Effect of a Bone Marrow-Derived Extracellular Matrix on Cell Adhesion and Neural Induction of Dental Pulp Stem Cells

Researchers evaluated the effect of a decellularized ECM, derived from bone marrow stem cells, on the neuronal differentiation of mesenchymal stem cells extracted from dental pulp stem cells.
[Frontiers in Cell and Developmental Biology]
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Acellular Bioscaffolds Redirect Cardiac Fibroblasts and Promote Functional Tissue Repair in Rodents and Humans with Myocardial Injury

Scientists used acellular biologic extracellular matrix scaffolds (bioscaffolds) to stimulate pathways of muscle repair and restore tissue function. They showed that acellular bioscaffolds with bioinductive properties can redirect cardiac fibroblasts to rebuild microvascular networks and avoid tissue fibrosis.
[Scientific Reports]
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Detachment of Cell Sheets from Clinically Ubiquitous Cell Culture Vessels by Ultrasonic Vibration

Scientists developed a simple but versatile cell sheet fabrication method using ubiquitous culture dishes/flasks without any coating or temperature modulation. Confluent mouse myoblasts were exposed to ultrasonic vibration from underneath and detached as cell sheets from entire culture surfaces.
[Scientific Reports]
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The Tumor Microenvironment in Cholangiocarcinoma Progression

Investigators summarize current understandings of the tumor microenvironment and intercellular communications in cholangiocarcinoma and their role in tumor progression.
[Hepatology]
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New Wound-Healing Research Project Wins NASA Tick of Approval

A group of Australian scientists have caught the attention of NASA with a novel technology development that could potentially heal wounds in days rather than weeks without using stitches.
[Southern Cross University]
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Innervation: The Missing Link for Biofabricated Tissues and Organs

The authors assert that innervation should be included as a necessary component for tissue and organ biofabrication, and that strategies to orchestrate host axonal integration are advantageous to ensure proper function, tolerance, assimilation, and bio-regulation with the recipient post-implant.
[NPJ Regenerative Medicine]
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Lack of Collagen XVIII Leads to Lipodystrophy and Perturbs Hepatic Glucose and Lipid Homeostasis

Researchers observed that, in the high caloric diet, the overall adiposity was decreased by 30%, serum triglyceride values were three-fold higher and the steatotic area in liver was two-fold larger in the collagen XVIII knockout mice compared with the controls.
[The Journal of Physiology]
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Materials Design for Bone-Tissue Engineering

The authors provide an overview of materials-design considerations for bone-tissue-engineering applications in both disease modeling and treatment of injuries and disease in humans.
[Nature Reviews Materials]
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Matrix Metalloproteinase Inhibitor and Sunscreen Effective Compounds from Rumex crispus L.: Isolation, Identification, Bioactivity and Molecular Docking Study

Molecular docking studies on anthranoid, flavonoid, tannin and naphthalene skeletons with matrix metalloproteinase enzymes were applied for the first time. Various chromatographic methods were used for isolation studies.
[Phytochemical Analysis]
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Targeting Focal Adhesion Kinase in Cancer Cells and the Tumor Microenvironment

Scientists discuss the role of nuclear focal adhesion kinase (FAK) as a driver for tumor cell survival as well as potential therapeutic strategies to target FAK in both tumors and the tumor microenvironment
[Experimental and Molecular Medicine]
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Vascularized Silk Electrospun Fiber for Promoting Oral Mucosa Regeneration

To endow the fiber with the function of promoting angiogenesis and oral mucosa regeneration, surface-aminated liposomes encapsulating leptin, as well as silk fiber membranes that had been immersed overnight in polydopamine solution were synthesized.
[NPG Asia Materials]
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