Suppressive Myeloid Cells Are Expanded by Biliary Tract Cancer-Derived Cytokines In Vitro and Associate with Aggressive Disease

Activated signaling pathways and cytokine production were evaluated in a panel of human biliary tract cancer (BTC) cell lines. Human peripheral blood mononuclear cells were cultured with BTC supernatants, with and without cytokine neutralising antibodies, and analysed by flow cytometry or immunoblot.
[British Journal of Cancer]
Ware, M. B., Zaidi, M. Y., Yang, J., Turgeon, M. K., Krasinskas, A., Mace, T. A., Keenan, K., Farren, M. R., Ruggieri, A. N., Li, Y., Zhang, C., Chen, Z., Young, G. S., Elnaggar, O., Che, Z., Maithel, S. K., Bekaii-Saab, T., El-Rayes, B., & Lesinski, G. B. (2020). Suppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease. British Journal of Cancer, 1–10. https://doi.org/10.1038/s41416-020-1018-0 Cite
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Follicular Helper T Cell Profiles Predict Response to Costimulation Blockade in Type 1 Diabetes

Unbiased bioinformatics analysis identified that inducible costimulatory molecule (ICOS)+ folliular helper T cells and other ICOS+ populations, including peripheral helper T cells, were highly sensitive to costimulation blockade.
[Nature Immunology]
Edner, N. M., Heuts, F., Thomas, N., Wang, C. J., Petersone, L., Kenefeck, R., Kogimtzis, A., Ovcinnikovs, V., Ross, E. M., Ntavli, E., Elfaki, Y., Eichmann, M., Baptista, R., Ambery, P., Jermutus, L., Peakman, M., Rosenthal, M., & Walker, L. S. K. (2020). Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0744-z Cite
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Single-Cell Atlas of Colonic CD8+ T Cells in Ulcerative Colitis

Scientists compiled an unbiased atlas of human colonic CD8+ T cells in health and ulcerative colitis using single-cell transcriptomics with T-cell receptor repertoire analysis and mass cytometry.
[Nature Medicine]
Corridoni, D., Antanaviciute, A., Gupta, T., Fawkner-Corbett, D., Aulicino, A., Jagielowicz, M., Parikh, K., Repapi, E., Taylor, S., Ishikawa, D., Hatano, R., Yamada, T., Xin, W., Slawinski, H., Bowden, R., Napolitani, G., Brain, O., Morimoto, C., Koohy, H., & Simmons, A. (2020). Single-cell atlas of colonic CD8 + T cells in ulcerative colitis. Nature Medicine, 1–11. https://doi.org/10.1038/s41591-020-1003-4 Cite
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LW-213 Induces Cell Apoptosis in Human Cutaneous T-cell Lymphomas by Activating PERK–eIF2α–ATF4–CHOP Axis

Researchers showed that LW-213 dose-dependently inhibited human cutaneous T-cell lymphoma cell lines with IC50 values of around 10 μM, meanwhile it potently inhibited primary leukemia cells derived from peripheral blood of T-cell lymphoma patients.
[Acta Pharmacologica Sinica]
Yu, X., Zhu, M., Wang, J., Li, H., Hu, P., Qing, Y., Wang, X., Wang, H., Wang, Z., Xu, J., Guo, Q., & Hui, H. (2020). LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK–eIF2α–ATF4–CHOP axis. Acta Pharmacologica Sinica, 1–11. https://doi.org/10.1038/s41401-020-0466-7 Cite
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Comparative Effects of Graphene and Molybdenum Disulfide on Human Macrophage Toxicity

M1 and M2 macrophage viability and activation were mainly found to be unaffected by few‐layer graphene and MoS2 at doses up to 50 µg mL−1.
[Small]
Lin, H., Ji, D.-K., Lucherelli, M. A., Reina, G., Ippolito, S., Samorì, P., & Bianco, A. (n.d.). Comparative Effects of Graphene and Molybdenum Disulfide on Human Macrophage Toxicity. Small, n/a(n/a), 2002194. https://doi.org/10.1002/smll.202002194 Cite
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Genmab Announces European Myeloma Network and Janssen Achieve Positive Topline Results from Phase III APOLLO Study of Daratumumab in Combination with Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

Genmab A/S announced that the European Myeloma Network in collaboration with Janssen Research & Development, LLC reported positive results from the Phase III APOLLO study of the subcutaneous formulation of daratumumab in combination with pomalidomide and dexamethasone (Pd) versus Pd alone as treatment for patients with relapsed or refractory multiple myeloma who have previously been treated with lenalidomide and a proteasome inhibitor.
[Genmab A/S]
Press Release

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FDA Approves Monjuvi® (Tafasitamab-cxix) in Combination with Lenalidomide for the Treatment of Adult Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

MorphoSys AG and Incyte announced that the FDA has approved Monjuvi in combination with lenalidomide for the treatment of adult patients with relapsed or refractory DLBCL not otherwise specified, including DLBCL arising from low grade lymphoma, and who are not eligible for autologous stem cell transplant.
[MorphoSys AG]
Press Release

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Engineering CAR-T Cells for Next-Generation Cancer Therapy

Investigators highlight recent strategies to improve chimeric antigen therapy (CAR)-T cell therapy by engineering the CAR protein, T cells, and the interaction between T cells and other components in the tumor microenvironment.
[Cancer Cell]
Hong, M., Clubb, J. D., & Chen, Y. Y. (2020). Engineering CAR-T Cells for Next-Generation Cancer Therapy. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.07.005 Cite
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MSCs-Released TGFβ1 Generate CD4+CD25+Foxp3+ in T-Reg Cells of Human SLE PBMC

The authors used a post-test control group design. MSCs were obtained from human umbilical cord blood and characterized according to their surface antigen expression and multilineage differentiation capacities.
[Journal of the Formosan Medical Association]
Darlan, D. M., Munir, D., Putra, A., & Jusuf, N. K. (2020). MSCs-released TGFβ1 generate CD4+CD25+Foxp3+ in T-reg cells of human SLE PBMC. Journal of the Formosan Medical Association. https://doi.org/10.1016/j.jfma.2020.06.028 Cite
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Alteration of Immunophenotype of Human Macrophages and Monocytes after Exposure to Cigarette Smoke

Using human monocyte-derived macrophages (MDMs) from healthy donors, researchers found that cigarette smoke exposure was not associated with significant changes in the production of pro inflammatory cytokines by MDMs.
[Scientific Reports]
da Silva, C. O., Gicquel, T., Daniel, Y., Bártholo, T., Vène, E., Loyer, P., Pôrto, L. C., Lagente, V., & Victoni, T. (2020). Alteration of immunophenotype of human macrophages and monocytes after exposure to cigarette smoke. Scientific Reports, 10(1), 12796. https://doi.org/10.1038/s41598-020-68753-1 Cite
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An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

Researchers present a global map of cysteines in primary human T cells that are susceptible to covalent modification by electrophilic small molecules.
[Cell]
da Silva, C. O., Gicquel, T., Daniel, Y., Bártholo, T., Vène, E., Loyer, P., Pôrto, L. C., Lagente, V., & Victoni, T. (2020). Alteration of immunophenotype of human macrophages and monocytes after exposure to cigarette smoke. Scientific Reports, 10(1), 12796. https://doi.org/10.1038/s41598-020-68753-1 Cite
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The Immunology of Renal Cell Carcinoma

Renal cell carcinoma is considered to be an immunogenic tumor but is known to mediate immune dysfunction in large part by eliciting the infiltration of immune-inhibitory cells, such as regulatory T cells and myeloid-derived suppressor cells, into the tumor microenvironment.
[Nature Reviews Nephrology]
Díaz-Montero, C. M., Rini, B. I., & Finke, J. H. (2020). The immunology of renal cell carcinoma. Nature Reviews Nephrology, 1–15. https://doi.org/10.1038/s41581-020-0316-3 Cite
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