Science Money Slashed in EU’s €1.8-Trillion Budget Deal

A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
[Nature News]
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Epigenetics in Modulating Immune Functions of Stromal and Immune Cells in the Tumor Microenvironment

The authors review recent studies demonstrating how specific epigenetic mechanisms drive aspects of stromal and immune cell differentiation with implications for the development of solid tumor therapeutics, focusing on the pancreatic ductal adenocarcinoma tumor microenvironment as a representative of solid tumors.
[Cellular & Molecular Immunology]
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sTim-3 Alleviates Liver Injury via Regulation of the Immunity Microenvironment and Autophagy

Researchers investigated the role of soluble T-cell immunoglobulin domain and mucin domain-containing molecule-3 in inhibition of release of inflammatory mediators.
[Cell Death Discovery]
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B Cell Zone Reticular Cell Microenvironments Shape CXCL13 Gradient Formation

Investigators suggest that reticular cells of the B cell zone generated microenvironments that shaped both immobilized and soluble CXCL13 gradients.
[Nature Communications]
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Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly

Scientists used a tension sensor based on ZO-1, a scaffolding protein that links the junctional membrane to the cytoskeleton, to determine if tight junctions carried a mechanical load.
[Cell Reports]
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A Multi-Layered Scaffold for Regeneration of Smooth Muscle and Connective Tissue Layers

Researchers demonstrated that differently‐oriented scaffold fibers direct cell and ECM organization, and that scaffold fibers and ECM protein networks were maintained after decellularization.
[Journal of Biomedical Materials Research Part A]
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Hyperglycemia Is Associated with Impaired Muscle Signaling and Aerobic Adaptation to Exercise

The authors data point to chronic hyperglycemia as a potential negative regulator of aerobic adaptation, in part, via glucose-mediated modifications of the ECM, impaired vascularization and aberrant mechanical signaling in muscle.
[Nature Metabolism]
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Collagen: Quantification, Biomechanics and Role of Minor Subtypes in Cartilage

The authors introduce the roles of collagen subtypes and crosslinks and describe modern assays that enable a deep understanding of tissue physiology and disease states.
[Nature Reviews Materials]
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Mutations in COMP Cause Familial Carpal Tunnel Syndrome

Researchers report the identification of two mutations in cartilage oligomeric matrix protein that segregated with carpal tunnel syndrome in two large families with or without multiple epiphyseal dysplasia.
[Nature Communications]
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Basement Membrane Damage by ROS- and JNK-Mediated Mmp2 Activation drives Macrophage Recruitment to Overgrown Tissue

Investigators utilize an overgrowth tumor model in larval Drosophila imaginal discs that are attached by numerous macrophages. They report that changes to the microenvironment of the overgrown tissue were important for recruiting macrophages.
[Nature Communications]
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Pro-Angiogenic Scaffold-Free Bio Three-Dimensional Conduit Developed from Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Promotes Peripheral Nerve Regeneration

Researchers investigated the efficacy and mechanism of the Bio 3D conduit composed of xeno-free human induced pluripotent stem cell–derived mesenchymal stem cells.
[Scientific Reports]
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