New Wound-Healing Research Project Wins NASA Tick of Approval

A group of Australian scientists have caught the attention of NASA with a novel technology development that could potentially heal wounds in days rather than weeks without using stitches.
[Southern Cross University]
New wound-healing research project wins NASA tick of approval - Southern Cross University. (n.d.). Retrieved June 12, 2020, from https://www.scu.edu.au/engage/news/2020/new-wound-healing-research-project-wins-nasa-tick-of-approval.php Cite
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Innervation: The Missing Link for Biofabricated Tissues and Organs

The authors assert that innervation should be included as a necessary component for tissue and organ biofabrication, and that strategies to orchestrate host axonal integration are advantageous to ensure proper function, tolerance, assimilation, and bio-regulation with the recipient post-implant.
[NPJ Regenerative Medicine]
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Lack of Collagen XVIII Leads to Lipodystrophy and Perturbs Hepatic Glucose and Lipid Homeostasis

Researchers observed that, in the high caloric diet, the overall adiposity was decreased by 30%, serum triglyceride values were three-fold higher and the steatotic area in liver was two-fold larger in the collagen XVIII knockout mice compared with the controls.
[The Journal of Physiology]
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Materials Design for Bone-Tissue Engineering

The authors provide an overview of materials-design considerations for bone-tissue-engineering applications in both disease modeling and treatment of injuries and disease in humans.
[Nature Reviews Materials]
Koons, G. L., Diba, M., & Mikos, A. G. (2020). Materials design for bone-tissue engineering. Nature Reviews Materials, 1–20. https://doi.org/10.1038/s41578-020-0204-2 Cite
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Matrix Metalloproteinase Inhibitor and Sunscreen Effective Compounds from Rumex crispus L.: Isolation, Identification, Bioactivity and Molecular Docking Study

Molecular docking studies on anthranoid, flavonoid, tannin and naphthalene skeletons with matrix metalloproteinase enzymes were applied for the first time. Various chromatographic methods were used for isolation studies.
[Phytochemical Analysis]
Uzun, M., Guvenalp, Z., Kazaz, C., & Demirezer, L. O. (n.d.). Matrix metalloproteinase inhibitor and sunscreen effective compounds from Rumex crispus L.: isolation, identification, bioactivity and molecular docking study. Phytochemical Analysis, n/a(n/a). https://doi.org/10.1002/pca.2948 Cite
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Targeting Focal Adhesion Kinase in Cancer Cells and the Tumor Microenvironment

Scientists discuss the role of nuclear focal adhesion kinase (FAK) as a driver for tumor cell survival as well as potential therapeutic strategies to target FAK in both tumors and the tumor microenvironment
[Experimental and Molecular Medicine]
Targeting focal adhesion kinase in cancer cells and the tumor microenvironment | Experimental & Molecular Medicine. (n.d.). Retrieved June 12, 2020, from https://www.nature.com/articles/s12276-020-0447-4 Cite
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Vascularized Silk Electrospun Fiber for Promoting Oral Mucosa Regeneration

To endow the fiber with the function of promoting angiogenesis and oral mucosa regeneration, surface-aminated liposomes encapsulating leptin, as well as silk fiber membranes that had been immersed overnight in polydopamine solution were synthesized.
[NPG Asia Materials]
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Reversible Suppression of T Cell Function in the Bone Marrow Microenvironment of Acute Myeloid Leukemia

Investigators found a significant association between T cell infiltration in the bone marrow microenvironment of newly diagnosed patients with acute myeloid leukemia (AML) and increased overall survival. Functional studies aimed at establishing the degree of T cell suppression in patients with AML revealed impaired T cell function in many patients.
[Proceedings of the National Academy of Sciences of the United States of America]
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Integrin α5β1, as a Receptor of Fibronectin, Binds the FbaA Protein of Group A Streptococcus to Initiate Autophagy during Infection

The authors stimulated cells and infected mice with M and FbaA mutants of M1 Group A Streptococcus strain SF370 or with purified M and FbaA proteins, and found that only FbaA protein was involved in autophagy induction.
[mBio]
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Aggrecanase-Selective Tissue Inhibitor of Metalloproteinase-3 (TIMP3) Protects Articular Cartilage in a Surgical Mouse Model of Osteoarthritis

The authors tested whether the selectivity of [-1A]TIMP3 was beneficial compared with that of the wild-type TIMP3 in preventing or delaying the onset of the degenerative effects in a mouse model of osteoarthritis. They generated transgenic mice that overexpressed TIMP3 or [-1A]TIMP3 driven by a chondrocyte-specific type II collagen promoter
[Scientific Reports]
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In silico Analysis Reveals EP300 As a panCancer Inhibitor of Anti-Tumor Immune Response via Metabolic Modulation

Based on the TCGA database, scientists defined specific, altered genes associated with different tumor immune microenvironment types, which might represent new predictive markers or targets for immuno-therapeutic approaches.
[Scientific Reports]
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Organoid Polymer Functionality and Mode of Klebsiella pneumoniae Membrane Antigen Presentation Regulates Ex Vivo Germinal Center Epigenetics in Young and Aged B Cells2

Polyethylene glycol-based immune organoids were developed to elucidate the effects of polymer end-point chemistry, integrin ligands, and mode of K. pneumoniae antigen presentation on germinal center-like B cell phenotype and epigenetics, to better define the lymph node microenvironment factors regulating ex vivo germinal center dynamics.
[Advanced Functional Materials]
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