Stiffening of the Extracellular Matrix Is a Sufficient Condition for Airway Hyperreactivity

The authors hypothesized that stiffening of the airway ECM is a core pathological change sufficient to support excessive bronchoconstriction even in the absence of inflammation.
[Journal of Applied Psychology]
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Sphere Fluidics and ClexBio Introduce CYTRIX Microfluidic Hydrogel Kit

Sphere Fluidics Limited and ClexBio has announced the launch of the biocompatible CYTRIX Microfluidic Hydrogel Kit. This kit allows researchers to study valuable cells over many weeks rather than days in defined microenvironments that mimic the natural ECM.
[Sphere Fluidics Limited]
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Kindlin-3 Disrupts an Intersubunit Association in the Integrin LFA1 to Trigger Positive Feedback Activation by Rap1 and talin1

Using single-molecule measurements, the authors revealed the distinct dynamics of talin1 and kindlin-3 interactions with the integrin LFA1 and their functions in LFA1 activation and LFA1-mediated adhesion.
[Science Signaling]
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Regulatory Properties of Vitronectin and Its Glycosylation in Collagen Fibril Formation and Collagen-Degrading Enzyme Cathepsin K Activity

Investigators discovered that vitronectin promoted collagen fibril formation and inhibited cathepsin K activity, and observed its activation in vitro.
[Scientific Reports]
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Tissue Mechanics in Stem Cell Fate, Development, and Cancer

The authors review how dysregulation of tissue-level force increases risk of malignancy, promotes tumor progression, and can induce a stem-like phenotype in tumor cells to drive tumor aggression and treatment resistance.
[Developmental Cell]
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NFAT Signaling in Human Mesenchymal Stromal Cells Affects Extracellular Matrix Remodeling and Anti-Fungal Immune Responses

RNA-sequencing analysis of zymosan-treated MSCs showed that calcineurin-NFAT inhibition affects extracellular matrix genes, but not cytokine expression that is under the control of the NF-κB pathway.
[iScience]
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Vapor-Phased Fabrication and Modulation of Cell-Laden Scaffolding Materials

Investigators reported a vapor-phased fabrication process for constructing 3D modulated scaffold materials via simple steps based on controlling mass transport of vapor sublimation and deposition.
[Nature Communications]
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Synthetic Extracellular Matrices with Tailored Adhesiveness and Degradability Support Lumen Formation during Angiogenic Sprouting

The authors showed that long, perfusable tubes only developed if hydrogel adhesiveness and degradability were fine-tuned to support the initial collective invasion of endothelial cells and, at the same time, allowed for matrix remodeling to permit the opening of lumens.
[Nature Communications]
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TP53 Missense Mutations in PDAC Are Associated with Enhanced Fibrosis and an Immunosuppressive Microenvironment

Analysis of human pancreatic ductal adenocarcinoma (PDAC) patient data from The Cancer Genome Atlas revealed a negative association between the presence of missense mutp53 and infiltration of CD8+ T cells into the tumor.
[Proceedings of the National Academy of Sciences of the United States of America]
Maddalena, M., Mallel, G., Nataraj, N. B., Shreberk-Shaked, M., Hassin, O., Mukherjee, S., Arandkar, S., Rotkopf, R., Kapsack, A., Lambiase, G., Pellegrino, B., Ben-Isaac, E., Golani, O., Addadi, Y., Hajaj, E., Eilam, R., Straussman, R., Yarden, Y., Lotem, M., & Oren, M. (2021). TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment. Proceedings of the National Academy of Sciences, 118(23). https://doi.org/10.1073/pnas.2025631118 Cite
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Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors

Current approaches to bioprinting such implants fall into one of two categories, each with their own advantages and limitations. First are those that can be 3D bioprinted and then directly implanted into the body and second those that require further in vitro culture after bioprinting to engineer more mature tissues prior to implantation.
[iScience]
Freeman, F. E., Burdis, R., & Kelly, D. J. (2021). Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors. Trends in Molecular Medicine, 0(0). https://doi.org/10.1016/j.molmed.2021.05.001 Cite
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Inhibition of Aberrant Tissue Remodeling by Mesenchymal Stromal Cells Singly Coated with Soft Gels Presenting Defined Chemomechanical Cues

The authors showed that MSCs singly coated with a soft conformal gel presenting defined chemomechanical cues promoted matrix remodeling by secreting soluble interstitial collagenases in response to the presence of tumour necrosis factor alpha.
[Nature Biomedical Engineering]
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