3D Printed Deformable Sensors

The authors developed an in situ 3D printing system that estimated the motion and deformation of the target surface to adapt the toolpath in real time. With this printing system, a hydrogel-based sensor was printed on a porcine lung under respiration-induced deformation.
[Science Advances]
[zotpress items='{6445218:I7M3QLAA}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Humidity‐Triggered Relaxation of Polyelectrolyte Complexes as a Robust Approach to Generate Extracellular Matrix Biomimetic Films

Scientists report a facile approach to generate ECM biomimetic films based on the humidity‐triggered relaxation of polyelectrolyte complex nanoparticles.
[Advanced Healthcare Materials]
[zotpress items='{6445218:QTFHS4X6}’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Regulation of Heterogeneous Cancer-Associated Fibroblasts: The Molecular Pathology of Activated Signaling Pathways

Pro-inflammatory cytokines, such as leukemia inhibitory factor and interleukin-6, were secreted by both cancer cells and cancer associated fibroblasts (CAFs), and mediated the epigenetic modification of CAFs. This enhanced the pro-tumorigenic function of CAFs mediated by promoting actomyosin contractility and ECM remodeling to form the tracks used for collective cancer cell migration.
[Journal of Experimental & Clinical Cancer Research]
[zotpress items='{6445218:PXHXPHAP}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Lassen Therapeutics Launches to Discover and Develop Novel Antibody Therapeutics Including Lead Program Targeting IL-11 to Treat Fibrosis and Oncology

Lassen Therapeutics announced it has emerged from stealth and secured $31 million in Series A financing to develop antibodies as potential treatments for fibrosis, rare diseases and oncology.
[Lassen Therapeutics]
Bookmark

No account yet? Register

Share

Bellicum Receives FDA IND Clearance to Initiate a Phase I/II Clinical Trial for BPX-603, a Dual-Switch GoCAR-T® for HER2+ Solid Tumors

Bellicum Pharmaceuticals, Inc. announced clearance by the FDA of its investigational new drug application for BPX-603. BPX-603 is a GoCAR-T® product candidate targeting solid tumors that express human epidermal growth factor receptor 2 (HER2).
[Bellicum Pharmaceuticals, Inc.]
Bookmark

No account yet? Register

Share

Simulating the Human Colorectal Cancer Microenvironment in 3D Tumor-Stroma Co-Cultures In Vitro and In Vivo

Researchers successfully converted three in-house-derived primed human PSC lines to a naive state and an expanded pluripotent stem cell (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
[Scientific Reports]
[zotpress items='{6630899:FXJ5EK29}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Exosomes: A Potential Therapeutic Tool Targeting Communications between Tumor Cells and Macrophages

Scientists summarize the roles and mechanisms of exosomes in the interaction between tumor cells and macrophages and the potential methods by which exosomes are used to target the communication between tumor cells and macrophages to treat cancer.
[Molecular Therapy]
[zotpress items='{6445212:B8TJPNID}’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Dissecting Intratumour Heterogeneity of Nodal B-Cell Lymphomas at the Transcriptional, Genetic and Drug-Response Levels

Researchers identified transcriptionally distinct malignant subpopulations and compared their drug-response and genomic profiles. Malignant subpopulations from the same patient responded strikingly differently to anti-cancer drugs ex vivo, which recapitulated subpopulation-specific drug sensitivity during in vivo treatment.
[Nature Cell Biology]
[zotpress items='{6445212:C4WPWT79}’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Fabrication of Stiffness Gradients of GelMA Hydrogels using a 3D Printed Micromixer

A co-culture consisting of human adipose tissue-derived mesenchymal stem cellsand human umbilical cord vein endothelial cells was encapsulated in the gradient construct.
[Macromolecular Bioscience]
[zotpress items='{6445218:NQV852J4}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
Editorial
Bookmark

No account yet? Register

Share

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

Intravenous delivery of immunity- and matrix-regulatory cells, derived from human embryonic stem cells, inhibited both pulmonary inflammation and fibrosis in mouse models of lung injury, and significantly improved the survival rate of the recipient mice in a dose-dependent manner, likely through paracrine regulatory mechanisms.
[Cell Research]
[zotpress items='{1254621:B8CWTHSN}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share
Share