A Somatic Evolutionary Model of the Dynamics of Aneuploid Cells during Hematopoietic Reconstitution

Researchers demonstrated by Monte Carlo modeling that two mechanisms could underlie this aneuploidy peak: rapid expansion of the engrafted hematopoietic stem and progenitor cell population and bone marrow microenvironment degradation caused by pre-transplantation radiation treatment.
[Scientific Reports]
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Hematopoietic Stem Cell Metabolism during Development and Aging

Researchers highlight how mitochondrial metabolism determines hematopoietic stem cell (HSC) fate, and especially focus on the links between mitochondria, endoplasmic reticulum, and lysosomes in HSC metabolism.
[Developmental Cell]
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Signaling Input from Divergent Pathways Subverts B Cell Transformation

The authors analyzed 1,148 patient-derived B-cell leukemia samples, and found that individual mutations did not promote leukemogenesis unless they converged on one single oncogenic pathway that was characteristic of the differentiation stage of transformed B cells.
[Nature]
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Dual Roles of PU.1 in the Expression of PD-L2: Direct Transactivation with IRF4 and Indirect Epigenetic Regulation

The knockdown of the hematopoietic cell–specific transcription factors PU.1 and IRF4 decreased PD-L2 expression in GM-CSF-induced mouse bone marrow–derived dendritic cells.
[Journal of Immunology]
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The Career Cost of COVID-19 to Female Researchers, and How Science Should Respond

Early data on the effects of the coronavirus pandemic on scientific-publishing output suggest that female researchers, particularly those at early-career stages, are the hardest hit. Submissions to preprint servers, such as arXiv, rose more quickly for male authors than for female authors as nations adopted social-isolation measures.
[Nature News]
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EU Leaders Slash Science Spending in €1.8 Trillion Deal

Following a marathon EU summit in Brussels, national leaders agreed to a €1.8 trillion, seven-year budget and pandemic recovery fund that will spend €81 billion on Horizon Europe, the main EU research program.
[Science Insider]
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‘Ethically Troubling.’ University Reopening Plans Put Professors, Students on Edge

Come August, hundreds of universities across the United States are poised to reopen their campuses with a mix of online and in-person courses. Only a handful are aiming for an entirely online semester. But as the machinery of higher education cranks back into action, faculty, staff, and students are voicing concerns that, with COVID-19 cases surging in many parts of the country, employees are being forced to put their health—and the health of others—at unnecessary risk.
[ScienceInsider]
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Pioneering Duplication Detector Trawls Thousands of Coronavirus Preprints

Amid concerns that the torrent of research papers on COVID-19 could be leading to an excess of sloppy work, a computer scientist who develops automated programs to spot duplicate images in research papers is running his software across the world’s coronavirus preprints. So far, his efforts have yielded mixed success and some controversy.
[Nature News]
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Characteristics of Cells with Engraftment Capacity within CD34+ Cell Population upon G-CSF and Plerixafor Mobilization

Investigators assessed the hematopoietic stem cell content within the CD34+ fraction of graft samples from three groups of patients: 1-Good Mobilizer patients receiving G-CSF only, 2-Poor Mobilizer (PM) patients receiving G-CSF only, 3-PM patients receiving G-CSF + Plerixafor.
[Leukemia]
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Determinants and Role of Chromatin Organization in Acute Leukemia

The authors provide detailed discussion of the nature of 3D interactions and the way that they are disrupted in acute leukemia.
[Leukemia]
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Preeclampsia in Pregnancy Affecting the Stemness and Differentiation Potency of Hematopoietic Stem Cells of the Umbilical Cord Blood

Scientists investigated the effects of preeclampsia in pregnancy on the stemness and differentiation potency of umbilical cord blood-hematopoietic stem cells.
[BMC Pregnancy and Childbirth]
Nordin, F., Idris, M. R. M., Mahdy, Z. A., & Wahid, S. F. A. (2020). Preeclampsia in pregnancy affecting the stemness and differentiation potency of haematopoietic stem cell of the umbilical cord blood. BMC Pregnancy and Childbirth, 20(1), 399. https://doi.org/10.1186/s12884-020-03084-7 Cite
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