Machine Learning Identification of Specific Changes in Myeloid Cell Phenotype during Bloodstream Infections

An eight-color antibody panel was used to identify seven monocyte and two dendritic cell subsets. In the learning cohort, immunophenotyping was applied to control subjects, postoperative heart surgery patients, as a model of noninfectious inflammatory responses, and blood culture-positive patients.
[Scientific Reports]
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Single-Cell Profiling Reveals the Importance of CXCL13/CXCR5 Axis Biology in Lymphocyte-Rich Classic Hodgkin Lymphoma

Researchers examined the immune cell profile of eight cell suspension samples of Lymphocyte-rich classic Hodgkin lymphoma (LR-CHL) in comparison to 20 samples of the mixed cellularity and nodular sclerosis subtypes of CHL.
[Proceedings of the National Academy of Sciences of the United States of America]
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Activation of Toll-Like Receptor 2 Enhances Peripheral and Tumor-Infiltrating CD8+ T Cell Cytotoxicity in Patients with Gastric Cancer

Scientists investigated the regulation of TLR activation to CD8+ T cells has not been fully elucidated in gastric cancer.
[BMC Immunology]
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Mechanism of Neutrophil Extracellular Traps Generation and Their Role in Trophoblast Apoptosis in Gestational Diabetes Mellitus

The authors revealed the mechanism of neutrophil extracellular traps generation and their role in trophoblast apoptosis in gestational diabetes mellitus.
[Cellular Signalling]
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CAR T Cells with Dual Targeting of CD19 and CD22 in Pediatric and Young Adult Patients with Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia: A Phase I Trial

Scientists conducted a Phase I trial in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia to test AUTO3, autologous transduced T cells expressing both anti-CD19 and anti-CD22 CARs.
[Nature Medicine]
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Trellis Rx Furthers Commitment to Advancing the Specialty Pharmacy Practice and Patient Outcomes with Integration of Scipher Medicine® PrismRA® Precision-Medicine Technology into Clinical Pathways

Researchers announced the integration of PrismRA® into its clinical pathway for patients living with rheumatoid arthritis. Scipher Medicine, the manufacturer of PrismRA, is a precision immunology company helping providers determine the most effective therapy for their patients.
[Trellis Rx (BusinessWire, Inc.)]
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Phase II Evaluation of Stereotactic Ablative Radiotherapy (SABR) and Immunity in 11C-Choline-PET/CT-Identified Oligometastatic Castration-Resistant Prostate Cancer

Stereotactic ablative radiotherapy induces anti-tumor immunity in clinical and preclinical studies, but immunological biomarkers are lacking.
[Clinical Cancer Research]
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Eosinophil Extracellular Traps Drive Asthma Progression through Neuro-Immune Signals

Scientists showed that eosinophil extracellular traps in bronchoalveolar lavage fluid are associated with the severity of asthma in patients.
[Nature Cell Biology]
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Hallmarks of Response, Resistance, and Toxicity to Immune Checkpoint Blockade

Our understanding of the impact of host-intrinsic factors has evolved substantially over the past decade, with greater insights on these factors and on tumor and immune co-evolution.
[Cell]
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Immunoregulation by Type I Interferons in the Peritoneal Cavity

The authors provide an overview of the major immune cell populations that reside in the peritoneal cavity and highlight their contribution to the initiation, progression, or resolution of peritoneal diseases.
[Journal of Leukocyte Biology]
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ENHERTU® (Fam-Trastuzumab Deruxtecan-nxki) Granted Breakthrough Therapy Designation in US for Patients with HER2-Positive Metastatic Breast Cancer Treated with One or More Prior Anti-HER2-Based Regimens

The FDA has granted ENHERTU® Breakthrough Therapy Designation in the US for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received one or more prior anti-HER2-based regimens.
[FDA (BusinessWire, Inc.)]
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