Scientists showed that loss of diaphanous-related formin mDia2 led to impaired engraftment of long-term hematopoietic stem cells and loss of competitive hematopoietic stem and progenitor cell repopulation.
1254621 2J85DYDT items 1 apa default asc 1
Researchers tested 129 FDA-approved anticancer drugs in a tet2-deficient zebrafish model and showed that topoisomerase 1 (TOP1)-targeted drugs and PARP1 inhibitors selectively killed tet2-mutant HSPCs.
1254621 3V3HCRBD items 1 apa default asc 1
The authors examine aspects of Mixed Lineage Leukemia Translocated to, 10 (MLLT10), contextualizing its function in benign and malignant hematopoiesis.
1254621 PRVKI6PN items 1 apa default asc 1
To model the natural HSC niche in vitro, researchers optimized the HSC medium composition with a panel of cytokines and valproic acid and used an artificial 3D bone marrow-like scaffold made of polydimethylsiloxane.
1254621 UGED6JY4 items 1 apa default asc 1
AbbVie announced that the FDA will review a supplemental New Drug Application (sNDA) for IMBRUVICA® in combination with rituximab for the treatment of WM, a rare and incurable type of non-Hodgkin’s lymphoma.
By comparing leukemic stem cells (LSCs) to leukemic blasts and healthy hematopoietic stem and progenitor cells (HSPCs), researchers validated candidate LSC markers and highlight novel and potentially targetable proteins that are absent or only lowly expressed in HSPCs.
1254621 3ETN5BFM items 1 apa default asc 1
The authors investigated whether donor natural killer cells and interleukin-2 gene modification exerted anti-relapse effects on allogeneic hematopoietic stem-cell transplantation after establishing a mouse model of acute leukemia.
1254621 5ANWZBC6 items 1 apa default asc 1
In order to explore the possibility of HLA-mismatched hematopoietic stem cell transplantation from family donors beyond haploidentical relatives, the authors conducted a prospective Phase I/II study of 2-HLA-haplotype-mismatched hematopoietic stem cell transplantation (HSCT).
[Bone Marrow Transplantation]
1254621 U7VMZV2E items 1 apa default asc 1
Mutations of calreticulin were associated with an early clonal dominance at the level of hematopoietic stem and progenitor cells with no significant increase during granulo/monocytic differentiation in most cases.
1254621 BVSZZWVH items 1 apa default asc 1
Researchers showed that S100A6 regulated intracellular and mitochondria calcium buffering of HSC upon cytokine stimulation and have demonstrated that Akt activator SC79 reverted the levels of intracellular and mitochondrial calcium in HSC.
1254621 QHGPDEJK items 1 apa default asc 1
The authors isolated a mouse strain with a single missense mutation, MlklD139V, that altered the two-helix ‘brace’ that connects the killer four-helix bundle and regulatory pseudokinase domains.
6445218 M2IZUMZB items 1 apa default asc 1