Immune Infiltrate and Tumor Microenvironment Transcriptional Programs Stratify Pediatric Osteosarcoma into Prognostic Groups at Diagnosis

RNA sequencing of 79 osteosarcoma diagnostic biopsies identified stable independent components that recapitulated the tumor and microenvironment cell composition.
[Cancer Research]
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Matrix Metalloproteinases (MMP) 3 and 9 as Biomarkers of Severity in COVID-19 Patients

Investigators studied serum MMP3 and MMP9 as potential biomarkers of COVID-19 severity, in 108 hospitalized patients with different World Health Organization severity stage and in 48 controls.
[Scientific Reports]
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A Computational Modeling of Invadopodia Protrusion into an Extracellular Matrix Fiber Network

Researchers presented a computational framework for the characterization of invadopodia protrusions which allowed two way interactions between intracellular branched actin network and ECM fibers network.
[Scientific Reports]
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Canonical TGFβ Signaling Induces Collective Invasion in Colorectal Carcinogenesis through a Snail1- and Zeb1-Independent Partial EMT

The authors investigated the impact of oncogenic transformation and the microenvironment on tumor cell invasion using genetically engineered organoids as colorectal cancer models.
[Oncogene]
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Multi-Omic Analysis Reveals Divergent Molecular Events in Scarring and Regenerative Wound Healing

Scientists profiled scarring versus YAP-inhibition-induced wound regeneration at the transcriptional, protein, and tissue levels, and showed that disrupting YAP mechanotransduction yielded regenerative repair by fibroblasts with activated Trps1 and Wnt signaling.
[Cell Stem Cell]
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Cartesian Therapeutics Doses Patient with First Allogeneic RNA Cell Therapy for Multiple Myeloma

Cartesian Therapeutics announced that it has dosed the first patient in a Phase I/IIa multicenter clinical study evaluating Descartes-25, engineered to deliver a combination of synergistically active anti-myeloma therapies directly to tumor microenvironment, in patients with multiple myeloma.
[Cartesian Therapeutics]
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A Muscle Cell-Macrophage Axis Involving Matrix Metalloproteinase 14 Facilitates Extracellular Matrix Remodeling with Mechanical Loading

Using single-cell RNA-seq, scientists identified macrophages as a source of matrix metalloproteinase 14 in muscle following a hypertrophic exercise stimulus in mice.
[FASEB Journal]
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Injectable Amnion Hydrogel-Mediated Delivery of Adipose-Derived Stem Cells for Osteoarthritis Treatment

Investigators evaluated the efficacy of intraarticular injections of amnion membrane hydrogels with and without adipose-derived stem cells in reducing inflammation and cartilage degeneration in a collagenase-induced osteoarthritis rat model.
[Proceedings of the National Academy of Sciences of the United States of America]
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Alginate/Gelatin-Based Hydrogel with Soy Protein/ Peptide Powder for 3D Printing Tissue-Engineering Scaffolds to Promote Angiogenesis

Researchers prepared inks that exhibited excellent shear-thinning behavior, which contributed to extrusion-based printing, and also showed good crosslinking ability by calcium chloride.
[Macromolecular Bioscience]
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Urine Peptidome in Combination with Transcriptomics Analysis Highlights MMP7, MMP14 and PCSK5 for Further Investigation in Chronic Kidney Disease

Through investigating chronic kidney disease-associated transcriptomics datasets, several proteases were highlighted including members of matrix metalloproteinases and serine proteases.
[PLoS One]
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Development of a Hybrid Nanoink for 3D Bioprinting of Heterogeneous Tumor Models

Scientists reported a hybrid nanoink composed of alginate, gelatin methacryloyl, and cellulose nanocrystal, designed for multinozzle microextrusion 3D printing of tumor models.
[ACS Biomaterials Science & Engineering]
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