Mitochondria in Skin Health, Aging, and Disease

Scientists discuss the essential role of mitochondria in regulating normal and abnormal skin physiology and the possibility of targeting this organelle in various skin disorders.
[Cell Death & Disease]
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Efficient CRISPR/Cas9-Mediated Gene Ablation in Human Keratinocytes to Recapitulate Genodermatoses: Modeling of Netherton Syndrome

Researchers have established a highly efficient method for precise deletion of critical gene sequences in primary human keratinocytes, based on CRISPR/Cas9-mediated gene editing.
[Molecular Therapy-Methods & Clinical Development]
Gálvez, V., Chacón-Solano, E., Bonafont, J., Mencía, Á., Di, W.-L., Murillas, R., Llames, S., Vicente, A., Rio, M. D., Carretero, M., & Larcher, F. (2020). Efficient CRISPR/Cas9-mediated gene ablation in human keratinocytes to recapitulate genodermatoses: Modeling of Netherton Syndrome. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2020.05.031 Cite
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New Wound-Healing Research Project Wins NASA Tick of Approval

A group of Australian scientists have caught the attention of NASA with a novel technology development that could potentially heal wounds in days rather than weeks without using stitches.
[Southern Cross University]
New wound-healing research project wins NASA tick of approval - Southern Cross University. (n.d.). Retrieved June 12, 2020, from https://www.scu.edu.au/engage/news/2020/new-wound-healing-research-project-wins-nasa-tick-of-approval.php Cite
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Hair-Bearing Human Skin Generated Entirely from Pluripotent Stem Cells

Scientists report an organoid culture system that generated complex skin from human PSCs. They used stepwise modulation of the transforming growth factor β and fibroblast growth factor signaling pathways to co-induce cranial epithelial cells and neural crest cells within a spherical cell aggregate.
[Nature]
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Sanofi: FDA Approves Dupixent® (Dupilumab) as First Biologic Medicine for Children Aged 6 to 11 Years with Moderate-to-Severe Atopic Dermatitis

The US FDA have approved Dupixent® for children aged 6 to 11 years with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.
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Achilles Therapeutics Doses First Patient in Phase I/II Study in Recurrent or Metastatic Malignant Melanoma

Achilles Therapeutics have announced that it has dosed the first patient in a Phase I/II study of a clonal neoantigen T cell therapy in patients with recurrent or metastatic malignant melanoma.
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Common Germline Variants of the Human Apoe Gene Modulate Melanoma Progression and Survival

Scientists reported that, in a reversal of their effect on Alzheimer’s disease, the APOE4 and APOE2 variants conferred favorable and poor outcomes in melanoma, respectively.
[Nature Medicine]
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Overcoming Genetically-Based Resistance Mechanisms to PD-1 Blockade

Human melanoma cell lines with JAK1/2 knockout became insensitive to interferon-induced antitumor effects, while B2M knockout were no longer recognized by antigen-specific T cells and hence, resistant to cytotoxicity.
[Cancer Discovery]
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Extracellular Serine Controls Epidermal Stem Cell Fate and Tumor Initiation

Researchers revealed extracellular serine as a critical determinant of epidermal stem cell fate and provided insight into how nutrient availability was integrated with stem cell fate decisions during tumor initiation.
[Nature Cell Biology]
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The Msi1-mTOR Pathway Drives the Pathogenesis of Mammary and Extramammary Paget’s Disease

Investigators identified MSI1 ectopic overexpression in basal epithelial cells of human Paget’s disease (PD) skin, and showed that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological, single-cell and molecular levels.
[Cell Research]
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Activin-Mediated Alterations of the Fibroblast Transcriptome and Matrisome Control the Biomechanical Properties of Skin Wounds

The authors provided mechanistic insight into the roles of activin in wound repair and fibrosis and identified the functional consequences of alterations in the wound matrisome at the biomechanical level.
[Nature Communications]
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