Category Archives: Hepatic Cell

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A Rapid Juvenile Murine Model of Nonalcoholic Steatohepatitis (NASH): Chronic Intermittent Hypoxia Exacerbates Western Diet-Induced NASH

Researchers designed a study to establish a rapid juvenile murine NASH model, and determined whether the combination of chronic intermittent hypoxia and a western-style diet could fully display key pathologic features of NASH.

[Life Sciences]

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IL37 Overexpression Inhibits Autophagy and Apoptosis Induced by Hepatic Ischemia Reperfusion Injury via Modulating AMPK/mTOR/ULLK1 Signaling Pathways

Scientists investigated the potential role of IL37 in hepatic ischemia reperfusion injury and its underlying molecular mechanism.

[Life Sciences]

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S-Adenosylmethionine Upregulates the Angiotensin Receptor-Binding Protein ATRAP via the Methylation of HuR in NAFLD

The authors explored the effect of supplementary S-adenosylmethionine, which was the main biological methyl donor in mammalian cells, in regulating AT1R-associated protein (ATRAP), which was the negative regulator of AT1R.

[Cell Death & Disease]

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Liver Alanine Catabolism Promotes Skeletal Muscle Atrophy and Hyperglycaemia in Type 2 Diabetes

Researchers revealed a metabolic inter-tissue cross-talk that links skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.

[Nature Metabolism]

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A Tumor-Suppressive Circular RNA Mediates Uncanonical Integrin Degradation by the Proteasome in Liver Cancer

Investigators showed that polyadenylate-binding protein 1 (circPABPC1) was preferentially lost in tumor cells from clinical samples and inhibited both intrahepatic and distant metastases in a mouse xenograft model.

[Science Advances]

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DNA Damage Response Protein CHK2 Regulates Metabolism in Liver Cancer

Investigators showed that checkpoint kinase 2 (CHK2), a central effector of DNA damage response, regulated cellular energy production by affecting glycolysis and mitochondrial functions.

[Cancer Research]

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E3 Ubiquitin Ligase Grail Promotes Hepatic Steatosis through Sirt1 Inhibition

Scientists demonstrated that gene related to anergy in lymphocytes regulated the lipid accumulation in hepatic steatosis via interaction with sirtuin 1.

[Cell Death & Disease]

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LINC01419-Mediated Epigenetic Silencing of ZIC1 Promotes Metastasis in Hepatocellular Carcinoma through thePI3K/Akt Signaling Pathway

LINC01419 enhances the methylation of zinc finger of the cerebellum (ZIC1) promoter, inhibits ZIC1 expression, and activates the PI3K/Akt signaling pathway, thereby enhancing the malignant phenotypes of hepatocellular carcinoma cells in vitro as well as tumor formation and metastasis in vivo.

[Laboratory Investigation]

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Interferon Regulatory Factor 1 (IRF-1) Downregulates Checkpoint Kinase 1 (CHK1) through miR-195 to Upregulate Apoptosis and PD-L1 Expression in Hepatocellular Carcinoma (HCC) Cells

IRF-1 induces miR-195 to suppress CHK1 protein expression. Both increased IRF-1 and decreased CHK1 upregulate cellular apoptosis and PD-L1 expression in HCC.

[British Journal of Cancer]

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N-n-Butyl Haloperidol Iodide Ameliorates Liver Fibrosis and Hepatic Stellate Cell Activation in Mice

Researchers revealed that c-Jun was bound to the TGF-β receptor II (TGFBR2) promoter, whereas N-n-Butyl haloperidol iodide suppressed the binding of c-Jun to the TGFBR2 promoter to restrain TGF-β signaling and inhibit α-smooth muscle actin and collagen I upregulation.

[Acta Pharmacologica Sinica]