Nance-Horan Syndrome-Like 1 Protein Negatively Regulates Scar/WAVE-Arp2/3 Activity and Inhibits Lamellipodia Stability and Cell Migration

The authors identified Nance-Horan Syndrome-like 1 protein as a direct binding partner of the Scar/WAVE complex, which co-localized at protruding lamellipodia.
[Nature Communications]
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Host Responses to Implants Revealed by Intravital Microscopy

Scientists discuss how intravital microscopy can reveal regenerative and pathological responses to implants, including wound healing and graft integration, which depend on the time-controlled activation of macrophages and early neovascularization, and adverse reactions.
[Nature Reviews Materials]
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Establishment of a Striped Catfish Skin Explant Model for Studying the Skin Response in Aeromonas hydrophila Infections

Investigators used striped catfish to establish an ex vivo skin explant tissue culture model to explore host pathogen interaction. They concluded that this ex vivo skin explant model could serve as a teleost skin infection model for monitoring pathogenesis under various infection conditions.
[Scientific Reports]
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Quantitative Assessment of Sensitizing Potency Using a Dose–Response Adaptation of GARDskin

Scientists analyzed dose–response relationships in the GARDskin assay to identify chemical-specific concentrations that were sufficient to induce a positive response in the assay.
[Scientific Reports]
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Integrin α5β1 Nano-Presentation Regulates Collective Keratinocyte Migration Independent of Substrate Rigidity

The authors used a highly specific integrin α5β1 peptidomimetic combined with nanopatterned hydrogels to show that keratinocyte sheets regulated their migration ability at an optimal integrin α5β1 nanospacing.
[eLife]
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EGFR-Mediated Epidermal Stem Cell Motility Drives Skin Regeneration through COL17A1 Proteolysis

Researchers conducted culture experiments that proved epidermal growth factor receptor (EGFR) activation drove human keratinocyte stem cell motility.
[Journal of Cell Biology]
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Silencing of Nesprin-2 Inhibits the Differentiation of Myofibroblasts from Fibroblasts Induced by Mechanical Stretch

Investigators constructed a cell model of hypertrophic scar (HTs) and explored the role of Nesprin-2 in this process. Myofibroblasts and fibroblasts were isolated from HTs and healthy skin tissues of the same patient.
[International Wound Journal]
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Antiproliferative Activity of Aqueous and Polyphenol-Rich Extracts of Larrea divaricata Cav. on a Melanoma Cell Line

The effects of Larrea divaricata, polyphenols and quercetin-3-methyl ether were assessed on B16F10 melanoma cells by determining the proliferation, viability, apoptosis induction and the expression and phosphorylation of STAT3.
[Natural Product Research]
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Dynamic Changes in Epithelial Cell Packing during Tissue Morphogenesis

Scientists highlight how morphogenetic processes are achieved by cell-shape changes, cell rearrangements, and oriented cell division. They describe approaches that have the potential to engineer 3D tissues for both basic science and translational purposes.
[Current Biology]
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Athenex Announces Phased European Launch of Klisyri® (Tirbanibulin) for the Treatment of Actinic Keratosis

Anthenex launched Klisyri® in Germany and the UK. Klisyri received approval by the European Commission and the UK Medicines & Healthcare products Regulatory Agency in July and August of 2021, respectively, for the topical treatment of actinic keratosis of the face and scalp in adults.
[Athenex, Inc.]
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Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin

By forced expression of the ectodysplasin-A in human epidermal keratinocytes sweat gland (SwG) culture medium, human epidermal keratinocytes were efficiently converted into SwG cells.
[Advanced Science]
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