A Single Day of TGF-β1 Exposure Activates Chondrogenic and Hypertrophic Differentiation Pathways in Bone Marrow-Derived Stromal Cells

Investigators found that a single day of TGF-β1 exposure was sufficient to trigger bone marrow-derived MSC chondrogenic differentiation and tissue formation, similar to 21 days of TGF-β1 exposure.
[Communications Biology]

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MaTAR25 lncRNA Regulates the Tensin1 Gene to Impact Breast Cancer Progression

Researchers report on Mammary Tumor Associated RNA 25 (MaTAR25), a nuclear enriched and chromatin associated lncRNA that plays a role in mammary tumor cell proliferation, migration, and invasion, both in vitro and in vivo.
[Nature Communications]
Chang, K.-C., Diermeier, S. D., Yu, A. T., Brine, L. D., Russo, S., Bhatia, S., Alsudani, H., Kostroff, K., Bhuiya, T., Brogi, E., Pappin, D. J., Bennett, C. F., Rigo, F., & Spector, D. L. (2020). MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression. Nature Communications, 11(1), 6438. https://doi.org/10.1038/s41467-020-20207-y Cite
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Bio-Artificial Pleura using Autologous Dermal Fibroblast Sheets to Mitigate Air Leaks During Thoracoscopic Lung Resection

The authors demonstrated both safeties of transplantation of a cultured human autologous dermal fibroblast sheet to lung air leaks.
[npj Regenerative Medicine]
Kanzaki, M., Takagi, R., Washio, K., Kokubo, M., Mitsuboshi, S., Isaka, T., & Yamato, M. (2021). Bio-artificial pleura using autologous dermal fibroblast sheets to mitigate air leaks during thoracoscopic lung resection. Npj Regenerative Medicine, 6(1), 1–8. https://doi.org/10.1038/s41536-020-00113-z Cite
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DNA Damage in Human Glomerular Endothelial Cells Induces Nodular Glomerulosclerosis via an ATR and ANXA2 Pathway

In in vitro studies, collagen type VI secretion from human renal glomerular endothelial cells was assessed by measuring the decrease in the cytoplasmic COL6-positive cells and an increase in the amount of COL6 in the culture medium.
[Scientific Reports]
Fujii, A., Sunatani, Y., Furuichi, K., Fujimoto, K., Adachi, H., Iwabuchi, K., & Yokoyama, H. (2020). DNA damage in human glomerular endothelial cells induces nodular glomerulosclerosis via an ATR and ANXA2 pathway. Scientific Reports, 10(1), 22206. https://doi.org/10.1038/s41598-020-79106-3 Cite
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Human Biomimetic Liver Microphysiology Systems in Drug Development and Precision Medicine

Biomimetic human liver imcrophysiology systems have evolved from simpler 2D cell models, spheroids and organoids to address the increasing need to understand patient-specific mechanisms of complex and rare diseases, the response to therapeutic treatments, and the absorption, distribution, metabolism, excretion and toxicity of potential therapeutics.
[Nature Reviews Gastroenterology & Hepatology]
Gough, A., Soto-Gutierrez, A., Vernetti, L., Ebrahimkhani, M. R., Stern, A. M., & Taylor, D. L. (2020). Human biomimetic liver microphysiology systems in drug development and precision medicine. Nature Reviews Gastroenterology & Hepatology, 1–17. https://doi.org/10.1038/s41575-020-00386-1 Cite
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Biomaterials and 3D Bioprinting Strategies to Model Glioblastoma and the Blood–Brain Barrier

An overview of current 3D‐bioprinted glioblastoma (GBM) and blood-brain barrier (BBB) models is provided, elaborating on the microenvironmental compositions of GBM and BBB, relevant biomaterials to mimic the native tissues, and bioprinting strategies to implement the model fabrication.
[Advanced Materials]

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Hypomorph Mutation-Directed Small-Molecule Protein-Protein Interaction Inducers to Restore Mutant SMAD4-Suppressed TGF-β Signaling

The authors explored a variant-directed chemical biology approach to reverse the lost function of tumor suppressors using SMAD4 as an example. SMAD4, a central mediator of the TGF-β pathway, is recurrently mutated in many tumors.
[Cell Chemical Biology]

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Metacrine Reports Positive Results from Phase I Trial of MET642

Metacrine, Inc. has reported preliminary results from its Phase I trial of MET642, a farnesoid X receptor (FXR) agonist being developed for the treatment of non-alcoholic steatohepatitis and inflammatory bowel disease. Findings show that treatment with MET642 was safe and generally well-tolerated and demonstrated a sustained pharmacokinetic profile and robust FXR target engagement after 14 days of daily oral dosing in healthy volunteers.
[Metacrine, Inc.]

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MTF Biologics’ SomaGen® Meshed and Leneva® Allografts Receive American Podiatric Medical Association Seal of Approval

MTF Biologics® has received the coveted American Podiatric Medical Association (APMA) Seal of Approval for two MTF Biologics Wound Care tissues, SomaGen® Meshed, Allograft Dermal Matrix and Leneva®, Allograft Adipose Matrix. To receive the seal, both tissues were reviewed by a panel of experienced APMA podiatric physicians.
[MTF Biologics®]

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Improving the Colonization and Functions of Wharton’s Jelly-Derived Mesenchymal Stem Cells by a Synergetic Combination of Porous Polyurethane Scaffold with an Albumin-Derived Hydrogel

Wharton’s jelly-derived mesenchymal stem cells were seeded on a polyurethane scaffold combined with a hydrogel based on bovine serum albumin .
[Biomedical Materials]
Lutzweiler, G., Barthes, J., Charles, A. L., Ball, V., Louis, B., Geny, B., & Vrana, N. E. (2020). Improving the colonization and functions of Wharton’s Jelly-derived mesenchymal stem cells by a synergetic combination of porous polyurethane scaffold with an albumin-derived hydrogel. Biomedical Materials, 16(1), 015005. https://doi.org/10.1088/1748-605x/abaf05 Cite
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Locally Applied Stem Cell Exosome-Scaffold Attenuates Nerve Injury-Induced Pain in Rats

Researchers developed an alginate scaffold with human umbilical cord mesenchymal stem cell exosomes to treat nerve injury-induced pain. In vitro studies of PC12 and HEK293 cells were used to evaluate the neuroprotective and neurotrophic effects of exosomes.
[Journal of Pain Research]
Hsu, J.-M., Shiue, S.-J., Yang, K. D., Shiue, H.-S., Hung, Y.-W., Pannuru, P., Poongodi, R., Lin, H.-Y., & Cheng, J.-K. (2020, December 4). <p>Locally Applied Stem Cell Exosome-Scaffold Attenuates Nerve Injury-Induced Pain in Rats</p>. Journal of Pain Research. https://doi.org/10.2147/JPR.S286771 Cite
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