Physiological Levels of 25-Hydroxyvitamin D3 Induce a Suppressive CD4+ T Cell Phenotype Not Reflected in the Epigenetic Landscape

The authors analyzed the influence of its precursor 25-hydroxyvitamin D3 on the differentiation of human CD4+ T cells applying physiological concentrations in vitro.
[Scandinavian Journal of Immunology]
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OSE Immunotherapeutics Receives First Notice of Allowance of a Patent for Use of Tedopi® after Failure with PD-1 or PD-L1 Immune Checkpoint Inhibitor Treatment in HLA-A2 Positive Cancer Patients

OSE Immunotherapeutics SA announced that the Japanese Patent Office has issued the notice of allowance for a new patent covering Tedopi®, a combination of neoepitopes, for use after failure with PD-1 or PD-L1 immune checkpoint inhibitor treatment in HLA-A2 positive cancer patients.
[OSE Immunotherapeutics SA]
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LRG1: An Emerging Player in Disease Pathogenesis

Emphasis is given to the role that leucine-rich α-2 glycoprotein 1 (LRG1) plays as a vasculopathic factor where it disrupts the cellular interactions normally required for the formation and maintenance of mature vessels, thereby indirectly contributing to the establishment of a highly hypoxic and immunosuppressive microenvironment.
[Journal of Biomedical Science]
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Tissue-Resident Immune Cells in Humans

Scientists propose a five-point checklist for defining resident immune cell types in humans and describe the currently known features of resident immune cells, their mechanisms of development, and their putative functional roles within various human organs.
[Annual Reviews of Immunology]
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Tumor Microenvironment and Its Clinicopathological and Prognostic Associations in Surgically Resected Cutaneous Angiosarcoma

Pretreated specimens were evaluated by immunohistochemistry for programmed cell death protein 1 and its ligand, densities of tumor infiltrative lymphocytes, as well as c-MYC and Ki-67 expressions.
[Clinical and Translational Oncology]
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NK Cells in the Brain: Implications for Brain Tumor Development and Therapy

Natural killer (NK) cells lend themselves to off-the-shelf applications owing to their favorable safety profile and retained efficacy in an allogeneic setting.
[Trends in Molecular Medicine]
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Proximity of Immune and Tumor Cells Underlies Response to BRAF/MEK-Targeted Therapies in Metastatic Melanoma Patients

In a TCGA-melanoma dataset, tumor cellularity exhibited additive prognostic value in the immune score signature to predict overall survival in patients with early-stage melanoma.
[npj Precision Oncology]
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Single‐Cell Immune Mapping of Melanoma Sentinel Lymph Nodes Reveals an Actionable Immunotolerant Microenvironment

Researchers used mass cytometry by time-of-flight, flow cytometry, and T cell receptor immunosequencing to conduct simultaneous single-cell analyses of immune cells in the sentinel lymph nodes of melanoma patients.
[Clinical Cancer Research]
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First Patient Dosed in Phase I/IIa Trial of Lung Cancer Immunotherapy Vaccine

Cancer Research UK, Vaccitech plc and the Ludwig Institute for Cancer Research, announced the first patient dosed in the MAGE trial, which is testing a novel immunotherapeutic, VTP-600, in patients with the most common type of lung cancer.
[Ludwing Cancer Research]
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Development of the Immune System in the Human Embryo

Fetal B-1 and B-2 B cells involved in innate and adaptive immune responses, respectively, arise in staggered waves of development from distinct progenitors.
[Pediatric Research]
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Evaxion Biotech Receives Regulatory Clearance to Initiate Phase II Trial of EVX-01 in Combination with KEYTRUDA® for Treatment of Melanoma

Evaxion Biotech A/S announced it received clearance from the Australia Therapeutic Goods Administration to initiate a Phase IIb trial of its patient specific cancer immunotherapy EVX-01 in combination with Merck & Co., Inc.’s anti-PD-1 therapy KEYTRUDA®.
[Evaxion Biotech A/S]
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