Deletion of lncRNA XACT Does Not Change Expression Dosage of X-linked Genes, but Affects Differentiation Potential in human PSCs

Scientists reported that a common mechanism for the initiation of the erosion of X chromosome inactivation of female human PSCs depended on XIST loss but not XACT accumulation on inactive X chromosomes.
[Cell Reports]
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Characterization of a Commercially Available Line of iPSC Hepatocytes as Models of Hepatocyte Function and Toxicity for Regulatory Purposes

The authors assessed similarities and differences between commercially available iPSC hepatocytes and primary human hepatocytes in preliminary assays of drug metabolism, hepatotoxicity, and drug transport.
[Journal of Pharmacological and Toxicological Methods]
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Chromosome Compartments on the Inactive X Guide TAD Formation Independently of Transcription during X-Reactivation

Investigators combined a mouse iPSC reprogramming system and high-resolution Hi-C to produce a time course combining gene reactivation, chromatin opening and chromosome topology during X-reactivation.
[Nature Communications]
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An Overview on Promising Somatic Cell Sources Utilized for the Efficient Generation of Induced Pluripotent Stem Cells

Scientists provide an overview of promising easily accessible somatic cell sources isolated in non-invasive or minimally invasive manner such as keratinocytes, urine cells, and peripheral blood mononuclear cells used for the generation of human iPSCs derived from healthy and diseased subjects.
[Stem Cell Reviews and Reports]
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BlueRock Therapeutics Announces First Patient Dosed with DA01 in Phase I Study in Patients with Advanced Parkinson’s Disease

BlueRock Therapeutics announced the dose administration for the first patient in a Phase I, open-label study of PSC-derived dopaminergic neurons in patients with advanced Parkinson’s disease.
[BlueRock Therapeutics]
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Chemical Combinations Potentiate Human Pluripotent Stem Cell-Derived 3D Pancreatic Progenitor Clusters toward Functional β Cells

To efficiently cluster hPSC-derived pancreatic progenitors into 3D structures, scientists discovered 10 chemicals that not only retained the pancreatic progenitors in 3D clusters but also enhanced their potentiality towards NKX6.1+/INS+β cells.
[Nature Communications]
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Highly Parallelized Human Embryonic Stem Cell Differentiation to Cardiac Mesoderm in Nanoliter Chambers on a Microfluidic Chip

Scientists differentiated human ESCs to early cardiac mesodermal cells in microfluidic chambers that had a volume of only 30 nanoliters, using discontinuous medium perfusion. To confirm cell pluripotency, they tracked hESC proliferation and immunostained the cells for pluripotency markers SOX2 and OCT3/4.
[Biomedical Microdevices]
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High Throughput Screening Identifies SOX2 as a Super Pioneer Factor That Inhibits DNA Methylation Maintenance at Its Binding Sites

Using a highly parallelized approach to investigate pioneer transcription factor (PF) ability to bind methylated DNA and induce DNA demethylation, researchers showed the complex interdependence between DNA methylation and transcription factor binding; while some PFs did not affect the methylation status of their binding sites, they identified PFs that could protect DNA from methylation and others that could induce DNA demethylation at methylated binding sites.
[Nature Communications]
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The Therapeutic Potential of Multiclonal Tumoricidal T Cells Derived from Tumor Infiltrating Lymphocyte-1 derived iPS Cells

Researchers established tumor-specific tumor-infiltrating lymphocytes (TIL)-derived iPS cells with human colorectal cancer specimens to confirm their hypothesis that the anti-tumor effect could be enhanced by TIL regeneration.
[Communications Biology]
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Tissue Mechanics in Stem Cell Fate, Development, and Cancer

The authors review how dysregulation of tissue-level force increases risk of malignancy, promotes tumor progression, and can induce a stem-like phenotype in tumor cells to drive tumor aggression and treatment resistance.
[Developmental Cell]
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Sorrento and Researchers at Karolinska Institutet Have Signed a Research Collaboration Agreement on iPSC-Derived Dimeric Antigen Receptor-Modified Natural Killer (DAR-NK) Cells With The Vision to Bring “Off-The-Shelf” NK Cell-Based Cancer Treatments Rapidly to Patients

Sorrento Therapeutics, Inc. announced that the Company has entered into an additional collaborative agreement with NextGenNK Competence Center-associated research groups at the Department of Medicine, Huddinge, Karolinska Institutet  in Stockholm, Sweden, aimed at producing novel cell-based therapeutics using natural killer cells derived from induced pluripotent stem cells.
[Sorrento Therapeutics, Inc.]
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