Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
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Marker Therapeutics Receives USAN Approval for “Zelenoleucel” as Nonproprietary Name for MT-401, Multi-Tumor-Associated Antigen Targeted T Cell Product for Acute Myeloid Leukemia

Marker Therapeutics, Inc. announced that the United States Adopted Names Council has approved “zelenoleucel” as the nonproprietary name for MT-401, a multi-tumor-associated antigen-specific T cell product candidate for the treatment of patients with acute myeloid leukemia following allogeneic stem cell transplant in both adjuvant and active disease settings.
[Marker Therapeutics, Inc.]
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Diaphanous-Related Formin mDia2 Regulates Beta2 Integrins to Control Hematopoietic Stem and Progenitor Cell Engraftment

Scientists showed that loss of diaphanous-related formin mDia2 led to impaired engraftment of long-term hematopoietic stem cells and loss of competitive hematopoietic stem and progenitor cell repopulation.
[Nature Communications]
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Synthetic Lethal Targeting of TET2-Mutant Hematopoietic Stem and Progenitor Cells (HSPCs) with TOP1-Targeted Drugs and PARP1 Inhibitors

Researchers tested 129 FDA-approved anticancer drugs in a tet2-deficient zebrafish model and showed that topoisomerase 1 (TOP1)-targeted drugs and PARP1 inhibitors selectively killed tet2-mutant HSPCs.
[Leukemia]
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MLLT10 in Benign and Malignant Hematopoiesis

The authors examine aspects of Mixed Lineage Leukemia Translocated to, 10 (MLLT10), contextualizing its function in benign and malignant hematopoiesis.
[Experimental Hematology]
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Biomimetic Reconstruction of the Hematopoietic Stem Cell Niche for In Vitro Amplification of Human Hematopoietic Stem Cells

To model the natural HSC niche in vitro, researchers optimized the HSC medium composition with a panel of cytokines and valproic acid and used an artificial 3D bone marrow-like scaffold made of polydimethylsiloxane.
[PLoS One]
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IMBRUVICA® (Ibrutinib) Seeks to Expand US Label with Long-Term Data in Waldenström’s Macroglobulinemia (WM)

AbbVie announced that the FDA will review a supplemental New Drug Application (sNDA) for IMBRUVICA® in combination with rituximab for the treatment of WM, a rare and incurable type of non-Hodgkin’s lymphoma.
[AbbVie Inc.]
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Quantitative Proteomics Reveals Specific Metabolic Features of Acute Myeloid Leukemia Stem Cells

By comparing leukemic stem cells (LSCs) to leukemic blasts and healthy hematopoietic stem and progenitor cells (HSPCs), researchers validated candidate LSC markers and highlight novel and potentially targetable proteins that are absent or only lowly expressed in HSPCs.
[Blood]
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Anti-Relapse Effects of Donor Natural Killer Cells and IL-2 Gene Modification on Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia

The authors investigated whether donor natural killer cells and interleukin-2 gene modification exerted anti-relapse effects on allogeneic hematopoietic stem-cell transplantation after establishing a mouse model of acute leukemia.
[Cancer Biomarkers]
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Allogeneic Hematopoietic Stem Cell Transplantation from a 2-HLA-Haplotype-Mismatched Family Donor for Posttransplant Relapse: A Prospective Phase I/II Study

In order to explore the possibility of HLA-mismatched hematopoietic stem cell transplantation from family donors beyond haploidentical relatives, the authors conducted a prospective Phase I/II study of 2-HLA-haplotype-mismatched hematopoietic stem cell transplantation (HSCT).
[Bone Marrow Transplantation]
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Different Impact of Calreticulin Mutations on Human Hematopoiesis in Myeloproliferative Neoplasms

Mutations of calreticulin were associated with an early clonal dominance at the level of hematopoietic stem and progenitor cells with no significant increase during granulo/monocytic differentiation in most cases.
[Oncogene]
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