraparib Sensitize Melanoma Cells to Ionizing Radiation

The effects of Talazoparib and Niraparib in combination with ionizing radiation on cell death, clonogenicity and cell cycle arrest were studied in healthy primary fibroblasts and primary melanoma cells.
[Genes]
Jonuscheit, S., Jost, T., Gajdošová, F., Wrobel, M., Hecht, M., Fietkau, R., & Distel, L. (2021). PARP Inhibitors Talazoparib and Niraparib Sensitize Melanoma Cells to Ionizing Radiation. Genes, 12(6), 849. https://doi.org/10.3390/genes12060849 Cite
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Induction of T Helper 17 Cell Response by Interleukin-7 in Patients with Primary Cutaneous Melanoma

The aim of this study was to assess the effect of Interleukin-7 signaling on T helper 17 responses in patients with primary cutaneous melanoma.
[Melanoma Research]
He, H., Qiao, B., Guo, S., Cui, H., Li, N., Liu, H., Qin, J., He, J., Yang, X., Xue, W., & Wang, Y. (2021). Induction of T helper 17 cell response by interleukin-7 in patients with primary cutaneous melanoma. Melanoma Research, Publish Ahead of Print. https://doi.org/10.1097/CMR.0000000000000751 Cite
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Non-coding RNAs in Melanoma: Biological Functions and Potential Clinical Applications

The authors summarize the recent research progress on the effects of non-coding RNAs (ncRNAs) on melanoma and attempt to elucidate the role of ncRNAs as molecular markers or potential targets will provide promising application perspectives of melanoma.
[Molecular Therapy-Oncolytics]
Peng, Q., & Wang, J. (2021). Non-Coding RNAs in Melanoma: Biological Functions and Potential Clinical Applications. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.05.012 Cite
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Six-and-a-Half-Year Outcomes for Opdivo (Nivolumab) in Combination with Yervoy (Ipilimumab) Continue to Demonstrate Durable Long-Term Survival Benefits in Patients with Advanced Melanoma

Bristol Myers Squibb, Inc. announced new six-and-a-half-year data from CheckMate -067, a randomized, double-blind, Phase III clinical trial, demonstrating durable improvement in survival with first-line Opdivo (nivolumab) plus Yervoy (ipilimumab) therapy and Opdivo monotherapy, versus Yervoy alone, in patients with advanced melanoma.
[Bristol Myers Squibb, Inc.]
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Genmab Announces That Janssen Has Received Positive CHMP Opinion Recommending DARZALEX® (Daratumumab) Subcutaneous (SC) Formulation for Patients with Newly Diagnosed Light-Chain (AL) Amyloidosis

Genmab, Inc. announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion and recommended granting marketing authorization for the daratumumab subcutaneous (SC) formulation (daratumumab and hyaluronidase-fihj), known as DARZALEX® SC in the European Union, in combination with bortezomib, cyclophosphamide, and dexamethasone for the treatment of adult patients with newly diagnosed systemic light-chain amyloidosis.
[Genmab, Inc. (Globenews Wire, Inc.)]
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Photobiomodulation Therapy for Hair Regeneration: A Synergetic Activation of β-CATENIN in Hair Follicle Stem Cells by ROS and Paracrine WNTs

Photobiomodulation therapy was found to drive quiescent hair follicle stem cell activation and alleviate hair follicle atrophy.
[Cell Stem Cell]
Jin, H., Zou, Z., Chang, H., Shen, Q., Liu, L., & Xing, D. (2021). Photobiomodulation therapy for hair regeneration: A synergetic activation of β-CATENIN in hair follicle stem cells by ROS and paracrine WNTs. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.04.015 Cite
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High Proliferation and Delamination during Skin Epidermal Stratification

Scientists used centrosomes, that organize the mitotic spindle, to test whether cell division orientation and stratification are linked.
[Nature Communications]
Damen, M., Wirtz, L., Soroka, E., Khatif, H., Kukat, C., Simons, B. D., & Bazzi, H. (2021). High proliferation and delamination during skin epidermal stratification. Nature Communications, 12(1), 3227. https://doi.org/10.1038/s41467-021-23386-4 Cite
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Keratinocyte-Derived Microvesicle Particles Mediate Ultraviolet B Radiation–Induced Systemic Immunosuppression

Researchers used both pharmacologic and genetic approaches in cells and mice to show that both the platelet-activating factor receptor and enzyme acid sphingomyelinase were necessary for UVB-MVP generation.
[Journal of Clinical Investigation]
Liu, L., Awoyemi, A. A., Fahy, K. E., Thapa, P., Borchers, C., Wu, B. Y., McGlone, C. L., Schmeusser, B., Sattouf, Z., Rohan, C. A., Williams, A. R., Cates, E. E., Knisely, C., Kelly, L. E., Bihl, J. C., Cool, D. R., Sahu, R. P., Wang, J., Chen, Y., … Travers, J. B. (2021). Keratinocyte-derived microvesicle particles mediate ultraviolet B radiation–induced systemic immunosuppression. The Journal of Clinical Investigation, 131(10). https://doi.org/10.1172/JCI144963 Cite
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Integrated Metabolomic Analysis and Cytokine Profiling Define Clusters of Immuno-Metabolic Correlation in New-Onset Psoriasis

Researchers analyzed the metabolic and cytokine/chemokine profiles in serum and skin from patients with new-onset psoriasis and healthy subjects by HR-MAS NMR and Bio-Plex immunoassay.
[Scientific Reports]
Tarentini, E., Odorici, G., Righi, V., Paganelli, A., Giacomelli, L., Mirisola, V., Mucci, A., Benassi, L., D’Aversa, E., Lasagni, C., Kaleci, S., Reali, E., & Magnoni, C. (2021). Integrated metabolomic analysis and cytokine profiling define clusters of immuno-metabolic correlation in new-onset psoriasis. Scientific Reports, 11(1), 10472. https://doi.org/10.1038/s41598-021-89925-7 Cite
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Longitudinal Profiling of the Burn Patient Cutaneous and Gastrointestinal Microbiota: A Pilot Study

Scientists found significant reduction in alpha diversity on the burn wound compared to spared skin throughout the sampling period as well as reduction in common skin commensal bacteria such as Propionibacterium acnes and Staphylococcus epidermitis.
[Scientific Reports]
Lima, K. M., Davis, R. R., Liu, S. Y., Greenhalgh, D. G., & Tran, N. K. (2021). Longitudinal profiling of the burn patient cutaneous and gastrointestinal microbiota: a pilot study. Scientific Reports, 11(1), 10667. https://doi.org/10.1038/s41598-021-89822-z Cite
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