Functional Characterization of a Bioengineered Liver after Heterotopic Implantation in Pigs

Researchers reported a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver scaffold previously reendothelialized with human umbilical vein endothelial cells.
[Communications Biology]
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circSPG21 Protects against Intervertebral Disc Disease by Targeting miR-1197/ATP1B3

Scientists investigated the mechanism by which circRNA acted as competitive endogenous RNA in the regulation of degenerative intervertebral disc disease. Decreased expression of circSPG21 was detected in degenerated nucleus pulposus cells (NPCs), the function of circSPG21 in NPCs was explored and verified, and the downstream target of circSPG21 was investigated.
[Experimental and Molecular Medicine]
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Engineering Living Therapeutics with Synthetic Biology

Investigators conceptualize how synthetic biology approaches can be applied to program living cells with therapeutic functions and discuss the advantages that they offer over conventional therapies in terms of flexibility, specificity and predictability, as well as challenges for their development.
[Nature Reviews Drug Discovery]
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The Extracellular Matrix Glycoprotein ADAMTSL2 Is Increased in Heart Failure and Inhibits TGFβ Signaling in Cardiac Fibroblasts

The authors aimed to determine a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motifs-like (ADAMTSL) levels in failing hearts, and to elucidate the role of ADAMTSL2 in fibrosis using cultured human cardiac fibroblasts
[Scientific Reports]
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The Landscape of Tumor Cell States and Ecosystems in Diffuse Large B Cell Lymphoma

Researchers implemented EcoTyper, a machine-learning framework integrating transcriptome deconvolution and single-cell RNA sequencing, to characterize clinically relevant diffuse large B cell lymphoma cell states and ecosystems.
[Cancer Cell]
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Atovaquone-HSA Nano-Drugs Enhance the Efficacy of PD-1 Blockade Immunotherapy by Alleviating Hypoxic Tumor Microenvironment

The authors exploited atovaquone/albumin nanoparticles to improve bioavailability and tumor targeting of atovaquone, enhancing the efficacy of anti-PD-1 therapy by normalizing tumor hypoxia.
[Journal of Nanobiotechnology]
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Harnessing 3D Collagen Hydrogel-Directed Conversion of Human GMSCs into SCP-Like Cells to Generate Functionalized Nerve Conduits

Gingiva-derived mesenchymal stem cells (GMSCs) under 3D-culture in soft collagen hydrogel showed significantly increased expression of a panel of genes related to development/differentiation of neural crest stem-like cells and/or Schwann cell precursor-like cells and associated with NOTCH3 signaling pathway activation as compared to their 2D-cultured counterparts.
[NPJ Regenerative Medicine]
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Biomimetic Cartilage-Lubricating Polymers Regenerate Cartilage in Rats with Early Osteoarthritis

Investigators showed that hyaluronan backbones grafted with lubricin-like sulfonate-rich polymers or with lipid-like phosphocholine-rich polymers together enhanced cartilage regeneration in a rat model of early osteoarthritis.
[Nature Biomedical Engineering]
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BMP7 Reduces the Fibrocartilage Chondrocyte Phenotype

Scientists demonstrated that short-term exposure to BMP7 decreased the fibrocartilage chondrocyte phenotype. The BMP7-dependent reduction of Collagen type I protein expression seemed MMP2-dependent and inhibition of Smad2/3-PAI1 activity was identified as a potential pathway via which BMP7 exerted its anti-fibrotic action.
[Scientific Reports]
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3D Printing Scaffold Vaccine for Antitumor Immunity

Researchers developed 3D printed scaffolds loaded with immunoregulators for enhanced cancer immunotherapy. Compared to the traditional hydrogel, the 3D-scaffold with porous structure endowed similar functions compared with real lymphoid organs by recruitment of a great number of immune cells.
[Advanced Materials]
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Tendon and Multiomics: Advantages, Advances, and Opportunities

Tendons heal by fibrosis, which hinders function and increases re-injury risk. Yet the biology that leads to degeneration and regeneration of tendons is not completely understood. The authors review the current literature pertaining to multiomics in tendon and the potential of these platforms to improve tendon regeneration.
[NPJ Regenerative Medicine]
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