Rapid Reprogramming of Tumor Cells into Cancer Stem Cells on Double-Network Hydrogels

Researchers showed that a double-network hydrogel could rapidly reprogram differentiated cancer cells into cancer stem cells.
[Nature Biomedical Engineering]
Suzuka, J., Tsuda, M., Wang, L., Kohsaka, S., Kishida, K., Semba, S., Sugino, H., Aburatani, S., Frauenlob, M., Kurokawa, T., Kojima, S., Ueno, T., Ohmiya, Y., Mano, H., Yasuda, K., Gong, J. P., & Tanaka, S. (2021). Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels. Nature Biomedical Engineering, 1–12. https://doi.org/10.1038/s41551-021-00692-2 Cite
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Scaffold-Free Cell-Based Tissue Engineering Therapies: Advances, Shortfalls and Forecast

The authors critically discuss advancements and shortfalls of scaffold-free cell-based tissue engineering strategies, along with pioneering concepts that have the potential to transform regenerative and reparative medicine.
[NPJ Regenerative Medicine]
De Pieri, A., Rochev, Y., & Zeugolis, D. I. (2021). Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast. Npj Regenerative Medicine, 6(1), 1–15. https://doi.org/10.1038/s41536-021-00133-3 Cite
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An Update on Stem Cells Applications in Burn Wound Healing

Investigators discussed the wound-healing process, present methods used for stem cells administration, methods of enhancing stem cells potency and human studies.
[Experimental Dermatology]
Ullah, S., Mansoor, S., Ayub, A., Ejaz, M., Zafar, H., Feroz, F., Khan, A., & Ali, M. (2021). An update on stem cells applications in burn wound healing. Tissue and Cell, 72, 101527. https://doi.org/10.1016/j.tice.2021.101527 Cite
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Functional Tissue-Engineered Bone-Like Graft Made of a Fibrin Scaffold and TG2 Gene-Modified EMSCs for Bone Defect Repair

A novel biofunctional live tissue-engineered bone-like graft was designed and constructed using a fibrin scaffold loaded with TG2 gene-modified ectomesenchymal stem cells (TG2-EMSCs) derived from nasal respiratory mucosa for bone defect repair.
[NPG Asia Materials]
Shi, W., Que, Y., Zhang, X., Bian, L., Yu, X., Tang, X., Yang, G., Dai, Y., Bi, S., Lv, D., Weng, Y., Wu, W., Zhang, Z., Lu, X., & Lu, N. (2021). Functional tissue-engineered bone-like graft made of a fibrin scaffold and TG2 gene-modified EMSCs for bone defect repair. NPG Asia Materials, 13(1), 1–18. https://doi.org/10.1038/s41427-021-00297-w Cite
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Computational and Experimental Characterization of the Novel ECM Glycoprotein SNED1 and Prediction of its Interactome

Pathway analysis of the predicted SNED1 interactome further revealed that it may contribute to signaling through cell surface receptors, such as integrins, and participate in the regulation of ECM organization and developmental processes.
[Biochemical Journal]
Vallet, S. D., Davis, M. N., Barque, A., Thahab, A. H., Ricard-Blum, S., & Naba, A. (n.d.). Computational and experimental characterization of the novel ECM glycoprotein SNED1 and prediction of its interactome. Biochemical Journal. https://doi.org/10.1042/BCJ20200675 Cite
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Global Proteomic Analysis of Extracellular Matrix in Mouse and Human Brain Highlights Relevance to Cerebrovascular Disease

Scientists developed an approach to extract the cerebrovascular extracellular matrix from mouse and human post-mortem normal brain tissues.
[Journal of Cerebral Blood Flow and Metabolism]
Pokhilko, A., Brezzo, G., Handunnetthi, L., Heilig, R., Lennon, R., Smith, C., Allan, S. M., Granata, A., Sinha, S., Wang, T., Markus, H. S., Naba, A., Fischer, R., Van Agtmael, T., Horsburgh, K., & Cader, M. Z. (2021). Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease. Journal of Cerebral Blood Flow & Metabolism, 0271678X211004307. https://doi.org/10.1177/0271678X211004307 Cite
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Peptide-Based Scaffolds for the Culture and Maintenance of Primary Human Hepatocytes

Researchers report the use of a nanofibrous hydrogel as a 3D scaffold for the culture and maintenance of functional primary human hepatocytes.
[Scientific Reports]
MacPherson, D., Bram, Y., Park, J., & Schwartz, R. E. (2021). Peptide-based scaffolds for the culture and maintenance of primary human hepatocytes. Scientific Reports, 11(1), 6772. https://doi.org/10.1038/s41598-021-86016-5 Cite
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EPB41L5 Controls Podocyte Extracellular Matrix Assembly by Adhesome-Dependent Force Transmission

Scientists showed by analysis of in vitro and in vivo models that a loss of the podocyte-specific FERM-domain protein EPB41L5 results in impaired extracellular matrix assembly.
[Cell Reports]
Maier, J. I., Rogg, M., Helmstädter, M., Sammarco, A., Schilling, O., Sabass, B., Miner, J. H., Dengjel, J., Walz, G., Werner, M., Huber, T. B., & Schell, C. (2021). EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission. Cell Reports, 34(12). https://doi.org/10.1016/j.celrep.2021.108883 Cite
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Inhibition of ERK 1/2 Kinases Prevents Tendon Matrix Breakdown

The authors showed that extracellular-signal regulated kinase (ERK) 1/2 were highly phosphorylated in mechanically unloaded tendon fascicles in a vascular niche-dependent manner.
[Scientific Reports]
Blache, U., Wunderli, S. L., Hussien, A. A., Stauber, T., Flückiger, G., Bollhalder, M., Niederöst, B., Fucentese, S. F., & Snedeker, J. G. (2021). Inhibition of ERK 1/2 kinases prevents tendon matrix breakdown. Scientific Reports, 11(1), 6838. https://doi.org/10.1038/s41598-021-85331-1 Cite
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Elastin-Specific MRI of Extracellular Matrix-Remodeling following Hepatic Radiofrequency-Ablation in a VX2 Liver Tumor Model

To investigate the potential of an elastin-specific MR agent for the assessment of extracellular matrix remodeling in the periablational rim following radiofrequency ablation in a VX2 rabbit liver tumor-model, twelve New-Zealand-White-rabbits were implanted in the left liver lobe with VX2 tumor chunks from donor animals.
[Scientific Reports]
Collettini, F., Reimann, C., Brangsch, J., Chapiro, J., Savic, L. J., Onthank, D. C., Robinson, S. P., Karst, U., Buchholz, R., Keller, S., Hamm, B., Goldberg, S. N., & Makowski, M. R. (2021). Elastin-specific MRI of extracellular matrix-remodelling following hepatic radiofrequency-ablation in a VX2 liver tumor model. Scientific Reports, 11(1), 6814. https://doi.org/10.1038/s41598-021-86417-6 Cite
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Membrane Type 1 Matrix Metalloproteinase Promotes LDL Receptor Shedding and Accelerates the Development of Atherosclerosis

Investigators report that membrane type 1-matrix metalloproteinase co-immunoprecipitates and co-localizes with low-density lipoprotein receptor (LDLR) and promotes LDLR cleavage.
[Nature Communications]
Alabi, A., Xia, X.-D., Gu, H.-M., Wang, F., Deng, S.-J., Yang, N., Adijiang, A., Douglas, D. N., Kneteman, N. M., Xue, Y., Chen, L., Qin, S., Wang, G., & Zhang, D.-W. (2021). Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis. Nature Communications, 12(1), 1889. https://doi.org/10.1038/s41467-021-22167-3 Cite
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