Uncovering Mutation-Specific Morphogenic Phenotypes and Paracrine-Mediated Vessel Dysfunction in a Biomimetic Vascularized Mammary Duct Platform

Scientists introduced a 3D microfluidic platform that juxtaposes a human mammary duct in proximity to a perfused endothelial vessel.
[Nature Communications]
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Risk Factors for Endothelial Cell Loss after Descemet Membrane Endothelial Keratoplasty (DMEK)

The authors dentified the risk factors for endothelial cell density (ECD) loss after descemet membrane endothelial keratoplasty (DMEK) and analyse whether donor tissues from cold versus organ culture differ in terms of ECD loss after DMEK.
[Scientific Reports]
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United Kingdom Plans ‘Office for Talent’ to Smooth Entry for Top Scientists

The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map.
[ScienceInsider]
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Hong Kong Universities Rattled by New Security Law

Academics in Hong Kong are facing new worries today after the mainland government abruptly imposed a controversial new security law that critics say could infringe on human rights and chill academic freedom.
[ScienceInsider]
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Amidst Uncertainty, Flexibility Is Key in Higher Ed, Faculty Say

Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year.
[The Scientist]
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Molecular Dissection of CRC Primary Tumors and Their Matched Liver Metastases Reveals Critical Role of Immune Microenvironment, EMT and Angiogenesis in Cancer Metastasis

Scientists assembled gene co-expression networks and identified metastasis-correlated gene networks of immune-suppression, epithelial–mesenchymal transition (EMT) and angiogenesis as the key events and potentially synergistic drivers associated with colorectal cancer metastasis.
[Scientific Reports]
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Embryonic Circulating Endothelial Progenitor Cells

The authors review in the literature concerning the features, origin and physiological functions of embryonic and fetal circulating endothelial progenitors.
[Angiogenesis]
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Splice Variants of lncRNA RNA ANRIL Exert Opposing Effects on Endothelial Cell Activities Associated with Coronary Artery Disease

Overexpression of ANRIL transcript NR_003529 increased monocyte adhesion to endothelial cells (ECs) and transendothelial monocyte migration (TEM), whereas knockdown of NR_003529 expression reduced monocyte adhesion to ECs and TEM.
[RNA Biology]
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Increased Levels of VEGF-C and Macrophage Infiltration in Lipedema Patients without Changes in Lymphatic Vascular Morphology

The histological and molecular characterization was conducted on anatomically-matched skin and fat biopsies as well as serum samples from eleven lipedema and ten BMI-matched healthy patients.
[Scientific Reports]
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PPARα Activation Directly Upregulates Thrombomodulin in the Diabetic Retina

Investigators performed genome-wide analyses of gene expression and PPARα binding sites in vascular endothelial cells treated with the selective proliferator-activated receptor α (PPARα) modulator pemafibrate and identified 221 target genes of PPARα including THBD, which encodes thrombomodulin.
[Scientific Reports]
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Extracellular Matrix Dynamics in Vascular Remodeling

The authors summarize how extracellular matrix (ECM) dynamics control vascular remodeling, and further indicate potential diagnostic biomarkers and therapeutic targets in the ECM for corresponding vascular diseases.
[American Journal of Physiology-Cell Physiology]
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