Researchers found that suppression of EGFR signaling promoted liver progenitor cell‐to‐hepatocyte differentiation via the MEK‐ERK‐SOX9 cascade.
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Mechanism dissection revealed that miR-92a-2-5p from the exosomes could target the 3′UTR of androgen receptor (AR) mRNA to suppress AR translation, altering the PHLPP/p-AKT/β-catenin signaling to increase liver cancer cells invasion.
[Cell Death & Differentiation]
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Liu, G., Ouyang, X., Sun, Y., Xiao, Y., You, B., Gao, Y., Yeh, S., Li, Y., & Chang, C. (2020). The miR-92a-2-5p in exosomes from macrophages increases liver cancer cells invasion via altering the AR/PHLPP/p-AKT/β-catenin signaling. Cell Death & Differentiation, 1–15. https://doi.org/10.1038/s41418-020-0575-3 Cite
Scientists found that luteolin (20 μM) + lycopene (10 μM) was the best therapeutic combination in sodium palmitate (PA)-induced HepG2 cells, and significantly improved cell viability and lipid accumulation in PA-induced HepG2 cells and primary hepatocytes.
Researchers explored the relationship between the relevant regulatory factors and the epithelial-mesenchymal transition signaling pathways in the various intrahepatic cells.
[Biomedicine & PharmacoTherapy]
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Using in vitro and in vivo approaches, the authors evaluated apoptosis and lipid metabolism. IFN-α-2b induced changes in hepatic cholesterol mass due to decreased synthesis and increased secretion.
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Quiroga, A. D., Vera, M. C., Ferretti, A. C., Lucci, A., Comanzo, C. G., Lambertucci, F., Ceballos, M. P., & Carrillo, M. C. (2020). IFN-α-2b induces apoptosis by decreasing cellular cholesterol levels in rat preneoplastic hepatocytes. Cytokine, 133, 155172. https://doi.org/10.1016/j.cyto.2020.155172 Cite
The roles of calcium silicate (CS)-activated H9 cells in liver injury repair were tested by cell tracking and immunohistochemical staining. Results indicated that high concentrations of CS extracts initially enhanced definitive endodermal (DE) lineage, followed by gradual DE differentiation at low CS concentrations.
[Applied Materials Today]
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Zheng, L., Lü, D., Zhang, F., Xing, M., Wang, X., Jia, X., Shu, X., Li, P., Lü, S., Chang, J., & Long, M. (2020). Regulation of hepatic differentiation of human embryonic stem cells by calcium silicate extracts for liver injury repairing. Applied Materials Today, 20, 100730. https://doi.org/10.1016/j.apmt.2020.100730 Cite
Assembly Biosciences, Inc. have announced the initiation of a Phase II trial of their potent, second-generation core inhibitor, ABI-H2158, for patients with HBeAg positive chronic hepatitis B infection without cirrhosis.
[Assembly Biosciences, Inc.]
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Assembly Biosciences Initiates Phase 2 Trial Evaluating Second-Generation Core Inhibitor ABI-H2158 for Chronic Hepatitis B Infection : Assembly Biosciences, Inc. (n.d.). Retrieved June 26, 2020, from https://investor.assemblybio.com/news-releases/news-release-details/assembly-biosciences-initiates-phase-2-trial-evaluating-second Cite
Celsion Corporation have affirmed that the independent data monitoring mommittee is scheduled to meet during the first half of July to conduct the second pre-planned interim safety and efficacy analysis of the Phase III OPTIMA Study with ThermoDox® plus radiofrequency ablation in patients with hepatocellular carcinoma, or primary liver cancer.
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Celsion Affirms July Timing for Second Interim Analysis of the Phase III OPTIMA Study of ThermoDox® in Primary Liver Cancer | Celsion Corporation. (n.d.). Retrieved June 26, 2020, from https://investor.celsion.com/news-releases/news-release-details/celsion-affirms-july-timing-second-interim-analysis-phase-iii Cite
Researchers investigated whether hepatocyte-derived miR-200b-3p governed angiogenesis in hepatocellular carcinoma (HCC) by targeting endothelial erythroblast transformation-specific-related gene (ERG).
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Scientists showed that tumor vascular function as well as pericyte coverage was significantly impaired in mice with conditional knockout of platelet-derived growth factor (PDGFB) in platelets.
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On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.