Lassen Therapeutics Launches to Discover and Develop Novel Antibody Therapeutics Including Lead Program Targeting IL-11 to Treat Fibrosis and Oncology

Lassen Therapeutics announced it has emerged from stealth and secured $31 million in Series A financing to develop antibodies as potential treatments for fibrosis, rare diseases and oncology.
[Lassen Therapeutics]
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Bellicum Receives FDA IND Clearance to Initiate a Phase I/II Clinical Trial for BPX-603, a Dual-Switch GoCAR-T® for HER2+ Solid Tumors

Bellicum Pharmaceuticals, Inc. announced clearance by the FDA of its investigational new drug application for BPX-603. BPX-603 is a GoCAR-T® product candidate targeting solid tumors that express human epidermal growth factor receptor 2 (HER2).
[Bellicum Pharmaceuticals, Inc.]
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Simulating the Human Colorectal Cancer Microenvironment in 3D Tumor-Stroma Co-Cultures In Vitro and In Vivo

Researchers successfully converted three in-house-derived primed human PSC lines to a naive state and an expanded pluripotent stem cell (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
[Scientific Reports]
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Exosomes: A Potential Therapeutic Tool Targeting Communications between Tumor Cells and Macrophages

Scientists summarize the roles and mechanisms of exosomes in the interaction between tumor cells and macrophages and the potential methods by which exosomes are used to target the communication between tumor cells and macrophages to treat cancer.
[Molecular Therapy]
AbstractGraphical Abstract
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Dissecting Intratumour Heterogeneity of Nodal B-Cell Lymphomas at the Transcriptional, Genetic and Drug-Response Levels

Researchers identified transcriptionally distinct malignant subpopulations and compared their drug-response and genomic profiles. Malignant subpopulations from the same patient responded strikingly differently to anti-cancer drugs ex vivo, which recapitulated subpopulation-specific drug sensitivity during in vivo treatment.
[Nature Cell Biology]
Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels | Nature Cell Biology. (n.d.). Retrieved June 16, 2020, from https://www.nature.com/articles/s41556-020-0532-x Cite
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Fabrication of Stiffness Gradients of GelMA Hydrogels using a 3D Printed Micromixer

A co-culture consisting of human adipose tissue-derived mesenchymal stem cellsand human umbilical cord vein endothelial cells was encapsulated in the gradient construct.
[Macromolecular Bioscience]
Lavrentieva, A., Fleischhammer, T., Enders, A., Pirmahboub, H., Bahnemann, J., & Pepelanova, I. (n.d.). Fabrication of Stiffness Gradients of GelMA Hydrogels Using a 3D Printed Micromixer. Macromolecular Bioscience, n/a(n/a), 2000107. https://doi.org/10.1002/mabi.202000107 Cite
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Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

Intravenous delivery of immunity- and matrix-regulatory cells, derived from human embryonic stem cells, inhibited both pulmonary inflammation and fibrosis in mouse models of lung injury, and significantly improved the survival rate of the recipient mice in a dose-dependent manner, likely through paracrine regulatory mechanisms.
[Cell Research]
Wu, J., Song, D., Li, Z., Guo, B., Xiao, Y., Liu, W., Liang, L., Feng, C., Gao, T., Chen, Y., Li, Y., Wang, Z., Wen, J., Yang, S., Liu, P., Wang, L., Wang, Y., Peng, L., Stacey, G. N., … Hao, J. (2020). Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis. Cell Research, 1–16. https://doi.org/10.1038/s41422-020-0354-1 Cite
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Cell Type Specific Adhesion to Surfaces Functionalised by Amine Plasma Polymers

The increased resistance observed for the non-endothelial cell types was accompanied by an increased rate of cellular attachment, even though spontaneous migration was comparable to the control, i.e., to the standard cultivation surface. As demonstrated on fibroblasts, the resistance to trypsin was similar in serum-supplemented and serum-free media.
[Scientific Reports]
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Neural Stem Cell Delivery via Porous Collagen Scaffolds Promotes Neuronal Differentiation and Locomotion Recovery in Spinal Cord Injury

Scientists demonstrated that grafts based on porous collagen-based scaffolds, similar to biomaterials utilized clinically in induced regeneration, could deliver and protect embryonic neural stem cells at spinal cord injury (SCI) sites, leading to significant improvement in locomotion recovery in an experimental mouse SCI model.
[NPJ Regenerative Medicine]
Kourgiantaki, A., Tzeranis, D. S., Karali, K., Georgelou, K., Bampoula, E., Psilodimitrakopoulos, S., Yannas, I. V., Stratakis, E., Sidiropoulou, K., Charalampopoulos, I., & Gravanis, A. (2020). Neural stem cell delivery via porous collagen scaffolds promotes neuronal differentiation and locomotion recovery in spinal cord injury. Npj Regenerative Medicine, 5(1), 1–14. https://doi.org/10.1038/s41536-020-0097-0 Cite
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Decellularized Muscle-Derived Hydrogels Support In Vitro Cardiac Microtissue Fabrication

Researchers compared decellularized ECM from cardiac muscle, skeletal muscle, aorta, liver, small intestine submucosa, and human umbilical cord, in terms of their biocompatibility and potential for differentiation of human embryonic stem cell‐derived cardiac progenitor cells to cardiovascular lineage cells.
[Journal of Biomedical Materials Research Part B-Applied Biomaterials]
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