YAP1 Regulates the Self-Organized Fate Patterning of hESC-Derived Gastruloids

Investigators interrogated the contribution of the Hippo signaling effector YAP1 to the formation of the three germ layers by analyzing human ESC-derived 2D-micropatterned gastruloids.
[Stem Cell Reports]
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Early Human Embryonic Development: Blastocyst Formation to Gastrulation

The authors discuss new insights into human embryogenesis gathered from successes in culturing human embryos in vitro and stem-cell-based embryo models.
[Developmental Cell]
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Pluristyx Announces Strategic Alliance with panCELLa and Implant Therapeutics of Offer ‘Off-the-Shelf’ Induced Pluripotent Stem Cells

Pluristyx, Inc., panCELLa, and Implant Therapeutics announced they have entered into a manufacturing and distribution strategic alliance that offers cell therapy companies streamlined access to the next generation of safe, universal, cost-effective, “off-the-shelf” iPSCs.
[Pluristyx, Inc.]
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Histone Variant macroH2A1.1 Enhances Non-homologous End Joining-Dependent DNA Double-Strand-Break Repair and Reprogramming Efficiency of Human iPSCs

Researchers evaluated the splicing isoforms of histone variant macroH2A1, macroH2A1.1 and macroH2A1.2, as potential regulators of DNA damage repair during iPSC reprogramming.
[Stem Cells]
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Selective Elimination of Pluripotent Stem Cells by PIKfyve Specific Inhibitors

Scientists showed that PIKfyve inhibitors could selectively eliminate pluripotent embryonal carcinoma cells, ESCs, and iPSCs under conditions where differentiated cells remained viable.
[Stem Cell Reports]
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Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells

Researchers studied maturity-onset diabetes of the young 1 using human iPSC-derived pancreatic β-like patient and isogenic control cell lines in two different 3D contexts.
[Diabetes]
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Integrated Fibroblast Growth Factor Signal Disruptions in Human iPS Cells for Prediction of Teratogenic Toxicity of Chemicals

Investigators developed a reporter assay using human iPSCs to detect changes in the fibroblast growth factor signaling pathway, a pathway essential for limb morphogenesis.
[Journal of Bioscience and Bioengineering]
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Transcriptional Programs Regulating Neuronal Differentiation Are Disrupted in DLG2 Knockout Human Embryonic Stem Cells and Enriched for Schizophrenia and Related Disorders Risk Variants

Scientists integrated human genetics with transcriptomic data from differentiation of human ESCs into cortical excitatory neurons.
[Nature Communications]
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Genome-Wide CRISPR Screen Identifies Puf60 as a Novel Stemness Gene of Mouse Embryonic Stem Cells

To study the mechanisms in ESC self-renewal, screening and identification of key genes maintaining ESC self-renewal were performed by a genome-wide CRISPR-Cas9 knockout virus library.
[Stem Cells and Development]
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Human Airway Lineages Derived from Pluripotent Stem Cells Reveal the Epithelial Responses to SARS-CoV-2 Infection

Investigators presented a human iPSC-derived airway epithelial platform, composed of the major airway epithelial cell types, that was permissive to SARS-CoV-2 infection.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
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Stem Cells at Odds with Telomere Maintenance and Protection

The authors discuss insights into telomere protection in ESCs versus somatic cells and summarize findings on telomerase regulation as a function of pluripotency.
[Trends in Cell Biology]
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