Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
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A Flowable Placental Formulation Prevents Bleomycin-Induced Dermal Fibrosis in Aged Mice

Researchers investigated the anti-fibrotic activity of a flowable placental formulation using a bleomycin-induced dermal fibrosis model in aged mice.
[European Journal of Human Genetics]
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Signaling Inhibitors Accelerate the Conversion of Mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment

Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
[Scientific Reports]
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Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix

Direct co-culture with postnatal cardiac fibroblasts increased cardiomyocyte binucleation, which could be inhibited by RGD peptide treatment.
[Circulation Research]
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Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

The authors explore current strategies that shift immune cell metabolism to pro-inflammatory states in the tumor microenvironment and highlight a need to better replicate physiologic conditions to select targets, clarify mechanisms, and optimize metabolic inhibitors.
[Molecular Cell]
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Drop-on-Demand Cell Bioprinting via Laser Induced Side Transfer (LIST)

Researchers showed that LIST-printed HUVECS present negligible loss of viability and maintain their abilities to migrate, proliferate and form intercellular junctions.
[Scientific Reports]
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Proteomic Profiling of Striatal Tissue of a Rat Model of Parkinson’s Disease after Implantation of Collagen-Encapsulated Human Umbilical Cord Mesenchymal Stem Cells

Human umbilical cord-MSCs were encapsulated into collagen hydrogels and implanted into the striatum of hemi‐parkinsonian male Sprague Dawley rats. One or 14 days after implantation, the area of interest was dissected using a cryostat.
[Journal of Tissue Engineering and Regenerative Medicine]
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Cross Talk between Mesenchymal and Glioblastoma Stem Cells: Communication beyond Controversies

The authors discuss recent findings on the complex nature of MSCs, focusing on their elusive impact on glioblastoma progression and aggressiveness by direct cell‐cell interaction and via secretome, also facing the perspectives and challenges in treatment strategies.
[Stem Cells Translational Medicine]
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Intercellular Adhesion Stiffness Moderates Cell Decoupling as a Function of Substrate Stiffness

Researchers modeled a three-dimensional cell pair on a patterned substrate, a simple laboratory setup to study intercellular interactions. They explicitly modeled focal adhesions and adherens junctions. These mechanosensing adhesions matured, becoming stabilized by force.
[Biophysical Journal]
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Nanoparticle Delivery of Immunostimulatory Oligonucleotides Enhances Response to Checkpoint Inhibitor Therapeutics

Researchers found that their engineered nanoparticles carrying a CpG DNA ligand of TLR9 could suppress tumor growth in several animal models of various cancers, resulting in an abscopal effect on distant tumors, and improving responsiveness to anti-CTLA4 treatment with combinatorial effects after intratumoral administration.
[Proceedings of the National Academy of Sciences of the United States of America]
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Allosteric Communications between Domains Modulate the Activity of Matrix Metalloprotease-1

Investigators showed that communications between the catalytic and hemopexin domains of matrix metalloprotease-1 on type-1 collagen fibrils correlated with its activity.
[Biophysical Journal]
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