S100A6 Is a Critical Regulator of Hematopoietic Stem Cells

Researchers showed that S100A6 regulated intracellular and mitochondria calcium buffering of HSC upon cytokine stimulation and have demonstrated that Akt activator SC79 reverted the levels of intracellular and mitochondrial calcium in HSC.
[Leukemia]
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A Missense Mutation in the MLKL Brace Region Promotes Lethal Neonatal Inflammation and Hematopoietic Dysfunction

The authors isolated a mouse strain with a single missense mutation, MlklD139V, that altered the two-helix ‘brace’ that connects the killer four-helix bundle and regulatory pseudokinase domains.
[Nature Communications]
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ADP Receptor P2y12 Prevents Excessive Primitive Hematopoiesis in Zebrafish by Inhibiting Gata1

By using mass spectrometry combined with RNA sequencing, scientists showed that absence of P2y12 induced excessive erythropoiesis, evidenced by significantly increased expression of mature erythrocytes marker α-globin, β-globin.
[Acta Pharmacologica Sinica]
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Emmes Announces Its Work on a Phase III Clinical Trial for Breakthrough Therapy Designation Product

Emmes announced that it provided the Phase III clinical trial support for a new investigational cell therapy that offers a promising treatment opportunity for patients who need an allogeneic bone marrow transplant.
[Emmes (PR Newswire, Inc.)]
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Allogeneic Cord Blood Transfusions Prevent Fetal Haemoglobin Depletion in Preterm Neonates. Results of the CB-TrIP Study

Investigators monitored fetal haemoglobin levels in 25 preterm neonates until 36 weeks of post‐menstrual age; patients received repeated red blood cell (RBC) units from allogeneic cord blood (cord‐RBCs) or from adult donors, depending on whether cord‐RBCs were available.
[British Journal of Haematology]
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Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development

Scientists used single-cell RNA sequencing to interrogate the rare CD34+ progenitor and the more differentiated CD34 fractions in the human postnatal thymus.
[Immunity]
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Enhanced Collection of Phenotypic and Engrafting Human Cord Blood Hematopoietic Stem Cells at 4°C

Researchers demonstrated that collecting and processing of human cord blood at 4°C within minutes of the baby’s birth results in significantly enhanced numbers of rigorously defined phenotypic hematopoietic stem cell and self‐renewing NSG immune‐deficient mouse engrafting and SCID‐repopulating cells.
[Stem Cells]
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Fabrication of Stiffness Gradients of GelMA Hydrogels using a 3D Printed Micromixer

A co-culture consisting of human adipose tissue-derived mesenchymal stem cellsand human umbilical cord vein endothelial cells was encapsulated in the gradient construct.
[Macromolecular Bioscience]
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Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

Researchers showed that Bacille-Calmette-Guérin vaccination in healthy human volunteers induced a persistent transcriptional program connected to myeloid cell development and function within the hematopoietic stem and progenitor cell compartment in the bone marrow.
[Cell Host & Microbe]
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Partner Therapeutics Announces Initiation of Clinical Trial Evaluating Leukine® in T Cell Replete HLA-mismatched Haploidentical Stem Cell Transplant

Partner Therapeutics announced the enrollment of the first patient dosed in a Phase II investigator-initiated study evaluating the efficacy and safety of Leukine® in T cell replete HLA-mismatched haploidentical stem cell transplant recipients who are receiving post-transplant cyclophosphamide.
[Partner Therapeutics, Inc.]
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