Neural Metabolic Imbalance Induced by MOF Dysfunction Triggers Pericyte Activation and Breakdown of Vasculature

The authors showed that neural-specific depletion of three members of the non-specific lethal chromatin complex—Mof, Kansl2 or Kansl3—unexpectedly led to severe vascular defects and brain hemorrhaging.
[Nature Cell Biology]
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Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

Scientists showed that tri-cellular combinations of human induced pluripotent stem cells (iPSC)-derived cardiomyocytes, cardiac fibroblasts, and cardiac endothelial cells enhanced maturation in easily constructed, scaffold-free, three-dimensional microtissues.
[Cell Stem Cell]
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Blocking Endothelial Apoptosis Revascularises the Retina in a Model of Ischemic Retinopathy

Researchers investigated the role of endothelial cell (EC) apoptosis in retinal hypoxia using a mouse model of ischemic retinopathy, in which vessel closure and EC apoptosis caused capillary regression and retinal ischemia followed by neovascularisation.
[Journal of Clinical investigation]
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Molecular Mechanisms of Methylglyoxal-Induced Aortic Endothelial Dysfunction in Human Vascular Endothelial Cells

Investigators found that methylglyoxal significantly induced autophagy, declined the pro-angiogenic effect, decreased proliferation, migration, and formation of tube-like structures, and increased autophagic vacuoles, flux and autophagosomes in the HAoEC in a dose-dependent manner.
[Cell Death & Disease]
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NRP2 as an Emerging Angiogenic Player; Promoting Endothelial Cell Adhesion and Migration by Regulating Recycling of α5 Integrin

The authors demonstrated that neuropilin (NRP)2 promoted Rac-1 mediated endothelial cell adhesion and migration over fibronectin matrices in a mechanistically distinct fashion to NRP1, showing no dependence on β3 integrin expression, or VEGF stimulation
[Frontiers in Cell and Developmental Biology]
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Angiogenic Cytokines Can Reflect the Synovitis Severity and Treatment Response to Biologics in Rheumatoid Arthritis

To determine the clinical significance of angiogenic cytokines in rheumatoid arthritis (RA), the levels of pro-angiogenic cytokines, including VEGF, placenta growth factor, and IL-6, were measured in the synovial fluid and sera of RA patients using ELISA.
[Experimental and Molecular Medicine]
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Amplification of Transglutaminase 2 Enhances Tumor-Promoting Inflammation in Gastric Cancers

Scientists investigated a novel role for transglutaminase 2 (TGM2) in the development of tumor-promoting inflammation and recruitment of tumor-associated macrophages to gastric cancer (GC) tissues. When estimated by array comparative genomic hybridization and droplet digital PCR, the copy numbers of the TGM2 gene were amplified in 13.6% of GC patients and positively associated with TGM2 expression.
[Experimental and Molecular Medicine]
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Glucose-Induced Duration-Dependent Genome-Wide DNA Methylation Changes in Human Endothelial Cells

Researchers investigated the effects of glucose on whole-genome DNA methylation in small and large vessel endothelial cell lines exposed to basal or high glucose-containing media for variable lengths of time. Using the Infinium EPIC array, they obtained 773,133 CpG sites for analysis.
[American Journal of Physiology-Cell Physiology]
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Endothelial Dysfunction in Nonalcoholic Steatohepatitis with Low Cardiac Disease Risk

Investigators prospectively evaluated endothelial function by assessing flow-mediated dilatation of the brachial artery in patients with biopsy-proven nonalcoholic fatty liver disease. This prospective study included 139 patients, all of whom were nondiabetic.
[Scientific Reports]
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The Biomarker HE4 (WFDC2) Promotes a Pro-Angiogenic and Immunosuppressive Tumor Microenvironment via Regulation of STAT3 Target Genes

HE4 was found to activate STAT3 signaling and promote upregulation of the pro-angiogenic STAT3 target genes IL8 and HIF1A in immune cells, ovarian cancer cells, and endothelial cells. Moreover, HE4 promoted increased in tube formation in an in vitro model of angiogenesis, which was also dependent upon STAT3 signaling.
[Scientific Reports]
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Endothelial-to-Mesenchymal Transition in Anticancer Therapy and Normal Tissue Damage

The authors review the role of hypoxia and reactive oxygen species as the main stimulating factors of tissue damage due to vascular damage and endothelial-to-mesenchymal transition (EndMT). They consider drugs that may be clinically useful for regulating EndMT in various diseases.
[Experimental and Molecular Medicine]
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