Euscaphic Acid and Tormentic Acid Protect Vascular Endothelial Cells against Hypoxia-Induced Apoptosis via PI3K/AKT or ERK 1/2 Signaling Pathway

Euscaphic acid protected vascular endothelial cells against hypoxia-induced apoptosis via ERK1/2 signaling pathway, and tormentic acid brought its efficacy into full play via PI3K/AKT and ERK1/2 signaling pathways.
[Life Sciences]
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Sirtuins Family as a Target in Endothelial Cell Dysfunction: Implications for Vascular Aging

The authors summarize how sirtuin 1 and other sirtuins may contribute to endothelial cell function and how presence of diseased conditions may alter their expressions to cause endothelial dysfunction.
[Biogerontology ]
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LncRNA SNHG1 Regulates Vascular Endothelial Cell Proliferation and Angiogenesis via miR-196a

The authors found SNHG1 was upregulated in TNF-α-treated HUVECs. They silenced SNHG1 and found it inhibited vascular endothelial cell proliferation and angiogenesis.
[Journal of Molecular Histology]
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Chi-Med Announces Surufatinib Granted US FDA Fast Track Designations for the Treatment of Both Pancreatic and Non-Pancreatic Neuroendocrine Tumors

Hutchison China MediTech Limited announced that the FDA has granted two Fast Track Designations for the development of surufatinib, for the treatment of both advanced and progressive pancreatic neuroendocrine tumors (NET) and extra-pancreatic NET in patients who are not amenable for surgery.
[Hutchison China MediTech Limited]
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S-Phase Kinase-Associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis In Vivo

Researchers investigated whether S-phase kinase-associated protein-2 plays a role in the regulation of endothelial progenitor cell senescence, which is closely associated with aging-related vasculopathy.
[Scientific Reports]
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Vascular Permeability in Retinopathy Is Regulated by VEGFR2 Y949 Signaling to VE-Cadherin

By challenging mouse models representing different steps in VEGFA/VEGF receptor 2 (VEGFR2)-induced vascular permeability, researchers showed that targeting signaling downstream of VEGFR2 pY949 limited vascular permeability in retinopathy induced by high oxygen or by laser-wounding.
[eLife]
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miR-548aq-3p Is a Novel Target of Far Infrared Radiation Which Predicts Coronary Artery Disease Endothelial Colony Forming Cell Responsiveness

Gene Ontology (GO) analysis of far infrared radiation (FIR) up-regulated genes indicated that the pathways enriched in FIR-responsive endothelial colony forming cells were involved in cell viability, angiogenesis and transcription.
[Scientific Reports]
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Notch Signaling Drives Synovial Fibroblast Identity and Arthritis Pathology

Scientists identified a critical role for NOTCH3 signaling in the differentiation of perivascular and sublining fibroblasts that expressed CD90. Using single-cell RNA sequencing and synovial tissue organoids, they found that NOTCH3 signaling drove both transcriptional and spatial gradients—emanating from vascular endothelial cells outwards—in fibroblasts.
[Nature Communications]
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A Necroptotic-Independent Function of MLKL in Regulating Endothelial Cell Adhesion Molecule Expression

Investigators demonstrated that mixed-lineage kinase domain-like protein (MLKL) promoted vascular inflammation by regulating the expression of adhesion molecules ICAM1, VCAM1, and E-selectin in endothelial cells.
[Cell Death & Disease]
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LncRNA OIP5-AS1 Promotes Cell Proliferation and Migration and Induces Angiogenesis via Regulating miR-3163/VEGFA in Hepatocellular Carcinoma

Scientists explored the inherent mechanism of lncRNA OIP5-AS1 -AS1 in hepatocellular carcinoma (HCC). In the first place, qRT-PCR found that OIP5-AS1 and VEGFA expressions were significantly increased while miR-3163 was obviously reduced in HCC cells and tissues.
[Cancer Biology & Therapy]
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