Analyzing Signaling Activity and Function in Hematopoietic Cells

The authors discuss the requirements, potential, and limitations of the different current technologies for the analysis of hematopoietic stem and progenitor cell signaling and its effect on cell fates.
[Journal of Experimental Medicine]
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Genome Researchers Question Security Provisions in New US Senate Bill

Buried in a bill approved by the US Senate to help the United States compete with China is language that is drawing fire from human genome researchers. It would require the NIH to develop new security protocols aimed at preventing the misuse of US-funded genomic data by China and other nations.
[Science]
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Inhibition of the DNA Damage Response Phosphatase PPM1D Reprograms Neutrophils to Enhance Anti-Tumor Immune Responses

Scientists showed that mice with genetic knockout of Ppm1d or with conditional knockout of Ppm1d in the hematopoietic system, in myeloid cells, or in neutrophils all displayed significantly reduced growth of syngeneic melanoma or lung carcinoma tumors.
[Nature Communications]
Uyanik, B., Goloudina, A. R., Akbarali, A., Grigorash, B. B., Petukhov, A. V., Singhal, S., Eruslanov, E., Chaloyard, J., Lagorgette, L., Hadi, T., Baidyuk, E. V., Sakai, H., Tessarollo, L., Ryffel, B., Mazur, S. J., Lirussi, F., Garrido, C., Appella, E., & Demidov, O. N. (2021). Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses. Nature Communications, 12(1), 3622. https://doi.org/10.1038/s41467-021-23330-6 Cite
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Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage Ambiguous Stem Cell Leukemia

The authors described a distinct subgroup of acute leukemia with expression of myeloid, T lymphoid and stem cell markers driven by aberrant allele-specific deregulation of BCL11B, a master transcription factor responsible for thymic T-lineage commitment and specification.
[Cancer Discovery]
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Plasma from Patients with Bacterial Sepsis or Severe COVID-19 Induces Production of Suppressive Myeloid Cells from Human Hematopoietic Progenitor Cells In Vitro

To examine the ontogeny and function of MS1 cells, scientists developed a cellular model for inducing CD14+ MS1 monocytes by treating human hematopoietic stem and progenitor cells from healthy bone marrow donors in culture with plasma from patients with severe bacterial infection or SARS-CoV-2 infection.
[Science Translational Medicine]
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Biologic Assignment Trial of Reduced-Intensity Hematopoietic Cell Transplantation Based on Donor Availability in Patients 50–75 Years of Age with Advanced Myelodysplastic Syndrome

Investigators conducted a multicenter biologic assignment trial comparing reduced-intensity hematopoietic cell transplantation to hypomethylating therapy or best supportive care in subjects 50-75 years of age with intermediate-2 or high-risk de novo myelodysplastic syndromes.
[Journal of Clinical Oncology]
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Association of Diet Quality with Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events

Researchers conducted a cohort study to examine whether there was an association between diet quality and the prevalence of clonal hematopoiesis of indeterminate potential.
[JAMA Cardiology]
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Fanconi Anemia Proteins Participate in a Break-Induced-Replication-Like Pathway to Counter Replication Stress

Scientists showed that Fanconi anemia (FA)-mutated cells were hypersensitive to persistent replication stress and that FA proteins played a role in the break-induced-replication-like pathway for fork restart.
[Nature Structural & Molecular Biology]
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Targeted PI3K/AKT-Hyperactivation Induces Cell Death in Chronic Lymphocytic Leukemia

Scientists hypothesized that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT (PI3K/AKT)-signaling pathway may have been leveraged to trigger chronic lymphocytic leukemia cell death.
[Nature Communications]
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Interrogation of Novel CDK2/9 Inhibitor Fadraciclib (CYC065) as a Potential Therapeutic Approach for AML

In AML cell lines, myeloid cell leukemia 1 was downregulated following treatment with fadraciclib, resulting in a rapid induction of apoptosis.
[Cell Death Discovery]
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Cabozantinib Promotes Erythroid Differentiation in K562 Erythroleukemia Cells through Global Changes in Gene Expression and JNK Activation

The authors reported that cabozantinib could promote differentiation in erythroid leukemia cells and found that K562 erythroid leukemia cells treated with 1 μM cabozantinib for 72 hours underwent erythroid lineage differentiation.
[Cancer Gene Therapy]
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