Experimental Gene Therapy for Hemophilia Probably Did Not Cause Patient’s Liver Tumor

UniQure has concluded that a virus used widely in gene therapy was very unlikely to have caused liver cancer in a hemophilia patient in a clinical trial.
[Science]
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A Rapid Juvenile Murine Model of Nonalcoholic Steatohepatitis (NASH): Chronic Intermittent Hypoxia Exacerbates Western Diet-Induced NASH

Researchers designed a study to establish a rapid juvenile murine NASH model, and determined whether the combination of chronic intermittent hypoxia and a western-style diet could fully display key pathologic features of NASH.
[Life Sciences]
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IL37 Overexpression Inhibits Autophagy and Apoptosis Induced by Hepatic Ischemia Reperfusion Injury via Modulating AMPK/mTOR/ULLK1 Signaling Pathways

Scientists investigated the potential role of IL37 in hepatic ischemia reperfusion injury and its underlying molecular mechanism.
[Life Sciences]
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S-Adenosylmethionine Upregulates the Angiotensin Receptor-Binding Protein ATRAP via the Methylation of HuR in NAFLD

The authors explored the effect of supplementary S-adenosylmethionine, which was the main biological methyl donor in mammalian cells, in regulating AT1R-associated protein (ATRAP), which was the negative regulator of AT1R.
[Cell Death & Disease]
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Liver Alanine Catabolism Promotes Skeletal Muscle Atrophy and Hyperglycaemia in Type 2 Diabetes

Researchers revealed a metabolic inter-tissue cross-talk that links skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.
[Nature Metabolism]
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A Tumor-Suppressive Circular RNA Mediates Uncanonical Integrin Degradation by the Proteasome in Liver Cancer

Investigators showed that polyadenylate-binding protein 1 (circPABPC1) was preferentially lost in tumor cells from clinical samples and inhibited both intrahepatic and distant metastases in a mouse xenograft model.
[Science Advances]
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DNA Damage Response Protein CHK2 Regulates Metabolism in Liver Cancer

Investigators showed that checkpoint kinase 2 (CHK2), a central effector of DNA damage response, regulated cellular energy production by affecting glycolysis and mitochondrial functions.
[Cancer Research]
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E3 Ubiquitin Ligase Grail Promotes Hepatic Steatosis through Sirt1 Inhibition

Scientists demonstrated that gene related to anergy in lymphocytes regulated the lipid accumulation in hepatic steatosis via interaction with sirtuin 1.
[Cell Death & Disease]
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LINC01419-Mediated Epigenetic Silencing of ZIC1 Promotes Metastasis in Hepatocellular Carcinoma through thePI3K/Akt Signaling Pathway

LINC01419 enhances the methylation of zinc finger of the cerebellum (ZIC1) promoter, inhibits ZIC1 expression, and activates the PI3K/Akt signaling pathway, thereby enhancing the malignant phenotypes of hepatocellular carcinoma cells in vitro as well as tumor formation and metastasis in vivo.
[Laboratory Investigation]
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Interferon Regulatory Factor 1 (IRF-1) Downregulates Checkpoint Kinase 1 (CHK1) through miR-195 to Upregulate Apoptosis and PD-L1 Expression in Hepatocellular Carcinoma (HCC) Cells

IRF-1 induces miR-195 to suppress CHK1 protein expression. Both increased IRF-1 and decreased CHK1 upregulate cellular apoptosis and PD-L1 expression in HCC.
[British Journal of Cancer]
Yan, Y., Zheng, L., Du, Q., Cui, X., Dong, K., Guo, Y., & Geller, D. A. (2021). Interferon regulatory factor 1 (IRF-1) downregulates Checkpoint kinase 1 (CHK1) through miR-195 to upregulate apoptosis and PD-L1 expression in Hepatocellular carcinoma (HCC) cells. British Journal of Cancer, 1–11. https://doi.org/10.1038/s41416-021-01337-6 Cite
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N-n-Butyl Haloperidol Iodide Ameliorates Liver Fibrosis and Hepatic Stellate Cell Activation in Mice

Researchers revealed that c-Jun was bound to the TGF-β receptor II (TGFBR2) promoter, whereas N-n-Butyl haloperidol iodide suppressed the binding of c-Jun to the TGFBR2 promoter to restrain TGF-β signaling and inhibit α-smooth muscle actin and collagen I upregulation.
[Acta Pharmacologica Sinica]
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