Tracing the Emergence of Primordial Germ Cells from Bilaminar Disc Rabbit Embryos and Pluripotent Stem Cells

Using newly derived rabbit PSCs, investigators showed robust and rapid induction of rabbit primordial germ cell (rbPGC)-like cells in vitro with WNT and BMP morphogens, which revealed SOX17 as the critical regulator of rbPGC fate as in several non-rodent mammals.
[Cell Reports]
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HNF Collaborates with Rarebase on a Drug Discovery Platform to Develop Treatments for Charcot-Marie-Tooth (CMT)

The Hereditary Neuropathy Foundation (HNF), in partnership with Rarebase, is leading the charge in the first-ever research initiative to tackle multiple types of CMT in one project, with a primary goal to test candidate drugs in patient-derived cellular models, specifically; iPSC-derived neurons.
[The Hereditary Neuropathy Foundation]
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Century Therapeutics and Outpace Bio Enter Research Collaboration in CAR Engineering

Century Therapeutics, a biotechnology company developing iPSC-derived cell therapies in immuno-oncology, and Outpace Bio, announced a research collaboration in CAR engineering.
[Century Therapeutics]
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Joint Single-Cell Multiomic Analysis in Wnt3a Induced Asymmetric Stem Cell Division

Investigators developed an approach to jointly profile the epigenome and transcriptome in the same single cell. Utilizing this method, they profiled H3K27me3 and H3K4me3 levels along with gene expression in mouse ESCs with localized Wnt3a signaling, revealing the cell type-specific maps of the epigenome and transcriptome in divided daughter cells.
[Nature Communications]
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A Polycomb Domain Found in Committed Cells Impairs Differentiation When Introduced into PRC1 in Pluripotent Cells

ESCs expressing a chimeric CBX7 were impaired in their ability to properly form embryoid bodies and neural progenitor cells and showed reduced activation of lineage-specific genes across differentiation.
[Molecular Cell]
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Induced Pluripotent Stem Cells for Inherited Optic Neuropathies—Disease Modeling and Therapeutic Development

The authors discuss disease modeling and the therapeutic strategies being explored with iPSC technologies for the 2 most common inherited optic neuropathies, namely, dominant optic atrophy and Leber hereditary optic neuropathy. The rationale and translational advances for cell-based and gene-based therapies are explored, as well as opportunities for neuroprotection and drug screening.
[Journal of Neuro-Ophthalmology]
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Nuclear Transporter Importin-13 Plays a Key Role in the Oxidative Stress Transcriptional Response

Scientists performed transcriptomic analysis on wild-type and Importin-13-knockout mouse ESCs, revealing enrichment of differentially expressed genes involved in stress responses and apoptosis regulation.
[Nature Communications]
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Distinct Roles of Haspin in Stem Cell Division and Male Gametogenesis

Researchers showed that mouse ESCs that lacked or overexpressed haspin, albeit prone to chromosome misalignment during metaphase, could still divide, expand and differentiate.
[Scientific Reports]
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PLCγ2 Regulates TREM2 Signaling and Integrin-Mediated Adhesion and Migration of Human iPSC-Derived Macrophages

To explore the relationship between PLCγ2 and TREM2 and the role of PLCγ2 in regulating immune cell function, the authors generated human iPSC- derived macrophages from isogenic lines with homozygous PLCG2 knockout.
[Scientific Reports]
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miR-27b Antagonizes BMP Signaling in Early Differentiation of Human Induced Pluripotent Stem Cells

Researchers used miR-27b-inducible human iPSCs (hiPSCs) to investigate the roles of miR-27b in the undifferentiated and early-differentiated stages. In undifferentiated hiPSCs, miR-27b suppressed the expression of pluripotency markers and cell proliferation.
[Scientific Reports]
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Loss of Resf1 Reduces the Efficiency of Embryonic Stem Cell Self-Renewal and Germline Entry

The authors used Resf1 knockout cell lines to determine the requirements of RESF1 for ESC self-renewal and for in vitro specification of ESCs into primordial germ cell-like cells
[Life Science Alliance]
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