Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
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The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and is Essential for Teratoma Formation

Scientists examined the effect of mutations in 703 genes from nearly 70 chromatin-modifying complexes on human ESC growth. While the vast majority of chromatin-associated complexes were essential for ESC growth, the only complexes that conferred growth advantage upon mutation of their members, were the repressive complexes LSD-CoREST and BHC.
[Stem Cell Reports]
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Signaling Inhibitors Accelerate the Conversion of Mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment

Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
[Scientific Reports]
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Derivation of Oocyte-Like Cells from Putative Embryonic Stem Cells and Parthenogenetically Activated into Blastocysts in Goat

Scientists demonstrated that goat putative ESCs were successfully in vitro differentiated into primordial germ cells and oocyte-like cells using bone morphogenetic protein-4 and trans-retinoic acid.
[Scientific Reports]
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Epigenetic Priming by Dppa2 and 4 in Pluripotency Facilitates Multi-Lineage Commitment

Differentiation assays revealed that developmental pluripotency associated 2 and 4 (Dppa2/4) double knockout mouse ESCs failed to exit pluripotency and differentiate efficiently.
[Nature Structural & Molecular Biology]
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In Vitro Differentiated Human Stem Cell-Derived Neurons Reproduce Synaptic Synchronicity Arising during Neurodevelopment

Scientists generated human iPSC-derived neurons exhibiting spontaneous oscillatory activity after cultivation of up to six months, which resembled early oscillations observed in rodent neurons. This behavior was found in neurons generated using a more “native” embryoid body protocol, in contrast to a “fast” protocol based on NGN2 overexpression.
[Stem Cell Reports]
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A Simple, Quick, and Efficient CRISPR/Cas9 Genome Editing Method for Human Induced Pluripotent Stem Cells

The authors report an electroporation-mediated plasmid CRISPR/Cas9 delivery approach for genome editing in iPSCs. With this approach, an edited iPSC cell line could be obtained within two weeks.
[Acta Pharmacologica Sinica]
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BRPF3-HUWE1-Mediated Regulation of MYST2 Is Required for Differentiation and Cell-Cycle Progression in Embryonic Stem Cells

Researchers provided novel insights into understanding the functions of Brpf3 in proper differentiation as well as cell-cycle progression of ESCs via regulation of Myst2 stability by obstructing Huwe1-mediated ubiquitination.
[Cell Death & Differentiation]
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Tooth Formation: Are the Hardest Tissues of the Human Body Hard to Regenerate?

Approaches for whole-tooth regeneration utilizing adult stem cells, iPSCs, or tooth germ cells transplantation are emerging as promising alternatives to overcome existing in vitro tissue generation hurdles. The authors discuss the most recent advances in cellular signaling guiding dental tissue genesis.
[International Journal of Molecular Sciences]
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A lncRNA-miRNA-mRNA Network for Human Primed, Naive and Extended Pluripotent Stem Cells

Researchers successfully converted three in-house-derived primed human PSC lines (H10, H24, and iPS) to a naive state and an expanded pluripotent stem cell (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
[PLoS One]
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AgeX Therapeutics and Pluristyx Announce Manufacturing, Marketing, and Distribution Agreement to Expand Access to Clinical-Grade Human Pluripotent Stem Cells for Therapeutic Applications

AgeX Therapeutics, Inc. and Pluristyx, Inc. have announced they have entered into a manufacturing, marketing, and distribution agreement through which Pluristyx will undertake these activities on behalf of AgeX with respect to AgeX’s research- and clinical-grade ESI brand human ESCs.
[AgeX Therapeutics Inc.]
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