TGFβ Biology in Cancer Progression and Immunotherapy

The authors introduce the mechanisms underlying TGFβ signaling in tumors and their microenvironment and discuss approaches to inhibit these signaling mechanisms as well as the use of these approaches in cancer immunotherapies and their potential adverse effects.
[Nature Reviews Clinical Oncology]
Derynck, R., Turley, S. J., & Akhurst, R. J. (2020). TGFβ biology in cancer progression and immunotherapy. Nature Reviews Clinical Oncology, 1–26. https://doi.org/10.1038/s41571-020-0403-1 Cite
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Evidence of Macrophage Modulation in the Mouse Pubic Symphysis Remodeling during the End of First Pregnancy and Postpartum

Investigators used morphological and high-sensitivity molecular techniques to identify both macrophage association with ECM remodeling and the immunological processes involved in pubic symphysis changes from inflammatory mediators D18 to 3dpp.
[Scientific Reports]
Castelucci, B. G., Pereira, A. H. M., Fioramonte, M., Carazzolle, M. F., de Oliveira, P. S. L., Franchini, K. G., Kobarg, J., Martins-de-Souza, D., Joazeiro, P. P., & Consonni, S. R. (2020). Evidence of macrophage modulation in the mouse pubic symphysis remodeling during the end of first pregnancy and postpartum. Scientific Reports, 10(1), 12403. https://doi.org/10.1038/s41598-020-68676-x Cite
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Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis

Fibrosis, or the accumulation of ECM, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, scientists cross-examined human primary cells from various tissues treated with TGF-β, as well as kidney and liver fibrosis models.
[Cell Reports Medicine]
Zhang, J., Muise, E. S., Han, S., Kutchukian, P. S., Costet, P., Zhu, Y., Kan, Y., Zhou, H., Shah, V., Huang, Y., Saigal, A., Akiyama, T. E., Shen, X.-L., Cai, T.-Q., Shah, K., Carballo-Jane, E., Zycband, E., Yi, L., Tian, Y., … Pinto, S. (2020). Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis. Cell Reports Medicine, 1(4). https://doi.org/10.1016/j.xcrm.2020.100056 Cite
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Extracellular Cold-Inducible RNA-Binding Protein Regulates Neutrophil Extracellular Trap Formation and Tissue Damage in Acute Pancreatitis

Scientists studied the role of extracellular cold-inducible RNA-binding protein, a novel damage-associated-molecular-pattern molecule, in severe acute pancreatitis.
[Laboratory Investigation]
Linders, J., Madhi, R., Rahman, M., Mörgelin, M., Regner, S., Brenner, M., Wang, P., & Thorlacius, H. (2020). Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis. Laboratory Investigation, 1–13. https://doi.org/10.1038/s41374-020-0469-5 Cite
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Functionalisation of a Heat-Derived and Bio-Inert Albumin Hydrogel with Extracellular Matrix by Air Plasma Treatment

Stable and translucent human serum albumin hydrogels were created by controlled thermal gelation and the addition of sodium chloride. The resulting bio-inert hydrogel was then subjected to air plasma treatment which functionalised its surface, enabling the attachment of basement membrane matrix
[Scientific Reports]
Ong, J., Zhao, J., Levy, G. K., Macdonald, J., Justin, A. W., & Markaki, A. E. (2020). Functionalisation of a heat-derived and bio-inert albumin hydrogel with extracellular matrix by air plasma treatment. Scientific Reports, 10(1), 12429. https://doi.org/10.1038/s41598-020-69301-7 Cite
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French Science Bill Promises Boost to Public R&D

The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider]
Press Release

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Foreign Researchers Accused of Hiding Links to Chinese Military

Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
[The Scientist]
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Mouse CD163 Deficiency Strongly Enhances Experimental Collagen-Induced Arthritis

Scientists investigated development of collagen-induced arthritis and collagen antibody-induced arthritis in CD163-deficient C57BL/6 mice.
[Scientific Reports]
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Regeneration of the Rotator Cuff Tendon-to-Bone Interface Using Umbilical Cord-Derived Mesenchymal Stem Cells and Gradient Extracellular Matrix Scaffolds from Adipose Tissue in a Rat Model

Researchers investigated the efficacy of a biomimetic hydroxyapatite-gradient scaffold isolated from adipose tissue with umbilical cord derived MSCs on the regeneration of the structure of the tendone-to-bone interface by analyzing the histological and biomechanical changes in a rat repair model.
[Acta Biomaterialia]
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Clinical Trials Rebound After COVID-19 Crash, but Can Enrollment Gains Continue?

For the hundreds of thousands of people enrolling in clinical trials every year—and for whom experimental therapies can offer a last hope—a new report provides some welcome news: Enrollment in clinical studies in the United States is on the rebound after disruptions caused by the COVID-19 pandemic.
[ScienceInsider]
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Science Money Slashed in EU’s €1.8-Trillion Budget Deal

A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
[Nature News]
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