Clinical Outcomes of Individualized Busulfan-Dosing in Hematopoietic Stem Cell Transplantation in Chinese Children Undergoing with Therapeutic Drug Monitoring

Therapeutic drug monitoring and individualization of busulfan dosage were essential to improve the efficacy and safety of busulfan-based regimen in Chinese pediatric hematopoietic stem cell transplantation recipients.
[Bone Marrow Transplantation]
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Pterostilbene Downregulates BCR/ABL and Induces Apoptosis of T315I-Mutated BCR/ABL-Positive Leukemic Cells

Scientists examined the antileukemic effects of pterostilbene, a natural methylated polyphenol analog of resveratrol that is predominantly found in berries and nuts, using various human and murine leukemic cells, as well as bone marrow samples obtained from patients with leukemia.
[Scientific Reports]
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The Association of Graft-Versus-Leukemia Effect and Graft-Versus Host Disease in Haploidentical Transplantation with Post-Transplant Cyclophosphamide for AML

Investigators used a series of landmark analyses to investigate the association of of graft-versus-host disease in the setting of haploidentical SCT (haploSCT) with post-transplant cyclophosphamide in 805 acute myeloid leukemia patients following haploSCT.
[Bone Marrow Transplantation]
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TRAF6 Functions as a Tumor Suppressor in Myeloid Malignancies by Directly Targeting MYC Oncogenic Activity

To identify signaling states that cooperate with pre-leukemic cells, the authors used an in vivo RNAi screening approach and identified one of the most prominent genes as the ubiquitin ligase TRAF6.
[Cell Stem Cell]
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Mechanical Phenotyping of Acute Promyelocytic Leukemia Reveals Unique Biomechanical Responses in Retinoic Acid-Resistant Populations

Using mechano-node-pore sensing, a single-cell mechanical phenotyping platform, and patient-derived APL cell lines, scientists discovered that ATRA-resistant APL cells were less mechanically pliable.
[iScience]
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PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response

Using Pich knock-out mouse models, the authors provided evidence for a mechanistic link between PICH deficiency and defective hematopoiesis.
[Advanced Science]
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Melflufen or Pomalidomide plus Dexamethasone for Patients with Multiple Myeloma Refractory to Lenalidomide (OCEAN): A Randomized, Head-to-Head, Open-Label, Phase III Study

Researchers determined whether melflufen plus dexamethasone would provide a progression-free survival benefit compared with pomalidomide plus dexamethasone in patients with previously treated multiple myeloma.
[Lancet Haematology]
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Novel Inhibitor of Hematopoietic Cell Kinase as a Potential Therapeutic Agent for Acute Myeloid Leukemia

Scientists investigated in vitro, ex vivo and in vivo effects of a novel chemical compound targeting HCK inhibition, in combination with the most used drugs for the treatment of myelodysplastic syndrome and de novo acute myeloid leukemia, 5-Azacytidine and Cytarabine.
[Cancer Immunology Immunotherapy]
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Lower RNA Expression of ALDH1A1 Distinguishes the Favorable Risk Group in Acute Myeloid Leukemia

Scientists review studies characterizing the role of ALDH1A1 in acute myeloid leukemia and its potential as a therapeutic target.
[Molecular Biology Reports]
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IMV Announces First Patient Dosed in the VITALIZE Phase IIB Clinical Study Evaluating its Lead Compound, MVP-S, in Combination with KEYTRUDA® (pembrolizumab) in Patients with r/r DLBCL

IMV, Inc., a clinical-stage company developing a portfolio of immune-educating therapies based on its novel DPX platform to treat solid and hematologic cancers, announced a first patient dosed in the VITALIZE Phase IIB clinical trial.
[IMV Inc.]
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HUTCHMED Receives Breakthrough Therapy Designation in China for HMPL-523 for Treatment of Primary Immune Thrombocytopenia

HUTCHMED Limited announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation to HMPL-523, a novel, investigational spleen tyrosine kinase inhibitor, for the treatment of chronic adult primary immune thrombocytopenia patients who have received at least one prior therapy.
[HUTCHMED Limited (Globe Newswire, Inc.)]
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