Coagulome and the Tumor Microenvironment: An Actionable Interplay

The study of the coagulome provides unprecedented opportunities to explore the tumor microenvironment and to better predict the hemostatic complications.
[Trends in Cancer]
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The Clinical Potential of Articular Cartilage-Derived Progenitor Cells: A Systematic Review

The authors summarize the state-of-the-art research on articular cartilage-derived progenitor cells for use in cartilage repair therapies.
[NPJ Regenerative Medicine]
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3D Hanging Spheroid Plate for High-Throughput CAR T Cell Cytotoxicity Assay

Scientists presented a 3D hanging spheroid plate, which facilitated the formation of spheroids and the separation of unbound and dead cells from spheroids during cytotoxicity assays.
[Journal of Nanobiotechnology]
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Engineered Human Blood–Brain Barrier Microfluidic Model for Vascular Permeability Analysis

The authors described an in vitro model of the human blood–brain barrier self-assembled within microfluidic devices from stem-cell-derived or primary brain endothelial cells, and primary brain pericytes and astrocytes.
[Nature Protocols]
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LC3-Associated Phagocytosis in Bone Marrow Macrophages Suppresses Acute Myeloid Leukemia Progression through STING Activation

Scientists investigated the role of macrophage LC3-associated phagocytosis within the bone marrow microenvironment of acute myeloid leukemia.
[Journal of Clinical Investigation]
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Synthetic Matrix Scaffolds Engineer the In Vivo Tumor Immune Microenvironment for Immunotherapy Screening

Investigators deployed engineered biomaterials as a scaffold to increase tumor formation rate, decrease disease latency, and diminish variability of immune infiltrates into tumors formed from murine mammary carcinoma cell lines implanted into syngeneic mice.
[Advanced Materials]
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NOXXON Provides Progress Update on the Expansion Arms of the Phase I/II GLORIA Trial with NOX-A12 in Brain Cancer Patients

NOXXON Pharma N.V. announced that the Data Safety Monitoring Board positively evaluated safety data from the initial four weeks of treatment of the first patient enrolled in the GLORIA clinical trial expansion arm.
[NOXXON Pharma N.V.]
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The Synthetic Artificial Stem Cell (SASC): Shifting the Paradigm of Cell Therapy in Regenerative Engineering

Scientists engineered a SASC system which mimicked the paracrine effect of the stem cell secretome and provided tailorability of the composition for targeted tissue regeneration.
[Proceedings of the National Academy of Sciences of the United States of America]
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An MMP-Degradable and Conductive Hydrogel to Stabilize HIF-1α for Recovering Cardiac Functions

A conductive and injectable hydrogel crosslinked by matrix metalloproteinase (MMP)-sensitive peptides was rationally constructed to stabilize hypoxia-inducible factor-1α (HIF-1α) to recover heart functions after myocardial infarction.
[Theranostics]
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Design and Development of Biomimetic Electrospun Sulphonated Polyether Ether Ketone Nanofibrous Scaffold for Bone Tissue Regeneration Applications: In Vitro and In Vivo Study

Researchers probed the use of new biomimetic sulphonated polyether ether ketone-based nanofibrous scaffold to deliver amine functionalized hydroxyapatite nanoparticles loaded resveratrol for its potent functionality in osteogenic differentiation.
[Journal of Biomaterials Science-Polymer Edition]
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Three-Dimension Co-Culture of Hematopoietic Stem Cells and Differentiated Osteoblasts on Gallic Acid Grafted-Chitosan Scaffold as a Model of Hematopoietic Stem Cells Niche

Investigators proposed a 3D environment based on gallic acid grafted-chitosan scaffold and osteoblasts differentiated from human umbilical cord mesenchymal stem cells to recapitulate the main components of hematopoietic stem cells niche.
[Stem Cell Reviews and Reports]
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