Scientists report that eukaryotic protein translation elongation factor 1α2 (EEF1A2) mediates the epithelial–mesenchymal transformation, to promote the metastasis of lung adenocarcinoma cells in vitro and in vivo.
[British Journal of Cancer]
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Jia, L., Ge, X., Du, C., Chen, L., Zhou, Y., Xiong, W., Xiang, J., Li, G., Xiao, G., Fang, L., & Li, Z. (2021). EEF1A2 interacts with HSP90AB1 to promote lung adenocarcinoma metastasis via enhancing TGF-β/SMAD signalling. British Journal of Cancer, 1–11. https://doi.org/10.1038/s41416-020-01250-4 Cite
The authors demonstrate a robust and simple approach to form collagen substrates with different topographies by evaporating droplets of a collagen solution.
Scientists evaluated whether esophageal cancer cell acquisition of stronger malignant characteristics and refractoriness to chemoradiotherapy are mediated by cancer-associated fibroblasts.
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Katsube, R., Noma, K., Ohara, T., Nishiwaki, N., Kobayashi, T., Komoto, S., Sato, H., Kashima, H., Kato, T., Kikuchi, S., Tazawa, H., Kagawa, S., Shirakawa, Y., Kobayashi, H., & Fujiwara, T. (2021). Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer. Scientific Reports, 11(1), 1693. https://doi.org/10.1038/s41598-021-81465-4 Cite
Researchers investigated whole neurogenic bladder’s progression changes, as well as the expression of TGF-β1 fibrosis pathway-related proteins in bilateral spinal nerve-amputated juvenile rats.
The authors detail recent advances in our understanding of the functions of TGF-β superfamily members and their corresponding receptors, signaling pathways, and downstream molecular targets in regulating human extravillous trophoblasts invasion from studies using various in vitro or ex vivo experimental models.
[Trends in Endocrinology and Metabolism]
The authors hypothesized that localized presentation of transforming growth factor (TGF)-β1 and bone morphogenetic protein-2 to engineered human MSC tubes mimicking femoral diaphyses induces endochondral ossification.
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Herberg, S., Varghai, D., Alt, D. S., Dang, P. N., Park, H., Cheng, Y., Shin, J.-Y., Dikina, A. D., Boerckel, J. D., Rolle, M. W., & Alsberg, E. (2021). Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration. Communications Biology, 4(1), 1–16. https://doi.org/10.1038/s42003-020-01576-y Cite
Researchers report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone.
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Wandel, M. B., Bell, C. A., Yu, J., Arno, M. C., Dreger, N. Z., Hsu, Y.-H., Pitto-Barry, A., Worch, J. C., Dove, A. P., & Becker, M. L. (2021). Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering. Nature Communications, 12(1), 446. https://doi.org/10.1038/s41467-020-20610-5 Cite
Integrin α‐subunits were investigated systematically for their expression over the course of hepatic stellate cells activation and their distribution on fibroblasts and other systemic primary cells.
[Journal of Pathology]
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Nishimichi, N., Tsujino, K., Kanno, K., Sentani, K., Kobayashi, T., Chayama, K., Sheppard, D., & Yokosaki, Y. (n.d.). Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis. The Journal of Pathology, n/a(n/a). https://doi.org/https://doi.org/10.1002/path.5618 Cite
Nature uses ECM scaffolds to organize biominerals into hierarchical structures over various length scales. This has inspired the design of biomimetic mineralization scaffolds, with DNA nanostructures being among the most promising. DNA nanotechnology makes use of molecular recognition to controllably give 1D, 2D and 3D nanostructures.
[Nature Reviews Chemistry]
The authors revealed a mechanism by which the nucleus mechanically generates migration paths for mesenchymal stem cells (MSCs) in confining microenvironments. MSCs migrate robustly in nanoporous, confining hydrogels that are viscoelastic and plastic but not in hydrogels that are more elastic.
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The authors suggested that the hypoxic microenvironment stimulates glioma to generate miR-1246- and miR-10b-5p-rich exosomes that are delivered to normoxic glioma cells to promote their migration and invasion; treatment targeting miR-1246 and miR-10b-5p may impair the motility of gliomas, providing a novel direction for the development of antitumor therapy.
[Experimental and Molecular Medicine]
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Qian, M., Chen, Z., Guo, X., Wang, S., Zhang, Z., Qiu, W., Qi, Y., Zhang, S., Xu, J., Zhao, R., Xue, H., & Li, G. (2021). Exosomes derived from hypoxic glioma deliver miR-1246 and miR-10b-5p to normoxic glioma cells to promote migration and invasion. Laboratory Investigation, 1–13. https://doi.org/10.1038/s41374-020-00522-0 Cite