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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Increased Uterine Arterial Tone, Stiffness and Remodeling with Augmented Matrix Metalloproteinase-1 and -7 in Uteroplacental Ischemia-Induced Hypertensive Pregnancy
[Biochemical Pharmacology] Scientists tested whether hypertensive pregnancy involved localized aberrations in uterine arterial tone, stiffness and remodeling by matrix metalloproteinases.
A Single Chain Variable Fragment Antibody (TN 64) Cognate to Fibronectin Type III Repeats Promotes Corneal Wound Healing by Inhibiting Fibrosis
[International Immunopharmacology] The authors showed that Tn64 bound to Tn fn repeats 3–5. Unlike other Tn fn domains, Tn fn 3–5 displayed no inhibition of fibronectin matrix assembly.
Resistance Training-Induced Changes in Muscle Proteolysis and Extracellular Matrix Remodeling Biomarkers in the Untrained and Trained States
[European Journal Of Applied Physiology] Scientists examined how proteolysis-related biomarkers and ECM remodeling factors respond to a bout of resistance training in the untrained and trained state.
Sophoridine Exerts Anti-Arthritic Effects on Fibroblast-Like Synoviocytes and Collagen-Induced Arthritis in Rats
[Phytotherapy Research] A collagen-induced arthritis rat model and tumor necrosis factor alpha-induced fibroblast-like synoviocytes were utilized to investigate the inhibitory effect of Sophoridine on hreumatoid arthritis.
Engineering Approaches for Understanding Mechanical Memory in Cancer Metastasis
[APL Bioengineering] Investigators explore the evolving mechanical landscape during metastasis, emphasizing the significance of mechanical memory and its influence on cell behavior.
Engineering Large-Scale Self-Mineralizing Bone Organoids with Bone Matrix-Inspired Hydroxyapatite Hybrid Bioinks
[Advanced Materials] Bioprinted scaffolds facilitate the long-term cultivation and progressive maturation of extensive bioprinted bone organoids, foster multicellular differentiation, and offer valuable insights into the initial stages of bone formation.
Injectable In Situ Gelling Methylcellulose-Based Hydrogels for Bone Tissue Regeneration
[Journal Of Materials Chemistry B] In vitro biological characterization revealed the beneficial impact of CaP and CaPGO, indicating their potential in promoting cell adhesion, proliferation and osteogenic differentiation.
Reducing Nogo-B Improves Hepatic Fibrosis by Inhibiting BACe1-Mediated Autophagy
[Tissue Engineering And Regenerative Medicine] Knocking down Nogo-B caused the downregulation of pro-fibrotic genes and inhibited the viability of hepatic stellate cells. Nogo-B knockdown prevented CCL4-induced fibrosis, accompanied by downregulation of the extracellular matrix.
A Highly Biocompatible CE-Crosslinked Collagen Implant with Exceptional Anti-calcification and Collagen Regeneration Capabilities for Aging Skin Rejuvenation
[Journal Of Materials Chemistry B] A novel collagen crosslinking agent (CE) was synthesized through a reaction involving chitosan quaternary ammonium salt with 1,4-butanediol diglycidyl ether. Compared to collagen crosslinked with glutaraldehyde, the CE-crosslinked collagen implant exhibited notable stability and durability.
Aflatoxin B1 Inhibited the Development of Primary Myoblasts of Grass Carp (Ctenopharyngodon idella) by Degrading Extracellular Matrix
[Ecotoxicology And Environmental Safety] Scientists suggested that AFB1 damaged the cell morphology, induced oxidative damage and apoptosis, and degraded ECM components, in turn inhibiting myoblast development by activating the p38MAPK/urokinase-type plasminogen activator/matrix metalloproteinase/ECM signaling pathway.
Curcumin Regulates Pulmonary Extracellular Matrix Remodeling and Mitochondrial Function to Attenuate Pulmonary Fibrosis by Regulating the miR-29a-3p/DNMT3A Axis
[Biomedicine & Pharmacotherapy] Human pulmonary fibroblasts were transfected with miR-29a-3p, and RT-qPCR, immunostaining, and western blotting were performed to determine the expression of DNMT3A and extracellular matrix collagen-1 and fibronectin-1 levels.
Engineered Exosomes with ATF5-Modified mRNA Loaded in Injectable Thermogels Alleviate Osteoarthritis by Targeting the Mitochondrial Unfolded Protein Response
[ACS Applied Materials & Interfaces] Investigators successfully validated the pivotal role of activating transcription factor 5 (ATF5) in upregulating the UPRmt, mitigating IL-1β-induced inflammation and mitochondrial dysfunction, and promoting balanced metabolism in articular cartilage ECM, proving its potential as a promising therapeutic target for osteoarthritis.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
