Mapping Protein Carboxymethylation Sites Provides Insights into Their Role in Proteostasis and Cell Proliferation

In primary endothelial cells, investigators showed that glyoxal induced cell cycle perturbation and that carboxymethyllysine modification reduced acetylation of tubulins and impaired microtubule dynamics.
[Nature Communications]
[zotpress userid=’7992332′ items=’DDDDDDDD’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

VEGF-A, PDGF-BB and HB-EGF Engineered for Promiscuous Super Affinity to the Extracellular Matrix Improve Wound Healing in a Model of Type 1 Diabetes

In the type 1 diabetic NOD mouse model, engineered growth factors improved both re-epithelialization and granulation tissue formation.
[NPJ Regenerative Medicine]
[zotpress userid=’7992332′ items=’DDDDDDDD’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Requirement of Direct Contact between Chondrocytes and Macrophages for the Maturation of Regenerative Cartilage

Researchers examined the host cells that promoted cartilage maturation via cell–cell contact. Based on analysis of the transplanted chondrocytes, they examined the contribution of endothelial cells and macrophages.
[Scientific Reports]
[zotpress userid=’7992332′ items=’DDDDDDDD’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses

The authors identified the protein syndesmos to specifically interact with cZNF292 in endothelial cells by RNA affinity purification and subsequent mass spectrometry analysis.
[Circulation Research]
[zotpress userid=’7992332′ items=’EEEEEEEE’ style=’apa’ cite=’yes’]
AbstractFull Article
Bookmark

No account yet? Register

Share

Fibroblast Transition to an Endothelial “Trans” State Improves Cell Reprogramming Efficiency

Scientists explored a novel strategy leveraging endothelial cell plasticity to enhance reprogramming efficiency. Rat cardiac endothelial cells and fibroblasts were treated with Gata4, Mef2c, and Tbx5 to assess the cardio-differentiation potential of these cells.
[Scientific Reports]
[zotpress userid=’7992332′ items=’EEEEEEEE’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Three-Dimensional Printing of Bioceramic-Induced Macrophage Exosomes: Immunomodulation and Osteogenesis/Angiogenesis

3D printed macrophage exosomes scaffolds, exhibiting a predefined structure and persistent release of exosomes, displayed distinct immunomodulatory effects and improved osteogenesis/angiogenesis.
[NPG Asia Materials]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Modulation of Cell Signaling and Sulfation in Cardiovascular Development and Disease

Immunocytochemical analysis confirmed SULF1/SULF2 expression in endothelial cell lining of blood vessels and in developing cardiomyocytes, but not in the adult cardiomyocytes despite persisting at reduced levels in the adult endothelial cells.
[Scientific Reports]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

A Fresh Look at Coronary Microembolization

The authors characterize the features and mechanisms of coronary microembolization and discuss the clinical trials of drugs and devices for prevention and treatment.
[Nature Reviews Cardiology]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Denali Therapeutics Announces Strategic Partner Takeda Exercises Option to Co-Develop and Co-Commercialize DNL593 (PTV:PGRN)

Denali Therapeutics, Inc. announced that its strategic partner Takeda Pharmaceutical Company Limited has exercised an option to co-develop and co-commercialize DNL593, an investigational, brain-penetrant progranulin replacement therapy for the potential treatment of frontotemporal dementia-granulin.
[Denali Therapeutics, Inc.]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Multimodal On-Chip Nanoscopy and Quantitative Phase Imaging Reveals the Nanoscale Morphology of Liver Sinusoidal Endothelial Cells

Researchers presented an integrated chip-based optical nanoscopy combined with quantitative phase microscopy to obtain 3D morphology of liver sinusoidal endothelial cells.
[Proceedings of the National Academy of Sciences of the United States of America]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

A Method for Rapid Flow-Cytometric Isolation of Endothelial Nuclei and RNA from Archived Frozen Brain Tissue

Scientists developed an approach to examine endothelial RNA expression by using an endothelial-specific marker to isolate nuclei from abundant archived frozen brain tissues.
[Laboratory Investigation]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share
Share