Cosmc Controls B Cell Homing

Scientists report that B cell-specific deletion of the X-linked gene, Cosmc, and the consequent decrease of protein O-glycosylation, induced developmental blocks of mouse B cells.
[Nature Communications]
Zeng, J., Eljalby, M., Aryal, R. P., Lehoux, S., Stavenhagen, K., Kudelka, M. R., Wang, Y., Wang, J., Ju, T., von Andrian, U. H., & Cummings, R. D. (2020). Cosmc controls B cell homing. Nature Communications, 11(1), 3990. https://doi.org/10.1038/s41467-020-17765-6 Cite
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Multifunctional Oncolytic Nanoparticles Deliver Self-Replicating IL-12 RNA to Eliminate Established Tumors and Prime Systemic Immunity

Investigators describe self-replicating RNAs encapsulated in lipid nanoparticles (LNPs), which combined three key elements: an LNP composition that potently promoted immunogenic cancer cell death, RNA that stimulated danger sensors in transfected cells and RNA-encoded interleukin (IL)-12 for modulation of immune cells.
[Nature Cancer]
Li, Y., Su, Z., Zhao, W., Zhang, X., Momin, N., Zhang, C., Wittrup, K. D., Dong, Y., Irvine, D. J., & Weiss, R. (2020). Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity. Nature Cancer, 1–12. https://doi.org/10.1038/s43018-020-0095-6 Cite
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Enhancing Myocardial Repair with CardioClusters

Mesenchymal stem cells, endothelial progenitor cells and c-Kit+ cardiac interstitial cells when cultured together spontaneously formed scaffold-free 3D microenvironments termed CardioClusters.
[Nature Communications]
Monsanto, M. M., Wang, B. J., Ehrenberg, Z. R., Echeagaray, O., White, K. S., Alvarez, R., Fisher, K., Sengphanith, S., Muliono, A., Gude, N. A., & Sussman, M. A. (2020). Enhancing myocardial repair with CardioClusters. Nature Communications, 11(1), 3955. https://doi.org/10.1038/s41467-020-17742-z Cite
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Dodecin As Carrier Protein for Immunizations and Bioengineering Applications

Researchers present the dodecin from Mycobacterium tuberculosis (mtDod) as a new scaffold protein. MtDod is a homododecameric complex of spherical shape, high stability and robust assembly, which allows the attachment of cargo at its surface.
[Scientific Reports]
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Functional Characterization of Three-Dimensional Cortical Cultures for In Vitro Modeling of Brain Networks

Scientists present an experimental system based on 3D scaffold-based cortical neuron cultures in which they expressed the genetically encoded calcium indicator GCaMP6f to record neuronal activity at the millimeter-scale.
[iScience]
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Pancreatic Ductal Adenocarcinoma Progression Is Restrained by Stromal Matrix

Experimentally manipulating stromal matrix with an anti– lysyl oxidase like-2 antibody in syngeneic orthotopic pancreatic ductal adenocarcinoma mouse models significantly decreased matrix content, led to lower tissue stiffness, lower contrast retention on computed tomography, and accelerated tumor growth, resulting in diminished overall survival.
[Journal of Clinical Investigation]
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Amyloid Aggregates Accumulate in Melanoma Metastasis Modulating YAP Activity

Using secretome analyses, the authors revealed the extracellular accumulation of amyloidogenic proteins, i.e. premelanosome protein, in metastatic melanoma, together with proteins that assist amyloid maturation into fibrils.
[EMBO Reports]
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Targeting Hypoxia-Driven Metabolic Reprogramming to Constrain Tumor Progression and Metastasis

The authors aims to understand the biological processes, key events, and consequences regarding the hypoxia-driven metabolic adaptation of tumor cells.
[International Journal of Molecular Sciences]
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Twitter Account of Embattled #MeTooSTEM Founder Suspended

Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
[ScienceInsider]
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Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma

Researchers examined how regulation and function of gene products that provide the target epitopes for CD8+ T cell anti-tumor immunity influence therapeutic efficacy and resistance.
[Immunity]
Effern, M., Glodde, N., Braun, M., Liebing, J., Boll, H. N., Yong, M., Bawden, E., Hinze, D., Boorn-Konijnenberg, D. van den, Daoud, M., Aymans, P., Landsberg, J., Smyth, M. J., Flatz, L., Tüting, T., Bald, T., Gebhardt, T., & Hölzel, M. (2020). Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.07.007 Cite
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The Mesenchymal Context in Inflammation, Immunity and Cancer

Investigators provide a concise overview of the contextual contribution of fibroblastic mesenchymal cells in physiology and disease and bring into focus emerging evidence for both their heterogeneity at the single-cell level and their tissue-specific, spatiotemporal functional diversity.
[Nature Immunology]
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Correlative Study of Epigenetic Regulation of Tumor Microenvironment in Spindle Cell Melanomas and Cutaneous Malignant Peripheral Nerve Sheath Tumors

Scientists investigated the epigenetic regulation of promoters and gene bodies and their effect on the tumor microenvironment composition of cutaneous malignant peripheral nerve sheath tumors and spindle cell melanomas.
[Scientific Reports]
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