Inhibition of senescence-induced upregulation of hypoxia-inducible factor-2α expression during matrix maturation, but not during the proliferation stage of osteoblast differentiation, reversed the age-related decrease in Runx2 and Ocn expression.
[Experimental and Molecular Medicine]
1254621 CB2ULXIC items 1 apa default asc 1
Lee, S. Y., Park, K. H., Lee, G., Kim, S.-J., Song, W.-H., Kwon, S.-H., Koh, J.-T., Huh, Y. H., & Ryu, J.-H. (2021). Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss. Experimental & Molecular Medicine, 1–14. https://doi.org/10.1038/s12276-021-00594-y Cite
This review examines the current knowledge of heparan sulfate proteoglycans in the stem cell niche, human stem cell models, and their role in the development of 3D models that mimic the in vivo neural extracellular matrix.
[Seminars in Thrombosis and Hemostasis]
1254621 MDFV92TJ items 1 apa default asc 1
Using synthetic hyaluronic acid hydrogels as a chemically and mechanically tunable system to preserve lymphatic endothelial cell phenotypes, scientists demonstrated that low matrix elasticity primed lymphatic cord‐like structure formation directed by a high concentration of vascular endothelial growth factor‐C (VEGF‐C).
6445212 PJP2E5LE items 1 apa default asc 1
Alderfer, L., Russo, E., Archilla, A., Coe, B., & Hanjaya‐Putra, D. (2021). Matrix stiffness primes lymphatic tube formation directed by vascular endothelial growth factor-C. The FASEB Journal, 35(5), e21498. https://doi.org/https://doi.org/10.1096/fj.202002426RR Cite
Researchers demonstrated that a reduced opticin levels in ROP vitreous are regulated by matrix metalloproteinases (MMPs) secreted by activated microglia.
6445212 R8EQTLPR items 1 apa default asc 1
Patnaik, S., Rai, M., Jalali, S., Agarwal, K., Badakere, A., Puppala, L., Vishwakarma, S., Balakrishnan, D., Rani, P. K., Kekunnaya, R., Chhablani, P. P., Chakrabarti, S., & Kaur, I. (2021). An interplay of microglia and matrix metalloproteinase MMP9 under hypoxic stress regulates the opticin expression in retina. Scientific Reports, 11(1), 7444. https://doi.org/10.1038/s41598-021-86302-2 Cite
The authors hypothesized that stiffening of the airway extracellular matrix is a core pathological change sufficient to support excessive bronchoconstriction even in the absence of inflammation.
[Journal of Applied Physiology]
1254621 HWZBKXGL items 1 apa default asc 1
Jamieson, R. R., Stasiak, S. E., Polio, S. R., Augspurg, R. D., McCormick, C. A., Ruberti, J. W., & Parameswaran, H. (2021). Stiffening of the Extracellular Matrix is a Sufficient Condition for Airway Hyperreactivity. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00554.2020 Cite
Foresee Pharmaceuticals Co., Ltd. announced the initiation of patient dosing in the Phase II/III clinical trial of FP-025, its highly selective oral MMP-12 inhibitor, in adult patients with severe to critical COVID-19 with associated Acute Respiratory Distress Syndrome.
[Foresee Pharmaceuticals Co., Ltd.]
1254621 nan items 1 apa default asc 1
Rosiglitazone significantly inhibited high glucose-induced proliferation, oxidative stress, inflammatory responses and extracellular matrix accumulation in mouse mesangial cells.
1254621 PZ5MN9CT items 1 apa default asc 1
Zhao, D., Guo, J., Liu, L., & Huang, Y. (2021). Rosiglitazone attenuates high glucose-induced proliferation, inflammation, oxidative stress and extracellular matrix accumulation in mouse mesangial cells through the Gm26917/miR-185-5p pathway. Endocrine Journal, advpub. https://doi.org/10.1507/endocrj.EJ20-0783 Cite
The authors embedded MCF10A normal human breast epithelial cells in two different matrices – collagen type I, and collagen type I+10% Matrigel; treatment with calcitriol resulted in flatter epithelial structures.
[Tissue Engineering Part A]
Scientists investigated the role of CD148 in the profibrotic phenotype of fibroblasts in idiopathic pulmonary fibrosis. Conditional CD148 fibroblast-specific knockout mice were generated and exposed to bleomycin, and then assessed for pulmonary fibrosis.
[American Journal of Respiratory and Critical Care Medicine]
1254621 RKFI4667 items 1 apa default asc 1
Tsoyi, K., Liang, X., De Rossi, G., Ryter, S. W., Xiong, K., Chu, S. G., Liu, X., Ith, B., Celada, L. J., Romero, F., Robertson, M. J., Esposito, A. J., Poli, S., El-Chemaly, S., Perrella, M. A., Shi, Y., Whiteford, J., & Rosas, I. O. (2021). CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.202008-3100OC Cite
The authors provide a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue.
[Biomedicine & Pharmacotherapy]
6445212 QCPPNQ2M items 1 apa default asc 1
Augustine, R., Dan, P., Hasan, A., Khalaf, I. M., Prasad, P., Ghosal, K., Gentile, C., McClements, L., & Maureira, P. (2021). Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells. Biomedicine & Pharmacotherapy, 138, 111425. https://doi.org/10.1016/j.biopha.2021.111425 Cite
Researchers performed genome‐wide expression analysis comparing fibroblasts in normal, inflammatory and tumor‐associated skin. Cancer‐associated fibroblasts exhibit a fibrotic gene signature in wound‐induced tumors, demonstrating persistent extracellular matrix remodeling within these tumors.
1254621 SHQDZUGD items 1 apa default asc 1
Van Hove, L., Lecomte, K., Roels, J., Vandamme, N., Vikkula, H.-K., Hoorens, I., Ongenae, K., Hochepied, T., Donati, G., Saeys, Y., Quist, S. R., Watt, F. M., van Loo, G., & Hoste, E. (2021). Fibrotic enzymes modulate wound-induced skin tumorigenesis. EMBO Reports, n/a(n/a), e51573. https://doi.org/10.15252/embr.202051573 Cite