So Close, and Yet So Far Away: The Dichotomy of the Specific Immune Response and Inflammation in Psoriasis and Atopic Dermatitis

The authors compare genetics, microbiome, T‐cell infiltrate and resulting epithelial response in psoriasis and atopic dermatitis.
[Journal of Internal Medicine]
Schäbitz, A., Eyerich, K., & Garzorz‐Stark, N. (n.d.). So close, and yet so far away: The dichotomy of the specific immune response and inflammation in psoriasis and atopic dermatitis. Journal of Internal Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/joim.13235 Cite
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The Ubiquitin Proteasome System and Skin Fibrosis

The ubiquitin proteasome system is a key regulatory factor in the proliferation, differentiation, and collagen secretion of skin fibroblasts.
[Molecular Diagnosis & Therapy]
Shen, W., Zhang, Z., Ma, J., Lu, D., & Lyu, L. (2021). The Ubiquitin Proteasome System and Skin Fibrosis. Molecular Diagnosis & Therapy. https://doi.org/10.1007/s40291-020-00509-z Cite
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Altered Ratio of Dendritic Cell Subsets in Skin-Draining Lymph Nodes Promotes Th2-Driven Contact Hypersensitivity

Researchers demonstrated that altered dendritic cell representation in the skin-draining lymph nodes during sensitization to allergens caused Th2-driven contact hypersensitivity.
[Proceedings of the National Academy of Sciences of the United States of America]
Miller, H. L., Andhey, P. S., Swiecki, M. K., Rosa, B. A., Zaitsev, K., Villani, A.-C., Mitreva, M., Artyomov, M. N., Gilfillan, S., Cella, M., & Colonna, M. (2021). Altered ratio of dendritic cell subsets in skin-draining lymph nodes promotes Th2-driven contact hypersensitivity. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2021364118 Cite
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ARNT Deficiency Represses Pyruvate Dehydrogenase Kinase 1 to Trigger ROS Production and Melanoma Metastasis

Researchers showed that the increase in glucose uptake and mitochondrial oxidative phosphorylation confers metastatic ability as a result of aryl hydrocarbon receptor nuclear translocator (ARNT) deficiency.
[Oncogenesis]
Huang, C.-R., Chang, T.-W., Lee, C.-T., Shen, C.-J., Chang, W.-C., & Chen, B.-K. (2021). ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis. Oncogenesis, 10(1), 1–15. https://doi.org/10.1038/s41389-020-00299-3 Cite
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Dermal Fibroblasts Cultured from Donors with Type 2 Diabetes Mellitus Retain an Epigenetic Memory Associated with Poor Wound Healing Responses

Dermal fibroblasts (DF) are critical for effective wound healing, so the authors sought to establish whether there were any differences in DF cultured from Type 2 diabetes mellitus donors or those without diabetes.
[Scientific Reports]
Al-Rikabi, A. H. A., Tobin, D. J., Riches-Suman, K., & Thornton, M. J. (2021). Dermal fibroblasts cultured from donors with type 2 diabetes mellitus retain an epigenetic memory associated with poor wound healing responses. Scientific Reports, 11(1), 1474. https://doi.org/10.1038/s41598-020-80072-z Cite
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UV-Exposure, Endogenous DNA Damage, and DNA Replication Errors Shape the Spectra of Genome Changes in Human Skin

Investigators sequenced genomes of single cell-derived clonal lineages obtained from primary skin cells of a large cohort of healthy individuals across a wide range of ages.
[PLoS Genetics]
Saini, N., Giacobone, C. K., Klimczak, L. J., Papas, B. N., Burkholder, A. B., Li, J.-L., Fargo, D. C., Bai, R., Gerrish, K., Innes, C. L., Schurman, S. H., & Gordenin, D. A. (2021). UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin. PLOS Genetics, 17(1), e1009302. https://doi.org/10.1371/journal.pgen.1009302 Cite
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Amniotic Fluid-Derived Multipotent Stromal Cells Drive Diabetic Wound Healing through Modulation of Macrophages

Researchers obtained third trimester amniotic fluid from term cesarean delivery and isolated and expanded MSCs in vitro. They then generated 10 mm wounds in Leprdb/db diabetic mouse skin, and splinted them open to allow for humanized wound modeling.
[Journal of Translational Medicine]
Subhan, B. S., Kwong, J., Kuhn, J. F., Monas, A., Sharma, S., & Rabbani, P. S. (2021). Amniotic fluid-derived multipotent stromal cells drive diabetic wound healing through modulation of macrophages. Journal of Translational Medicine, 19(1), 16. https://doi.org/10.1186/s12967-020-02674-5 Cite
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Omega-7 Oil Increases Telomerase Activity and Accelerates Healing of Grafted Burn and Donor Site Wounds

The authors investigated the efficacy of Omega-7 isolated from the sea buckthorn oil in ovine burn wound healing models. In vitro, proliferation and migration assays using cultured primary ovine keratinocytes were performed with or without 0.025% and 0.08% Omega-7, respectively.
[Scientific Reports]
Niimi, Y., Pérez-Bello, D., Ihara, K., Fukuda, S., Jacob, S., Andersen, C. R., Baljinnyam, T., Kim, J., Alharbi, S., Prough, D. S., & Enkhbaatar, P. (2021). Omega-7 oil increases telomerase activity and accelerates healing of grafted burn and donor site wounds. Scientific Reports, 11(1), 975. https://doi.org/10.1038/s41598-020-79597-0 Cite
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Circulating Tumor DNA Is Detectable in Canine Histiocytic Sarcoma, Oral Malignant Melanoma, and Multicentric Lymphoma

Researchers used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the plasma of cancer-affected dogs. They detected circulating tumor DNA in 21/23 of histiocytic sarcoma, 2/8of oral melanoma, and 12/13 of lymphoma cases.
[Scientific Reports]
Prouteau, A., Denis, J. A., De Fornel, P., Cadieu, E., Derrien, T., Kergal, C., Botherel, N., Ulvé, R., Rault, M., Bouzidi, A., François, R., Dorso, L., Lespagnol, A., Devauchelle, P., Abadie, J., André, C., & Hédan, B. (2021). Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma. Scientific Reports, 11(1), 877. https://doi.org/10.1038/s41598-020-80332-y Cite
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UNION Therapeutics A/S Receives FDA Approval for IND of Oral Next Generation PDE4-Inhibitor (Orismilast) for Investigation in Plaque Psoriasis

UNION therapeutics A/S announced that the FDA has approved an Investigational New Drug program (IND) for oral orismilast; a next generation PDE4-inhibitor for the treatment of plaque psoriasis in adults.
[UNION therapeutics A/S]
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InMed Announces Results of Second Phase I Clinical Trial of INM-755 CBN Cream in Healthy Subjects

InMed Pharmaceuticals Inc. announced top-line results from its 755-102-HV Phase I clinical trial. Results of the study indicate that INM-755 cream was safe and well-tolerated on induced open epidermal wounds, caused no systemic or serious adverse effects, and there were no subject withdrawals due to adverse events.
[InMed Pharmaceuticals Inc.]
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