Crosstalk between Cancer-Associated Fibroblasts and Immune Cells in the Tumor Microenvironment: New Findings and Future Perspectives

Investigators shed light on recent advances regarding the direct and indirect crosstalk between cancer-associated fibroblasts (CAFs) and infiltrating immune cells and further summarize the possible immunoinhibitory mechanisms induced by CAFs in the tumor microenvironment.
[Molecular Cancer]
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Extracellular Matrix and Cellular Senescence in Venous Leg Ulcers

Researchers found a strong correlation between decreased collagen area and presence of senescent cells in human chronic wounds, such as venous leg ulcer, diabetic foot ulcer, and pressure ulcer, supporting the use of collagen imaging in cutaneous wound assessment for a faster and non-invasive method to predict cellular senescence.
[Scientific Reports]
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Long-Term Maintenance of Functional Primary Human Hepatocytes in 3D Gelatin Matrices Produced by Solution Blow Spinning

The authors reported the successful generation of 3D thermally crosslinked preforms by using solution blow spinning (SBS) from porcine gelatin. They then used SBS mats as culturing substrates for human hepatocytes to create an array of 3D human liver tissue equivalents in 96-well format.
[Scientific Reports]
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Integrated Spatial Multiomics Reveals Fibroblast Fate during Tissue Repair

Scientists presented a multimodal -omics platform for the comprehensive study of cell populations in complex tissue, which allowed them to characterize the cells involved in wound healing across both time and space.
[Proceedings of the National Academy of Sciences of the United States of America]
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Spatially Confined Sub-Tumor Microenvironments in Pancreatic Cancer

Investigators deconvoluted the human pancreatic tumor microenvironment through large-scale integration of histology-guided regional multiOMICs with clinical data and patient-derived preclinical models.
[Cell]
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Targeting of the Tumor Immune Microenvironment by Metformin

The authors explain the basic mechanisms for the interactions and communications between immunosuppressive, anti-tumoral, and cancer cells within the tumor microenvironment (TME), and discuss the modulating effects of metformin on various cells and secretions in the TME.
[Journal of Cell Communication and Signaling]
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Three Subtypes of Lung Cancer Fibroblasts Define Distinct Therapeutic Paradigms

By functionally interrogating cancer-associated fibroblasts heterogeneity using the same therapeutics received by patients, the authors identified three functional subtypes: robustly protective of cancers and highly expressing HGF and FGF7; moderately protective of cancers and highly expressing FGF7; and those providing minimal protection.
[Cancer Cell]
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Matrix Stiffness Drives Stromal Autophagy and Promotes Formation of a Protumorigenic Niche

Researchers demonstrated that an increased physical rigidity of a fibroblast’s environment was sufficient to evoke stromal autophagy. Mechanistically, matrix stiffness was transmitted via Integrin αV receptors and focal adhesion kinase, resulting in stabilization of AMPK at focal adhesion structures.
[Proceedings of the National Academy of Sciences of the United States of America]
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Targeting Neurons in the Tumor Microenvironment with Bupivacaine Nanoparticles Reduces Breast Cancer Progression and Metastases

The authors designed PEGylated lipid nanoparticles loaded with a non-opioid analgesic, bupivacaine, to target neurons within breast cancer tumors and suppress nerve-to-cancer cross-talk.
[Science Advances]
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Irbesartan, an Angiotensin II Type 1 Receptor Blocker, Inhibits Colitis-Associated Tumorigenesis by Blocking the MCP-1/CCR2 Pathway

Irbesartan suppressedmonocyte chemoattractant protein-1 (MCP-1) production and the accumulation of Ly6C+CCR2+ monocytes and fibrocytes in the inflamed colon, downregulated the expression of type 1 collagen and matrix metalloproteinase 9 and inhibited the development of intestinal fibrosis and tumors.
[Scientific Reports]
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Surface Oncology Announces New Randomized Phase II Clinical Study Evaluating SRF388 in Patients with First-Line Hepatocellular Carcinoma in Clinical Collaboration with Roche

Surface Oncology, an immuno-oncology company developing next-generation immunotherapies that target the tumor microenvironment, announced details about its plan to initiate a randomized Phase II clinical study evaluating SRF388, in combination with Roche’s atezolizumab and bevacizumab, in patients with treatment-naïve hepatocellular carcinoma.
[Surface Oncology]
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