Early-Onset Autoimmunity Associated with SOCS1 Haploinsufficiency

By whole-exome/genome sequencing scientists identified heterozygous, autosomal-dominant, germline loss-of-function mutations in the SOCS1 gene in ten patients from five unrelated families with early onset autoimmune manifestations.
[Nature Communications]
Hadjadj, J., Castro, C. N., Tusseau, M., Stolzenberg, M.-C., Mazerolles, F., Aladjidi, N., Armstrong, M., Ashrafian, H., Cutcutache, I., Ebetsberger-Dachs, G., Elliott, K. S., Durieu, I., Fabien, N., Fusaro, M., Heeg, M., Schmitt, Y., Bras, M., Knight, J. C., Lega, J.-C., … Rieux-Laucat, F. (2020). Early-onset autoimmunity associated with SOCS1 haploinsufficiency. Nature Communications, 11(1), 5341. https://doi.org/10.1038/s41467-020-18925-4 Cite
Full Article
Bookmark

No account yet? Register

0
Share

A Trispecific Killer Engager Molecule Against CLEC12A Effectively Induces NK-Cell Mediated Killing of AML Cells

To target acute myeloid leukemia blasts and leukemic stem cells using natural killer (NK) cells, scientists developed a trispecific killer engager molecule containing a humanized anti-CD16 heavy chain camelid single-domain antibody that activates NK cells.
[Leukemia]
Arvindam, U. S., van Hauten, P. M. M., Schirm, D., Schaap, N., Hobo, W., Blazar, B. R., Vallera, D. A., Dolstra, H., Felices, M., & Miller, J. S. (2020). A trispecific killer engager molecule against CLEC12A effectively induces NK-cell mediated killing of AML cells. Leukemia, 1–11. https://doi.org/10.1038/s41375-020-01065-5 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Exosomal LGALS9 in the Cerebrospinal Fluid of Glioblastoma Patients Suppressed Dendritic Cell Antigen Presentation and Cytotoxic T-Cell Immunity

Researchers found that glioblastoma multiforme-cerebrospinal fluid-exosomes (GBM-CSF-Exos) contained a unique protein, LGALS9 ligand, which bound to the TIM3 receptor of dendritic cells (DCs) in the CSF to inhibit antigen recognition, processing and presentation by DCs, leading to failure of the cytotoxic T-cell-mediated antitumor immune response.
[Cell Death & Disease]
Wang, M., Cai, Y., Peng, Y., Xu, B., Hui, W., & Jiang, Y. (2020). Exosomal LGALS9 in the cerebrospinal fluid of glioblastoma patients suppressed dendritic cell antigen presentation and cytotoxic T-cell immunity. Cell Death & Disease, 11(10), 1–16. https://doi.org/10.1038/s41419-020-03042-3 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Mesenchymal Stem Cells: a Potential Treatment Approach for Refractory Chronic Spontaneous Urticaria

Scientists found that the T cell subsets and inflammatory molecules were not affected by MSC treatment during the follow-up period. In control patients, a significant decrease was detected only at the Th2 subset, TGF-β1, PGE2, IDO and anti-FcεRI levels on the 14th day of treatment.
[Stem Cell Reviews and Reports]
Özgül Özdemir, R. B., Özdemir, A. T., Kırmaz, C., Ovalı, E., Ölmez, E., Kerem, H., Evrenos, M. K., & Deniz, G. (2020). Mesenchymal Stem Cells: a Potential Treatment Approach for Refractory Chronic Spontaneous Urticaria. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10059-w Cite
Abstract
Bookmark

No account yet? Register

0
Share

Immune Receptor Inhibition through Enforced Phosphatase Recruitment

Researchers present an alternative approach for attenuating cell-surface receptor signaling, termed receptor inhibition by phosphatase recruitment.
[Nature]
Immune receptor inhibition through enforced phosphatase recruitment | Nature. (n.d.). Retrieved October 21, 2020, from https://www.nature.com/articles/s41586-020-2851-2#Abs1 Cite
Abstract
Bookmark

No account yet? Register

0
Share

TGF-β Suppresses Type 2 Immunity to Cancer

The authors showed that depletion of transforming growth factor-β receptor 2 (TGFβR2) in CD4+ T cells, but not CD8+ T cells, halts cancer progression as a result of tissue healing and remodeling of the blood vasculature, causing cancer cell hypoxia and death in distant avascular regions.
[Nature]
Liu, M., Kuo, F., Capistrano, K. J., Kang, D., Nixon, B. G., Shi, W., Chou, C., Do, M. H., Stamatiades, E. G., Gao, S., Li, S., Chen, Y., Hsieh, J. J., Hakimi, A. A., Taniuchi, I., Chan, T. A., & Li, M. O. (2020). TGF-β suppresses type 2 immunity to cancer. Nature, 1–6. https://doi.org/10.1038/s41586-020-2836-1 Cite
AbstractPress Release
Bookmark

No account yet? Register

0
Share

ASLAN Pharmaceuticals to Develop ASLAN003 as Next Generation DHODH Inhibitor in Autoimmune Conditions

ASLAN Pharmaceuticals announced that it plans to develop ASLAN003, its next generation inhibitor of dihydroorotate dehydrogenase, in autoimmune conditions, such as multiple sclerosis.
[ASLAN Pharmaceuticals]
Press Release
Bookmark

No account yet? Register

0
Share

tPA Mobilizes Immune Cells that Exacerbate Hemorrhagic Transformation in Stroke

Scientists determined the impact of tissue plasminogen activator (tPA) on immune cells and investigated the association between observed immune alteration with hemorrhagic transformation in ischemic stroke patients and in a rat model of embolic stroke.
[Circulation Research]
Shi Kaibin, Zou Ming, Jia Dong-mei, Shi Samuel, Yang Xiaoxia, Liu Qiang, Dong Jingfei, Sheth Kevin N, Wang Xiaoying, & Shi Fu-Dong. (n.d.). tPA Mobilizes Immune Cells that Exacerbate Hemorrhagic Transformation in Stroke. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.120.317596 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Naive CD8+ T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity

Using mass cytometry, scientists uncovered a naive CD8+ T cell population expressing CD95 that was enriched in patients with high compared with low cardiovascular disease.
[Arteriosclerosis Thrombosis and Vascular Biology]
Padgett Lindsey E., Dinh Huy Q., Wu Runpei, Gaddis Dalia E., Araujo Daniel J., Winkels Holger, Nguyen Anh, McNamara Coleen A., & Hedrick Catherine C. (n.d.). Naive CD8+ T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity. Arteriosclerosis, Thrombosis, and Vascular Biology, 0(0), ATVBAHA.120.315106. https://doi.org/10.1161/ATVBAHA.120.315106 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Immunomodulatory Activity of IR700-Labelled Affibody Targeting HER2

Irradiating a co-culture of immature dendritic cells (DCs) and cancer cells exposed to light-activated ZHER2:2395-IR700 enhanced DC maturation, as indicated by augmented expression of CD86 and HLA-DR.
[Cell Death & Disease]
Immunomodulatory activity of IR700-labelled affibody targeting HER2 | Cell Death & Disease. (n.d.). Retrieved October 20, 2020, from https://www.nature.com/articles/s41419-020-03077-6 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Identification of Immune Landscape Signatures Associated with Clinical and Prognostic Features of Hepatocellular Carcinoma

Investigators combined immune landscape signatures with hepatocellular carcinoma clinical and prognostic features to classify them into distinct subtypes. The immunogenomic profiles, stromal cell features and immune cell composition of the subtypes were then systematically analyzed.
[Aging]
Aging | Identification of immune landscape signatures associated with clinical and prognostic features of hepatocellular carcinoma - Full Text. (n.d.). Retrieved October 20, 2020, from https://www.aging-us.com/article/103977/text Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share