Scientists isolated a novel human monoclonal antibody, 32A9, by phage display technology. They determined specificity, affinity, epitope and anti-tumor activity, and developed 32A9-based immunotherapy technologies for evaluating the potency of hepatocellular carcinoma treatment.
[Journal of Translational Medicine]
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Liu, X., Gao, F., Jiang, L., Jia, M., Ao, L., Lu, M., Gou, L., Ho, M., Jia, S., Chen, F., & Gao, W. (2020). 32A9, a novel human antibody for designing an immunotoxin and CAR-T cells against glypican-3 in hepatocellular carcinoma. Journal of Translational Medicine, 18(1), 295. https://doi.org/10.1186/s12967-020-02462-1 Cite
Investigators found that SMAD2 was highly expressed in hepatocellular carcinoma (HCC) and elevated SMAD2 expression predicted shorter overall survival time for HCC patients. SMAD2 promoted mobility and proliferation of HCC cells in vitro.
[Journal of Experimental & Clinical Cancer Research]
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Huang, Z., Wen, J., Yu, J., Liao, J., Liu, S., Cai, N., Liang, H., Chen, X., Ding, Z., & Zhang, B. (2020). MicroRNA-148a-3p inhibits progression of hepatocelluar carcimoma by repressing SMAD2 expression in an Ago2 dependent manner. Journal of Experimental & Clinical Cancer Research, 39(1), 150. https://doi.org/10.1186/s13046-020-01649-0 Cite
Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Researchers provide an update on the progress regarding the interactions between secretin and the biliary epithelia in normal and pathological conditions, underlining the aspects that suggests modulation of secretin pathway as a possible therapeutic approach for chronic cholestatic human liver disease.
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Wu, N., Baiocchi, L., Zhou, T., Kennedy, L., Ceci, L., Meng, F., Sato, K., Wu, C., Ekser, B., Kyritsi, K., Kundu, D., Chen, L., Meadows, V., Franchitto, A., Alvaro, D., Onori, P., Gaudio, E., Lenci, I., Francis, H., … Alpini, G. (n.d.). The Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.31484 Cite
To identify hepatocellular carcinoma (HCC) signaling networks that determine responses to kinase inhibitors (KIs), scientists applied a pharmacoproteomics approach integrating kinome activity in 17 HCC cell lines with their responses to 299 KIs, resulting in a comprehensive dataset of pathway-based drug response signatures.
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Pharmacoproteomics Identifies Kinase Pathways that Drive the Epithelial-Mesenchymal Transition and Drug Resistance in Hepatocellular Carcinoma: Cell Systems. (n.d.). Retrieved August 6, 2020, from https://www.cell.com/cell-systems/fulltext/S2405-4712(20)30249-0 Cite
Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
Terns Pharmaceuticals, Inc., has announced positive results from its completed Phase I single ascending dose and multiple ascending dose study of TERN-201, a semicarbazide-sensitive amine oxidase inhibitor, being developed for the treatment of non-alcoholic steatohepatitis (NASH).
Investigators showed that circ9119 could modulate apoptosis, and broadly, cell proliferation by competitively binding miR-26a, which targeted JAK1-STAT3, in hepatocellular carcinoma cell lines.
[Cell Death & Disease]
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Scientists identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.
[Signal Transduction and Targeted Therapy]
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Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms | Signal Transduction and Targeted Therapy. (n.d.). Retrieved July 31, 2020, from https://www.nature.com/articles/s41392-020-00253-0 Cite
Scientists showed that deletion of core clock components REV-ERBα and β in adult mouse hepatocytes disrupted diurnal rhythms of a subset of liver genes and altered the diurnal rhythm of de novo lipogenesis.
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By generating an ATF6 inducible patient-specific induced pluripotent stem cell line, researchers demonstrated that enhancing hepatic ER proteostasis preferentially reduced the secretion of amyloidogenic transthyretin.
[Stem Cell Reports]
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Giadone, R. M., Liberti, D. C., Matte, T. M., Rosarda, J. D., Torres-Arancivia, C., Ghosh, S., Diedrich, J. K., Pankow, S., Skvir, N., Jean, J. C., Yates, J. R., Wilson, A. A., Connors, L. H., Kotton, D. N., Wiseman, R. L., & Murphy, G. J. (2020). Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.07.003 Cite