Understanding of the Crosstalk between Normal Residual Hematopoietic Stem Cells and the Leukemic Niche in Acute Myeloid Leukemia

Investigators present evidence of the key role of the bone marrow niche in suppressing HSCs during leukemic progression and provide perspectives on how future research in this topic may be exploited to provide treatments for one of the key complications of acute myeloid leukemia.
[Experimental Hematology]
Batsivari, A., Grey, W., & Bonnet, P. D. (2021). Understanding of the crosstalk between normal residual hematopoietic stem cells and the leukemic niche in Acute Myeloid Leukemia. Experimental Hematology, 0(0). https://doi.org/10.1016/j.exphem.2021.01.004 Cite
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Lead in Synergism with IFNγ Acts on Bone Marrow-Resident Macrophages to Increase the Quiescence of Hematopoietic Stem Cells

Scientists found that lead (Pb)-increased quiescence of hematopoietic stem cells (HSCs) critically relied on a synergetic action of Pb and IFNγ on bone marrow-resident macrophages, but not a direct action of Pb on HSCs.
[Toxicological Sciences]
Zhao, Y., Li, Q., Zhu, T., He, J., Xue, P., Zheng, W., Yao, Y., Qu, W., Zhou, Z., Lu, R., Zhou, Z., He, R., He, M., & Zhang, Y. (2021). Lead in Synergism with IFNγ Acts on Bone Marrow-Resident Macrophages to Increase the Quiescence of Hematopoietic Stem Cells. Toxicological Sciences, kfab001. https://doi.org/10.1093/toxsci/kfab001 Cite
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Donor Characteristics and Intraoperative Total Nucleated Cell Count Influence Hematopoietic Progenitor Cell Yield of Healthy Donor Bone Marrow Grafts

Investigators retrospectively reviewed marrow harvests at our institution performed between 2009 and 2019. During this time, an intraoperative total nucleated cell count was measured after 50% of the projected final graft volume was collected.
[Pediatric Blood & Cancer]
Kalin, J., Nguyen, A. T. H., & Oshrine, B. (n.d.). Donor characteristics and intraoperative total nucleated cell count influence hematopoietic progenitor cell yield of healthy donor bone marrow grafts. Pediatric Blood & Cancer, n/a(n/a), e28902. https://doi.org/https://doi.org/10.1002/pbc.28902 Cite
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High Erythroferrone Expression in CD71+ Erythroid Progenitors Predicts Superior Survival in Myelodysplastic Syndromes

The authors analyzed the expression of erythroferrone and growth/differentiation factor 15 in CD71+ erythroid progenitors of 111 myelodysplastic syndrome patients and assessed their effects on patient survival.
[British Journal of Haematology]
Riabov, V., Mossner, M., Stöhr, A., Jann, J.-C., Streuer, A., Schmitt, N., Knaflic, A., Nowak, V., Weimer, N., Obländer, J., Palme, I., Schumann, C., Baldus, C. D., Schulze, T. J., Wuchter, P., Röhl, H., Jawhar, A., Weiss, C., Boch, T., … Nowak, D. (n.d.). High erythroferrone expression in CD71+ erythroid progenitors predicts superior survival in myelodysplastic syndromes. British Journal of Haematology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjh.17314 Cite
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Latest Culture Techniques: Cracking the Secrets of Bone Marrow to Mass-Produce Erythrocytes and Platelets Ex Vivo

Scientists discuss the latest culture techniques and technological approaches to obtain functional platelets and erythrocytes ex vivo.
[Haematologica]
Buduo, C. A. D., Aguilar, A., Soprano, P. M., Bocconi, A., Miguel, C. P., Mantica, G., & Balduini, A. (2020). Latest culture techniques: cracking the secrets of bone marrow to mass-produce erythrocytes and platelets <i>ex vivo. Haematologica. https://doi.org/10.3324/haematol.2020.262485 Cite
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Modeling, Optimization, and Comparable Efficacy of T Cell and Hematopoietic Stem Cell Gene Editing for Treating Hyper‐IgM Syndrome

Investigators developed a one‐size‐fits‐all editing strategy for effective T‐cell correction, selection, and depletion and investigated the therapeutic potential of T‐cell and hematopoietic stem/progenitor cell therapies in the hyper‐IgM syndrome mouse model.
[EMBO Molecular Medicine]
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SUMOylation Disassembles the Tetrameric Pyruvate Kinase M2 to Block Myeloid Differentiation of Leukemia Cells

Scientists found that SUMOylation of the M2 isoform of pyruvate kinase, a rate-limiting glycolytic enzyme catalyzing the dephosphorylation of phosphoenolpyruvate to pyruvate, is prevalent in a variety of leukemic cell lines as well as primary samples from patients with leukemia through multiple-reaction monitoring based targeted mass spectrometry analysis.
[Cell Death & Disease]
Xia, L., Jiang, Y., Zhang, X.-H., Wang, X.-R., Wei, R., Qin, K., & Lu, Y. (2021). SUMOylation disassembles the tetrameric pyruvate kinase M2 to block myeloid differentiation of leukemia cells. Cell Death & Disease, 12(1), 1–13. https://doi.org/10.1038/s41419-021-03400-9 Cite
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The TRACE-Seq Method Tracks Recombination Alleles and Identifies Clonal Reconstitution Dynamics of Gene Targeted Human Hematopoietic Stem Cells

The authors describe Tracking Recombination Alleles in Clonal Engraftment using sequencing (TRACE-Seq), a methodology that utilizes barcoded AAV6 donor template libraries, carrying in-frame silent mutations or semi-randomized nucleotides outside the coding region, to track the in vivo lineage contribution of gene-targeted hematopoietic stem and progenitor cell clones.
[Nature Communications]
Sharma, R., Dever, D. P., Lee, C. M., Azizi, A., Pan, Y., Camarena, J., Köhnke, T., Bao, G., Porteus, M. H., & Majeti, R. (2021). The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells. Nature Communications, 12(1), 472. https://doi.org/10.1038/s41467-020-20792-y Cite
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Interplay between Cofactors and Transcription Factors in Hematopoiesis and Hematological Malignancies

Investigators summarize the current knowledge regarding the models and functions of cofactor–transcription factor interplay in physiological hematopoiesis and highlight their implications in the etiology of hematological malignancies.
[Signal Transduction and Targeted Therapy]
Wang, Z., Wang, P., Li, Y., Peng, H., Zhu, Y., Mohandas, N., & Liu, J. (2021). Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies. Signal Transduction and Targeted Therapy, 6(1), 1–16. https://doi.org/10.1038/s41392-020-00422-1 Cite
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Selective Antisense Oligonucleotide Inhibition of Human IRF4 Prevents Malignant Myeloma Regeneration via Cell Cycle Disruption

Using diverse pre-clinical models, the authors investigated the role of interferon regulatory factor 4 (IRF4) in myeloma progenitor regeneration.
[Cell Stem Cell]
Mondala, P. K., Vora, A. A., Zhou, T., Lazzari, E., Ladel, L., Luo, X., Kim, Y., Costello, C., MacLeod, A. R., Jamieson, C. H. M., & Crews, L. A. (2021). Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.12.017 Cite
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Genome-Wide Analysis of Pseudogenes Reveals HBBP1’s Human-Specific Essentiality in Erythropoiesis and Implication in β-Thalassemia

Extensive functional assays demonstrated that HBBP1 was essential for erythropoiesis by binding the RNA-binding protein, HNRNPA1, to upregulate TAL1, a key regulator of erythropoiesis.
[Developmental Cell]
Ma, Y., Liu, S., Gao, J., Chen, C., Zhang, X., Yuan, H., Chen, Z., Yin, X., Sun, C., Mao, Y., Zhou, F., Shao, Y., Liu, Q., Xu, J., Cheng, L., Yu, D., Li, P., Yi, P., He, J., … Yu, J. (2021). Genome-wide analysis of pseudogenes reveals HBBP1’s human-specific essentiality in erythropoiesis and implication in β-thalassemia. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2020.12.019 Cite
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