ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

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Dysregulated Proteostasis in P.A53T-α-Synuclein Astrocytes Aggravates Lewy-Like Neuropathology in a Parkinson’S Disease iPSC Model

November 25, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Researchers differentiated patient-derived p.A53T-αSyn iPSC to ventral midbrain astrocytes and characterized them via comprehensive molecular, functional, and proteomic analyses.

Generation of hiPSC-Derived Brain Microvascular Endothelial Cells Using Directed Differentiation and Transcriptional Reprogramming

November 25, 2025

[Arteriosclerosis Thrombosis and Vascular Biology] Investigators combined directed differentiation of human iPSCs into BBB-primed endothelial cells with overexpression of FOXF2 and ZIC3, transcription factors critical for BMEC identity, to generate reprogrammed BMECs from 3 iPSC lines.

NANOG Governs Cell Metabolism and Redox Homeostasis in Human Naïve Embryonic Stem Cells

November 25, 2025

[EMBO Reports] Scientists systematically investigated functions of the core transcription factor NANOG in naïve hESCs. Acting as an upstream key regulator, NANOG directly activates genes associated with naïve pluripotency, acetyl-CoA synthesis, and anti-oxidation in a naïve pluripotency state- dependent manner, and represses the expression of extraembryonic lineage genes in naïve hESCs.

The eTM-Mir3699-MAN7 Mediated Cell Wall Degradation in Regulating Embryogenic Cell Formation during the Early Stage of Somatic Embryogenesis in Apple

November 25, 2025

[Horticulture Research] eTM3699, miR3699 and MANNAN7 (MAN7) were identified as key regulators of embryogenic cell formation through whole-transcriptome sequencing.

Lineage-Specific Enhancer Insertions Regulate Prdm14 to Drive the Rapid Transition from NaïVe to Formative Pluripotency in Rodents

November 25, 2025

[Development] Investigators demonstrated that POU5F1 and TFCP2L1 recognition sequences within Muroidea-specific cis-regulatory elements located downstream of Prdm14 are essential for its transcriptional upregulation in naïve embryonic stem cells

Dynamic Proteome Profiling of Differentiating Human Embryonic Stem Cells Towards Cardiomyocytes

November 25, 2025

[Scientific Reports] Scientists profiled the proteome of differentiating cells at the mesendoderm, cardiac mesoderm, cardiac progenitor cell, and cardiomyocyte stages using in-depth quantitative analysis via multiplexed tandem mass tag-based mass spectrometry.

Optimization of Gene Knockout Approaches and sgRNA Selection in hPSCs with Inducible Cas9 Expression

November 25, 2025

[Scientific Reports] Researchers generated a doxycycline-inducible spCas9-expressing hPSCs line and developed it into an optimized gene knockout system through systematically refining critical parameters.

Endocrine Disrupting Chemical Exposure during Differentiation Alters the Proliferation-Maturation Balance in Stem-Cell Islets

November 25, 2025

[Toxicological Sciences] The authors reported the first toxicological application of stem cell (SC) islets to investigate the developmental effect of endocrine disrupting chemicals. Using hiPSCs, they generated SC-islets and exposed them to a mixture of bisphenol A, bisphenol S, and trans-nonachlor during differentiation.

The Role of METTL3 in Transposable Elements Regulation and 2C-Like Program Induction in Mouse Embryonic Stem Cell

November 25, 2025

[Cell Regeneration] Scientists demonstrated that Mettl3 knockout in mESCs leads to widespread upregulation of transposable elements and 2-cell-like genes in a m⁶A enzyme activity-dependent manner, independent of culture conditions.

Urine-derived stem cells: The biomedical research of endothelial and cardiovascular tissue

November 25, 2025

[Biomedicine & Pharmacotherapy] Urine-derived stem cells can be reprogrammed into iPSCs. This expands opportunities for disease modeling, developing personalized therapies, and reconstructions.

CRISPR-Based Functional Genomics in Pluripotent Stem Cells

November 25, 2025

[Stem Cell Reviews and Reports] The authors provide a comprehensive evaluation of recent developments in CRISPR-Cas platforms, including gene knockouts, base and prime editing, and CRISPR activation or interference, as applied to PSC systems.

Pluristyx Collaborates with Breakthrough T1D to Make “Immune-Cloaked” and Safety Switch-Enabled Allogeneic Cell Line for Type 1 Diabetes Therapies

November 25, 2025

[Pluristyx] Pluristyx announced the launch of a project up to $1.4 million, supported and funded by Breakthrough T1D. The project will create and distribute a genetically engineered iPSC line, providing developers with an important new tool that serves as the starting material for manufacturing the next generation of islet replacement therapies.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.