Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver

Mutation of the hepatocyte nuclear factor (HNF)-1 binding site significantly decreased the promoter activity in hepatocytes, and the promoter carrying the mutated HNF-1 site was not transactivated by co-transfection of HNF-1 in a non-hepatic cell line.
[Scientific Reports]
Watanabe, T., Ozawa, A., Masuda, S., Yoshino, S., Ishida, E., Kondo, Y., Matsumoto, S., Katano-Toki, A., Horiguchi, K., Nakajima, Y., Yamada, E., Tomaru, T., Saito, T., Ishii, S., Shibusawa, N., Okada, S., Satoh, T., & Yamada, M. (2020). Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver. Scientific Reports, 10(1), 9999. https://doi.org/10.1038/s41598-020-66570-0 Cite
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PD173074 Blocks G1/S Transition via CUL3-Mediated Ubiquitin Protease in HepG2 and Hep3B Cells

Researchers found fibroblast growth factor receptor 4 (FGFR4) was overexpressed in hepatocellular carcinoma cell lines HepG2 and Hep3B. They used PD173074, an FGFR4 inhibitor, to explore the role of FGFR4 and its underlying mechanism in these cell lines.
[PLoS One]
Qiao, C., Qian, H., Wang, J., Zhao, T., Ma, P., Wang, S., Zhang, T., & Liu, X. (2020). PD173074 blocks G1/S transition via CUL3-mediated ubiquitin protease in HepG2 and Hep3B cells. PLOS ONE, 15(6), e0234708. https://doi.org/10.1371/journal.pone.0234708 Cite
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Chronic Viral Liver Diseases: Approaching the Liver Using T Cell Receptor-Mediated Gene Technologies

Investigators give an overview of T cell receptors identified from viral hepatitis research and discuss how translational lessons learned from cancer immunotherapy can be applied to the field.
[Cells]
Healy, K., Pasetto, A., Sobkowiak, M. J., Soon, C. F., Cornberg, M., Aleman, S., & Chen, M. S. (2020). Chronic Viral Liver Diseases: Approaching the Liver Using T Cell Receptor-Mediated Gene Technologies. Cells, 9(6), 1471. https://doi.org/10.3390/cells9061471 Cite
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Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
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Apatinib Prevents Natural Killer Cell Dysfunction to Enhance the Efficacy of Anti-PD-1 Immunotherapy in Hepatocellular Carcinoma

Using a syngeneic hepatoceullar carcinoma (HCC) mouse model, the authors demonstrated that treatment with apatinib resulted in attenuation of tumor growth and increased tumor vessel normalization. Results indicated that NK cells, but not CD4+ or CD8+ T cells mediated the therapeutic efficacy of apatinib in HCC mouse models.
[Cancer Gene Therapy]
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Delivery of Oligonucleotides to the Liver with GalNAc – From Research to Registered Therapeutic Drug

Scientists highlight some of the recent chemistry and preclinical advances in this space leading to this large number of clinical candidates against a diverse range of targets in liver hepatocytes.
[Molecular Therapy]
Bae, M., Lee, Y., Pham, T. X., Hu, S., Park, Y.-K., & Lee, J.-Y. (2020). Astaxanthin inhibits the reduction of glycolysis during the activation of hepatic stellate cells. Life Sciences, 256, 117926. https://doi.org/10.1016/j.lfs.2020.117926 Cite
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Astaxanthin Inhibits the Reduction of Glycolysis during the Activation of Hepatic Stellate Cells

Compared with quiescent hepatic stellate cells (HSCs), activated HSCs (aHSCs) had significantly lower expression of glucose transporter 1, the major glucose transporter in HSCs, and its transcription factor hypoxia-inducible factor 1α, which was markedly increased by astaxanthin in aHSCs.
[Life Sciences]
Bae, M., Lee, Y., Pham, T. X., Hu, S., Park, Y.-K., & Lee, J.-Y. (2020). Astaxanthin inhibits the reduction of glycolysis during the activation of hepatic stellate cells. Life Sciences, 256, 117926. https://doi.org/10.1016/j.lfs.2020.117926 Cite
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Hydrazinocurcumin and 5-Fluorouracil Enhance Apoptosis and Restrain Tumorigenicity of HepG2 Cells via Disrupting the PTEN-Mediated PI3K/Akt Signaling Pathway

Scientists investigated the role and mechanism of hydrazinocurcumin (HZC) in regulating HepG2 cell apoptosis and tumorigenicity, and its synergistic effects with 5-fluorouracil (5-Fu). HepG2 cells were treated with HZC and/or 5-Fu to analyze the possible synergistic effects on cell proliferation, apoptosis and cell cycle distribution in vitro using EdU staining.
[Biomedicine & PharmacoTherapy]
Zhou, Y., Zhang, M., Zhang, Z., Jia, Y., Zhang, C., & Peng, L. (2020). Hydrazinocurcumin and 5-fluorouracil enhance apoptosis and restrain tumorigenicity of HepG2 cells via disrupting the PTEN-mediated PI3K/Akt signaling pathway. Biomedicine & Pharmacotherapy, 129, 109851. https://doi.org/10.1016/j.biopha.2020.109851 Cite
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SOX9 Enhances Sorafenib Resistance through Upregulating ABCG2 Expression in Hepatocellular Carcinoma

The authors found that sorafenib treatment increased the proportion of SOX9 positive cells in hepatocellular carcinoma (HCC) cell lines. Overexpression of exogenous SOX9 in HCC increased sorafenib resistance both in vitro and in vivo, whereas down-regulation led to inhibition of sorafenib resistance.
[Biomedicine & PharmacoTherapy]
Wang, M., Wang, Z., Zhi, X., Ding, W., Xiong, J., Tao, T., Yang, Y., Zhang, H., Zi, X., Zhou, W., & Huang, G. (2020). SOX9 enhances sorafenib resistance through upregulating ABCG2 expression in hepatocellular carcinoma. Biomedicine & Pharmacotherapy, 129, 110315. https://doi.org/10.1016/j.biopha.2020.110315 Cite
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Anti-Inflammatory, Hepatoprotective and Antioxidant Activity of Ellagitannin Isolated from Melaleuca styphelioides

The hepatoprotective activity of styphelioidin was tested using the CCl4-challenged HepG2 cell model by measuring alanine aminotransferase and aspartate aminotransferase levels in HepG2 cells treated with styphelioidin for one hour followed by 40 mM CCl4.
[Phytochemistry]
Al-Sayed, E., Korinek, M., Esmat, A., Chen, G.-Y., Cheng, Y.-B., Hsieh, P.-W., Chen, B.-H., & Hwang, T.-L. (2020). Anti-inflammatory, hepatoprotective and antioxidant activity of ellagitannin isolated from Melaleuca styphelioides. Phytochemistry, 177, 112429. https://doi.org/10.1016/j.phytochem.2020.112429 Cite
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