Current Progress of Rehabilitative Strategies in Stem Cell Therapy for Spinal Cord Injury: A Review

Scientists summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of spinal cord injury.
[NPJ Regenerative Medicine]
[zotpress userid=’7992332′ items=’DDDDDDDD’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Evolutionary Epigenomic Analysis in Mammalian Early Embryos Reveal Species-Specific Innovations and Conserved Principles of Imprinting

Through analysis of oocytes and early embryos in human, bovine, porcine, rat, and mouse, researchers revealed remarkable species-specific innovations as no single animal model fully recapitulated the human epigenetic transition.
[Science Advances]
[zotpress userid=’7992332′ items=’DDDDDDDD’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Chemically Defined Stem Cell Microniche Engineering by Microfluidics Compatible with iPSCs’ Growth in 3D Culture

Researchers reported the development of a chemically defined, artificial 3D microniche for iPSCs’ growth and reliable expansion, constructed with degradable polyethyleneglycol-co-polycaprolactone and RGDfk-functionalized dendritic polyglycerol precursors according to bioorthogonal strain-promoted azide-alkyne cycloaddition by droplet-based microfluidics.
[Biomaterials]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

MAP2K6 Remodels Chromatin and Facilitates Reprogramming by Activating Gatad2b-Phosphorylation Dependent Heterochromatin Loosening

The authors identified mitogen-activated protein kinase kinase 6 as a chromatin relaxer and found that it could significantly enhance reprogramming.
[Cell Death & Differentiation]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

O-GlcNAcylation of Sox2 at Threonine 258 Regulates the Self-Renewal and Early Cell Fate of Embryonic Stem Cells

Investigators showed that O-GlcNAcylation of Sox2 at threonine 258 regulated mouse ESC self-renewal and early cell fate.
[Experimental and Molecular Medicine]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Advantages and Prospects of Stem Cells in Nanotoxicology

The authors summarize the effects of nanomaterials on the proliferation and differentiation of ESCs, mesenchymal stem cells and neural stem cells.
[Chemosphere]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Pluripotency Transcription Factors at the Focus: The Phase Separation Paradigm in Stem Cells

Scientists review the state-of-the-art knowledge of compartmentalization in the cell nucleus and the relevance of this process for transcriptional regulation, particularly in PSCs.
[Biochemical Society Transactions]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Lin Ma Named 2021 STEM CELLS Young Investigator

Dr. Lin Ma is the recipient of STEM CELLS’s Young Investigator Award for 2021. Her work on engineering hypoimmunogenic human PSCs exemplifies the potential of the field and promise of this young next generation of researchers.
[ALPHAMED PRESS (EurekAlert!)]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Cytovia and Cellectis Expand Their TALEN® Gene-Edited iNK Partnership to Enable Broader Collaboration in China

Cytovia Therapeutics, Inc. and Cellectis announced that they have expanded their collaboration of TALEN® gene-edited iPSC-derived natural killer (NK) and chimeric antigen receptor (CAR)-NK cells to include new CAR target and development in China by Cytovia’s joint venture entity, CytoLynx Therapeutics.
[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Transplantation of Human Embryonic Stem Cells Alleviates Motor Dysfunction in AAV2-Htt171-82Q Transfected Rat Model of Huntington’s Disease

The authors observed if transplantation of superparamagnetic iron oxide nanoparticle-labeled human ESCs could migrate in the neural degenerated area and improve motor dysfunction in an AAV2-Htt171-82Q transfected Huntington rat model.
[Stem Cell Research & Therapy]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Long-Term Repair of Porcine Articular Cartilage Using Cryopreservable, Clinically Compatible Human Embryonic Stem Cell-Derived Chondrocytes

Investigators described the development, transcriptomic ontogenetic characterization and quality assessment at the single cell level, as well as the scaled manufacturing of an allogeneic human PSC-derived articular chondrocyte formulation that exhibited long-term functional repair of porcine articular cartilage.
[NPJ Regenerative Medicine]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share
Share