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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
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Metabolic Reprogramming through PIM3 Inhibition Reverses Hypoxia-Induced CAR-T Cell Dysfunction in Solid Tumors
[Journal of Translational Medicine] The authors identified PIM3 as a previously underexplored target that links hypoxia to CAR-T cell dysfunction and demonstrates that PIM3 inhibition can reverse these effects.
Tumor-Associated Macrophages Produce PGE2 to Promote CD8+ T Cell Exhaustion and Drive Resistance to PD-L1 Blockade in Microsatellite Stable Colorectal Cancer
[Cancer Research] Scientists sought to better understand the mechanisms of resistance to anti-PD-L1 therapy in colorectal cancer by characterizing the immune profiles of microsatellite stable and microsatellite instable tumor models.
Strategies to Enhance CAR-T Cell Persistence in Hematologic Malignancies: From Molecular Design to Clinical Optimization
[American Journal of Hematology] The authors examine current strategies to enhance CAR-T cell durability, focusing on recent advances in CAR structural design, gene editing techniques, ex vivo culture optimization, clinical management approaches, and in vivo preparation.
Tetraspanin 13 Enhances Immune Evasion in Breast Cancer by Promoting MHC-I Degradation
[Cancer Research] Scientists identified a role for tetraspanin 13 in regulating major histocompatibility complex class I expression on the surface of tumor cells, which is required for the recognition of tumor-specific antigens by CD8+ T cells.
Cancer Suppresses Mitochondrial Chaperone Activity in Macrophages to Drive Immune Evasion
[Nature Immunology] Researchers identified TNF receptor-associated protein-1 (TRAP1), a mitochondrial HSP90 chaperone, as a metabolic checkpoint that restrains oxidative respiration and limits macrophage suppressive function.
Neutrophils and Neutrophil Extracellular Traps: Double-Edged Swords in Cancer Pathophysiology and Therapy Resistance
[Cell Communication and Signaling] Neutrophils have garnered focus in cancer research due to their participation in cancer initiation, proliferation and metastasis. As important players in the tumor microenvironment, tumor-associated neutrophils are viewed as “a double-edged sword” in cancer pathophysiology.
Interferon Regulatory Factor 1 Enhances T Cell Differentiation in Patients with Myasthenia Gravis
[Neural Regeneration Research] The authors explored the function of interferon regulatory factor 1 in myasthenia gravis, with an aim to understand the underlying mechanisms.
Peanut Allergy Oral Immunotherapy Drives Single-Cell Multi-Omic Changes in Peanut-Reactive T Cells Associated with Sustained Unresponsiveness
[Nature Immunology] Researchers analyzed single-cell RNA and protein immunophenotypes and T cell receptor repertoires of peanut reactive CD4+ T cells from a Phase II peanut oral immunotherapy trial cohort.
New Power in Cancer Immunotherapy: The Rise of Chimeric Antigen Receptor Macrophage (CAR-M)
[Journal of Translational Medicine] Scientists highlight the construction strategies and preclinical and clinical studies of CAR-engineered macrophages, introduce the anti-tumor mechanisms, and discuss their advantages and disadvantages compared with other CAR-engineered effector cells.
Genome-Edited Allogeneic CAR-T Cells: The Next Generation of Cancer Immunotherapies
[Journal of Hematology & Oncology] The authors summarize the progress of universal allogeneic CAR-T cell therapies, addresses the critical challenges, and discusses the future directions for their clinical implementation.
Single-Cell Analysis of Human Thymus and Peripheral Blood Unveils the Dynamics of T Cell Development and Aging
[Nature Aging] Using single-cell sequencing, scientists analyzed 387,762 cells from human thymus and peripheral blood of young and aged individuals. Aged thymus were enriched in mature T cells with low SOX4 expression and inflammatory profiles but depleted of thymic epithelial cells and expression of tissue-restricted antigens.
Structural Immunity: Immune Cells As Architects of Tissue Barriers
[Nature Reviews Immunology] Scientists place independent findings from several groups into a working model of immune cells as the architects of tissue barriers, to present a framework on which new concepts and findings in this area can develop.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
