Direct Reprogramming of Human Umbilical Vein- and Peripheral Blood-Derived Endothelial Cells into Hepatic Progenitor Cells

Scientists showed that a set of three transcription factors, FOXA3, HNF1A, and HNF6, could induce human umbilical vein endothelial cells to directly acquire the properties of human hepatic progenitor cells.
[Nature Communications]
Inada, H., Udono, M., Matsuda-Ito, K., Horisawa, K., Ohkawa, Y., Miura, S., Goya, T., Yamamoto, J., Nagasaki, M., Ueno, K., Saitou, D., Suyama, M., Maehara, Y., Kumamaru, W., Ogawa, Y., Sekiya, S., & Suzuki, A. (2020). Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells. Nature Communications, 11(1), 5292. https://doi.org/10.1038/s41467-020-19041-z Cite
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The Unsung Heroes of the Nobel-Winning Hepatitis C Discovery

A tight-knit team of scientists worked feverishly to identify the deadly virus. Only one of them was awarded the Nobel.
[Nature News]
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ER-Resident Oxidoreductases Are Glycosylated and Trafficked to the Cell Surface to Promote Matrix Degradation by Tumor Cells

Investigators showed that GALA induced the glycosylation of the ER-resident calnexin (Cnx) in breast and liver cancer. Glycosylated Cnx and its partner ERp57 are trafficked to invadosomes, which are sites of ECM degradation.
[Nature Cell Biology]
Ros, M., Nguyen, A. T., Chia, J., Le Tran, S., Le Guezennec, X., McDowall, R., Vakhrushev, S., Clausen, H., Humphries, M. J., Saltel, F., & Bard, F. A. (2020). ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells. Nature Cell Biology, 1–11. https://doi.org/10.1038/s41556-020-00590-w Cite
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Preparation, Characterization and Therapeutic Properties of Gum Arabic-Stabilized Gallic Acid Nanoparticles

Gallic acid nanoparticles were evaluated for the in vitro cytotoxicity, cell uptake and cell migration in four types of human cancer cell lines including breast adenocarcinoma, HepG2 hepatocellular cancer, HT-29 colorectal adenocarcinoma, and MCF-10A breast epithelial cell lines.
[Scientific Reports]
Hassani, A., Azarian, M. M. S., Ibrahim, W. N., & Hussain, S. A. (2020). Preparation, characterization and therapeutic properties of gum arabic-stabilized gallic acid nanoparticles. Scientific Reports, 10(1), 17808. https://doi.org/10.1038/s41598-020-71175-8 Cite
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PDSS2-Del2, a New Variant of PDSS2, Promotes Tumor Cell Metastasis and Angiogenesis in Hepatocellular Carcinoma via Activating NF-κB

PDSS2‐Del2 levels correlated significantly with microvessel counts in hepatocellular carcinoma (HCC) tumor tissues. Importantly, PDSS2‐Del2 overexpression functionally promoted HCC metastasis as demonstrated by in vitro and in vivo migration assays.
[Molecular Oncology]
Zeng, T., Tang, Z., Liang, L., Suo, D., Li, L., Li, J., Yuan, Y., Guan, X.-Y., & Li, Y. (n.d.). PDSS2-Del2, a new variant of PDSS2, promotes tumor cell metastasis and angiogenesis in hepatocellular carcinoma via activating NF-κB. Molecular Oncology, n/a(n/a). https://doi.org/10.1002/1878-0261.12826 Cite
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Identification of Human Long Non-Coding RNAs Associated with Nonalcoholic Fatty Liver Disease and Metabolic Homeostasis

Scientists experimentally demonstrated the responsiveness of selected hepatic long non-coding (lnc)RNAs to defined metabolic milieus in a liver-specific humanized mouse model. By extracting a concise list of protein-coding genes that qwew persistently correlated with lncRNAs in general and nonalcoholic fatty liver disease populations, they predicted the specific function for each human lncRNA metabolic regulators.
[Journal of Clinical Investigation]
Ruan, X., Li, P., Ma, Y., Jiang, C., Chen, Y., Shi, Y., Gupta, N., Seifuddin, F., Pirooznia, M., Ohnishi, Y., Yoneda, N., Nishiwaki, M., Dumbovic, G., Rinn, J. L., Higuchi, Y., Kawai, K., Suemizu, H., & Cao, H. (2020). Identification of human long non-coding RNAs associated with nonalcoholic fatty liver disease and metabolic homeostasis. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI136336 Cite
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Evolutionary Conservation of Long Non-coding RNAs in Non-Alcoholic Fatty Liver Disease

The authors give a comprehensive catalogue of well reported lncRNAs in non-alcoholic fatty liver disease (NAFLD) and classify them using sequence and synteny-based evolutionary conservation across rodents, nonhuman primate and human species.
[Life Sciences]
Rohilla, S., Awasthi, A., Kaur, S., & Puria, R. (2020). Evolutionary conservation of long non-coding RNAs in non-alcoholic fatty liver disease. Life Sciences, 118560. https://doi.org/10.1016/j.lfs.2020.118560 Cite
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Hepatocyte-Intrinsic Type I Interferon Signaling Reprograms Metabolism and Reveals a Novel Compensatory Mechanism of the Tryptophan-Kynurenine Pathway in Viral Hepatitis

IFN-I specifically rewired tryptophan metabolism and induced hepatic tryptophan oxidation to kynurenine via Tdo2, correlating with altered concentrations of serum metabolites upon viral infection.
[PLoS Pathogens]
Lercher, A., Popa, A. M., Viczenczova, C., Kosack, L., Klavins, K., Agerer, B., Opitz, C. A., Lanz, T. V., Platten, M., & Bergthaler, A. (2020). Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis. PLOS Pathogens, 16(10), e1008973. https://doi.org/10.1371/journal.ppat.1008973 Cite
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hnRNPU Functions as a Novel Therapeutic Target of c‐Myc in the Progression of Hepatocellular Carcinoma

Mechanismly, c‐Myc regulated hnRNPU expression at the transcriptional level, and meanwhile hnRNPU stabilizes the mRNA of c‐MYC. Investigators found that the hnRNPU and c‐Myc regulatory loop exerted a synergistic effect on the proliferation and self‐renewal of hepatocellular carcinoma (HCC), and promoted the HCC progression.
[Febs Letters]
Zhang, B., Wang, H.-Y., Zhao, D.-X., Wang, D.-X., Zeng, Q., Xi, J.-F., Nan, X., He, L.-J., Zhou, J.-N., Pei, X.-T., & Yue, W. (n.d.). hnRNPU Functions as a Novel Therapeutic Target of c-Myc in the Progression of Hepatocellular Carcinoma. FEBS Letters, n/a(n/a). https://doi.org/10.1002/1873-3468.13943 Cite
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Mirum Pharmaceuticals Announces Partnership With EVERSANA to Support Launch and Commercialization of Maralixibat for Alagille Syndrome in the United States

Mirum Pharmaceuticals, Inc. announced it has partnered with EVERSANA™, a leading provider of commercial services to the life science industry, to lead the US market access, distribution and patient services for maralixibat.
[Mirum Pharmaceuticals, Inc.]
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Scientific Pioneers Recognized by 2020 Royal Society of Edinburgh Medals

The Royal Society of Edinburgh, Scotland’s National Academy, has announced the winners of its highly prestigious medals, which recognize exceptional achievement in science, academia and public engagement.
[The Royal Society of Edinburgh]
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