Convergent Somatic Mutations in Metabolism Genes in Chronic Liver Disease

Scientists analyzed somatic mutations from 1,590 genomes across 34 liver samples, including healthy controls, alcohol-related liver disease and non-alcoholic fatty liver disease. Seven of the 29 patients with liver disease had mutations in FOXO1, the major transcription factor in insulin signaling.
[Nature]
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Long-Read Sequencing Reveals the Structural Complexity of Genomic Integration of HBV DNA in Hepatocellular Carcinoma

Researchers applied long-read sequencing to precisely elucidate the hepatitis B virus (HBV) integration pattern in the human hepatocellular genome.
[NPJ Genomic Medicine]
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Hansoh Pharma and OliX Pharmaceuticals Enter into Licensing and Collaboration Agreement to Develop and Commercialize siRNA Therapeutics in Greater China

Hansoh Pharmaceutical Group Co, Ltd and OliX Pharmaceuticals, Inc. announced a licensing and collaboration agreement to discover, develop and commercialize siRNA therapeutics in key targeted indications in Greater China, which includes mainland China, Taiwan, Hong Kong and Macau.
[Hansoh Pharmaceutical Group Co, Ltd (GlobeNewswire, Inc.)]
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Long-Term Maintenance of Functional Primary Human Hepatocytes in 3D Gelatin Matrices Produced by Solution Blow Spinning

The authors reported the successful generation of 3D thermally crosslinked preforms by using solution blow spinning (SBS) from porcine gelatin. They then used SBS mats as culturing substrates for human hepatocytes to create an array of 3D human liver tissue equivalents in 96-well format.
[Scientific Reports]
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A Modified Animal Model of Hepatic Regeneration Induced by Hilar Bile Duct Ligation

Scientists aimed to establish a new type of rapid liver hyperplasia model induced mainly by bile acid pathway through hepatoenteral circulation with hilar bile duct ligation. Immunohistochemistry results confirmed the proliferation of hepatocytes in the unligated liver lobe.
[Scientific Reports]
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p53-Mediated Redox Control Promotes Liver Regeneration and Maintains Liver Function in Response to CCl4

Researchers showed that p53 functioned to support repair and recovery from CCl4-mediated liver damage, controlled reactive oxygen species and limited the development of hepatocellular carcinoma, in part through the activation of a detoxification cytochrome P450, CYP2A5.
[Cell Death & Differentiation]
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SIRT2-Mediated Deacetylation and Deubiquitination of C/EBPβ Prevents Ethanol-Induced Liver Injury

Liver-specific Sirutin 2 (SIRT2) deficiency sensitized mice to alcoholic liver disease, whereas transgenic SIRT2 overexpression in hepatocytes significantly prevented ethanol-induced liver injury via normalization of hepatic steatosis, lipid peroxidation, and hepatocyte apoptosis.
[Cell Discovery]
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Novel Therapeutic Targets for Cholestatic and Fatty Liver Disease

Cholestatic and non-alcoholic fatty liver disease share several key pathophysiological mechanisms which can be targeted by novel therapeutic concepts that are currently developed for both areas.
[Gut]
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Application of CRISPR-Cas9 Based Gene Editing to Study the Pathogenesis of Colon and Liver Cancer Using Organoids

Genetically modified organoids have been developed by sequential knockout and knockin of driver mutations by genome editing followed by niche-based selection.
[Hepatology International]
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Surface Oncology Announces New Randomized Phase II Clinical Study Evaluating SRF388 in Patients with First-Line Hepatocellular Carcinoma in Clinical Collaboration with Roche

Surface Oncology, an immuno-oncology company developing next-generation immunotherapies that target the tumor microenvironment, announced details about its plan to initiate a randomized Phase II clinical study evaluating SRF388, in combination with Roche’s atezolizumab and bevacizumab, in patients with treatment-naïve hepatocellular carcinoma.
[Surface Oncology]
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Conditions for Maintenance of Hepatocyte Differentiation and Function in 3D Cultures

Spheroid cultures of primary human hepatocytes are used in studies of hepatic drug metabolism and toxicity. The authors performed an in-depth analysis of the influence of various culture conditions to find the optimal conditions for the maintenance of an in vivo like phenotype.
[iScience]
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