Hypoxia-Inducible Factor-2α Mediates Senescence-Associated Intrinsic Mechanisms of Age-Related Bone Loss

Inhibition of senescence-induced upregulation of hypoxia-inducible factor-2α expression during matrix maturation, but not during the proliferation stage of osteoblast differentiation, reversed the age-related decrease in Runx2 and Ocn expression.
[Experimental and Molecular Medicine]
Lee, S. Y., Park, K. H., Lee, G., Kim, S.-J., Song, W.-H., Kwon, S.-H., Koh, J.-T., Huh, Y. H., & Ryu, J.-H. (2021). Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss. Experimental & Molecular Medicine, 1–14. https://doi.org/10.1038/s12276-021-00594-y Cite
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Three-Dimensional Human Neural Stem Cell Models to Mimic Heparan Sulfate Proteoglycans and the Neural Niche

This review examines the current knowledge of heparan sulfate proteoglycans in the stem cell niche, human stem cell models, and their role in the development of 3D models that mimic the in vivo neural extracellular matrix.
[Seminars in Thrombosis and Hemostasis]
Peall, I. W., Okolicsanyi, R. K., Griffiths, L. R., & Haupt, L. M. (2021). Three-Dimensional Human Neural Stem Cell Models to Mimic Heparan Sulfate Proteoglycans and the Neural Niche. Seminars in Thrombosis and Hemostasis, 47(03), 308–315. https://doi.org/10.1055/s-0041-1724117 Cite
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Matrix Stiffness Primes Lymphatic Tube Formation Directed by Vascular Endothelial Growth Factor-C

Using synthetic hyaluronic acid hydrogels as a chemically and mechanically tunable system to preserve lymphatic endothelial cell phenotypes, scientists demonstrated that low matrix elasticity primed lymphatic cord‐like structure formation directed by a high concentration of vascular endothelial growth factor‐C (VEGF‐C).
[FASEB Journal]
Alderfer, L., Russo, E., Archilla, A., Coe, B., & Hanjaya‐Putra, D. (2021). Matrix stiffness primes lymphatic tube formation directed by vascular endothelial growth factor-C. The FASEB Journal, 35(5), e21498. https://doi.org/https://doi.org/10.1096/fj.202002426RR Cite
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An Interplay of Microglia and Matrix Metalloproteinase MMP9 under Hypoxic Stress Regulates the Opticin Expression in Retina

Researchers demonstrated that a reduced opticin levels in ROP vitreous are regulated by matrix metalloproteinases (MMPs) secreted by activated microglia.
[Scientific Reports]
Patnaik, S., Rai, M., Jalali, S., Agarwal, K., Badakere, A., Puppala, L., Vishwakarma, S., Balakrishnan, D., Rani, P. K., Kekunnaya, R., Chhablani, P. P., Chakrabarti, S., & Kaur, I. (2021). An interplay of microglia and matrix metalloproteinase MMP9 under hypoxic stress regulates the opticin expression in retina. Scientific Reports, 11(1), 7444. https://doi.org/10.1038/s41598-021-86302-2 Cite
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Stiffening of the Extracellular Matrix Is a Sufficient Condition for Airway Hyperreactivity

The authors hypothesized that stiffening of the airway extracellular matrix is a core pathological change sufficient to support excessive bronchoconstriction even in the absence of inflammation.
[Journal of Applied Physiology]
Jamieson, R. R., Stasiak, S. E., Polio, S. R., Augspurg, R. D., McCormick, C. A., Ruberti, J. W., & Parameswaran, H. (2021). Stiffening of the Extracellular Matrix is a Sufficient Condition for Airway Hyperreactivity. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00554.2020 Cite
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Foresee Pharmaceuticals Announces Dosing of First Patient in Phase II/III Clinical Trial of FP-025 for Treatment of COVID-19 Associated ARDS

Foresee Pharmaceuticals Co., Ltd. announced the initiation of patient dosing in the Phase II/III clinical trial of FP-025, its highly selective oral MMP-12 inhibitor, in adult patients with severe to critical COVID-19 with associated Acute Respiratory Distress Syndrome.
[Foresee Pharmaceuticals Co., Ltd.]
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Rosiglitazone Attenuates High Glucose-Induced Proliferation, Inflammation, Oxidative Stress and Extracellular Matrix Accumulation in Mouse Mesangial Cells through the Gm26917/miR-185-5p Pathway

Rosiglitazone significantly inhibited high glucose-induced proliferation, oxidative stress, inflammatory responses and extracellular matrix accumulation in mouse mesangial cells.
[Endocrine Journal]
Zhao, D., Guo, J., Liu, L., & Huang, Y. (2021). Rosiglitazone attenuates high glucose-induced proliferation, inflammation, oxidative stress and extracellular matrix accumulation in mouse mesangial cells through the Gm26917/miR-185-5p pathway. Endocrine Journal, advpub. https://doi.org/10.1507/endocrj.EJ20-0783 Cite
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Matrix Composition Modulates Vitamin D3’s Effects on 3D Collagen Fiber Organization by MCF10A Cells

The authors embedded MCF10A normal human breast epithelial cells in two different matrices – collagen type I, and collagen type I+10% Matrigel; treatment with calcitriol resulted in flatter epithelial structures.
[Tissue Engineering Part A]
Hasan, N., Zhang, Y., Georgakoudi, I., Sonnenschein, C., & Soto, A. M. (2021). Matrix composition modulates vitamin D3’s effects on 3D collagen fiber organization by MCF10A cells. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2020.0371 Cite
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CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis

Scientists investigated the role of CD148 in the profibrotic phenotype of fibroblasts in idiopathic pulmonary fibrosis. Conditional CD148 fibroblast-specific knockout mice were generated and exposed to bleomycin, and then assessed for pulmonary fibrosis.
[American Journal of Respiratory and Critical Care Medicine]
Tsoyi, K., Liang, X., De Rossi, G., Ryter, S. W., Xiong, K., Chu, S. G., Liu, X., Ith, B., Celada, L. J., Romero, F., Robertson, M. J., Esposito, A. J., Poli, S., El-Chemaly, S., Perrella, M. A., Shi, Y., Whiteford, J., & Rosas, I. O. (2021). CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.202008-3100OC Cite
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Stem Cell-Based Approaches in Cardiac Tissue Engineering: Controlling the Microenvironment for Autologous Cells

The authors provide a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue.
[Biomedicine & Pharmacotherapy]
Augustine, R., Dan, P., Hasan, A., Khalaf, I. M., Prasad, P., Ghosal, K., Gentile, C., McClements, L., & Maureira, P. (2021). Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells. Biomedicine & Pharmacotherapy, 138, 111425. https://doi.org/10.1016/j.biopha.2021.111425 Cite
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Fibrotic Enzymes Modulate Wound‐Induced Skin Tumorigenesis

Researchers performed genome‐wide expression analysis comparing fibroblasts in normal, inflammatory and tumor‐associated skin. Cancer‐associated fibroblasts exhibit a fibrotic gene signature in wound‐induced tumors, demonstrating persistent extracellular matrix remodeling within these tumors.
[EMBO Reports]
Van Hove, L., Lecomte, K., Roels, J., Vandamme, N., Vikkula, H.-K., Hoorens, I., Ongenae, K., Hochepied, T., Donati, G., Saeys, Y., Quist, S. R., Watt, F. M., van Loo, G., & Hoste, E. (2021). Fibrotic enzymes modulate wound-induced skin tumorigenesis. EMBO Reports, n/a(n/a), e51573. https://doi.org/10.15252/embr.202051573 Cite
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