Azacitidine for Relapse of Acute Myeloid Leukemia or Myelodysplastic Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation, Multicenter PALG Analysis

Researchers conducted retrospective multicenter analysis of patients diagnosed with acute myeloid leukemia or myelodysplastic syndromes who had hematological relapse after allogeneic hematopoietic stem cell transplantation and were treated with azacitidine for this indication.
[European Journal of Haematology]
Drozd‐Sokołowska, J., Karakulska‐Prystupiuk, E., Biecek, P., Kobylińska, K., Piekarska, A., Dutka, M., Waszczuk‐Gajda, A., Mądry, K., Kopińska, A., Gołos, A., Góra‐Tybor, J., Szwedyk, P., Bołkun, Ł., Czyż, A., Giebel, S., Basak, G. W., & Dwilewicz‐Trojaczek, J. (n.d.). Azacitidine for relapse of acute myeloid leukemia or myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation, multicenter PALG analysis. European Journal of Haematology, n/a(n/a). https://doi.org/https://doi.org/10.1111/ejh.13628 Cite
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Outcome of Haploidentical versus Matched Sibling Donors in Hematopoietic Stem Cell Transplantation for Adult Patients with Acute Lymphoblastic Leukemia: A Study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Investigators retrospectively analyzed adult patients with acute lymphoblastic leukemia who underwent their first allogeneic stem cell transplantation in first or second complete remission between 2012 and 2018, either from a T cell replete Haplo or matched sibling donor donor.
[Journal of Hematology & Oncology]
Nagler, A., Labopin, M., Houhou, M., Aljurf, M., Mousavi, A., Hamladji, R.-M., Al Zahrani, M., Bondarenko, S., Arat, M., Angelucci, E., Koc, Y., Gülbas, Z., Sica, S., Bourhis, J. H., Canaani, J., Brissot, E., Giebel, S., & Mohty, M. (2021). Outcome of haploidentical versus matched sibling donors in hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Journal of Hematology & Oncology, 14(1), 53. https://doi.org/10.1186/s13045-021-01065-7 Cite
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Phenotypic Characterization of Leukemia-Initiating Stem Cells in Chronic Myelomonocytic Leukemia

Scientists found that leukemic stem cells in chronic myelomonocytic leukemia resided in a CD34+/CD38 fraction of the malignant clone.
[Leukemia]
Eisenwort, G., Sadovnik, I., Keller, A., Ivanov, D., Peter, B., Berger, D., Stefanzl, G., Bauer, K., Slavnitsch, K., Greiner, G., Gleixner, K. V., Sperr, W. R., Willmann, M., Sill, H., Bettelheim, P., Geissler, K., Deininger, M., Rülicke, T., & Valent, P. (2021). Phenotypic characterization of leukemia-initiating stem cells in chronic myelomonocytic leukemia. Leukemia, 1–12. https://doi.org/10.1038/s41375-021-01227-z Cite
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Bio-Path Holdings Announces Successful Completion of Safety Cohort of Triple Combination of Prexigebersen, Decitabine and Venetoclax in Stage II of Phase II Clinical Trial in Acute Myeloid Leukemia

Bio-Path Holdings, Inc. announced the successful completion of the safety run-in of the Stage II of the Phase II clinical study of prexigebersen, a liposomal Grb2 antisense, for the treatment of acute myeloid leukemia (AML), in combination with frontline therapies, decitabine and venetoclax, in AML patients.
[Bio-Path Holdings, Inc.]
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Attrition of X Chromosome Inactivation in Aged Hematopoietic Stem Cells

Researchers demonstrated that LaminA/C defined a distinct repressive nuclear compartment for X chromosome inactivation (XCI) in young HSCs, and its reduction in aged HSCs correlated with an impairment in the overall control of XCI.
[Stem Cell Reports]
Grigoryan, A., Pospiech, J., Krämer, S., Lipka, D., Liehr, T., Geiger, H., Kimura, H., Mulaw, M. A., & Florian, M. C. (2021). Attrition of X Chromosome Inactivation in Aged Hematopoietic Stem Cells. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.03.007 Cite
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Protein S-Nitrosylation Regulates Proteostasis and Viability of Hematopoietic Stem Cell during Regeneration

Investigators found increased nitric oxide during HSC regeneration with an accumulation of protein aggregation.
[Cell Reports]
Yi, W., Zhang, Y., Liu, B., Zhou, Y., Liao, D., Qiao, X., Gao, D., Xie, T., Yao, Q., Zhang, Y., Qiu, Y., Huang, G., Chen, Z., Chen, C., & Ju, Z. (2021). Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration. Cell Reports, 34(13). https://doi.org/10.1016/j.celrep.2021.108922 Cite
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Post-Transplant Food Anaphylaxis in an Adult Cord Blood Transplant Recipient (Ms. No. IJHM-D-20-01037R1)

Scientists describe a case of new-onset food anaphylaxis after cord blood transplantation (CBT) in an adult patient that demonstrated that post-CBT allergen-challenge was not a risk for long-term allergic sensitization, even in adult recipients.
[International Journal of Hematology]
Kawahara, A., Nakanishi, T., Goto, M., Akao, K., Katsuragi, T., & Tsukada, J. (2021). Post-transplant food anaphylaxis in an adult cord blood transplant recipient (Ms. No. IJHM-D-20-01037R1). International Journal of Hematology. https://doi.org/10.1007/s12185-021-03140-8 Cite
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A Single-Cell Resolution Developmental Atlas of Hematopoietic Stem and Progenitor Cell Expansion in Zebrafish

Using single-cell RNA-sequencing, researchers deciphered a dynamic atlas covering 28,777 cells and nine major cell types of zebrafish caudal hematopoietic tissue.
[Proceedings of the National Academy of Sciences of the United States of America]
Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.-D. J., & Liu, F. (2021). A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences, 118(14). https://doi.org/10.1073/pnas.2015748118 Cite
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Ontogenic Shifts in Cellular Fate Are Linked to Proteotype Changes in Lineage-Biased Hematopoietic Progenitor Cells

Through deep coverage of the cellular proteome of fetal and adult lympho-myeloid multipotent progenitors, common lymphoid progenitors, and granulocyte-monocyte progenitors, researchers established that features traditionally attributed to adult hematopoiesis were conserved across lymphoid and myeloid lineages.
[Cell Reports]
Jassinskaja, M., Pimková, K., Arh, N., Johansson, E., Davoudi, M., Pereira, C.-F., Sitnicka, E., & Hansson, J. (2021). Ontogenic shifts in cellular fate are linked to proteotype changes in lineage-biased hematopoietic progenitor cells. Cell Reports, 34(12). https://doi.org/10.1016/j.celrep.2021.108894 Cite
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Reconciling Flux Experiments for Quantitative Modeling of Normal and Malignant Hematopoietic Stem/Progenitor Dynamics

Investigators showed that in vivo flux experiments that came from different laboratories could all be reconciled into a single unifying model, even though they had previously been interpreted as being contradictory.
[Stem Cell Reports]
Takahashi, M., Barile, M., Chapple, R. H., Tseng, Y., Nakada, D., Busch, K., Fanti, A.-K., Säwén, P., Bryder, D., Höfer, T., & Göttgens, B. (2021). Reconciling Flux Experiments for Quantitative Modeling of Normal and Malignant Hematopoietic Stem/Progenitor Dynamics. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.02.020 Cite
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First Blood: The Endothelial Origins of Hematopoietic Progenitors

Sequential waves of definitive hematopoiesis arise from yolk sac and intembryonic hemogenic endothelia through an endothelial-to-hematopoietic transition.
[Angiogenesis]
Canu, G., & Ruhrberg, C. (2021). First blood: the endothelial origins of hematopoietic progenitors. Angiogenesis. https://doi.org/10.1007/s10456-021-09783-9 Cite
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