Category Archives: Hepatic Cell

Hepatic Cell News is an online publication and email newsletter covering the top research on hepatocytes and liver diseases.
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The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. The newsletter covers areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!

Therapeutic Effects of TM4SF5-Targeting Chimeric and Humanized Monoclonal Antibodies in Hepatocellular and Colon Cancer Models

The authors evaluated the effects of chimeric Ab27 using cancer cells expressing endogenous transmembrane 4 L six family member 5 (TM4SF5) or stably overexpressing TM4SF5 in vivo and in vitro.
[Molecular Therapy-Oncolytics]
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Melatonin Is a Potential Oncostatic Agent to Inhibit HepG2 Cell Proliferation through Multiple Pathways

Researchers investigated melatonin’s antitumor molecular mechanisms to inhibit the proliferation of HepG2 cells.
[Heliyon]
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Is It Time for Chronopharmacology in NASH?

Scientists describe the potential for chronopharmacology in non-alcoholic steatohepatitis (NASH), discuss how the major NASH drug candidates are influenced by circadian biology, and encourage greater consideration of the timing of drug administration in the design of future clinical trials.
[Journal of Hepatology]
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Aligos Therapeutics Begins Dosing in Chronic Hepatitis B Patients in Its Phase I Antisense Oligonucleotide Study (ALG-020572-401)

Aligos Therapeutics, Inc. announced that the first chronic hepatitis B patient has been dosed in the multiple ascending dose portion of Study ALG-020572-401 which is evaluating antisense oligonucleotide ALG-020572.
[Aligos Therapeutics, Inc.]
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Whole-Genome Sequencing Reveals the Evolutionary Trajectory of HBV-Related Hepatocellular Carcinoma Early Recurrence

Investigators performed whole-genome sequencing on 40 pairs of primary and early-recurrent hepatitis B virus (HBV)-related hepatocellular carcinoma tumors from patients who received curative resection, and from four patients whose primary and recurrent tumor were extensively sampled.
[Signal Transduction and Targeted Therapy]
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Fasting Improves Therapeutic Response in Hepatocellular Carcinoma through p53-Dependent Metabolic Synergism

Scientists showed in hepatocellular carcinoma (HCC) cells, xenografts, and patient-derived organoids that fasting improved sorafenib efficacy and acted synergistically to sensitize sorafenib-resistant HCC.
[Science Advances]
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Galectin-1 Confers Resistance to Doxorubicin in Hepatocellular Carcinoma Cells through Modulation of P-glycoprotein Expression

Researchers investigated the molecular mechanism underlying galectin-1-mediated chemoresistance in hepatocellular carcinoma cells, particularly the involvement of P-glycoprotein in this effect.
[Cell Death & Disease]
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A Blood-Based Noninvasive miRNA Signature for Predicting Survival Outcomes in Patients with Intrahepatic Cholangiocarcinoma

The authors established a novel miRNA signature that could robustly predict survival outcomes in resected tissues and liquid biopsies to improve the clinical management of patients with intrahepatic cholangiocarcinoma.
[British Journal of Cancer]
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Hippo Signaling in the Liver: Role in Development, Regeneration and Disease

The authors summarize the diverse roles of Hippo signaling in liver biology and highlight areas where outstanding questions remain to be investigated.
[Nature Reviews Gastroenterology & Hepatology]
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89bio Reports Positive Topline Results from an Expansion Cohort of the Phase Ib/IIa Trial of Pegozafermin (BIO89-100) for the Treatment of NASH

89bio, Inc. announced positive topline results from an open-label expansion cohort of 20 patients in the Phase Ib/IIa proof-of-concept study evaluating pegozafermin for the treatment of non-alcoholic steatohepatitis (NASH).
[89bio, Inc.]
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CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular Carcinoma

Three metastasis-associated circRNAs identified in a previous circRNA-sequencing study were screened and validated in two hepatocellular carcinoma (HCC) cohorts. CircRPN2 was downregulated in highly metastatic HCC cell lines and HCC tissues with metastasis.
[Cancer Research]
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