Induced Pluripotent Stem Cells for the Treatment of Liver Diseases: Novel Concepts

The authors conclude the current state of efforts to derive human iPSCs for potential use in the modeling and treatment of liver disease.
[Cells Tissues Organs]
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DURECT Corporation Announces Initiation of Patient Recruitment in Phase II Safety and Efficacy Study of DUR-928 in COVID-19 Patients with Acute Liver or Kidney Injury

DURECT Corporation announced it has initiated recruiting patients for its randomized, double-blind, placebo-controlled, multi-center Phase II study to evaluate the safety and efficacy of DUR-928 in hospitalized COVID-19 infected patients with acute liver or kidney injury.
[DURECT Corporation]
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BeiGene Announces Acceptance of a Supplemental New Drug Application for Tislelizumab in Patients with Previously Treated Unresectable Hepatocellular Carcinoma in China

BeiGene, Ltd. announced that the Center for Drug Evaluation of the China National Medical Products Administration has accepted a supplemental new drug application of BeiGene’s anti-PD-1 antibody tislelizumab for the treatment of patients with previously treated unresectable hepatocellular carcinoma, the most common form of liver cancer.
[BeiGene, Ltd. (GlobeNewswire, Inc.)]
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United Kingdom Plans ‘Office for Talent’ to Smooth Entry for Top Scientists

The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map.
[ScienceInsider]
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Hong Kong Universities Rattled by New Security Law

Academics in Hong Kong are facing new worries today after the mainland government abruptly imposed a controversial new security law that critics say could infringe on human rights and chill academic freedom.
[ScienceInsider]
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Amidst Uncertainty, Flexibility Is Key in Higher Ed, Faculty Say

Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year.
[The Scientist]
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miR‐125b Loss Activated HIF1α/pAKT Loop, Leading to Trans‐Arterial Chemoembolization Resistance in Hepatocellular Carcinoma

Scientists aimed to identify key molecular signatures and related pathways leading to hepatocellular carcinoma resistance to trans‐arterial chemoembolization (TACE), with the hope of developing effective approaches in pre‐selecting patients with survival benefit from TACE.
[Hepatology]
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Human Hepatic In Vitro Models Reveal Distinct Anti-NASH Potencies of PPAR Agonists

Investigators reproduced key non-alcoholic steatohepatitis (NASH) characteristics in vitro by exposing primary human hepatocytes, human skin stem cell-derived hepatic cells, HepaRG and HepG2 cell lines, as well as LX-2 cells to multiple factors that play a role in the onset of NASH.
[Cell Biology and Toxicology]
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Longevity and Replenishment of Human Liver-Resident Memory T Cells and Mononuclear Phagocytes

Allografts were rapidly infiltrated by recipient leukocytes, which recapitulated the liver myeloid and lymphoid composition, and underwent partial reprogramming with acquisition of CD68/CD206 on MNPs and CD69/CD103 on T cells.
[Journal of Experimental Medicine]
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Fibrillar Collagen Type I Participates in the Survival and Aggregation of Primary Hepatocytes Cultured on Soft Hydrogels

Researchers evaluated the role of fibrillar collagens and basement membrane-associated matrix on actin cytoskeleton organization and the function of rat primary hepatocytes cultured on soft elastic polyacrylamide hydrogels.
[Bioinspiration & Biomimetics]
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Doublecortin-Like Kinase 1 Promotes Hepatocyte Clonogenicity and Oncogenic Programming via Non-Canonical β-Catenin-Dependent Mechanism

Spheroids derived from doublecortin-like kinase 1 (DCLK1)-overexpressing hepatoma cells showed high level expression of active β-catenin, α-fetoprotein, and SOX9, suggesting that DCLK1 overexpression induced clonogenicity and dedifferentiated phenotypes in hepatoma cells.
[Scientific Reports]
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